Page last updated: 2024-08-26

alphaxalone and brexanolone

alphaxalone has been researched along with brexanolone in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's3 (50.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
DiMeglio, CM; Fesik, SW; Makriyannis, A1
Anderson, A; Boyd, AC; Byford, A; Campbell, AC; Gemmell, DK; Hamilton, NM; Hill, DR; Hill-Venning, C; Lambert, JJ; Maidment, MS; Marshall, RJ; May, V; Peters, JA; Rees, DC; Stevenson, D; Sundaram, H1
Anderson, A; Boyd, AC; Clark, JK; Fielding, L; Gemmell, DK; Hamilton, NM; Maidment, MS; May, V; McGuire, R; McPhail, P; Sansbury, FH; Sundaram, H; Taylor, R1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Atucha, E; Berger, ML; Hammerschmidt, F; Sieghart, W; Zolle, I1
Akk, G; Covey, DF; Elias, G; Evers, AS; Krishnan, K; Kudova, E; Li, P; Manion, BD; Mennerick, S; Qian, M; Taylor, A; Zorumski, CF1

Other Studies

6 other study(ies) available for alphaxalone and brexanolone

ArticleYear
Anesthetic steroid mobility in model membrane preparations as examined by high-resolution 1H and 2H NMR spectroscopy.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:5

    Topics: Anesthetics; Cell Membrane; Lipid Bilayers; Magnetic Resonance Spectroscopy; Pregnanes; Structure-Activity Relationship

1991
Anesthetic activity of novel water-soluble 2 beta-morpholinyl steroids and their modulatory effects at GABAA receptors.
    Journal of medicinal chemistry, 1997, May-23, Volume: 40, Issue:11

    Topics: Anesthesia; Anesthetics; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Membrane; Chromaffin System; Electric Conductivity; Electrophysiology; Male; Mice; Molecular Structure; Morpholines; Pregnanediones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Solubility; Structure-Activity Relationship; Water

1997
Conformationally constrained anesthetic steroids that modulate GABA(A) receptors.
    Journal of medicinal chemistry, 2000, Nov-02, Volume: 43, Issue:22

    Topics: Androstanols; Anesthetics; Animals; Brain; GABA Modulators; Hydrogen Bonding; In Vitro Techniques; Injections, Intravenous; Mice; Models, Molecular; Radioligand Assay; Rats; Receptors, GABA-A; Structure-Activity Relationship

2000
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Structure-activity relationship of etomidate derivatives at the GABA(A) receptor: Comparison with binding to 11beta-hydroxylase.
    Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15

    Topics: Anesthetics, Intravenous; Animals; Binding Sites; Chemistry, Pharmaceutical; Drug Design; Etomidate; Inhibitory Concentration 50; Male; Models, Chemical; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stereoisomerism; Steroid 11-beta-Hydroxylase; Structure-Activity Relationship

2009
Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.
    Journal of medicinal chemistry, 2014, Jan-09, Volume: 57, Issue:1

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; GABA Modulators; HEK293 Cells; Humans; Models, Molecular; Neurotransmitter Agents; Pregnanediones; Pregnanolone; Rats; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis

2014