Compounds > alprazolam

alprazolam and dextromethorphan

alprazolam has been researched along with dextromethorphan in 13 studies

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (61.54)	29.6817
2010's	4 (30.77)	24.3611
2020's	1 (7.69)	2.80

Authors

Authors	Studies
Artursson, P; Mateus, A; Matsson, P	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Boulton, DW; Carson, SW; DeVane, CL; Markowitz, JS; Nahas, Z; Risch, SC	1
Chavin, KD; DeVane, CL; Donovan, JL; Markowitz, JS; Taylor, RM	1
Chavin, KD; Devane, CL; Donovan, JL; Markowitz, JS; Ruan, Y; Taylor, RM	1
Chavin, KD; DeVane, CL; Donovan, JL; Markowitz, JS; Ruan, Y; Taylor, RM; Wang, JS	3
Chavin, KD; Donovan, JL; Lindsay DeVane, C; Markowitz, JS; Sipkes, L	1
Chavin, KD; DeVane, CL; Donovan, JL; Gefroh, HA; Gibson, BB; Markowitz, JS; Wang, JS	1
Juřica, J; Žourková, A	1
Mullins, ME; Rengarajan, A	1
Chen, L; van Breemen, RB	1

Reviews

1 review(s) available for alprazolam and dextromethorphan

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

6 trial(s) available for alprazolam and dextromethorphan

Article	Year
Siberian ginseng (Eleutheroccus senticosus) effects on CYP2D6 and CYP3A4 activity in normal volunteers. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:5 Topics: Adult; Alprazolam; Area Under Curve; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Eleutherococcus; Female; Half-Life; Humans; Male; Plant Extracts; Time Factors	2003
Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:2 Topics: Adult; Alprazolam; Area Under Curve; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dietary Supplements; Disulfides; Female; Garlic; Half-Life; Humans; Isoenzymes; Male; Sulfinic Acids	2003
Multiple-dose administration of Ginkgo biloba did not affect cytochrome P-450 2D6 or 3A4 activity in normal volunteers. Journal of clinical psychopharmacology, 2003, Volume: 23, Issue:6 Topics: Adult; Alprazolam; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dose-Response Relationship, Drug; Female; Ginkgo biloba; Humans; Male; Plant Extracts; Reference Values	2003
Multiple doses of saw palmetto (Serenoa repens) did not alter cytochrome P450 2D6 and 3A4 activity in normal volunteers. Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:6 Topics: Adult; Alprazolam; Androgen Antagonists; Anti-Anxiety Agents; Antitussive Agents; Area Under Curve; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Plant Extracts; Serenoa	2003
Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:12 Topics: Adult; Alprazolam; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextrorphan; Drug Interactions; Female; Half-Life; Humans; Male; Pharmaceutical Preparations; Plant Extracts; Valerian	2004
Dynamics and persistence of CYP2D6 inhibition by paroxetine. Journal of clinical pharmacy and therapeutics, 2013, Volume: 38, Issue:4 Topics: Adolescent; Adult; Aged; Alprazolam; Anxiety; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Depression; Dextromethorphan; Dextrorphan; Double-Blind Method; Female; Humans; Male; Middle Aged; Paroxetine; Young Adult	2013

Other Studies

6 other study(ies) available for alprazolam and dextromethorphan

Article	Year
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
Effect of St. John's wort (Hypericum perforatum) on cytochrome P-450 2D6 and 3A4 activity in healthy volunteers. Life sciences, 2000, Jan-21, Volume: 66, Issue:9 Topics: Adult; Alprazolam; Area Under Curve; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextrorphan; Drug Interactions; Female; Half-Life; Humans; Hypericum; Male; Mixed Function Oxygenases; Plant Extracts; Plants, Medicinal	2000
Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA, 2003, Sep-17, Volume: 290, Issue:11 Topics: Adult; Alprazolam; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Enzyme Induction; Female; Humans; Hypericum; Male; Plant Extracts; Substrate Specificity	2003
Green tea (Camellia sinensis) extract does not alter cytochrome p450 3A4 or 2D6 activity in healthy volunteers. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:9 Topics: Administration, Oral; Adult; Alprazolam; Camellia sinensis; Capsules; Catechin; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dietary Supplements; Drug Administration Schedule; Female; Half-Life; Humans; Male; Plant Extracts; Plant Leaves; Time Factors	2004
How often do false-positive phencyclidine urine screens occur with use of common medications? Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:6 Topics: Alprazolam; Carbazoles; Carvedilol; Clonazepam; Dextromethorphan; Diphenhydramine; Drug Interactions; False Positive Reactions; Gas Chromatography-Mass Spectrometry; Humans; Phencyclidine; Propanolamines; Retrospective Studies; Substance-Related Disorders; Tramadol	2013
Validation of a sensitive UHPLC-MS/MS method for cytochrome P450 probe substrates caffeine, tolbutamide, dextromethorphan, and alprazolam in human serum reveals drug contamination of serum used for research. Journal of pharmaceutical and biomedical analysis, 2020, Feb-05, Volume: 179 Topics: Alprazolam; Caffeine; Chromatography, High Pressure Liquid; Dextromethorphan; Drug Contamination; Herb-Drug Interactions; Humans; Serum; Tandem Mass Spectrometry; Tolbutamide	2020