alprazolam has been researched along with alpha-hydroxyalprazolam in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (17.39) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 8 (34.78) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Collins, RJ; Gall, M; Kamdar, BV | 1 |
| Hester, JB; Von Voigtlander, P | 1 |
| Kroboth, PD; Piraino, B; Schmith, VD; Smith, RB | 1 |
| DeVane, CL; Miller, RL | 1 |
| Abe, M; Furukawa, T; Kushiku, K; Matsuki, J; Morishita, H; Yamada, K | 1 |
| Canfield, DV; Crouch, DJ; Höld, KM; Maes, RA; Rollins, DE; Wilkins, DG | 1 |
| Andrenyak, DM; Canfield, DV; Crouch, DJ; Rollins, DE; Schulties, JE | 1 |
| Allqvist, A; Mirghani, RA; Svensson, JO; Wennerholm, A | 1 |
| Allqvist, A; Bertilsson, L; Gustafsson, LL; Mirghani, RA; Svensson, JO; Wennerholm, A | 1 |
| Jiang, Z; Tan, J; Tao, G; Xing, L; Yao, L; Zhang, Q; Zhu, Y | 1 |
| Allqvist, A; Bertilsson, L; Mirghani, RA; Miura, J | 1 |
| Honda, K; Nakamura, T; Shinozuka, T; Tanaka, E; Terada, M | 1 |
| Chronister, CW; Goldberger, BA; Merves, ML | 1 |
| Marin, SJ; McMillin, GA | 1 |
| Christianson, CD; Johnson, CJ; Laine, DF; Needham, SR; Sheaff, CN; Zimmer, JS | 1 |
| Bertilsson, L; Carrero, JJ; Diczfalusy, U; Heimbürger, O; Lindholm, B; Molanaei, H; Odar-Cederlöf, I; Qureshi, AR; Stenvinkel, P | 1 |
| Kalogria, E; Panderi, I; Pistos, C | 1 |
| Bertol, E; Boscolo Berto, R; Favretto, D; Mannaioni, G; Mari, F; Vaiano, F | 1 |
| Alcott, CJ; Coetzee, JF; Davis, JL; Galow-Kersh, NL; Hepworth-Warren, KL; Rice, S; Wong, DM | 1 |
| In, MK; Jeong, YD; Kim, JY; Kim, MK; Paeng, KJ; Suh, SI | 1 |
| Concheiro, M; Cruz, A; de-Castro-Ríos, A; Lendoiro, E; López-Rabuñal, A; López-Rivadulla, M | 1 |
| Apollonio, LG; Huestis, MA; Kaspar, CK; Lavins, ES; Michel, HM; Mitchell-Mata, CL; Sofalvi, S | 1 |
| Abarca, R; Gerona, R | 1 |
3 trial(s) available for alprazolam and alpha-hydroxyalprazolam
| Article | Year |
|---|---|
Alprazolam in end-stage renal disease: I. Pharmacokinetics.
Topics: Adult; Alprazolam; Double-Blind Method; Female; Humans; Kidney Failure, Chronic; Male; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis; Time Factors | 1991 |
Determination of alprazolam and alpha-hydroxyalprazolam in human plasma by gas chromatography/negative-ion chemical ionization mass spectrometry.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Calibration; Freezing; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Male; Reproducibility of Results; Solutions | 1996 |
Alprazolam as a probe for CYP3A using a single blood sample: pharmacokinetics of parent drug, and of alpha- and 4-hydroxy metabolites in healthy subjects.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Oxidoreductases, N-Demethylating | 2005 |
20 other study(ies) available for alprazolam and alpha-hydroxyalprazolam
| Article | Year |
|---|---|
Pharmacology of some metabolites of triazolam, alprazolam, and diazepam prepared by a simple, one-step oxidation of benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Hydroxylation; Male; Methods; Mice; Oxidation-Reduction; Triazolam; Triazoles | 1978 |
6-Aryl-4H-s-triazolo[4,3-a][1,4]benzodiazepines. Influence of 1-substitution on pharmacological activity.
Topics: Animals; Anti-Anxiety Agents; Apomorphine; Benzodiazepines; Body Temperature; Dextroamphetamine; Male; Mice; Motor Activity; Structure-Activity Relationship | 1979 |
Alprazolam, alpha-hydroxy- and 4-hydroxyalprazolam analysis in plasma by high-performance liquid chromatography.
Topics: Adult; Alprazolam; Buffers; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Male | 1988 |
[Pharmacological studies on alprazolam, and its main metabolites, alpha-OH-alprazolam and HB compound (author's transl)].
Topics: Alprazolam; Animals; Benzodiazepines; Dogs; Female; Guinea Pigs; Hemodynamics; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rabbits; Rats; Rats, Inbred Strains; Triazines | 1980 |
Quantitation of alprazolam and alpha-hydroxyalprazolam in human plasma using liquid chromatography electrospray ionization MS-MS.
Topics: Alprazolam; Anti-Anxiety Agents; Calibration; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Male; Reproducibility of Results; Sensitivity and Specificity; Substance Abuse Detection | 1999 |
Simultaneous quantification of alprazolam, 4- and alpha-hydroxyalprazolam in plasma samples using liquid chromatography mass spectrometry.
Topics: Alprazolam; Anti-Anxiety Agents; Humans; Reproducibility of Results; Sensitivity and Specificity | 2005 |
[Determination of alpha-hydroxytrizolam and alpha hydroxyaplrazolam from urine by acetylation derivatization using gas chromatography electron capture detection].
Topics: Acetylation; Adult; Alprazolam; Chromatography, Gas; Humans; Sensitivity and Specificity; Triazolam | 2004 |
Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers.
Topics: Alprazolam; Anti-Anxiety Agents; Antifungal Agents; Antimalarials; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Inhibitory Concentration 50; Ketoconazole; Mass Spectrometry; Microsomes, Liver; Quinidine; Stereoisomerism | 2007 |
Metabolic interaction between ethanol, high-dose alprazolam and its two main metabolites using human liver microsomes in vitro.
Topics: Alprazolam; Anti-Anxiety Agents; Central Nervous System Depressants; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Forensic Toxicology; Humans; In Vitro Techniques; Microsomes, Liver | 2007 |
Quantitation of benzodiazepines in blood and urine using gas chromatography-mass spectrometry (GC-MS).
Topics: Alprazolam; Benzodiazepines; Diazepam; Gas Chromatography-Mass Spectrometry; Humans; Lorazepam; Nordazepam; Oxazepam; Solid Phase Extraction; Triazolam | 2010 |
LC-MS/MS analysis of 13 benzodiazepines and metabolites in urine, serum, plasma, and meconium.
Topics: Alprazolam; Benzodiazepines; Chromatography, Liquid; Clonazepam; Flurazepam; Humans; Infant, Newborn; Meconium; Nordazepam; Oxazepam; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Triazolam | 2010 |
Use of conventional bioanalytical devices to automate DBS extractions in liquid-handling dispensing tips.
Topics: Alprazolam; Automation; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Humans; Midazolam; Tandem Mass Spectrometry | 2011 |
Metabolism of alprazolam (a marker of CYP3A4) in hemodialysis patients with persistent inflammation.
Topics: Adult; Aged; Algorithms; Alprazolam; Anti-Anxiety Agents; Biomarkers; Biotransformation; C-Reactive Protein; Cytochrome P-450 CYP3A; Female; Humans; Hydroxycholesterols; Hydroxylation; Male; Middle Aged; Orosomucoid; Renal Dialysis; Renal Insufficiency, Chronic | 2012 |
Hydrophilic interaction liquid chromatography/positive ion electrospray ionization mass spectrometry method for the quantification of alprazolam and α-hydroxy-alprazolam in human plasma.
Topics: Adult; Alprazolam; Chromatography, Liquid; Diterpenes; Female; Humans; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Linear Models; Male; Middle Aged; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2013 |
A mixed MDPV and benzodiazepine intoxication in a chronic drug abuser: determination of MDPV metabolites by LC-HRMS and discussion of the case.
Topics: Adult; Alprazolam; Benzodiazepines; Benzodioxoles; Chlordiazepoxide; Chromatography, Liquid; Diazepam; Humans; Hypnotics and Sedatives; Male; Mass Spectrometry; Nordazepam; Oxazepam; Psychotropic Drugs; Pyrrolidines; Substance-Related Disorders; Synthetic Cathinone; Temazepam | 2014 |
Pharmacokinetics and physiologic effects of alprazolam after a single oral dose in healthy mares.
Topics: Administration, Oral; Alprazolam; Animals; Ataxia; Conscious Sedation; Female; Horses; Hypnotics and Sedatives | 2015 |
Rapid determination of benzodiazepines, zolpidem and their metabolites in urine using direct injection liquid chromatography-tandem mass spectrometry.
Topics: Alprazolam; Benzodiazepines; Chromatography, Liquid; Flurazepam; Forensic Toxicology; Humans; Hypnotics and Sedatives; Limit of Detection; Pyridines; Tandem Mass Spectrometry; Triazolam; Zolpidem | 2015 |
LC-MS-MS Method for the Determination of Antidepressants and Benzodiazepines in Meconium.
Topics: Alprazolam; Antidepressive Agents; Benzodiazepines; Chromatography, Liquid; Clonazepam; Forensic Toxicology; Humans; Limit of Detection; Meconium; Nordazepam; Oxazepam; Reproducibility of Results; Solid Phase Extraction; Substance Abuse Detection; Tandem Mass Spectrometry; Venlafaxine Hydrochloride; Zolpidem | 2020 |
Development and Validation of an LC-MS-MS Method for the Detection of 40 Benzodiazepines and Three Z-Drugs in Blood and Urine by Solid-Phase Extraction.
Topics: Alprazolam; Azabicyclo Compounds; Benzodiazepines; Chromatography, Liquid; Diazepam; Forensic Toxicology; Humans; Hypnotics and Sedatives; Limit of Detection; Piperazines; Sleep Aids, Pharmaceutical; Solid Phase Extraction; Substance Abuse Detection; Tandem Mass Spectrometry; Zolpidem | 2020 |
Development and validation of an LC-MS/MS assay for the quantitative analysis of alprazolam, α-hydroxyalprazolam and hydrocodone in dried blood spots.
Topics: Alprazolam; Chromatography, Liquid; Dried Blood Spot Testing; Hydrocodone; Reproducibility of Results; Tandem Mass Spectrometry | 2023 |