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alphaxalone and gamma-aminobutyric acid

alphaxalone has been researched along with gamma-aminobutyric acid in 71 studies

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	20 (28.17)	18.7374
1990's	35 (49.30)	18.2507
2000's	10 (14.08)	29.6817
2010's	6 (8.45)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andre, JM; Boulanger, T; Durant, F; Hoffmann, R; Rognan, D; Vercauteren, DP; Wermuth, CG	1
Cadoni, C; Gee, KW	1
Capper, HR; Johnston, GA; Kerr, DI; Ong, J	1
David, JA; Pinnock, RD; Sattelle, DB; Wafford, KA	1
Kerr, DI; Ong, J	1
Cottrell, GA; Lambert, JJ; Peters, JA	2
Maksay, G; Simonyi, M	1
Maksay, G	1
McCabe, RT; Olsen, RW; Wamsley, JK; Yezuita, JP	1
Iversen, LL; Wong, EH	1
Eichinger, A; Sieghart, W	1
Casida, JE; Gee, KW; Lawrence, LJ; Palmer, CJ; Wang, X; Yamamura, HI	1
Olsen, RW	1
Clements-Jewery, S; Hunt, P	1
Casida, JE; Richardson, M; Saederup, E; Squires, RF	1
Maksay, G; Ticku, MK	1
Kofman, O; Myslobodsky, MS	1
Ticku, MK; Yu, R	1
Saederup, E; Squires, RF	1
Barnes, EM; Calkin, PA	1
Acosta-Burruel, M; Goodnough, DB; Hawkinson, JE; Kimbrough, CL; Wood, PL	1
Olsen, RW; Sapp, DW; Srinivasan, S; Tobin, AJ	1
Ai, J; Kahnberg, P; Nielsen, M; Saederup, E; Squires, RF; Sterner, O; Witt, MR	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Hill-Venning, C; Lambert, JJ; Peters, JA	1
Bertrand, PP; Galligan, JJ	1
Hadingham, KL; Horne, AL; Kemp, JA; Macaulay, AJ; Whiting, P	1
Biggio, G; Concas, A; Maciocco, E; Mascia, MP; Santoro, G	1
Biggio, G; Concas, A; Mascia, MP; Sanna, E; Santoro, G; Serra, M	1
Barker, JL; Harrison, NL; Lange, GD; Owen, DG	1
Johnston, GA; Kerr, DI; Ong, J	1
Barker, JL; Harrison, NL; Vicini, S	1
Angel, A; Halsey, MJ; Little, H; Meldrum, BS; Ross, JA; Rostain, JC; Wardley-Smith, B	1
Cullen, KD; Martin, RJ	1
Barker, JL; Dunlap, VS; Valeyev, AY	1
Bormann, J; Feigenspan, A; Wässle, H	1
Jackson, MB; Zhang, SJ	1
Biggio, G; Concas, A; Dazzi, L; Maciocco, E; Mascia, MP; Santoro, G	1
Hadingham, KL; Harkness, PC; Horne, AL; Kemp, JA; Whiting, P	1
Barker, JL; Cruciani, RA; Lange, GD; Mahan, LC; Smallwood, VV; Valeyev, AY	1
Biggio, G; Ghiani, CA; Maciocco, E; Sanna, E; Serra, M; Tuligi, G	1
Amato, F; Biggio, G; Deserra, T; Motzo, C; Murgia, A; Sanna, E	1
Bracamontes, J; Steinbach, JH; Ueno, S; Weiss, DS; Zorumski, C	1
Gavish, M; Paz, L; Peter, Y; Pick, CG; Schreiber, S; Weizman, R	1
Reith, CA; Sillar, KT	1
Greenfield, LJ; Macdonald, RL; Neelands, TR; Turner, RS; Zhang, J	1
Banerjee, PK; Brailowsky, S; Olsen, RW; Snead, OC; Tillakaratne, NJ; Tobin, AJ	1
Simmonds, MA; Sooksawate, T	1
Banerjee, PK; Liu, CC; Snead, OC	1
Maitra, R; Reynolds, JN	2
Davidoff, RA; Hackman, JC; Holohean, AM; Katz, JL; Valeyev, AY; Wood, PM	1
Amin, J; Moorefield, CN; Morris, KD	1
Breese, GR; Criswell, HE; McCown, TJ; Ming, Z; Mueller, RA	1
Chen, CL; Chiu, TH; Yang, YR	1
Carlson, BX; Engblom, AC; Kristiansen, U; Olsen, RW; Schousboe, A	1
Bence, M; Everest, H; Forrest-Owen, W; Lightman, SL; McArdle, CA; Williams, B	1
Feigenspan, A; Gustincich, S; Raviola, E	1
Adkins, CE; Bonnert, TP; Gonzalez, JE; Haldon, C; Kerby, J; McKernan, RM; Oades, K; Pillai, GV; Simpson, PB; Whiting, PJ	1
Minami, K; Okamoto, T; Shibuya, I; Shigematsu, A; Shiraishi, M; Ueno, S; Ueta, Y; Uezono, Y; Yanagihara, N	1
Breese, GR; Criswell, HE; Griffith, BL; Ming, Z	1
Krähenbühl, K; Lambert, S; Rudolph, U; Siegwart, R	1
Asproni, B; Biggio, G; Busonero, F; Cerri, R; Maciocco, E; Mascia, MP; Pau, A; Sanna, E; Talani, G	1
Allgaier, C; Rassler, C; Strecker, K; Wegner, F; Wohlfarth, K	1
Bandyopadhyaya, AK; Benz, A; Covey, DF; Evers, AS; Manion, BD; Mennerick, S; Rath, NP; Taylor, A; Zorumski, CF	1
Akk, G; Eaton, MM; Li, P; Steinbach, JH	1
Akk, G; Bracamontes, J; Eaton, MM; Li, P; Mennerick, S; Shu, HJ; Steinbach, JH	1
Akk, G; Li, P	1
Akk, G; Germann, AL; Shin, DJ; Steinbach, JH	1

Other Studies

71 other study(ies) available for alphaxalone and gamma-aminobutyric acid

Article	Year
Structure and molecular modeling of GABAA receptor antagonists. Journal of medicinal chemistry, 1992, May-29, Volume: 35, Issue:11 Topics: Alkaloids; Androstanes; Azasteroids; Azepines; Bicuculline; Crystallization; Dibenzazepines; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Heterocyclic Compounds, 4 or More Rings; Heterocyclic Compounds, Bridged-Ring; Isoxazoles; Lactones; Models, Molecular; Molecular Conformation; Molecular Structure; Piperidines; Pyridazines; Receptors, GABA-A; Structure-Activity Relationship; Tubocurarine; X-Ray Diffraction	1992
Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex. European journal of pharmacology, 1992, Oct-01, Volume: 227, Issue:2 Topics: Androstanes; Animals; Azasteroids; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanediol; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stereoisomerism	1992
Cortisone: a potent GABAA antagonist in the guinea-pig isolated ileum. The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:9 Topics: Androstanes; Animals; Azasteroids; Cortisone; Female; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Hydrocortisone; Ileum; In Vitro Techniques; Male; Models, Molecular; Muscle Contraction; Muscle, Smooth; Picrotoxin; Sesterterpenes	1990
GABA receptors on the cell-body membrane of an identified insect motor neuron. Proceedings of the Royal Society of London. Series B, Biological sciences, 1988, Jan-22, Volume: 232, Issue:1269 Topics: Androstanes; Animals; Azasteroids; Bicuculline; Chlorides; Cockroaches; Dibenzazepines; Dose-Response Relationship, Drug; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channels; Male; Membrane Potentials; Microelectrodes; Motor Neurons; Nipecotic Acids; Periplaneta; Picrotoxin; Receptors, GABA-A	1988
Modulation of spontaneous motility by GABAA receptor antagonism in the guinea pig isolated ileum. Neuroscience letters, 1989, Jun-19, Volume: 101, Issue:2 Topics: 3-Mercaptopropionic Acid; Acetylcholine; Androstanes; Animals; Azasteroids; Bicuculline; Carbachol; Female; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Muscle Contraction; Picrotoxin; Time Factors	1989
An electrophysiological investigation of the characteristics and function of GABAA receptors on bovine adrenomedullary chromaffin cells. Pflugers Archiv : European journal of physiology, 1989, Volume: 415, Issue:1 Topics: Acetylcholine; Action Potentials; Adrenal Medulla; Androstanes; Animals; Azasteroids; Bicuculline; Cattle; Cell Membrane; Chloride Channels; Chlorides; Chromaffin System; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Membrane Proteins; Picrotoxin; Propanidid; Receptors, Cholinergic; Receptors, GABA-A	1989
Kinetic modulation by GABAergic agents of high- and low-affinity binding of [3H]methyl beta-carboline-3-carboxylate. Journal of neurochemistry, 1988, Volume: 50, Issue:6 Topics: Androstanes; Animals; Azasteroids; Carbolines; Cerebral Cortex; GABA Antagonists; gamma-Aminobutyric Acid; Half-Life; Kinetics; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes	1988
GABAA receptor populations bind agonists and antagonists differentially and with opposite affinities. Journal of neurochemistry, 1988, Volume: 50, Issue:6 Topics: Affinity Labels; Androstanes; Animals; Azasteroids; Brain; Diazepam; Diazonium Compounds; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscimol; Photochemistry; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sulfanilic Acids; Synaptic Membranes	1988
A novel GABAA antagonist [3H]SR 95531: microscopic analysis of binding in the rat brain and allosteric modulation by several benzodiazepine and barbiturate receptor ligands. Synapse (New York, N.Y.), 1988, Volume: 2, Issue:2 Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Binding, Competitive; Brain; Brain Chemistry; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Male; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter	1988
Modulation of [3H]diazepam binding in rat cortical membranes by GABAA agonists. Journal of neurochemistry, 1985, Volume: 44, Issue:4 Topics: Androstanes; Animals; Azasteroids; Bicuculline; Cell Membrane; Cerebral Cortex; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Isonicotinic Acids; Isoxazoles; Muscimol; Piperidines; Rats; Receptors, GABA-A; Taurine	1985
Differential degradation of different benzodiazepine binding proteins by incubation of membranes from cerebellum or hippocampus with trypsin. Journal of neurochemistry, 1985, Volume: 45, Issue:1 Topics: Affinity Labels; Androstanes; Animals; Azasteroids; Cell Membrane; Cerebellum; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Molecular Weight; Peptide Fragments; Photochemistry; Rats; Receptors, GABA-A; Trypsin	1985
t-[3H]butylbicycloorthobenzoate: new radioligand probe for the gamma-aminobutyric acid-regulated chloride ionophore. Journal of neurochemistry, 1985, Volume: 45, Issue:3 Topics: Androstanes; Animals; Azasteroids; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chemical Phenomena; Chemistry; Chlorides; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Ionophores; Kinetics; Male; Rats; Receptors, GABA-A; Temperature	1985
gamma-Aminobutyric acid receptor binding antagonism by the amidine steroid RU5135. European journal of pharmacology, 1984, Aug-17, Volume: 103, Issue:3-4 Topics: Androstanes; Animals; Azasteroids; Barbiturates; Benzodiazepines; Bicuculline; Binding, Competitive; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Membranes; Muscimol; Rats; Receptors, GABA-A; Steroids, Heterocyclic	1984
A steroid derivative, R 5135, antagonizes the GABA/benzodiazepine receptor interaction. Neuropharmacology, 1981, Volume: 20, Issue:4 Topics: Androstanes; Animals; Azasteroids; Chlorides; Diazepam; gamma-Aminobutyric Acid; Glycine; Male; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Steroids, Heterocyclic; Strychnine	1981
[35S]t-butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to gamma-aminobutyric acid-A and ion recognition sites. Molecular pharmacology, 1983, Volume: 23, Issue:2 Topics: Androstanes; Animals; Azasteroids; Barbiturates; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Bromates; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Rats; Receptors, Cell Surface; Receptors, GABA-A; Temperature; Tissue Distribution	1983
Diazotization and thiocyanate differentiate agonists from antagonists for the high- and low-affinity receptors of gamma-aminobutyric acid. Journal of neurochemistry, 1984, Volume: 43, Issue:1 Topics: Androstanes; Animals; Azasteroids; Benzenesulfonates; Bicuculline; Cerebral Cortex; Diazonium Compounds; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Sulfanilic Acids; Thiocyanates; Tubocurarine	1984
Regular and lasting neocortical spiking produced by systemic administration of a steroid derivative in the rat. Neuropharmacology, 1983, Volume: 22, Issue:2 Topics: Action Potentials; Androstanes; Animals; Azasteroids; Behavior, Animal; Cerebral Cortex; Diazepam; Electroencephalography; Evoked Potentials, Visual; gamma-Aminobutyric Acid; Humans; Rats; Rats, Inbred Strains; Stereotyped Behavior; Steroids, Heterocyclic; Valproic Acid	1983
Chronic neurosteroid treatment produces functional heterologous uncoupling at the gamma-aminobutyric acid type A/benzodiazepine receptor complex in mammalian cortical neurons. Molecular pharmacology, 1995, Volume: 47, Issue:3 Topics: Androstanes; Animals; Azasteroids; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; Chlorides; Chlorine; Convulsants; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Mice; Mice, Inbred C57BL; Neurons; Pregnanolone; Radioisotopes; Radioligand Assay; Receptors, GABA-A; Sulfur Radioisotopes; Time Factors; Tritium	1995
Mono N-aryl ethylenediamine and piperazine derivatives are GABAA receptor blockers: implications for psychiatry. Neurochemical research, 1993, Volume: 18, Issue:7 Topics: Androstanes; Animals; Antidepressive Agents; Antipsychotic Agents; Azasteroids; Bicarbonates; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Ethylenediamines; Female; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	1993
gamma-Aminobutyric acid-A (GABAA) agonists down-regulate GABAA/benzodiazepine receptor polypeptides from the surface of chick cortical neurons. The Journal of biological chemistry, 1994, Jan-14, Volume: 269, Issue:2 Topics: Androstanes; Animals; Azasteroids; Blotting, Western; Cells, Cultured; Cerebral Cortex; Chick Embryo; Down-Regulation; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Molecular Weight; Neurons; Receptors, GABA-A	1994
Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site. European journal of pharmacology, 1996, May-23, Volume: 304, Issue:1-3 Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Cell Membrane; Cerebral Cortex; Desoxycorticosterone; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanolone; Pregnenolone; Protein Binding; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids	1996
Biphasic modulation of GABA(A) receptor binding by steroids suggests functional correlates. Neurochemical research, 1999, Volume: 24, Issue:11 Topics: Androstanes; Anesthetics; Animals; Azasteroids; Baculoviridae; Bicuculline; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression; Pregnanediones; Rats; Receptors, GABA-A; Recombinant Proteins; Spodoptera; Steroids; Sulfur Radioisotopes	1999
Honokiol and magnolol increase the number of [3H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites. Neurochemical research, 1999, Volume: 24, Issue:12 Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Binding Sites; Biphenyl Compounds; Cell Membrane; Central Nervous System Depressants; Cerebellum; Diflunisal; Drugs, Chinese Herbal; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Lignans; Muscimol; Picrotoxin; Propofol; Prosencephalon; Rats; Receptors, GABA-A; Tritium	1999
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
The interaction of steroids with inhibitory and excitatory amino acid receptors. Clinical neuropharmacology, 1992, Volume: 15 Suppl 1 Pt A Topics: Anesthetics; Animals; Cattle; Cells, Cultured; gamma-Aminobutyric Acid; Mice; Neurons; Pregnanediones; Pregnanolone; Receptors, Amino Acid; Receptors, Cell Surface; Steroids	1992
Alfaxalone, pentobarbital and diazepam potentiate gamma-aminobutyric acid-induced depolarizations in single myenteric neurons of guinea pig intestine. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:2 Topics: Anesthetics; Animals; Diazepam; Drug Synergism; gamma-Aminobutyric Acid; Guinea Pigs; Hydrocortisone; Intestines; Male; Membrane Potentials; Muscimol; Pentobarbital; Pregnanediones; Receptors, GABA-A	1992
The pharmacology of recombinant GABAA receptors containing bovine alpha 1, beta 1, gamma 2L sub-units stably transfected into mouse fibroblast L-cells. British journal of pharmacology, 1992, Volume: 107, Issue:3 Topics: Animals; Chlorides; GABA Antagonists; gamma-Aminobutyric Acid; L Cells; Ligands; Mice; Pentobarbital; Pregnanediones; Receptors, GABA-A; Recombinant Proteins; Transfection	1992
The general anesthetic propofol: a biochemical tool to study the function of the GABA-coupled chloride channel. Clinical neuropharmacology, 1992, Volume: 15 Suppl 1 Pt A Topics: Anesthetics; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; gamma-Aminobutyric Acid; Ion Channels; Male; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Inbred Strains	1992
The general anesthetic propofol enhances the function of gamma-aminobutyric acid-coupled chloride channel in the rat cerebral cortex. Journal of neurochemistry, 1990, Volume: 55, Issue:6 Topics: Anesthetics; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; gamma-Aminobutyric Acid; Male; Membrane Proteins; Pentobarbital; Picrotoxin; Pregnanediones; Propofol; Rats; Rats, Inbred Strains	1990
Potentiation of gamma-aminobutyric-acid-activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones. The Journal of physiology, 1987, Volume: 386 Topics: Anesthetics; Animals; Cells, Cultured; Chlorides; Drug Synergism; gamma-Aminobutyric Acid; Ion Channels; Neurons; Pregnanediones; Rats; Spinal Cord; Time Factors	1987
Modulation of GABAA receptor activity by alphaxalone. British journal of pharmacology, 1987, Volume: 90, Issue:3 Topics: Acetylcholine; Anesthetics; Animals; Cattle; Cells, Cultured; Chromaffin System; Flumazenil; gamma-Aminobutyric Acid; Membrane Potentials; Pregnanediones; Receptors, GABA-A	1987
Alfaxalone potentiates and mimics GABA-induced contractile responses in the guinea-pig isolated ileum. British journal of pharmacology, 1988, Volume: 95, Issue:1 Topics: Anesthetics; Animals; Bicuculline; Female; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Picrotoxin; Pregnanediones; Sesterterpenes	1988
A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1987, Volume: 7, Issue:2 Topics: Anesthetics; Animals; Cells, Cultured; Chlorides; Electric Conductivity; gamma-Aminobutyric Acid; Hippocampus; Membrane Potentials; Neural Inhibition; Pregnanediones; Rats	1987
Specific effects of drugs at pressure: animal investigations. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1984, Jan-07, Volume: 304, Issue:1118 Topics: Amino Acids; Anesthetics; Animals; Anticonvulsants; Atmospheric Pressure; Catecholamines; Central Nervous System Diseases; gamma-Aminobutyric Acid; Humans; Mice; Neurotransmitter Agents; Pregnanediones; Rats; Syndrome	1984
Dissimilar influences of some injectable anaesthetics on the responses of reticulo-spinal neurones to inhibitory transmitters in the lamprey. British journal of pharmacology, 1982, Volume: 77, Issue:3 Topics: Anesthetics; Animals; gamma-Aminobutyric Acid; Glycine; Ketamine; Lampreys; Medulla Oblongata; Neurons; Pentobarbital; Pregnanediones	1982
Pharmacological properties of fetal rat hippocampal GABAA receptors. Brain research. Developmental brain research, 1995, Apr-18, Volume: 85, Issue:2 Topics: Anesthetics; Animals; Cells, Cultured; Drug Synergism; Embryo, Mammalian; Fetus; gamma-Aminobutyric Acid; Hippocampus; Patch-Clamp Techniques; Pentobarbital; Pregnanediones; Rats; Receptors, GABA-A	1995
Pharmacology of GABA receptor Cl- channels in rat retinal bipolar cells. Nature, 1993, Jan-14, Volume: 361, Issue:6408 Topics: Animals; Animals, Newborn; Bicuculline; Cells, Cultured; Chloride Channels; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Membrane Potentials; Membrane Proteins; Neurons; Pentobarbital; Photoreceptor Cells; Picrotoxin; Pregnanediones; Rats; Receptors, GABA-A; Sesterterpenes; Strychnine	1993
Neuroactive steroids modulate GABAA receptors in peptidergic nerve terminals. Journal of neuroendocrinology, 1994, Volume: 6, Issue:5 Topics: Animals; Chloride Channels; Drug Synergism; Electric Conductivity; Estradiol; gamma-Aminobutyric Acid; Ion Channel Gating; Nerve Endings; Neuropeptides; Pituitary Gland, Posterior; Pregnanediones; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids	1994
Effects of propofol, pentobarbital and alphaxalone on t-[35S]butylbicyclophosphorothionate binding in rat cerebral cortex. European journal of pharmacology, 1994, Apr-15, Volume: 267, Issue:2 Topics: Anesthetics; Animals; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Diazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Male; Membranes; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Sulfur Radioisotopes	1994
The influence of the gamma 2L subunit on the modulation of responses to GABAA receptor activation. British journal of pharmacology, 1993, Volume: 108, Issue:3 Topics: Anesthetics; Animals; Fibroblasts; Flunitrazepam; gamma-Aminobutyric Acid; L Cells; Mice; Pentobarbital; Pregnanediones; Receptors, GABA-A; Recombinant Proteins; Transfection	1993
Characterization of the gamma-aminobutyric acidA receptor-channel complex composed of alpha 1 beta 2 and alpha 1 beta 3 subunits from rat brain. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2 Topics: Animals; Brain; Chlorides; CHO Cells; Cricetinae; Diazepam; gamma-Aminobutyric Acid; Membrane Potentials; Pentobarbital; Pregnanediones; Rats; Receptors, GABA-A; Transfection	1993
Biochemical evaluations of the effects of loreclezole and propofol on the GABAA receptor in rat brain. Biochemical pharmacology, 1996, Jun-14, Volume: 51, Issue:11 Topics: Anesthetics; Animals; Anticonvulsants; Brain; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes; Triazoles; Tritium	1996
Expression of native GABAA receptors in Xenopus oocytes injected with rat brain synaptosomes. Journal of neurochemistry, 1996, Volume: 67, Issue:5 Topics: Anesthetics; Animals; Brain; Cell Membrane; Chloride Channels; Chlorides; Diazepam; Female; GABA Antagonists; gamma-Aminobutyric Acid; Membrane Potentials; Oocytes; Picrotoxin; Pregnanediones; Pyridazines; Rats; Receptors, GABA-A; Synaptosomes; Xenopus laevis; Zinc Compounds	1996
Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Jan-15, Volume: 17, Issue:2 Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Bicuculline; Binding Sites; Binding, Competitive; Cell Line; Coturnix; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Ion Transport; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pentobarbital; Point Mutation; Pregnanediones; Pregnanolone; Protein Binding; Pyridazines; Receptors, GABA-A; Structure-Activity Relationship	1997
Effect of the pregnane-related GABA-active steroid alphaxalone on mice performance in the staircase test. Brain research, 1997, Aug-08, Volume: 765, Issue:1 Topics: Alprazolam; Anesthetics; Animals; Anti-Inflammatory Agents; Corticosterone; Dose-Response Relationship, Drug; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Muscimol; Pregnanediones; Pregnanes; Pregnenolone; Psychomotor Performance	1997
Pre- and postsynaptic modulation of spinal GABAergic neurotransmission by the neurosteroid, 5 beta-pregnan-3 alpha-ol-20-one. Brain research, 1997, Oct-03, Volume: 770, Issue:1-2 Topics: Anesthetics; Animals; Desoxycorticosterone; Electrophysiology; gamma-Aminobutyric Acid; Larva; Motor Neurons; Neural Inhibition; Neurotransmitter Agents; Pregnanediones; Pregnanes; Receptors, GABA-A; Spinal Cord; Synaptic Transmission; Tetrodotoxin; Xenopus laevis	1997
GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Jul-01, Volume: 18, Issue:13 Topics: Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Diuretics; DNA Primers; Furosemide; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Lanthanum; Neurons; Patch-Clamp Techniques; Pentobarbital; Phenobarbital; Picrotoxin; Polymerase Chain Reaction; Pregnanediones; Pregnenolone; Pyridines; Receptors, GABA-A; RNA, Messenger; Teratocarcinoma; Triazoles; Tumor Cells, Cultured; Zinc; Zolpidem	1998
Absence seizures decrease steroid modulation of t-[35S]butylbicyclophosphorothionate binding in thalamic relay nuclei. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:2 Topics: Action Potentials; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Epilepsy, Absence; gamma-Aminobutyric Acid; Hydroxybutyrates; Male; Pentobarbital; Pregnanediones; Rats; Rats, Sprague-Dawley; Sulfur Radioisotopes; Thalamic Nuclei	1998
Increased membrane cholesterol reduces the potentiation of GABA(A) currents by neurosteroids in dissociated hippocampal neurones. Neuropharmacology, 1998, Volume: 37, Issue:9 Topics: Animals; Cholesterol; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hippocampus; Liposomes; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pregnanediones; Pregnanolone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Steroids; Synapses; Synaptic Membranes	1998
Steroid-inhibition of [3H]gamma-hydroxybutyric acid (GHB) binding in thalamic relay nuclei increases during absence seizures. Brain research, 1998, Dec-07, Volume: 813, Issue:2 Topics: Anesthetics; Animals; Binding, Competitive; Cerebral Cortex; Desoxycorticosterone; Epilepsy, Absence; gamma-Aminobutyric Acid; Male; Neurons; Parietal Lobe; Pregnanediones; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thalamus; Tritium; Up-Regulation	1998
Modulation of GABA(A) receptor function by neuroactive steroids: evidence for heterogeneity of steroid sensitivity of recombinant GABA(A) receptor isoforms. Canadian journal of physiology and pharmacology, 1998, Volume: 76, Issue:9 Topics: Animals; Dose-Response Relationship, Drug; Female; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Pregnanediones; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Recombinant Proteins; Steroids; Xenopus laevis	1998
Subunit dependent modulation of GABAA receptor function by neuroactive steroids. Brain research, 1999, Feb-20, Volume: 819, Issue:1-2 Topics: Animals; Drug Synergism; Female; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Humans; In Vitro Techniques; Membrane Potentials; Microinjections; Oocytes; Patch-Clamp Techniques; Pregnanediones; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Xenopus laevis	1999
GABA-Induced Cl- current in cultured embryonic human dorsal root ganglion neurons. Journal of neurophysiology, 1999, Volume: 82, Issue:1 Topics: Adult; Baclofen; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chloride Channels; Convulsants; Crotonates; Embryo, Mammalian; gamma-Aminobutyric Acid; Ganglia, Spinal; Glycine; Humans; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentobarbital; Potassium Channels; Pregnanediones; Receptors, GABA-A; Taurine	1999
Differential modulation of the gamma-aminobutyric acid type C receptor by neuroactive steroids. Molecular pharmacology, 1999, Volume: 56, Issue:4 Topics: 5-alpha-Dihydroprogesterone; Animals; Anti-Inflammatory Agents; Desoxycorticosterone; gamma-Aminobutyric Acid; Humans; Oocytes; Patch-Clamp Techniques; Pregnanediones; Pregnanolone; Receptors, GABA; Receptors, Purinergic P1; Xenopus laevis	1999
Interactive role for neurosteroids in ethanol enhancement of gamma-aminobutyric acid-gated currents from dissociated substantia nigra reticulata neurons. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3 Topics: Anesthetics; Animals; Cells, Cultured; Central Nervous System Depressants; Desoxycorticosterone; Electrophysiology; Ethanol; gamma-Aminobutyric Acid; Ion Channel Gating; Neurons; Patch-Clamp Techniques; Pregnanediones; Rats; Steroids; Substantia Nigra	1999
Activation of rat locus coeruleus neuron GABA(A) receptors by propofol and its potentiation by pentobarbital or alphaxalone. European journal of pharmacology, 1999, Dec-15, Volume: 386, Issue:2-3 Topics: Anesthetics; Anesthetics, Intravenous; Animals; Baclofen; Barium Compounds; Bicuculline; Chlorides; Diazepam; Drug Synergism; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ionophores; Locus Coeruleus; Male; Neurons; Pentobarbital; Picrotoxin; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zinc Compounds	1999
A single glycine residue at the entrance to the first membrane-spanning domain of the gamma-aminobutyric acid type A receptor beta(2) subunit affects allosteric sensitivity to GABA and anesthetics. Molecular pharmacology, 2000, Volume: 57, Issue:3 Topics: Allosteric Regulation; Amino Acid Sequence; Anesthetics; Animals; Cells, Cultured; Chloride Channels; Electrophysiology; Etomidate; GABA Modulators; gamma-Aminobutyric Acid; Glycine; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Pentobarbital; Pregnanediones; Propofol; Protein Conformation; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Sequence Homology, Amino Acid; Spodoptera	2000
GABAA receptor mediated elevation of Ca2+ and modulation of gonadotrophin-releasing hormone action in alphaT3-1 gonadotropes. Journal of neuroendocrinology, 2000, Volume: 12, Issue:2 Topics: Anesthetics; Animals; Baclofen; Bicuculline; Biological Transport; Calcium; Calcium Channel Blockers; Cells, Cultured; Chlorides; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Mice; Muscimol; Nifedipine; Picrotoxin; Pituitary Gland; Pregnanediones; Receptors, GABA-A; Receptors, GABA-B	2000
Pharmacology of GABA(A) receptors of retinal dopaminergic neurons. Journal of neurophysiology, 2000, Volume: 84, Issue:4 Topics: Alkaline Phosphatase; Animals; Benzodiazepines; Bicuculline; Binding Sites; Dopamine; Dose-Response Relationship, Drug; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Mice; Mice, Transgenic; Neurons; Osmolar Concentration; Patch-Clamp Techniques; Picrotoxin; Pregnanediones; Protein Isoforms; Receptors, GABA-A; Retina; Sesterterpenes; Triazoles; Zinc	2000
alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential. The Journal of biological chemistry, 2001, Oct-19, Volume: 276, Issue:42 Topics: Animals; Benzodiazepines; Cell Line; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Mice; Models, Biological; Muscimol; Pentobarbital; Pregnanediones; Pregnanolone; Protein Binding; Protein Conformation; Receptors, GABA-A; Spectrometry, Fluorescence; Time Factors; Transfection	2001
A neurosteroid anesthetic, alphaxalone, inhibits nicotinic acetylcholine receptors in cultured bovine adrenal chromaffin cells. Anesthesia and analgesia, 2002, Volume: 95, Issue:4 Topics: Anesthetics; Animals; Calcium Channel Blockers; Cattle; Cells, Cultured; Chromaffin Cells; gamma-Aminobutyric Acid; Nicotine; Patch-Clamp Techniques; Perfusion; Picrotoxin; Pregnanediones; Receptors, GABA-A; Receptors, Nicotinic	2002
Comparison of effect of ethanol on N-methyl-D-aspartate- and GABA-gated currents from acutely dissociated neurons: absence of regional differences in sensitivity to ethanol. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:1 Topics: Anesthetics; Animals; Brain; Brain Chemistry; Cell Line; Central Nervous System Depressants; CHO Cells; Cricetinae; Electrophysiology; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Ion Channel Gating; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Pregnanediones; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	2003
Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2. BMC pharmacology, 2003, Nov-12, Volume: 3 Topics: Anesthetics, General; Animals; Cells, Cultured; Enflurane; Etomidate; gamma-Aminobutyric Acid; Humans; Point Mutation; Pregnanediones; Propofol; Protein Subunits; Rats; Receptors, GABA-A; Recombinant Proteins	2003
Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors. European journal of pharmacology, 2005, Jun-15, Volume: 516, Issue:3 Topics: Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Etomidate; Female; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Glycine; Humans; Hydrocarbons, Halogenated; Imidazoles; Male; Membrane Potentials; Oocytes; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Receptors, Serotonin, 5-HT3; Serotonin; Tritium; Xenopus laevis	2005
Auto-modulation of neuroactive steroids on GABA A receptors: a novel pharmacological effect. Neuropharmacology, 2007, Volume: 52, Issue:2 Topics: Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression; Humans; Isoxazoles; Membrane Potentials; Patch-Clamp Techniques; Pregnanediones; Protein Subunits; Receptors, GABA-A; Recombinant Proteins; Steroids	2007
Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues. Bioorganic & medicinal chemistry letters, 2010, Nov-15, Volume: 20, Issue:22 Topics: Anesthetics; Animals; Crystallography, X-Ray; gamma-Aminobutyric Acid; Magnetic Resonance Spectroscopy; Models, Molecular; Nitriles; Pregnanediones; Rats; Spectrophotometry, Infrared	2010
The benzodiazepine diazepam potentiates responses of α1β2γ2L γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists. Anesthesiology, 2013, Volume: 118, Issue:6 Topics: Anesthetics; Animals; Binding Sites; Diazepam; Drug Synergism; Etomidate; GABA Modulators; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Patch-Clamp Techniques; Pentobarbital; Pregnanediones; Rats; Receptors, GABA-A	2013
γ-aminobutyric acid type A α4, β2, and δ subunits assemble to produce more than one functionally distinct receptor type. Molecular pharmacology, 2014, Volume: 86, Issue:6 Topics: Animals; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; HEK293 Cells; Hippocampus; Humans; Pregnanediones; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Xenopus laevis	2014
Synaptic-type α1β2γ2L GABAA receptors produce large persistent currents in the presence of ambient GABA and anesthetic drugs. Molecular pharmacology, 2015, Volume: 87, Issue:5 Topics: Anesthetics; Animals; Cell Line; Chromosome Pairing; Etomidate; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Pentobarbital; Pregnanediones; Propofol; Rats; Receptors, GABA-A	2015
GABA Type A Receptor Activation in the Allosteric Coagonist Model Framework: Relationship between EC Molecular pharmacology, 2018, Volume: 93, Issue:2 Topics: Allosteric Regulation; Anesthetics; Animals; Binding Sites; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; gamma-Aminobutyric Acid; Models, Biological; Models, Theoretical; Mutation; Oocytes; Patch-Clamp Techniques; Pentobarbital; Pregnanediones; Propofol; Receptors, GABA-A; Xenopus laevis	2018