alprenolol and clonidine

alprenolol has been researched along with clonidine in 30 studies

Research

Studies (30)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (46.67)	18.7374
1990's	2 (6.67)	18.2507
2000's	10 (33.33)	29.6817
2010's	4 (13.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Campillo, NE; Guerra, A; Páez, JA	1
Akamatsu, M	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Neufeld, AH; Page, ED	1
Bertilsson, L; Haglund, K; Ostman, J; Rawlins, MD; Ringberger, VA; Sjöqvist, F	1
Hertz, L; Subbarao, KV	1
Ernsberger, P; Iacovitti, L; Reis, DJ	1
Dermon, CR; Kouvelas, ED	2
Agid, Y; Cash, R; Lasbennes, F; Sercombe, R; Seylaz, J	1
Delbarre, B; Schmitt, H	1
De Schaepdryver, AF; Lambelin, G; Roba, J	1
Day, MD; Roach, AG	1
Johnston, CI; Woodcock, EA	1
Altiere, RJ; Douglas, JS; Gillis, CN	1
Altszuler, N; Cherksey, B	1
Kawai, M; Nomura, Y; Sakaue, T; Segawa, T; Watanabe, C	1
Kawai, M; Motomori-Suzaki, E; Nomura, Y; Segawa, T; Yotsumoto, I	1

Other Studies

30 other study(ies) available for alprenolol and clonidine

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
In vitro determination of the ability of drugs to bind to adrenergic receptors. Investigative ophthalmology & visual science, 1977, Volume: 16, Issue:12 Topics: Alprenolol; Animals; Ciliary Body; Clonidine; Dihydroergotoxine; Dopamine; Epinephrine; In Vitro Techniques; Iris; Isoproterenol; Male; Phentolamine; Propranolol; Rabbits; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Timolol	1977
Monoamine metabolites in cerebrospinal fluid during treatment with clonidine or alprenolol. European journal of clinical pharmacology, 1977, Jan-03, Volume: 11, Issue:2 Topics: Adult; Alprenolol; Biogenic Amines; Blood Pressure; Clonidine; Dopamine; Female; Humans; Hypertension; Male; Middle Aged; Norepinephrine; Serotonin	1977
Effect of adrenergic agonists on glycogenolysis in primary cultures of astrocytes. Brain research, 1990, Dec-17, Volume: 536, Issue:1-2 Topics: Alprenolol; Animals; Astrocytes; Cells, Cultured; Clonidine; Glycogen; Isoproterenol; Mice; Norepinephrine; Potassium; Prazosin; Yohimbine	1990
Astrocytes cultured from specific brain regions differ in their expression of adrenergic binding sites. Brain research, 1990, May-28, Volume: 517, Issue:1-2 Topics: Alprenolol; Animals; Astrocytes; Brain; Cells, Cultured; Clonidine; Dihydroalprenolol; Glial Fibrillary Acidic Protein; Rats; Receptors, Adrenergic	1990
Quantitative analysis of the localization of adrenergic binding sites in chick brain. Journal of neuroscience research, 1989, Volume: 23, Issue:3 Topics: Alprenolol; Animals; Autoradiography; Brain; Chickens; Clonidine; Dihydroalprenolol; Dioxanes; Dioxins; Receptors, Adrenergic	1989
Adrenergic receptors on cerebral microvessels in control and parkinsonian subjects. Life sciences, 1985, Aug-12, Volume: 37, Issue:6 Topics: Aged; Alprenolol; Capillaries; Cerebrovascular Circulation; Clonidine; Dihydroalprenolol; Humans; Kinetics; Parkinson Disease; Prazosin; Quinazolines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Reference Values	1985
Binding properties, regional ontogeny and localization of adrenergic receptors in chick brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1988, Volume: 6, Issue:5 Topics: Alprenolol; Animals; Binding, Competitive; Brain; Chick Embryo; Chickens; Clonidine; Dihydroalprenolol; Dioxanes; Dioxins; Kinetics; Receptors, Adrenergic	1988
A further attempt to characterize sedative receptors activated by clonidine in chickens and mice. European journal of pharmacology, 1973, Volume: 22, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alprenolol; Animals; Chickens; Chloral Hydrate; Clonidine; Female; Hypnotics and Sedatives; Isoproterenol; Mice; Moxisylyte; Pindolol; Receptors, Drug; Reflex; Sleep; Yohimbine	1973
Antihypertensive activity of four blocking agents in spontaneously hypertensive rats. Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 200, Issue:1 Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Disease Models, Animal; Heart Rate; Hydralazine; Hypertension; Male; Propranolol; Rats; Sotalol	1972
Central alpha- and beta-adrenoceptors modifying arterial blood pressure and heart rate in conscious cats. British journal of pharmacology, 1974, Volume: 51, Issue:3 Topics: Albuterol; Alprenolol; Animals; Atropine; Bethanidine; Blood Pressure; Cats; Cerebral Ventricles; Clonidine; Dopamine; Epinephrine; Female; Heart Rate; Hexamethonium Compounds; Injections; Isoproterenol; Lidocaine; Male; Norepinephrine; Pempidine; Phentolamine; Practolol; Propranolol; Rabbits; Rats; Receptors, Adrenergic; Sotalol; Species Specificity; Time Factors	1974
Alpha-Adrenergic receptors modulate beta-receptor affinity in rat kidney membranes. Nature, 1980, Jul-10, Volume: 286, Issue:5769 Topics: Alprenolol; Animals; Cell-Free System; Clonidine; Guanosine Triphosphate; Isoproterenol; Kidney; Membranes; Phentolamine; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta	1980
Uptake and displacement of [3H]dihydroalprenolol, [3H]epinephrine and [3H]clonidine in isolated perfused rabbit lung. Biochemical pharmacology, 1982, Mar-15, Volume: 31, Issue:6 Topics: Alprenolol; Animals; Clonidine; Dihydroalprenolol; Epinephrine; In Vitro Techniques; Lung; Male; Perfusion; Phenoxybenzamine; Phentolamine; Rabbits; Receptors, Adrenergic, beta; Tritium	1982
Tolbutamide and glyburide differ in effectiveness to displace alpha- and beta-adrenergic radioligands in pancreatic islet cells and membranes. Diabetes, 1984, Volume: 33, Issue:5 Topics: Alprenolol; Animals; Cell Membrane; Clonidine; Dihydroalprenolol; Epinephrine; Glyburide; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Tolbutamide	1984
Specific binding of [3H]WB 4101, [3H]clonidine and [3H]dihydroalprenolol in cerebral cortical membranes in developing, adult and old rats. Japanese journal of pharmacology, 1984, Volume: 36, Issue:2 Topics: Aging; Alprenolol; Animals; Cerebral Cortex; Clonidine; Dihydroalprenolol; Dioxanes; Dioxins; Female; Male; Membranes; Rats; Rats, Inbred Strains; Synapses	1984
Influences of isoproterenol pretreatment on cerebral cortical bindings of [3H]clonidine and [3H]dihydroalprenolol in infant and adult rats. Brain research, 1983, Volume: 285, Issue:3 Topics: Alprenolol; Animals; Cerebral Cortex; Clonidine; Dihydroalprenolol; Female; Isoproterenol; Male; Rats; Rats, Inbred Strains; Tritium	1983