alphaxalone has been researched along with propofol in 84 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (17.86) | 18.2507 |
| 2000's | 9 (10.71) | 29.6817 |
| 2010's | 49 (58.33) | 24.3611 |
| 2020's | 11 (13.10) | 2.80 |
| Authors | Studies |
|---|---|
| Ai, J; Kahnberg, P; Nielsen, M; Saederup, E; Squires, RF; Sterner, O; Witt, MR | 1 |
| Anderson, A; Boyd, AC; Byford, A; Campbell, AC; Gemmell, DK; Hamilton, NM; Hill, DR; Hill-Venning, C; Lambert, JJ; Maidment, MS; Marshall, RJ; May, V; Peters, JA; Rees, DC; Stevenson, D; Sundaram, H | 1 |
| Altomare, C; Biggio, G; Franco, M; Latrofa, A; Liso, G; Sanna, E; Trapani, G; Usala, M | 1 |
| Asproni, B; Biggio, G; Busonero, F; Cerri, R; Mascia, MP; Pau, A; Sanna, E; Sanna, S; Talani, G | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Prince, RJ; Simmonds, MA | 2 |
| Biggio, G; Concas, A; Maciocco, E; Mascia, MP; Santoro, G | 1 |
| Hashim, MA; Waterman, AE | 1 |
| Biggio, G; Concas, A; Mascia, MP; Sanna, E; Santoro, G; Serra, M | 1 |
| Biggio, G; Concas, A; Dazzi, L; Maciocco, E; Mascia, MP; Santoro, G | 1 |
| Allen, SL; Brammer, A; West, CD | 1 |
| Biggio, G; Ghiani, CA; Maciocco, E; Sanna, E; Serra, M; Tuligi, G | 1 |
| Coderre, TJ; Gilron, I | 1 |
| Simmonds, MA; Sooksawate, T | 1 |
| Coderre, TJ; Gilron, I; Quirion, R | 1 |
| Chen, CL; Chiu, TH; Yang, YR | 1 |
| Carlson, BX; Engblom, AC; Kristiansen, U; Olsen, RW; Schousboe, A | 1 |
| Chang, CS; Olcese, R; Olsen, RW | 1 |
| Krähenbühl, K; Lambert, S; Rudolph, U; Siegwart, R | 1 |
| Asproni, B; Biggio, G; Busonero, F; Cerri, R; Maciocco, E; Mascia, MP; Pau, A; Sanna, E; Talani, G | 1 |
| Chen, CL; Chiu, TH; Tang, JS; Yang, YR | 1 |
| Clutton, RE; Mansel, JC; Strachan, FA | 1 |
| Ambros, B; Duke-Novakovski, T; Pasloske, KS | 1 |
| Martinez Taboada, F; Murison, PJ; Taboada, FM | 1 |
| Yates, D | 1 |
| Murison, PJ; Taboada, FM | 1 |
| Hall, WJ; Markos, F; Ruane-O'Hora, T | 1 |
| Keates, H; Whittem, T | 1 |
| Alibhai, H; Brodbelt, D; Jiménez, CP; Mathis, A; Mora, SS | 1 |
| Andaluz, A; Fresno, L; García, F; Moll, X; Torres, MD | 1 |
| Dzikiti, BT; Hartman, M; Stegmann, FG; Suarez, MA | 1 |
| Brearley, JC; Leece, EA; Michou, JN | 1 |
| Gil, AG; Illera, JC; Silván, G; Villa, A | 1 |
| Alibhai, HI; Brodbelt, DC; Mathis, A; Pinelas, R | 1 |
| Amengual, M; Auckburally, A; Bell, AM; Flaherty, D; Pawson, P; Scott, EM | 1 |
| Aprea, F; Corletto, F; Nelissen, P; White, RA | 1 |
| Braun, C; Cremer, J; Hofmeister, EH; Maney, JK; Shepard, MK | 1 |
| Herbert, GL; Murison, PJ | 1 |
| Andaluz, A; Domínguez, E; Espada, Y; Fresno, L; García, F; Novellas, R; Rivera Del Álamo, MM; Santos, L | 1 |
| Bettschart, R; Doebeli, A; Hartnack, S; Michel, E; Reichler, IM | 1 |
| Chandra, D; Homanics, GE; Iyer, SV | 1 |
| Cooke, A; Forde, N; Hasiuk, MM; Pang, DS; Ramey, K | 1 |
| Corletto, F; Okushima, S; Vettorato, E | 1 |
| del Álamo, AM; Mandsager, RE; Payton, ME; Riebold, TW | 1 |
| Bettschart-Wolfensberger, R; Campagna, I; Keller, S; Mosing, M; Schwarz, A | 1 |
| Aguilar, A; Andaluz, A; Costa, D; Leiva, M; Moll, X; Peña, T | 1 |
| Boyd, BJ; Goodchild, CS; Kolosov, A; Serrao, JM | 1 |
| Akk, G; Li, P | 1 |
| Hollmann, MW; Sear, JW | 1 |
| Hollmann, MW; Kharasch, ED | 1 |
| Goodchild, CS; Monagle, J; Serrao, JM; Siu, L; Worrell, J | 1 |
| Forman, SA; Stern, AT | 1 |
| Antkowiak, B; Rudolph, U | 1 |
| Forman, SA; Hotta, M; Nourmahnad, A; Stern, AT; Stewart, DS; Szabo, A; Ziemba, AM | 1 |
| Alef, M | 1 |
| Bester, L; Buck, RK; Fosgate, GT; Hartman, MJ; Smalle, TM; Zeiler, GE | 1 |
| Bauquier, S; Beths, T; Bigby, SE; Carter, JE | 2 |
| Chalmers, H; Hanna, B; Liao, P; Mackenzie, S; Mosley, C; Sinclair, M; Valverde, A | 1 |
| White, KL; Yates, D | 1 |
| Aoki, M; Kakizaki, M; Kushiro, A; Mae, N; Nagata, SI; Ohta, M; Wakuno, A | 1 |
| Barr, CA; Drobatz, KJ; Gianotti, G; Graffeo, CE; Silverstein, DC | 1 |
| Akk, G; Germann, AL; Shin, DJ; Steinbach, JH | 1 |
| Hardie, RJ; Radkey, DI; Smith, LJ | 1 |
| Carrera, I; Kästner, SBR; Kircher, P; Pasloske, K; Ranasinghe, MG; Söbbeler, FJ | 1 |
| Alstrup, AKO; Bertelsen, MF; Jensen, HM; Leite, CAC; Wang, T; Williams, CJA | 1 |
| Sear, JW | 1 |
| Akk, G; Cao, LQ; Chakrabarti, S; Evers, AS; Germann, AL; Mennerick, S; Montana, MC; Shin, DJ; Wozniak, DF; Yuede, CM | 1 |
| Ambros, B; Duke-Novakovski, T; Gaunt, MC; Taylor, SM | 1 |
| Kulendra, N; Norgate, D; Ter Haar, G; Veres-Nyéki, KO | 1 |
| Hampton, CE; Mandsager, RE; Riebold, TW | 1 |
| Dzikiti, BT; Labuscagne, S; Zeiler, GE | 1 |
| Bruns, TM; Kennedy, E; Lester, PA; Martin, T; Ouyang, Z; Xu, JJ; Yousuf, Z | 1 |
| Candy, EJ; Cockrem, JF; Sano, H; Weidgraaf, K; Yozova, ID | 1 |
| Fukui, S; Oyama, N; Tamura, J; Yamashita, K | 1 |
| Alvarado, F; Barr, CA; Chang, YM; Garden, OA; Luo, J | 1 |
| Abe, AS; Bertelsen, MF; Buchanan, R; Jensen, HM; Leite, CAC; Wang, T | 1 |
| Berke, K; Hodgson, D; Kapaldo, N; Klocke, E; McMurphy, R; Roush, J | 1 |
| Chen, IY; Itami, T; Kato, K; Sano, T; Tamogi, H; Wei, Y; Yamashita, K | 1 |
| Amsellem, P; Hamilton, S; Pan, PC; Savidge, C | 1 |
| Abu Ahmad, W; Ofri, R; Pe'er, O; Shilo-Benjamini, Y | 1 |
| Goodchild, CS; Serrao, JM | 1 |
| Bektas, R; Körner, M; Meier, V; Riond, B; Rohrer Bley, C; Wolf, F | 1 |
3 review(s) available for alphaxalone and propofol
| Article | Year |
|---|---|
New insights in the systemic and molecular underpinnings of general anesthetic actions mediated by γ-aminobutyric acid A receptors.
Topics: Anesthesia, General; Anesthetics, General; Brain Injuries; GABAergic Neurons; Hippocampus; Humans; Inflammation; Interneurons; Learning; Memory; Neuralgia; Pregnanediones; Propofol; Pyramidal Cells; Receptors, GABA-A; Spinal Cord | 2016 |
[Anaesthesia for canine caesarean section - an evidence-based approach].
Topics: Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, Inhalation; Anesthetics; Anesthetics, Intravenous; Animals; Cesarean Section; Dogs; Female; Oxygen; Pregnancy; Pregnanediones; Propofol; Risk Factors | 2017 |
Challenges of bringing a new sedative to market!
Topics: Anesthesia; Benzodiazepines; Clinical Trials as Topic; Conscious Sedation; Drug Recalls; Humans; Hypnotics and Sedatives; Pregnanediones; Propofol | 2018 |
34 trial(s) available for alphaxalone and propofol
| Article | Year |
|---|---|
Induction of anaesthesia with alfaxalone or propofol before isoflurane maintenance in cats.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Blood Gas Analysis; Cats; Female; Hemodynamics; Hysterectomy; Intubation, Intratracheal; Isoflurane; Monitoring, Intraoperative; Ovariectomy; Preanesthetic Medication; Pregnanediones; Propofol; Treatment Outcome | 2010 |
Effect of intravenous dose escalation with alfaxalone and propofol on occurrence of apnoea in the dog.
Topics: Anesthetics, Intravenous; Animals; Apnea; Cross-Over Studies; Dogs; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Male; Pregnanediones; Propofol | 2012 |
Evaluation of the quality of the recovery after administration of propofol or alfaxalone for induction of anaesthesia in dogs anaesthetized for magnetic resonance imaging.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Dogs; Female; Magnetic Resonance Imaging; Male; Methyl Ethers; Pregnanediones; Propofol; Sevoflurane | 2012 |
Comparison of alfaxalone and propofol administered as total intravenous anaesthesia for ovariohysterectomy in dogs.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics; Animals; Blood Pressure; Dogs; Female; Hypnotics and Sedatives; Hysterectomy; Ovariectomy; Pregnanediones; Propofol; Respiration | 2012 |
Comparison of pain on injection during induction of anaesthesia with alfaxalone and two formulations of propofol in dogs.
Topics: Anesthetics; Animals; Behavior, Animal; Chemistry, Pharmaceutical; Cross-Over Studies; Dog Diseases; Dogs; Drug Therapy, Combination; Female; Male; Pain; Pregnanediones; Propofol | 2012 |
Comparison of quality of recovery from anaesthesia in cats induced with propofol or alfaxalone.
Topics: Anesthesia Recovery Period; Anesthetics; Animals; Cat Diseases; Cats; Female; Male; Postoperative Complications; Pregnanediones; Propofol | 2012 |
An evaluation of anaesthetic induction in healthy dogs using rapid intravenous injection of propofol or alfaxalone.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Dogs; Female; Infusions, Intravenous; Male; Pregnanediones; Propofol | 2013 |
Effect of three anesthetic induction protocols on laryngeal motion during laryngoscopy in normal cats.
Topics: Anesthesia, General; Anesthetics; Animals; Arytenoid Cartilage; Cats; Female; Ketamine; Laryngoscopy; Male; Midazolam; Movement; Pregnanediones; Propofol; Video Recording | 2012 |
A comparison of cardiopulmonary and anesthetic effects of an induction dose of alfaxalone or propofol in dogs.
Topics: Anesthetics; Animals; Cross-Over Studies; Dogs; Female; Hypnotics and Sedatives; Pregnanediones; Propofol; Single-Blind Method | 2013 |
A comparison of alfaxalone and propofol on intraocular pressure in healthy dogs.
Topics: Anesthetics; Animals; Dogs; Female; Intraocular Pressure; Male; Pregnanediones; Propofol | 2014 |
Chronotropic effect of propofol or alfaxalone following fentanyl administration in healthy dogs.
Topics: Anesthetics; Animals; Blood Pressure; Dogs; Female; Fentanyl; Heart Rate; Male; Pregnanediones; Propofol | 2015 |
Evaluation of intravenous administration of alfaxalone, propofol, and ketamine-diazepam for anesthesia in alpacas.
Topics: Anesthesia; Anesthetics; Animals; Camelids, New World; Diazepam; Drug Therapy, Combination; Female; Injections, Intravenous; Ketamine; Male; Pregnanediones; Propofol | 2015 |
Comparison of the effects of propofol or alfaxalone for anaesthesia induction and maintenance on respiration in cats.
Topics: Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Cats; Double-Blind Method; Female; Hysterectomy; Ovariectomy; Pregnanediones; Propofol; Prospective Studies; Respiration; Treatment Outcome | 2015 |
Alfaxalone versus propofol in dogs: a randomised trial to assess effects on peri-induction tear production, intraocular pressure and globe position.
Topics: Anesthetics; Animals; Dogs; Eye; Female; Intraocular Pressure; Male; Orbit; Pregnanediones; Propofol; Tears | 2015 |
A Phase 1c Trial Comparing the Efficacy and Safety of a New Aqueous Formulation of Alphaxalone with Propofol.
Topics: Adolescent; Adult; Anesthesia; Anesthetics, Intravenous; Blood Pressure; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hypnotics and Sedatives; Male; Pregnanediones; Propofol; Water; Young Adult | 2015 |
Effects of thiopentone, propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs.
Topics: Animals; Arytenoid Cartilage; Cross-Over Studies; Dogs; Hypnotics and Sedatives; Laryngoscopy; Larynx; Movement; Pregnanediones; Propofol; Thiopental | 2017 |
Postinduction apnoea in dogs premedicated with acepromazine or dexmedetomidine and anaesthetized with alfaxalone or propofol.
Topics: Acepromazine; Anesthesia, General; Anesthetics, Combined; Animals; Apnea; Carbon Dioxide; Dexmedetomidine; Dogs; Female; Intubation, Intratracheal; Male; Preanesthetic Medication; Pregnanediones; Propofol; Respiratory Rate | 2017 |
Induction dose and recovery quality of propofol and alfaxalone with or without midazolam coinduction followed by total intravenous anesthesia in dogs.
Topics: Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Intravenous; Animals; Dogs; Intubation, Intratracheal; Midazolam; Pregnanediones; Propofol | 2017 |
Clinical comparison of alfaxalone, ketamine and propofol following medetomidine and methadone in dogs.
Topics: Anesthesia Recovery Period; Anesthesia, Intravenous; Animals; Dogs; Ketamine; Male; Medetomidine; Methadone; Orchiectomy; Preanesthetic Medication; Pregnanediones; Propofol | 2017 |
Evaluation of total intravenous anesthesia with propofol-guaifenesin-medetomidine and alfaxalone-guaifenesin-medetomidine in Thoroughbred horses undergoing castration.
Topics: Anesthesia, Intravenous; Anesthetics, Combined; Animals; Cardiovascular System; Guaifenesin; Horses; Male; Medetomidine; Orchiectomy; Pregnanediones; Propofol; Respiration | 2017 |
Effect of blood collection by the push-pull technique from an indwelling catheter versus direct venipuncture on venous blood gas values before and after administration of alfaxalone or propofol in dogs.
Topics: Anesthetics; Animals; Blood Gas Analysis; Blood Specimen Collection; Catheters, Indwelling; Dogs; Hypnotics and Sedatives; Pregnanediones; Propofol | 2017 |
Effect of rate of administration of propofol or alfaxalone on induction dose requirements and occurrence of apnea in dogs.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Apnea; Dogs; Female; Male; Preanesthetic Medication; Pregnanediones; Propofol | 2017 |
Comparison of the effects of alfaxalone and propofol with acepromazine, butorphanol and/or doxapram on laryngeal motion and quality of examination in dogs.
Topics: Acepromazine; Anesthesia; Anesthetics; Anesthetics, Combined; Animals; Butorphanol; Cross-Over Studies; Dog Diseases; Dogs; Doxapram; Female; Laryngoscopy; Larynx; Physical Examination; Pregnanediones; Propofol; Vocal Cord Paralysis | 2018 |
Effects of isoflurane, sevoflurane, propofol and alfaxalone on brain metabolism in dogs assessed by proton magnetic resonance spectroscopy (
Topics: Anesthetics, Inhalation; Animals; Brain; Brain Chemistry; Cross-Over Studies; Dogs; Female; Isoflurane; Male; Methyl Ethers; Pregnanediones; Propofol; Proton Magnetic Resonance Spectroscopy; Sevoflurane | 2018 |
CARDIOVASCULAR EFFECTS OF ALFAXALONE AND PROPOFOL IN THE BULLFROG, LITHOBATES CATESBEIANUS.
Topics: Anesthetics; Animals; Cardiovascular System; Hypnotics and Sedatives; Infusions, Intra-Arterial; Injections, Intramuscular; Pilot Projects; Pregnanediones; Propofol; Rana catesbeiana | 2018 |
A comparison of the effect of propofol and alfaxalone on laryngeal motion in nonbrachycephalic and brachycephalic dogs.
Topics: Anesthetics; Animals; Cohort Studies; Craniosynostoses; Dog Diseases; Dogs; Female; Larynx; Male; Pregnanediones; Propofol; Prospective Studies | 2018 |
Recovery characteristics of dogs following anesthesia induced with tiletamine-zolazepam, alfaxalone, ketamine-diazepam, or propofol and maintained with isoflurane.
Topics: Anesthesia; Animals; Cross-Over Studies; Diazepam; Dogs; Heart Rate; Isoflurane; Ketamine; Pregnanediones; Propofol; Prospective Studies; Reproducibility of Results; Retrospective Studies; Tiletamine; Zolazepam | 2019 |
Effects of chemical and mechanical stimulation on laryngeal motion during alfaxalone, thiopentone or propofol anaesthesia in healthy dogs.
Topics: Anesthesia; Anesthetics; Anesthetics, Intravenous; Animals; Cross-Over Studies; Dog Diseases; Dogs; Larynx; Pregnanediones; Propofol; Random Allocation; Thiopental; Vocal Cord Paralysis | 2019 |
A randomized cross-over trial assessing salivary and urinary cortisol concentrations after alfaxalone and propofol administration in healthy cats.
Topics: Anesthetics; Animals; Cats; Cross-Over Studies; Hydrocortisone; Hypnotics and Sedatives; Male; Pregnanediones; Propofol; Saliva | 2021 |
Laryngeal function in normal dogs administered isoflurane following partial clearance of alfaxalone or propofol.
Topics: Animals; Cross-Over Studies; Dogs; Isoflurane; Male; Pregnanediones; Propofol | 2021 |
Effects of sevoflurane, propofol or alfaxalone on neuromuscular blockade produced by a single intravenous bolus of rocuronium in dogs.
Topics: Androstanols; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Dogs; Female; Male; Methyl Ethers; Neuromuscular Blockade; Neuromuscular Nondepolarizing Agents; Pregnanediones; Propofol; Prospective Studies; Rocuronium; Sevoflurane | 2022 |
Effect of anesthetic induction with propofol, alfaxalone or ketamine on intraocular pressure in cats: a randomized masked clinical investigation.
Topics: Anesthetics; Animals; Cats; Intraocular Pressure; Ketamine; Midazolam; Pregnanediones; Propofol; Prospective Studies | 2023 |
Alfaxalone anaesthesia increases brain derived neurotrophic factor levels and preserves postoperative cognition by activating pregnane-X receptors: an in vitro study and a double blind randomised controlled trial.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, Intravenous; Australia; Brain-Derived Neurotrophic Factor; Cognition; Double-Blind Method; Humans; Pregnanolone; Propofol; Prospective Studies; Sevoflurane | 2022 |
Comparison of alfaxalone and propofol on haematological and serum biochemical variables in cats undergoing radiotherapy with sevoflurane maintenance.
Topics: Anesthesia, Intravenous; Animals; Cats; Pregnanediones; Propofol; Prospective Studies; Sevoflurane | 2023 |
47 other study(ies) available for alphaxalone and propofol
| Article | Year |
|---|---|
Honokiol and magnolol increase the number of [3H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites.
Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Binding Sites; Biphenyl Compounds; Cell Membrane; Central Nervous System Depressants; Cerebellum; Diflunisal; Drugs, Chinese Herbal; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Lignans; Muscimol; Picrotoxin; Propofol; Prosencephalon; Rats; Receptors, GABA-A; Tritium | 1999 |
Anesthetic activity of novel water-soluble 2 beta-morpholinyl steroids and their modulatory effects at GABAA receptors.
Topics: Anesthesia; Anesthetics; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Membrane; Chromaffin System; Electric Conductivity; Electrophysiology; Male; Mice; Molecular Structure; Morpholines; Pregnanediones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Solubility; Structure-Activity Relationship; Water | 1997 |
Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channel Agonists; Female; Humans; In Vitro Techniques; Oocytes; Patch-Clamp Techniques; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; Structure-Activity Relationship; Xenopus laevis | 1998 |
Synthesis, structure-activity relationships at the GABA(A) receptor in rat brain, and differential electrophysiological profile at the recombinant human GABA(A) receptor of a series of substituted 1,2-diphenylimidazoles.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Brain; Female; GABA-A Receptor Agonists; Humans; Imidazoles; In Vitro Techniques; Male; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Protein Subunits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Reflex; Stereoisomerism; Structure-Activity Relationship; Xenopus laevis | 2005 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Temperature and anion dependence of allosteric interactions at the gamma-aminobutyric acid-benzodiazepine receptor.
Topics: Animals; Anions; Binding, Competitive; Brain Chemistry; Drug Interactions; Flunitrazepam; Male; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Temperature | 1992 |
Propofol potentiates the binding of [3H]flunitrazepam to the GABAA receptor complex.
Topics: Animals; Binding, Competitive; Drug Synergism; Flunitrazepam; Male; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Tritium | 1992 |
The general anesthetic propofol: a biochemical tool to study the function of the GABA-coupled chloride channel.
Topics: Anesthetics; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; gamma-Aminobutyric Acid; Ion Channels; Male; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Inbred Strains | 1992 |
Effects of thiopentone, propofol, alphaxalone-alphadolone, ketamine and xylazine-ketamine on lower oesophageal sphincter pressure and barrier pressure in cats.
Topics: Anesthetics; Animals; Cats; Esophagogastric Junction; Female; Ketamine; Male; Pregnanediones; Pressure; Propofol; Random Allocation; Stomach; Thiopental; Xylazine | 1991 |
The general anesthetic propofol enhances the function of gamma-aminobutyric acid-coupled chloride channel in the rat cerebral cortex.
Topics: Anesthetics; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; gamma-Aminobutyric Acid; Male; Membrane Proteins; Pentobarbital; Picrotoxin; Pregnanediones; Propofol; Rats; Rats, Inbred Strains | 1990 |
Effects of propofol, pentobarbital and alphaxalone on t-[35S]butylbicyclophosphorothionate binding in rat cerebral cortex.
Topics: Anesthetics; Animals; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Diazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Male; Membranes; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Sulfur Radioisotopes | 1994 |
A comparison of propofol with other injectable anaesthetics in a rat model for measuring cardiovascular parameters.
Topics: Anesthesia, Intravenous; Anesthetics; Animals; Blood Pressure; Butyrophenones; Female; Fentanyl; Heart Rate; Male; Midazolam; Pentobarbital; Pregnanediones; Propofol; Rats; Respiration; Thiopental | 1993 |
Biochemical evaluations of the effects of loreclezole and propofol on the GABAA receptor in rat brain.
Topics: Anesthetics; Animals; Anticonvulsants; Brain; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes; Triazoles; Tritium | 1996 |
Preemptive analgesic effects of steroid anesthesia with alphaxalone in the rat formalin test. Evidence for differential GABA(A) Receptor modulation in persistent nociception.
Topics: Analgesics; Anesthetics; Animals; GABA Modulators; Male; Pentobarbital; Pregnanediones; Propofol; Rats; Receptors, GABA-A | 1996 |
Increased membrane cholesterol reduces the potentiation of GABA(A) currents by neurosteroids in dissociated hippocampal neurones.
Topics: Animals; Cholesterol; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hippocampus; Liposomes; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pregnanediones; Pregnanolone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Steroids; Synapses; Synaptic Membranes | 1998 |
Pre- versus postinjury effects of intravenous GABAergic anesthetics on formalin-induced Fos immunoreactivity in the rat spinal cord.
Topics: Adjuvants, Anesthesia; Analgesics; Analysis of Variance; Anesthetics; Anesthetics, Intravenous; Animals; Cell Nucleus; Coloring Agents; Cytoplasm; Disease Models, Animal; Fixatives; Formaldehyde; GABA Modulators; Immunoenzyme Techniques; Injections, Subcutaneous; Lumbar Vertebrae; Male; Pentobarbital; Pregnanediones; Propofol; Proto-Oncogene Proteins c-fos; Rats; Rats, Long-Evans; Spinal Cord | 1999 |
Activation of rat locus coeruleus neuron GABA(A) receptors by propofol and its potentiation by pentobarbital or alphaxalone.
Topics: Anesthetics; Anesthetics, Intravenous; Animals; Baclofen; Barium Compounds; Bicuculline; Chlorides; Diazepam; Drug Synergism; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ionophores; Locus Coeruleus; Male; Neurons; Pentobarbital; Picrotoxin; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zinc Compounds | 1999 |
A single glycine residue at the entrance to the first membrane-spanning domain of the gamma-aminobutyric acid type A receptor beta(2) subunit affects allosteric sensitivity to GABA and anesthetics.
Topics: Allosteric Regulation; Amino Acid Sequence; Anesthetics; Animals; Cells, Cultured; Chloride Channels; Electrophysiology; Etomidate; GABA Modulators; gamma-Aminobutyric Acid; Glycine; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Pentobarbital; Pregnanediones; Propofol; Protein Conformation; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Sequence Homology, Amino Acid; Spodoptera | 2000 |
A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation.
Topics: Adjuvants, Anesthesia; Allosteric Site; Amino Acid Sequence; Anesthetics; Anesthetics, Intravenous; Animals; Cloning, Molecular; DNA Mutational Analysis; Dose-Response Relationship, Drug; Etomidate; Kinetics; Ligands; Models, Biological; Molecular Sequence Data; Mutagenesis; Mutation; Oocytes; Patch-Clamp Techniques; Pentobarbital; Point Mutation; Pregnanediones; Propofol; Protein Structure, Tertiary; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Xenopus | 2003 |
Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2.
Topics: Anesthetics, General; Animals; Cells, Cultured; Enflurane; Etomidate; gamma-Aminobutyric Acid; Humans; Point Mutation; Pregnanediones; Propofol; Protein Subunits; Rats; Receptors, GABA-A; Recombinant Proteins | 2003 |
Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors.
Topics: Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Etomidate; Female; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Glycine; Humans; Hydrocarbons, Halogenated; Imidazoles; Male; Membrane Potentials; Oocytes; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Receptors, Serotonin, 5-HT3; Serotonin; Tritium; Xenopus laevis | 2005 |
Influence of external and intracellular pH on propofol-induced responses in rat locus coeruleus neurons.
Topics: Acidosis; Animals; Hydrogen-Ion Concentration; In Vitro Techniques; Locus Coeruleus; Male; Pentobarbital; Pregnanediones; Propofol; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2006 |
A comparison of microbial growth in alfaxalone, propofol and thiopental.
Topics: Anesthetics; Anesthetics, Intravenous; Colony Count, Microbial; Dose-Response Relationship, Drug; Drug Combinations; Escherichia coli; Kinetics; Microbial Sensitivity Tests; Pregnanediones; Propofol; Specimen Handling; Staphylococcus aureus; Thiopental; Treatment Outcome | 2008 |
Comparison of the anesthetic efficacy and cardiopulmonary effects of continuous rate infusions of alfaxalone-2-hydroxypropyl-beta-cyclodextrin and propofol in dogs.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Anesthetics, Intravenous; Animals; beta-Cyclodextrins; Blood Pressure; Body Temperature; Cardiac Output; Cross-Over Studies; Dogs; Heart Rate; Infusions, Intravenous; Pregnanediones; Propofol; Stroke Volume; Time Factors; Vascular Resistance | 2008 |
Effect of propofol and alfaxalone on pain after ovariohysterectomy in cats.
Topics: Analgesia; Analgesics; Anesthetics; Animals; Cats; Female; Hypnotics and Sedatives; Hysterectomy; Ovariectomy; Pain Measurement; Pain, Postoperative; Pregnanediones; Propofol | 2010 |
Ovariohysterectomy in cats.
Topics: Analgesics; Animals; Cats; Education, Veterinary; Female; Hysterectomy; Ovariectomy; Pain, Postoperative; Pregnanediones; Propofol; Time Factors | 2010 |
The effect of alphaxalone-alphadolone, propofol, and pentobarbitone anaesthesia on the β-endorphin and ACTH response to haemorrhage in the pig.
Topics: Adrenocorticotropic Hormone; Anesthesia; Anesthetics; Animals; beta-Endorphin; Blood Pressure; Heart Rate; Hemorrhage; Hypovolemia; Pentobarbital; Pregnanediones; Propofol; Swine | 2011 |
Effects of an intravenous bolus of alfaxalone versus propofol on intraocular pressure in sheep.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Anesthetics, Intravenous; Animals; beta-Cyclodextrins; Cross-Over Studies; Infusions, Intravenous; Intraocular Pressure; Miosis; Pregnanediones; Propofol; Prospective Studies; Pupil; Sheep; Time Factors | 2012 |
Heart and respiratory rates and adrenal response to propofol or alfaxalone in rabbits.
Topics: Adrenal Glands; Anesthetics; Anesthetics, Intravenous; Animals; Corticosterone; Heart Rate; Hydrocortisone; Pregnanediones; Propofol; Rabbits; Respiration | 2012 |
Eye position of cats anaesthetised with alfaxalone or propofol.
Topics: Anesthesia; Anesthetics; Animals; Cats; Female; Male; Ocular Physiological Phenomena; Pregnanediones; Propofol | 2013 |
Doppler evaluation of the effects of propofol, etomidate and alphaxalone on fetoplacental circulation hemodynamics in the pregnant ewe.
Topics: Anesthesia, Obstetrical; Anesthetics, Intravenous; Animals; Animals, Inbred Strains; Blood Flow Velocity; Etomidate; Female; Fetus; Heart Rate, Fetal; Placental Circulation; Pregnancy; Pregnanediones; Propofol; Pulsatile Flow; Random Allocation; Sheep, Domestic; Ultrasonography, Doppler; Ultrasonography, Prenatal; Umbilical Arteries; Vascular Resistance | 2013 |
Apgar score after induction of anesthesia for canine cesarean section with alfaxalone versus propofol.
Topics: Anesthesia; Animals; Animals, Newborn; Cesarean Section; Dogs; Female; Pregnancy; Pregnanediones; Propofol | 2013 |
GABAA-R α4 subunits are required for the low dose locomotor stimulatory effect of alphaxalone, but not for several other behavioral responses to alphaxalone, etomidate or propofol.
Topics: Anesthetics; Animals; Etomidate; Female; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Pregnanediones; Propofol; Protein Subunits; Receptors, GABA-A | 2014 |
Alphaxalone Reformulated: A Water-Soluble Intravenous Anesthetic Preparation in Sulfobutyl-Ether-β-Cyclodextrin.
Topics: Anesthetics, Intravenous; Animals; Arterial Pressure; beta-Cyclodextrins; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Excipients; Glycerol; Heart Rate; Lethal Dose 50; Male; Motor Activity; Pain Threshold; Pregnanediones; Propofol; Rats, Wistar; Reflex; Risk Assessment; Sleep; Solubility; Soybean Oil; Time Factors; Water | 2015 |
Synaptic-type α1β2γ2L GABAA receptors produce large persistent currents in the presence of ambient GABA and anesthetic drugs.
Topics: Anesthetics; Animals; Cell Line; Chromosome Pairing; Etomidate; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Pentobarbital; Pregnanediones; Propofol; Rats; Receptors, GABA-A | 2015 |
Another Steroid Hypnotic: More of the Same or Something Different?
Topics: Anesthetics, Intravenous; Animals; beta-Cyclodextrins; Excipients; Glycerol; Male; Pregnanediones; Propofol; Water | 2015 |
Steroid Anesthesia Revisited: Again.
Topics: Anesthetics, Intravenous; Animals; beta-Cyclodextrins; Excipients; Glycerol; Male; Pregnanediones; Propofol; Water | 2015 |
A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors.
Topics: Amino Acid Substitution; Anesthetics; Anesthetics, Intravenous; Animals; Barbiturates; Cysteine; Electrophysiological Phenomena; Etomidate; Female; Pregnanediones; Propofol; Receptors, GABA; Xenopus laevis | 2016 |
Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site.
Topics: Amino Acid Substitution; Anesthetics, Intravenous; Animals; Barbiturates; Binding Sites; Cysteine; Etomidate; Female; Ion Channel Gating; Mutation; Pregnanediones; Propofol; Receptors, GABA-A; Tryptophan; Xenopus | 2016 |
GABA Type A Receptor Activation in the Allosteric Coagonist Model Framework: Relationship between EC
Topics: Allosteric Regulation; Anesthetics; Animals; Binding Sites; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; gamma-Aminobutyric Acid; Models, Biological; Models, Theoretical; Mutation; Oocytes; Patch-Clamp Techniques; Pentobarbital; Pregnanediones; Propofol; Receptors, GABA-A; Xenopus laevis | 2018 |
Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam.
Topics: Animals; Cells, Cultured; Diazepam; Drug Synergism; Inhibitory Postsynaptic Potentials; Locomotion; Male; Mice; Neurons; Oocysts; Patch-Clamp Techniques; Pregnanediones; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; Xenopus | 2018 |
Effects of alfaxalone, thiopental, or propofol and diazepam on laryngeal motion in healthy dogs.
Topics: Anesthesia, General; Anesthetics; Animals; Arytenoid Cartilage; Diazepam; Dogs; Drug Combinations; Laryngoscopy; Pregnanediones; Propofol; Thiopental; Video Recording | 2018 |
Anesthetic agents affect urodynamic parameters and anesthetic depth at doses necessary to facilitate preclinical testing in felines.
Topics: Anesthesia Recovery Period; Anesthetics; Animals; Cats; Chloralose; Dexmedetomidine; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; Heart Rate; Isoflurane; Male; Models, Animal; Muscle Contraction; Muscle, Smooth; Pregnanediones; Pressure; Propofol; Urinary Bladder; Urodynamics | 2020 |
Comparison of the anesthetic effects between 5 mg/kg of alfaxalone and 10 mg/kg of propofol administered intravenously in cats.
Topics: Anesthetics; Animals; Apnea; Cat Diseases; Cats; Pregnanediones; Propofol | 2021 |
The impact of alfaxalone, propofol and ketamine on canine peripheral blood lymphocyte cytotoxicity in vitro.
Topics: Anesthetics; Animals; Dexamethasone; Dogs; Ketamine; Lymphocytes; Pregnanediones; Propofol | 2021 |
Pharmacodynamics of propofol and alfaxalone in rattlesnakes (Crotalus durissus).
Topics: Anesthetics; Animals; Blood Pressure; Crotalus; Heart Rate; Pregnanediones; Propofol | 2021 |
Comparison between propofol and alfaxalone anesthesia for the evaluation of laryngeal function in healthy dogs utilizing computerized software.
Topics: Anesthesia; Anesthetics; Animals; Dogs; Female; Male; Pregnanediones; Propofol; Software; Vocal Cord Paralysis | 2022 |