alprazolam and amitriptyline

alprazolam has been researched along with amitriptyline in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199010 (30.30)18.7374
1990's5 (15.15)18.2507
2000's11 (33.33)29.6817
2010's7 (21.21)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bertorini, TE; Lemmi, H; Silva, AB1
Castro, P; De Maertelaer, V; Hubain, PP; Mendlewicz, J; Mesters, P1
Banerji, JR; Brantingham, P; Mason, J; McEwan, GD; Munt, DF; Renton, RL; Scott, AP; Stevens, V; Strakova, JM1
Feighner, JP; Rickels, K; Smith, WT1
Coryell, W; Moranville, JT1
Lizondo, E; Nair, NP; Schwartz, G; Singh, AN; Suranyi-Cadotte, B1
Blaschke, D; Laakmann, G; Schmauss, M1
Eriksson, B; Nagy, A; Starmark, JE; Thelander, U1
Erman, MK; Fairchild, C; Giles, DE; Khatami, M; Roffwarg, HP; Rush, AJ; Schlesser, MA; Vasavada, N1
Feighner, JP1
Daly, I; Draper, RJ1
Fairchild, C; Giles, DE; Roffwarg, HP; Rush, AJ; Schlesser, MA; Tarell, J1
Baghai, T; Bossert-Zaudig, S; Faltermaier-Temizel, M; Laakman, G; Lorkowski, G1
Bellodi, L; Bertani, A; Brambilla, F; Panerai, A; Perna, G; Sacerdote, P1
Browne, M; Lapierre, YD; Oyewumi, K; Sarantidis, D1
Christiaens, F; Dellers, I; Denis, B; Lessire, H; Vankeerberghen, L; Verborgh, C1
Möller, HJ1
Akechi, T; Akizuki, N; Ito, T; Nakano, T; Okamura, M; Shimizu, K; Uchitomi, Y1
Koval'chuk, VV1
Batt, A; Boulanger, B; Nagarnaik, P1
Curry, SC; Smith, JC1
Eren Cevik, S; Guneysel, O; Tasyurek, T1

Reviews

2 review(s) available for alprazolam and amitriptyline

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Anxiety associated with comorbid depression.
    The Journal of clinical psychiatry, 2002, Volume: 63 Suppl 14

    Topics: Adult; Algorithms; Alprazolam; Amitriptyline; Antidepressive Agents; Anxiety Disorders; Benzodiazepines; Clinical Trials as Topic; Comorbidity; Decision Trees; Depressive Disorder; Diagnostic and Statistical Manual of Mental Disorders; Drug Therapy, Combination; Humans; Practice Patterns, Physicians'; Psychiatric Status Rating Scales; Severity of Illness Index; Treatment Outcome

2002

Trials

12 trial(s) available for alprazolam and amitriptyline

ArticleYear
Alprazolam and amitriptyline in the treatment of major depressive disorder: a double-blind clinical and sleep EEG study.
    Journal of affective disorders, 1990, Volume: 18, Issue:1

    Topics: Adult; Alprazolam; Amitriptyline; Biomarkers; Clinical Trials as Topic; Dexamethasone; Double-Blind Method; Electroencephalography; Female; Humans; Male; Middle Aged; Random Allocation; Sleep

1990
A comparison of alprazolam with amitriptyline in the treatment of patients with neurotic or reactive depression. A report of a randomised, double blind study by a General Practitioner Working Party.
    Irish journal of medical science, 1989, Volume: 158, Issue:5

    Topics: Adult; Aged; Alprazolam; Amitriptyline; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Patient Compliance; Random Allocation

1989
Alprazolam, amitriptyline, doxepin, and placebo in the treatment of depression.
    Archives of general psychiatry, 1985, Volume: 42, Issue:2

    Topics: Adult; Alcoholism; Alprazolam; Ambulatory Care; Amitriptyline; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Depressive Disorder; Doxepin; Female; Humans; Male; Outcome and Process Assessment, Health Care; Placebos; Psychiatric Status Rating Scales; Sleep Stages; Tachycardia; Vision Disorders; Xerostomia

1985
A double blind comparison of alprazolam and amitriptyline hydrochloride in the treatment of nonpsychotic depression.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1988, Volume: 33, Issue:3

    Topics: Adult; Alprazolam; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Psychological Tests

1988
Alprazolam compared to amitriptyline in the treatment of major depression.
    Acta psychiatrica Scandinavica, 1987, Volume: 75, Issue:6

    Topics: Adolescent; Adult; Aged; Alprazolam; Amitriptyline; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Random Allocation

1987
Alprazolam vs amitriptyline in depressions with reduced REM latencies.
    Archives of general psychiatry, 1985, Volume: 42, Issue:12

    Topics: Adolescent; Adult; Aged; Alprazolam; Amitriptyline; Benzodiazepines; Clinical Trials as Topic; Dexamethasone; Double-Blind Method; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Psychiatric Status Rating Scales; Random Allocation; Sleep, REM

1985
Benzodiazepines as antidepressants. A triazolobenzodiazepine used to treat depression.
    Modern problems of pharmacopsychiatry, 1982, Volume: 18

    Topics: Alprazolam; Amitriptyline; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Doxepin; Humans; Psychiatric Status Rating Scales

1982
Alprazolam and amitryptyline: a double blind comparison of anxiolytic and anti-depressant activity.
    Irish medical journal, 1983, Volume: 76, Issue:11

    Topics: Alprazolam; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents; Anxiety Disorders; Benzodiazepines; Clinical Trials as Topic; Depression; Double-Blind Method; Humans; Ireland

1983
Psychobiological predictors of antidepressant drug response.
    Pharmacopsychiatria, 1983, Volume: 16, Issue:6

    Topics: Alprazolam; Amitriptyline; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Depressive Disorder; Dexamethasone; Double-Blind Method; Humans; Hydrocortisone; Psychiatric Status Rating Scales; Sleep, REM

1983
Treatment of depressive outpatients with lorazepam, alprazolam, amytriptyline and placebo.
    Psychopharmacology, 1995, Volume: 120, Issue:1

    Topics: Adult; Aged; Alprazolam; Amitriptyline; Antidepressive Agents; Depression; Female; Humans; Lorazepam; Male; Middle Aged; Placebo Effect; Psychiatric Status Rating Scales; Time Factors; Treatment Outcome

1995
Alprazolam and amitriptyline in the treatment of moderate depression.
    International clinical psychopharmacology, 1994,Spring, Volume: 9, Issue:1

    Topics: Adolescent; Adult; Aged; Alprazolam; Amitriptyline; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Personality Inventory

1994
[Pharmacologic correction of psycho-emotive disorders in the rehabilitation of patients after removal of brain tumors].
    Voprosy onkologii, 2007, Volume: 53, Issue:6

    Topics: Adult; Alprazolam; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Brain Neoplasms; Depression; Doxepin; Emotions; Female; Humans; Male; Maprotiline; Middle Aged; Moclobemide; Mood Disorders; Neurosurgical Procedures; Nialamide; Sertraline; Thiazepines; Trazodone; Treatment Outcome

2007

Other Studies

19 other study(ies) available for alprazolam and amitriptyline

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
    Bioorganic & medicinal chemistry letters, 2005, Sep-15, Volume: 15, Issue:18

    Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution

2011
Polysomnography in idiopathic muscle pain syndrome (fibrositis).
    Arquivos de neuro-psiquiatria, 1991, Volume: 49, Issue:4

    Topics: Alprazolam; Amitriptyline; Clonazepam; Electroencephalography; Fatigue Syndrome, Chronic; Female; Fibromyalgia; Humans; Male; Monitoring, Physiologic; Sensory Thresholds; Sleep Wake Disorders

1991
Alprazolam for psychotic depression.
    Biological psychiatry, 1989, Feb-01, Volume: 25, Issue:3

    Topics: Adult; Alprazolam; Amitriptyline; Depressive Disorder; Female; Humans; Male; Perphenazine; Psychological Tests; Psychotic Disorders

1989
The specificity of drug classes for the anxiety and depressive disorders.
    Clinical neuropharmacology, 1986, Volume: 9 Suppl 4

    Topics: Adult; Aged; Alprazolam; Amitriptyline; Anxiety; Depressive Disorder; Female; Humans; Middle Aged; Promethazine

1986
Plasma interleukin-1 beta concentrations in panic disorder.
    Psychiatry research, 1994, Volume: 54, Issue:2

    Topics: Adult; Alprazolam; Amitriptyline; Antibodies, Monoclonal; Anxiety; Benzodiazepines; Cytokines; Female; Humans; Interleukin-1; Male; Middle Aged; Panic Disorder; Psychiatric Status Rating Scales; Severity of Illness Index; Time Factors; Treatment Outcome

1994
Successful prolonged cardiopulmonary resuscitation after a combined intoxication with a tricyclic antidepressant, a benzodiazepine and a neuroleptic.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2000, Volume: 7, Issue:3

    Topics: Adult; Alprazolam; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzodiazepines; Cardiopulmonary Resuscitation; Emergencies; Female; Humans; Lorazepam; Suicide, Attempted; Thiazines; Time Factors

2000
Clinical experience of the use of a pharmacological treatment algorithm for major depressive disorder in patients with advanced cancer.
    Psycho-oncology, 2008, Volume: 17, Issue:2

    Topics: Adult; Aged; Algorithms; Alprazolam; Amitriptyline; Antidepressive Agents; Anxiety Disorders; Benzodiazepines; Central Nervous System Stimulants; Clomipramine; Depressive Disorder, Major; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Methylphenidate; Middle Aged; Neoplasm Staging; Neoplasms; Prognosis; Severity of Illness Index

2008
Source characterization of nervous system active pharmaceutical ingredients in healthcare facility wastewaters.
    Journal of environmental management, 2011, Volume: 92, Issue:3

    Topics: Alprazolam; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Health Services for the Aged; Industrial Waste; Pharmaceutical Preparations; Sewage; Water Pollutants, Chemical

2011
Prolonged toxicity after amitriptyline overdose in a patient deficient in CYP2D6 activity.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2011, Volume: 7, Issue:3

    Topics: Alprazolam; Amitriptyline; Antidepressive Agents, Tricyclic; Body Temperature; Brain; Coma; Cytochrome P-450 CYP2D6; Drug Overdose; Electrocardiography; Female; Gas Chromatography-Mass Spectrometry; Genotype; Half-Life; Hemodynamics; Humans; Hypnotics and Sedatives; Magnetic Resonance Imaging; Middle Aged; Respiration, Artificial; Suicide, Attempted

2011
Intralipid emulsion treatment as an antidote in lipophilic drug intoxications.
    The American journal of emergency medicine, 2014, Volume: 32, Issue:9

    Topics: Adolescent; Adult; Alprazolam; Amitriptyline; Antidotes; Blood Pressure; Dibenzothiazepines; Drug Overdose; Fat Emulsions, Intravenous; Female; Fluoxetine; Glasgow Coma Scale; Heart Rate; Humans; Lamotrigine; Lipid Metabolism; Male; Metoprolol; Middle Aged; Nifedipine; Quetiapine Fumarate; Triazines; Young Adult

2014