alprenolol has been researched along with desipramine in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (36.84) | 18.7374 |
| 1990's | 1 (2.63) | 18.2507 |
| 2000's | 14 (36.84) | 29.6817 |
| 2010's | 9 (23.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Danelian, E; Hämäläinen, MD; Hansson, A; Karlén, A; Karlsson, R; Lennernäs, H; Löfâs, S; Winiwarter, S | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Faller, B; Wohnsland, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Caron, G; Ermondi, G | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Akamatsu, M | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Banerjee, SP; Chanda, SK; Kung, LS; Riggi, SJ | 1 |
| Brunswick, D; Frazer, A; Mendels, J; Sarai, K | 1 |
| Brown, BD; Davis, JM; Heinze, WJ; Pandey, GN | 1 |
| Friedhoff, AJ; Schwartz, R; Schweitzer, JW | 1 |
| Chiba, S | 5 |
| Chiba, S; Imai, Y | 1 |
| Biegon, A | 1 |
| Finberg, JP; Fishman, PH | 1 |
| Bach, GG; Cousineau, D; Goresky, CA; Rose, CP | 1 |
| Nishikawa, T; Shirayama, Y; Takahashi, K | 1 |
38 other study(ies) available for alprenolol and desipramine
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
SPR biosensor studies of the direct interaction between 27 drugs and a liposome surface: correlation with fraction absorbed in humans.
Topics: Humans; Intestinal Absorption; Liposomes; Pharmaceutical Preparations; Pharmacokinetics; Predictive Value of Tests; Surface Plasmon Resonance | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Development of beta-adrenergic receptor subsensitivity by antidepressants.
Topics: Alprenolol; Animals; Antidepressive Agents, Tricyclic; Brain; Desipramine; Doxepin; Iprindole; Kinetics; Male; Microsomes; Rats; Receptors, Adrenergic; Receptors, Adrenergic, beta | 1977 |
Desmethylimipramine-induced decrease in beta-adrenergic receptor binding in rat cerebral cortex.
Topics: Alprenolol; Animals; Cerebral Cortex; Depression, Chemical; Desipramine; In Vitro Techniques; Male; Rats; Receptors, Adrenergic; Receptors, Adrenergic, beta | 1978 |
Electroconvulsive shock treatment decrease beta-adrenergic receptor sensitivity in rat brain.
Topics: Alprenolol; Animals; Cerebral Cortex; Desipramine; Electroshock; Male; Rats; Receptors, Adrenergic; Receptors, Adrenergic, beta | 1979 |
Intact presynaptic terminals required for beta-adrenergic receptor regulation by desipramine.
Topics: Alprenolol; Animals; Cerebral Cortex; Desipramine; Hydroxydopamines; Kinetics; Rats; Receptors, Adrenergic; Receptors, Adrenergic, beta; Synapses | 1979 |
Mechanism of chronotropic and inotropic effects of phenylephrine.
Topics: Alprenolol; Animals; Atropine; Depression, Chemical; Desipramine; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Heart Rate; Heart Ventricles; In Vitro Techniques; Injections, Intra-Arterial; Levobunolol; Methoxamine; Myocardial Contraction; Phentolamine; Phenylephrine; Stimulation, Chemical; Tetrodotoxin | 1977 |
Pharmacologic analysis of positive chronotropic and inotropic responses to octopamine.
Topics: Alprenolol; Animals; Desipramine; Dogs; Dopamine; Dose-Response Relationship, Drug; Female; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Nicotine; Norepinephrine; Octopamine; Stimulation, Chemical; Tetrodotoxin | 1976 |
Absence of blocking effect of burimamide and metiamide on positive chronotropic and inotropic responses to histamine in isolated dog atrium.
Topics: Alprenolol; Animals; Burimamide; Depression, Chemical; Desipramine; Diphenhydramine; Dogs; Dose-Response Relationship, Drug; Heart Atria; Heart Rate; Histamine; Histamine Antagonists; In Vitro Techniques; Metiamide; Myocardial Contraction; Norepinephrine; Receptors, Histamine; Stimulation, Chemical; Tetrodotoxin; Thiourea; Tripelennamine | 1977 |
Pharmacological analysis of dopamine action on the isolated dog atrium.
Topics: Alprenolol; Animals; Desipramine; Dogs; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Heart Atria; Heart Rate; In Vitro Techniques; Nicotine; Norepinephrine; Tetrodotoxin; Tyramine | 1975 |
Effects of dopamine on the sinus rate and contraction of the canine isolated atrium preparation.
Topics: Alprenolol; Animals; Desipramine; Dogs; Dopamine; Female; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Norepinephrine; Sinoatrial Node; Tetrodotoxin; Tyramine | 1975 |
Pharmacologic analysis of papaverine-induced positive chronotropic and inotropic effects.
Topics: Alprenolol; Animals; Atropine; Desipramine; Heart; Heart Rate; In Vitro Techniques; Manganese; Myocardial Contraction; Norepinephrine; Papaverine; Stimulation, Chemical; Tetrodotoxin; Tyramine | 1976 |
Effect of chronic desipramine treatment on dihydroalprenolol, imipramine, and desipramine binding sites: a quantitative autoradiographic study in the rat brain.
Topics: Alprenolol; Animals; Autoradiography; Binding Sites; Brain; Desipramine; Dihydroalprenolol; Imipramine; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Time Factors; Tissue Distribution | 1986 |
Effect of the tricyclic antidepressant desipramine on beta-adrenergic receptors in cultured rat glioma C6 cells.
Topics: Adenylyl Cyclases; Alprenolol; Animals; Cells, Cultured; Cyclic AMP; Desipramine; Glioma; Isoproterenol; Rats; Receptors, Adrenergic, beta | 1987 |
Effect of beta-adrenergic blockade on in vivo norepinephrine release in canine heart.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Desipramine; Dogs; Indicator Dilution Techniques; Models, Biological; Myocardium; Norepinephrine; Phentolamine | 1984 |
Uncompetitive inhibition of [3H]1,3-di-o-tolyl-guanidine-defined sigma binding sites by desipramine, propranolol and alprenolol in rat brain.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Antidepressive Agents, Tricyclic; Desipramine; Guanidines; Kinetics; Male; Propranolol; Rats; Rats, Wistar; Receptors, sigma | 1997 |