alprazolam has been researched along with caffeine in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 13 (48.15) | 29.6817 |
| 2010's | 5 (18.52) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Greenblatt, DJ; Kaplan, GB; Shader, RI; Tai, NT | 1 |
| Baldwin, HA; File, SE | 1 |
| Jenck, F; Martin, JR; Moreau, JL | 1 |
| Lau, CE; Wang, J | 1 |
| Falk, JL; Lau, CE; Wang, Y | 2 |
| Arold, G; Bauer, S; Brockmöller, J; Roots, I; Schmider, J | 1 |
| Bickel, WK; Smith, BJ | 1 |
| Parle, M; Singh, N | 1 |
| Arold, G; Bauer, S; Diefenbach, K; Donath, F; Friede, M; Henneicke-von Zepelin, HH; Maurer, A; Roots, I | 1 |
| Chapman, CD; Dess, NK; Garrett, C; Gonzales, M | 1 |
| Ghosh, AK; Karmakar, P; Mukherjee, A; Saha, B; Saha, P; Samanta, S; Santra, CR | 1 |
| Amaral, VC; Campos, KF; Miguel, TT; Nunes-de-Souza, RL; Rico, JL | 1 |
| Alavi Nikje, MM; Soleimani, M; Tavakoli, Z | 1 |
| Chen, L; van Breemen, RB | 1 |
| Boy, D; Büttner, A; Kegler, R; Kolbe, V; Rentsch, D; Schmidt, B | 1 |
1 review(s) available for alprazolam and caffeine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
2 trial(s) available for alprazolam and caffeine
| Article | Year |
|---|---|
Simultaneous assessment of CYP3A4 and CYP1A2 activity in vivo with alprazolam and caffeine.
Topics: Adult; Alprazolam; Area Under Curve; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Female; Humans; Ketoconazole; Male; Middle Aged; Mixed Function Oxygenases; Reference Values; Rifampin | 1999 |
No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St John's wort extract.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Area Under Curve; Caffeine; Cardiotonic Agents; Central Nervous System Stimulants; Digoxin; Double-Blind Method; Drug Interactions; Female; Humans; Hypericum; Hypoglycemic Agents; Male; Middle Aged; Phytotherapy; Plant Extracts; Tolbutamide; Treatment Outcome | 2005 |
24 other study(ies) available for alprazolam and caffeine
| Article | Year |
|---|---|
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Separate and combined effects of caffeine and alprazolam on motor activity and benzodiazepine receptor binding in vivo.
Topics: Alprazolam; Animals; Brain Chemistry; Caffeine; Chromatography, High Pressure Liquid; Drug Interactions; Flumazenil; Male; Mice; Motor Activity; Receptors, GABA-A; Xanthines | 1990 |
Caffeine-induced anxiogenesis: the role of adenosine, benzodiazepine and noradrenergic receptors.
Topics: 2-Chloroadenosine; Adenosine; Alprazolam; Anxiety; Caffeine; Chlordiazepoxide; Clonidine; Flumazenil; Motor Activity; Muscle Relaxants, Central; Norepinephrine; Propranolol; Receptors, Adrenergic; Receptors, GABA-A; Receptors, Purinergic; Social Behavior | 1989 |
Dorsal periaqueductal gray-induced aversion as a simulation of panic anxiety: elements of face and predictive validity.
Topics: Alkaloids; Alprazolam; Animals; Anti-Anxiety Agents; Brain; Caffeine; Clonazepam; Conditioning, Operant; Male; Peripheral Nervous System; Placebos; Rats; Rats, Wistar; Stereotaxic Techniques; Yohimbine | 1995 |
Alprazolam, caffeine and their interaction: relating DRL performance to pharmacokinetics.
Topics: Alprazolam; Animals; Caffeine; Drug Interactions; Male; Rats; Reinforcement, Psychology | 1996 |
Differential reinforcement of low rate performance, pharmacokinetics and pharmacokinetic-pharmacodynamic modeling: independent interaction of alprazolam and caffeine.
Topics: Alprazolam; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Male; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology | 1997 |
Independent interaction of alprazolam and caffeine under chronic dose regimens on differential reinforcement of low-rate (DRL 45-s) performance.
Topics: Alprazolam; Animals; Caffeine; Central Nervous System Stimulants; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; GABA Modulators; Male; Rats; Rats, Sprague-Dawley; Reinforcement Schedule | 1997 |
Effects of alprazolam, caffeine, and zolpidem in humans trained to discriminate triazolam from placebo.
Topics: Adolescent; Adult; Alprazolam; Analysis of Variance; Caffeine; Discrimination, Psychological; Female; GABA Agonists; GABA Modulators; Humans; Male; Phosphodiesterase Inhibitors; Pyridines; Triazolam; Zolpidem | 2001 |
Sildenafil improves acquisition and retention of memory in mice.
Topics: Alprazolam; Amnesia; Animals; Caffeine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; GABA Modulators; GABA-A Receptor Antagonists; Learning; Male; Maze Learning; Memory; Mice; Phosphodiesterase Inhibitors; Physostigmine; Piperazines; Purines; Sildenafil Citrate; Sulfones; Transfer, Psychology | 2003 |
Stress-induced attenuation of acoustic startle in low-saccharin-consuming rats.
Topics: Acoustic Stimulation; Alprazolam; Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Drinking Behavior; Electroshock; Male; Rats; Reflex, Startle; Saccharin; Stress, Psychological; Sweetening Agents; Taste; Time Factors | 2008 |
Caffeine augments Alprazolam induced cytotoxicity in human cell lines.
Topics: Alprazolam; Anti-Anxiety Agents; Apoptosis; Caffeine; Cell Line, Tumor; Central Nervous System Stimulants; Drug Synergism; Glutathione; HeLa Cells; Humans; L-Lactate Dehydrogenase; Necrosis; Reactive Oxygen Species | 2009 |
Ethopharmacological evaluation of the rat exposure test: a prey-predator interaction test.
Topics: Adrenergic alpha-2 Receptor Antagonists; Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents; Caffeine; Central Nervous System Stimulants; Diazepam; Escape Reaction; Factor Analysis, Statistical; Fluoxetine; Food Chain; Imipramine; Male; Mice; Motor Activity; Posture; Predatory Behavior; Rats; Rats, Long-Evans; Time Factors; Yohimbine | 2013 |
Characterization and performance evaluation of functional monomer effect on molecular imprinted polyurethane foam.
Topics: Alprazolam; Caffeine; Chromatography, High Pressure Liquid; Drug Monitoring; Hydrogen-Ion Concentration; Methadone; Molecular Imprinting; Polymers; Polyurethanes; Salts; Solid Phase Extraction | 2019 |
Validation of a sensitive UHPLC-MS/MS method for cytochrome P450 probe substrates caffeine, tolbutamide, dextromethorphan, and alprazolam in human serum reveals drug contamination of serum used for research.
Topics: Alprazolam; Caffeine; Chromatography, High Pressure Liquid; Dextromethorphan; Drug Contamination; Herb-Drug Interactions; Humans; Serum; Tandem Mass Spectrometry; Tolbutamide | 2020 |
The adulterated XANAX pill: a fatal intoxication with etizolam and caffeine.
Topics: Alprazolam; Caffeine; Counterfeit Drugs; Diazepam; Fatal Outcome; Humans; Male; Middle Aged | 2020 |