alphaxalone has been researched along with pregnanolone in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.88) | 18.7374 |
| 1990's | 21 (51.22) | 18.2507 |
| 2000's | 12 (29.27) | 29.6817 |
| 2010's | 5 (12.20) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Cadoni, C; Gee, KW | 1 |
| Ticku, MK; Yu, R | 1 |
| Acosta-Burruel, M; Goodnough, DB; Hawkinson, JE; Kimbrough, CL; Wood, PL | 1 |
| Anderson, A; Boyd, AC; Byford, A; Campbell, AC; Gemmell, DK; Hamilton, NM; Hill, DR; Hill-Venning, C; Lambert, JJ; Maidment, MS; Marshall, RJ; May, V; Peters, JA; Rees, DC; Stevenson, D; Sundaram, H | 1 |
| Anderson, A; Boyd, AC; Clark, JK; Fielding, L; Gemmell, DK; Hamilton, NM; Maidment, MS; May, V; McGuire, R; McPhail, P; Sansbury, FH; Sundaram, H; Taylor, R | 1 |
| Hill-Venning, C; Lambert, JJ; Peters, JA | 1 |
| Kubli-Garfias, C; López y López, L; Perusquía, M | 1 |
| Hales, TG; Lambert, JJ; Peters, JA; Sturgess, NC | 1 |
| Cottrell, GA; Mistry, DK | 1 |
| File, SE; Simmonds, MA | 1 |
| Omand, WD; Roth, SH | 1 |
| Akhondzadeh, S; Stone, TW | 2 |
| Jackson, MB; Zhang, SJ | 1 |
| Jussofie, A | 2 |
| Prince, RJ; Simmonds, MA | 1 |
| Deutsch, SI; Koetzner, L; Mastropaolo, J; Morn, C; Riggs, R; Rosse, RB; Steinberg, K | 1 |
| Bracamontes, J; Steinbach, JH; Ueno, S; Weiss, DS; Zorumski, C | 1 |
| Fiszer de Plazas, S; Pignataro, L | 1 |
| Simmonds, MA; Sooksawate, T | 1 |
| Maitra, R; Reynolds, JN | 2 |
| Amin, J; Moorefield, CN; Morris, KD | 1 |
| Danhof, M; Gladdines, WW; Irth, H; Smulders, CJ; van der Graaf, PH; Visser, SA | 1 |
| DeBold, JF; Faccidomo, S; Fish, EW; Miczek, KA | 1 |
| Adkins, CE; Bonnert, TP; Gonzalez, JE; Haldon, C; Kerby, J; McKernan, RM; Oades, K; Pillai, GV; Simpson, PB; Whiting, PJ | 1 |
| Danhof, M; Gladdines, WW; Peletier, LA; van der Graaf, PH; Visser, SA | 1 |
| Belelli, D; Lambert, JJ; Ling, AT; Peters, JA; Weir, CJ; Wildsmith, JA | 1 |
| Brimelow, BC; Covey, DF; Jagodic, MM; Jevtovic-Todorovic, V; Jiang, X; Krishnan, K; Mennerick, S; Pathirathna, S; Todorovic, SM; Zorumski, CF | 1 |
| Ginsburg, BC; Lamb, RJ | 1 |
| France, CP; Javors, MA; McMahon, LR | 1 |
| Fink, RH; Gage, PW; Gaul, S; Liu, L; Ozsarac, N | 1 |
| Codocedo, JF; Huidobro-Toro, JP; Rodríguez, FE | 1 |
| Castillo-Melendez, M; Hirst, JJ; Walker, DW; Yawno, T | 1 |
| Akk, G; Covey, DF; Elias, G; Evers, AS; Krishnan, K; Kudova, E; Li, P; Manion, BD; Mennerick, S; Qian, M; Taylor, A; Zorumski, CF | 1 |
| Jenkin, G; Miller, SL; Mortale, M; Sutherland, AE; Walker, DW; Wallace, EM; Yawno, T | 1 |
| Langendijk, P; Plush, K; Rault, JL; Yawno, T | 1 |
| Meng, Z; Rowlett, JK | 1 |
| Higashi, T; Nakashima, K; Okumura, A; Sato, T; Yoshizawa, K | 1 |
| Goodchild, CS; Serrao, JM | 1 |
1 trial(s) available for alphaxalone and pregnanolone
| Article | Year |
|---|---|
Alfaxalone anaesthesia increases brain derived neurotrophic factor levels and preserves postoperative cognition by activating pregnane-X receptors: an in vitro study and a double blind randomised controlled trial.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, Intravenous; Australia; Brain-Derived Neurotrophic Factor; Cognition; Double-Blind Method; Humans; Pregnanolone; Propofol; Prospective Studies; Sevoflurane | 2022 |
40 other study(ies) available for alphaxalone and pregnanolone
| Article | Year |
|---|---|
Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex.
Topics: Androstanes; Animals; Azasteroids; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanediol; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stereoisomerism | 1992 |
Chronic neurosteroid treatment produces functional heterologous uncoupling at the gamma-aminobutyric acid type A/benzodiazepine receptor complex in mammalian cortical neurons.
Topics: Androstanes; Animals; Azasteroids; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; Chlorides; Chlorine; Convulsants; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Mice; Mice, Inbred C57BL; Neurons; Pregnanolone; Radioisotopes; Radioligand Assay; Receptors, GABA-A; Sulfur Radioisotopes; Time Factors; Tritium | 1995 |
Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site.
Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Cell Membrane; Cerebral Cortex; Desoxycorticosterone; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanolone; Pregnenolone; Protein Binding; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids | 1996 |
Anesthetic activity of novel water-soluble 2 beta-morpholinyl steroids and their modulatory effects at GABAA receptors.
Topics: Anesthesia; Anesthetics; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Membrane; Chromaffin System; Electric Conductivity; Electrophysiology; Male; Mice; Molecular Structure; Morpholines; Pregnanediones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Solubility; Structure-Activity Relationship; Water | 1997 |
Conformationally constrained anesthetic steroids that modulate GABA(A) receptors.
Topics: Androstanols; Anesthetics; Animals; Brain; GABA Modulators; Hydrogen Bonding; In Vitro Techniques; Injections, Intravenous; Mice; Models, Molecular; Radioligand Assay; Rats; Receptors, GABA-A; Structure-Activity Relationship | 2000 |
The interaction of steroids with inhibitory and excitatory amino acid receptors.
Topics: Anesthetics; Animals; Cattle; Cells, Cultured; gamma-Aminobutyric Acid; Mice; Neurons; Pregnanediones; Pregnanolone; Receptors, Amino Acid; Receptors, Cell Surface; Steroids | 1992 |
Structure activity relationship in the in vitro relaxation of uterine muscle induced by 5 alpha and 5 beta alphaxalones.
Topics: Anesthetics; Animals; Diestrus; Female; In Vitro Techniques; Pregnanediones; Pregnanolone; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Uterine Contraction | 1991 |
Steroid modulation of the GABAA receptor complex: electrophysiological studies.
Topics: Anesthetics; Animals; Cattle; Chromaffin System; Desoxycorticosterone; Electrophysiology; Hippocampus; Membrane Proteins; Pregnanediones; Pregnanolone; Rats; Receptors, GABA-A; Steroids | 1990 |
Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture.
Topics: Animals; Bemegride; Bicuculline; Cells, Cultured; GABA-A Receptor Antagonists; Membrane Potentials; Mice; Neurons; Pregnanediones; Pregnanes; Pregnanolone; Receptors, GABA-A; Spinal Cord | 1990 |
Myoclonic seizures in the mouse induced by alphaxalone and related steroid anaesthetics.
Topics: Anesthetics; Animals; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Myoclonus; Pregnanediones; Pregnanolone; Steroids | 1988 |
Pregnane steroid anesthetics exhibit selective action on the firing activity of an isolated neuron.
Topics: Animals; Astacoidea; In Vitro Techniques; Muscle Contraction; Neurons; Pregnanediones; Pregnanes; Pregnanolone | 1982 |
Potentiation by neurosteroids of muscimol/adenosine interactions in rat hippocampus.
Topics: Adenosine; Anesthetics; Animals; Anti-Anxiety Agents; Barium; Bicuculline; Chloride Channel Agonists; Drug Synergism; GABA-A Receptor Agonists; Hippocampus; Male; Muscimol; Neural Inhibition; Pregnanediones; Pregnanolone; Rats; Rats, Wistar | 1995 |
Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors.
Topics: Action Potentials; Adenosine; Alanine; Anesthetics; Animals; Anti-Anxiety Agents; Bicuculline; Corpus Striatum; Culture Techniques; Dose-Response Relationship, Drug; Electric Stimulation; GABA Agonists; GABA Antagonists; Hippocampus; Male; Muscimol; Neuronal Plasticity; Pregnanediones; Pregnanolone; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA; Receptors, Metabotropic Glutamate; Valine | 1995 |
Neuroactive steroids modulate GABAA receptors in peptidergic nerve terminals.
Topics: Animals; Chloride Channels; Drug Synergism; Electric Conductivity; Estradiol; gamma-Aminobutyric Acid; Ion Channel Gating; Nerve Endings; Neuropeptides; Pituitary Gland, Posterior; Pregnanediones; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids | 1994 |
Brain region-specific effects of neuroactive steroids on the affinity and density of the GABA-binding site.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Brain; Cerebellum; Desoxycorticosterone; Female; Hippocampus; Hypothalamus; Medulla Oblongata; Muscimol; Pregnanediones; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1993 |
Differential antagonism by epipregnanolone of alphaxalone and pregnanolone potentiation of [3H]flunitrazepam binding suggests more than one class of binding site for steroids at GABAA receptors.
Topics: Anesthetics; Animals; Brain; Flunitrazepam; In Vitro Techniques; Male; Membranes; Pregnanediones; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A | 1993 |
A new highly sensitive procedure--a prerequisite to evaluate the density of GABAA receptors and to study their allosteric properties in distinct areas of rat brain.
Topics: Allosteric Regulation; Animals; Binding Sites; Brain; Cerebellum; Desoxycorticosterone; Female; Frontal Lobe; Humans; Hydrogen-Ion Concentration; Muscimol; Pentobarbital; Pregnanediones; Pregnanolone; Progesterone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1993 |
Evaluation of in vivo interactions in mice between flurazepam and two neuroactive steroids.
Topics: Animals; Anticonvulsants; Behavior, Animal; Drug Interactions; Electric Stimulation; Flurazepam; GABA Modulators; Hypnotics and Sedatives; Male; Mice; Motor Activity; Pregnanediones; Pregnanolone; Receptors, GABA-A; Seizures | 1996 |
Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Bicuculline; Binding Sites; Binding, Competitive; Cell Line; Coturnix; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Ion Transport; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pentobarbital; Point Mutation; Pregnanediones; Pregnanolone; Protein Binding; Pyridazines; Receptors, GABA-A; Structure-Activity Relationship | 1997 |
Epipregnanolone acts as a partial agonist on a common neurosteroid modulatory site of the GABA(A) receptor complex in avian CNS.
Topics: Animals; Chickens; Drug Synergism; Flunitrazepam; GABA Agonists; Pregnanediones; Pregnanolone; Receptors, GABA; Tritium | 1997 |
Increased membrane cholesterol reduces the potentiation of GABA(A) currents by neurosteroids in dissociated hippocampal neurones.
Topics: Animals; Cholesterol; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hippocampus; Liposomes; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pregnanediones; Pregnanolone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Steroids; Synapses; Synaptic Membranes | 1998 |
Modulation of GABA(A) receptor function by neuroactive steroids: evidence for heterogeneity of steroid sensitivity of recombinant GABA(A) receptor isoforms.
Topics: Animals; Dose-Response Relationship, Drug; Female; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Pregnanediones; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Recombinant Proteins; Steroids; Xenopus laevis | 1998 |
Subunit dependent modulation of GABAA receptor function by neuroactive steroids.
Topics: Animals; Drug Synergism; Female; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Humans; In Vitro Techniques; Membrane Potentials; Microinjections; Oocytes; Patch-Clamp Techniques; Pregnanediones; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Xenopus laevis | 1999 |
Differential modulation of the gamma-aminobutyric acid type C receptor by neuroactive steroids.
Topics: 5-alpha-Dihydroprogesterone; Animals; Anti-Inflammatory Agents; Desoxycorticosterone; gamma-Aminobutyric Acid; Humans; Oocytes; Patch-Clamp Techniques; Pregnanediones; Pregnanolone; Receptors, GABA; Receptors, Purinergic P1; Xenopus laevis | 1999 |
High-performance liquid chromatography of the neuroactive steroids alphaxalone and pregnanolone in plasma using dansyl hydrazine as fluorescent label: application to a pharmacokinetic-pharmacodynamic study in rats.
Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Dansyl Compounds; Fluorescent Dyes; Hydrazines; Male; Pregnanediones; Pregnanolone; Rats; Rats, Wistar | 2000 |
Alcohol, allopregnanolone and aggression in mice.
Topics: Aggression; Anesthetics; Animals; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Female; Male; Mice; Pregnanediones; Pregnanolone | 2001 |
alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential.
Topics: Animals; Benzodiazepines; Cell Line; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Mice; Models, Biological; Muscimol; Pentobarbital; Pregnanediones; Pregnanolone; Protein Binding; Protein Conformation; Receptors, GABA-A; Spectrometry, Fluorescence; Time Factors; Transfection | 2001 |
Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA(A) receptor in vivo.
Topics: Algorithms; Anesthetics; Animals; Drug Interactions; Electroencephalography; Half-Life; Male; Models, Biological; Pregnanediones; Pregnanolone; Protein Binding; Rats; Rats, Wistar; Receptors, GABA-A; Steroids | 2002 |
The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors.
Topics: Anesthetics; Animals; Dose-Response Relationship, Drug; Evoked Potentials; Glycine; Oocytes; Patch-Clamp Techniques; Pregnanediones; Pregnanolone; Receptors, GABA-A; Recombinant Proteins; Structure-Activity Relationship; Xenopus laevis | 2004 |
New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids.
Topics: Anesthetics; Animals; Calcium Channels, T-Type; Estranes; Female; Ganglia, Spinal; Male; Membrane Potentials; Neurons, Afferent; Nitriles; Nociceptors; Oocytes; Pregnanediones; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Xenopus | 2005 |
Alphaxalone and epiallopregnanolone in rats trained to discriminate ethanol.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Male; Pregnanediones; Pregnanolone; Rats; Rats, Inbred Lew | 2005 |
Changes in relative potency among positive GABA(A) receptor modulators upon discontinuation of chronic benzodiazepine treatment in rhesus monkeys.
Topics: Animals; Behavior, Animal; Benzodiazepines; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Lorazepam; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanediones; Pregnanolone; Receptors, GABA-A; Substance Withdrawal Syndrome | 2007 |
The neuroactive steroids alphaxalone and pregnanolone increase the conductance of single GABAA channels in newborn rat hippocampal neurons.
Topics: Animals; Animals, Newborn; Cells, Cultured; Drug Combinations; GABA Modulators; Hippocampus; Ion Channels; Neurons; Pregnanediones; Pregnanolone; Rats; Receptors, GABA-A | 2007 |
Neurosteroids differentially modulate P2X ATP-gated channels through non-genomic interactions.
Topics: Adenosine Triphosphate; Animals; Cell Line; Desoxycorticosterone; Drug Interactions; Estradiol; Female; Genomics; Humans; Ion Channel Gating; Neurotransmitter Agents; Oocytes; Pregnanediones; Pregnanolone; Progesterone; Purinergic P2 Receptor Agonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Xenopus laevis | 2009 |
Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain.
Topics: Animals; Apoptosis; Brain; Cell Death; Cell Proliferation; Cerebellum; Cholestenone 5 alpha-Reductase; Embryo, Mammalian; Female; Finasteride; Gestational Age; Hippocampus; Neurotransmitter Agents; Pregnancy; Pregnanediones; Pregnanolone; Sheep | 2009 |
Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; GABA Modulators; HEK293 Cells; Humans; Models, Molecular; Neurotransmitter Agents; Pregnanediones; Pregnanolone; Rats; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis | 2014 |
The effects of betamethasone on allopregnanolone concentrations and brain development in preterm fetal sheep.
Topics: Anesthetics; Animals; Betamethasone; Blood Chemical Analysis; Brain; Catheters, Indwelling; Female; Glucocorticoids; Oligodendroglia; Placenta; Pregnancy; Pregnanediones; Pregnanolone; Progesterone; Sheep, Domestic | 2014 |
Allopregnanolone and social stress: regulation of the stress response in early pregnancy in pigs.
Topics: Adrenocorticotropic Hormone; Anesthetics; Animals; Behavior, Animal; Corticotropin-Releasing Hormone; Female; Hydrocortisone; Pregnancy; Pregnancy, Animal; Pregnanediones; Pregnanolone; Progesterone; Social Environment; Stress, Psychological; Sus scrofa; Swine | 2015 |
Self-administration of progesterone and synthetic neuroactive steroids by male rhesus monkeys.
Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; GABA Modulators; Macaca mulatta; Male; Neurotransmitter Agents; Pregnanediones; Pregnanolone; Progesterone; Receptors, GABA-A; Reinforcement, Psychology; Self Administration | 2016 |
Role of allopregnanolone biosynthesis in acute stress-induced anxiety-like behaviors in mice.
Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety Disorders; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Finasteride; Freezing Reaction, Cataleptic; Male; Mice, Inbred C57BL; Muscle Relaxants, Central; Muscle Strength; Muscle Tonus; Pregnanediones; Pregnanolone; Restraint, Physical; Stress, Psychological | 2017 |