Compounds > alprazolam

alprazolam and cimetidine

alprazolam has been researched along with cimetidine in 19 studies

Research

Studies (19)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (15.79)	18.7374
1990's	0 (0.00)	18.2507
2000's	9 (47.37)	29.6817
2010's	7 (36.84)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Artursson, P; Mateus, A; Matsson, P	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Desager, JP; Harvengt, C; Hulhoven, R; Pourbaix, S; Smith, RB	1
Abernethy, DR; Divoll, M; Greenblatt, DJ; Shader, RI	1
Abernethy, DR; Divoll, M; Greenblatt, DJ; Harmatz, JS; Moschitto, LJ; Shader, RI	1
Green, CE; Hirota, N; Ito, K; Iwatsubo, T; Shimada, N; Sugiyama, Y; Suzuki, H; Tyson, CA	1
Constantino, L; Dias, C; Dias, M; Soveral, G; Testa, B	1

Reviews

1 review(s) available for alprazolam and cimetidine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for alprazolam and cimetidine

Article	Year
Interaction of cimetidine with the triazolobenzodiazepines alprazolam and triazolam. Psychopharmacology, 1983, Volume: 80, Issue:3 Topics: Adult; Alprazolam; Anti-Anxiety Agents; Benzodiazepines; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Male; Metabolic Clearance Rate; Middle Aged; Triazolam	1983

Other Studies

17 other study(ies) available for alprazolam and cimetidine

Article	Year
Predicting blood-brain barrier permeation from three-dimensional molecular structure. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
Pharmacokinetic consequences of long term coadministration of cimetidine and triazolobenzodiazepines, alprazolam and triazolam, in healthy subjects. International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:8 Topics: Adult; Alprazolam; Anti-Anxiety Agents; Benzodiazepines; Cimetidine; Drug Interactions; Female; Half-Life; Humans; Kinetics; Male; Time Factors; Triazolam	1985
Pharmacokinetics of alprazolam. The Journal of clinical psychiatry, 1983, Volume: 44, Issue:8 Pt 2 Topics: Age Factors; Alprazolam; Anti-Anxiety Agents; Benzodiazepines; Biotransformation; Body Weight; Cimetidine; Female; Humans; Kinetics; Male; Sex Factors	1983
In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans. Biopharmaceutics & drug disposition, 2001, Volume: 22, Issue:2 Topics: Adult; Alprazolam; Anti-Anxiety Agents; Area Under Curve; Cimetidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Female; Humans; Intestinal Mucosa; Ketoconazole; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Recombinant Proteins	2001
Screening of the inhibitory effect of xenobiotics on alcohol metabolism using S9 rat liver fractions. Toxicology in vitro : an international journal published in association with BIBRA, 2012, Volume: 26, Issue:7 Topics: Alcohol Dehydrogenase; Alprazolam; Animals; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ethanol; Flunitrazepam; Fomepizole; Inhibitory Concentration 50; Liver; Pyrazoles; Rats; Rats, Wistar; Ribosomal Protein S9; Ribosomal Proteins; Tramadol; Xenobiotics	2012