alphaxalone has been researched along with bicuculline in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (41.38) | 18.7374 |
| 1990's | 11 (37.93) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andre, JM; Boulanger, T; Durant, F; Hoffmann, R; Rognan, D; Vercauteren, DP; Wermuth, CG | 1 |
| David, JA; Pinnock, RD; Sattelle, DB; Wafford, KA | 1 |
| Kerr, DI; Ong, J | 1 |
| Cottrell, GA; Lambert, JJ; Peters, JA | 1 |
| Iversen, LL; Wong, EH | 1 |
| Simmonds, MA; Turner, JP | 1 |
| Curtis, DR; Malik, R | 1 |
| Olsen, RW | 1 |
| Maksay, G; Ticku, MK | 1 |
| Ramanjaneyulu, R; Ticku, MK | 1 |
| Olsen, RW; Sapp, DW; Srinivasan, S; Tobin, AJ | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Baldwin, H; Britton, KT; Koob, GF; Page, M | 1 |
| Cottrell, GA; Mistry, DK | 1 |
| Healing, C; Hilton, T; Simmonds, M | 1 |
| Johnston, GA; Kerr, DI; Ong, J | 1 |
| Little, HJ; Wardley-Smith, B | 1 |
| Akhondzadeh, S; Stone, TW | 2 |
| Bormann, J; Feigenspan, A; Wässle, H | 1 |
| Biggio, G; Concas, A; Dazzi, L; Maciocco, E; Mascia, MP; Santoro, G | 1 |
| Bracamontes, J; Steinbach, JH; Ueno, S; Weiss, DS; Zorumski, C | 1 |
| Greenfield, LJ; Macdonald, RL; Neelands, TR; Turner, RS; Zhang, J | 1 |
| Chen, CL; Chiu, TH; Yang, YR | 1 |
| Bence, M; Everest, H; Forrest-Owen, W; Lightman, SL; McArdle, CA; Williams, B | 1 |
| Feigenspan, A; Gustincich, S; Raviola, E | 1 |
| Goodchild, CS; Nadeson, R | 1 |
| Hansen, SL; Sánchez, C; Sperling, BB | 1 |
| Covey, DF; Jevtovic-Todorovic, V; Pathirathna, S; Todorovic, SM | 1 |
29 other study(ies) available for alphaxalone and bicuculline
| Article | Year |
|---|---|
Structure and molecular modeling of GABAA receptor antagonists.
Topics: Alkaloids; Androstanes; Azasteroids; Azepines; Bicuculline; Crystallization; Dibenzazepines; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Heterocyclic Compounds, 4 or More Rings; Heterocyclic Compounds, Bridged-Ring; Isoxazoles; Lactones; Models, Molecular; Molecular Conformation; Molecular Structure; Piperidines; Pyridazines; Receptors, GABA-A; Structure-Activity Relationship; Tubocurarine; X-Ray Diffraction | 1992 |
GABA receptors on the cell-body membrane of an identified insect motor neuron.
Topics: Androstanes; Animals; Azasteroids; Bicuculline; Chlorides; Cockroaches; Dibenzazepines; Dose-Response Relationship, Drug; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channels; Male; Membrane Potentials; Microelectrodes; Motor Neurons; Nipecotic Acids; Periplaneta; Picrotoxin; Receptors, GABA-A | 1988 |
Modulation of spontaneous motility by GABAA receptor antagonism in the guinea pig isolated ileum.
Topics: 3-Mercaptopropionic Acid; Acetylcholine; Androstanes; Animals; Azasteroids; Bicuculline; Carbachol; Female; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Muscle Contraction; Picrotoxin; Time Factors | 1989 |
An electrophysiological investigation of the characteristics and function of GABAA receptors on bovine adrenomedullary chromaffin cells.
Topics: Acetylcholine; Action Potentials; Adrenal Medulla; Androstanes; Animals; Azasteroids; Bicuculline; Cattle; Cell Membrane; Chloride Channels; Chlorides; Chromaffin System; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Membrane Proteins; Picrotoxin; Propanidid; Receptors, Cholinergic; Receptors, GABA-A | 1989 |
Modulation of [3H]diazepam binding in rat cortical membranes by GABAA agonists.
Topics: Androstanes; Animals; Azasteroids; Bicuculline; Cell Membrane; Cerebral Cortex; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Isonicotinic Acids; Isoxazoles; Muscimol; Piperidines; Rats; Receptors, GABA-A; Taurine | 1985 |
Antagonism of inhibitory amino acids by the steroid derivative RU5135.
Topics: Amino Acids; Androstanes; Animals; Azasteroids; Bicuculline; Electrophysiology; Glycine; In Vitro Techniques; Medulla Oblongata; Muscimol; Optic Nerve; Picrotoxin; Rats; Steroids, Heterocyclic; Strychnine | 1985 |
Glycine antagonism by RU 5135.
Topics: Action Potentials; Androstanes; Animals; Azasteroids; Bicuculline; Cats; GABA Antagonists; Glycine; Homocysteine; Interneurons; Steroids, Heterocyclic; Strychnine | 1985 |
gamma-Aminobutyric acid receptor binding antagonism by the amidine steroid RU5135.
Topics: Androstanes; Animals; Azasteroids; Barbiturates; Benzodiazepines; Bicuculline; Binding, Competitive; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Membranes; Muscimol; Rats; Receptors, GABA-A; Steroids, Heterocyclic | 1984 |
Diazotization and thiocyanate differentiate agonists from antagonists for the high- and low-affinity receptors of gamma-aminobutyric acid.
Topics: Androstanes; Animals; Azasteroids; Benzenesulfonates; Bicuculline; Cerebral Cortex; Diazonium Compounds; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Sulfanilic Acids; Thiocyanates; Tubocurarine | 1984 |
RO5-4864 inhibits the binding of [35S]t-butylbicyclophosphorothionate to rat brain membranes.
Topics: Androstanes; Animals; Azasteroids; Benzodiazepinones; Bicuculline; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; Cell Membrane; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Flumazenil; Hippocampus; Male; Picrotoxin; Radioligand Assay; Rats | 1984 |
Biphasic modulation of GABA(A) receptor binding by steroids suggests functional correlates.
Topics: Androstanes; Anesthetics; Animals; Azasteroids; Baculoviridae; Bicuculline; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression; Pregnanediones; Rats; Receptors, GABA-A; Recombinant Proteins; Spodoptera; Steroids; Sulfur Radioisotopes | 1999 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Anxiolytic activity of steroid anesthetic alphaxalone.
Topics: Anesthetics; Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Conditioning, Operant; Drug Interactions; Injections, Intraperitoneal; Male; Pregnanediones; Rats; Rats, Inbred Strains | 1991 |
Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture.
Topics: Animals; Bemegride; Bicuculline; Cells, Cultured; GABA-A Receptor Antagonists; Membrane Potentials; Mice; Neurons; Pregnanediones; Pregnanes; Pregnanolone; Receptors, GABA-A; Spinal Cord | 1990 |
Alphaxalone reveals GABAA receptor-mediated inhibition in guinea-pig ileum.
Topics: Anesthetics; Animals; Bicuculline; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Isometric Contraction; Muscle, Smooth; Pregnanediones; Receptors, GABA-A | 1989 |
Alfaxalone potentiates and mimics GABA-induced contractile responses in the guinea-pig isolated ileum.
Topics: Anesthetics; Animals; Bicuculline; Female; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Picrotoxin; Pregnanediones; Sesterterpenes | 1988 |
In vivo interactions between the benzodiazepine antagonist Ro 15-1788 and the steroid anaesthetic althesin in rats.
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Benzodiazepinones; Bicuculline; Drug Synergism; Drug Therapy, Combination; Female; Flumazenil; Pregnanediones; Rats; Rats, Inbred Strains; Seizures | 1985 |
Potentiation by neurosteroids of muscimol/adenosine interactions in rat hippocampus.
Topics: Adenosine; Anesthetics; Animals; Anti-Anxiety Agents; Barium; Bicuculline; Chloride Channel Agonists; Drug Synergism; GABA-A Receptor Agonists; Hippocampus; Male; Muscimol; Neural Inhibition; Pregnanediones; Pregnanolone; Rats; Rats, Wistar | 1995 |
Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors.
Topics: Action Potentials; Adenosine; Alanine; Anesthetics; Animals; Anti-Anxiety Agents; Bicuculline; Corpus Striatum; Culture Techniques; Dose-Response Relationship, Drug; Electric Stimulation; GABA Agonists; GABA Antagonists; Hippocampus; Male; Muscimol; Neuronal Plasticity; Pregnanediones; Pregnanolone; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA; Receptors, Metabotropic Glutamate; Valine | 1995 |
Pharmacology of GABA receptor Cl- channels in rat retinal bipolar cells.
Topics: Animals; Animals, Newborn; Bicuculline; Cells, Cultured; Chloride Channels; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Membrane Potentials; Membrane Proteins; Neurons; Pentobarbital; Photoreceptor Cells; Picrotoxin; Pregnanediones; Rats; Receptors, GABA-A; Sesterterpenes; Strychnine | 1993 |
Effects of propofol, pentobarbital and alphaxalone on t-[35S]butylbicyclophosphorothionate binding in rat cerebral cortex.
Topics: Anesthetics; Animals; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Diazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Male; Membranes; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Sulfur Radioisotopes | 1994 |
Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Bicuculline; Binding Sites; Binding, Competitive; Cell Line; Coturnix; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Ion Transport; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pentobarbital; Point Mutation; Pregnanediones; Pregnanolone; Protein Binding; Pyridazines; Receptors, GABA-A; Structure-Activity Relationship | 1997 |
GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells.
Topics: Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Diuretics; DNA Primers; Furosemide; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Lanthanum; Neurons; Patch-Clamp Techniques; Pentobarbital; Phenobarbital; Picrotoxin; Polymerase Chain Reaction; Pregnanediones; Pregnenolone; Pyridines; Receptors, GABA-A; RNA, Messenger; Teratocarcinoma; Triazoles; Tumor Cells, Cultured; Zinc; Zolpidem | 1998 |
Activation of rat locus coeruleus neuron GABA(A) receptors by propofol and its potentiation by pentobarbital or alphaxalone.
Topics: Anesthetics; Anesthetics, Intravenous; Animals; Baclofen; Barium Compounds; Bicuculline; Chlorides; Diazepam; Drug Synergism; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ionophores; Locus Coeruleus; Male; Neurons; Pentobarbital; Picrotoxin; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zinc Compounds | 1999 |
GABAA receptor mediated elevation of Ca2+ and modulation of gonadotrophin-releasing hormone action in alphaT3-1 gonadotropes.
Topics: Anesthetics; Animals; Baclofen; Bicuculline; Biological Transport; Calcium; Calcium Channel Blockers; Cells, Cultured; Chlorides; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Mice; Muscimol; Nifedipine; Picrotoxin; Pituitary Gland; Pregnanediones; Receptors, GABA-A; Receptors, GABA-B | 2000 |
Pharmacology of GABA(A) receptors of retinal dopaminergic neurons.
Topics: Alkaline Phosphatase; Animals; Benzodiazepines; Bicuculline; Binding Sites; Dopamine; Dose-Response Relationship, Drug; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Mice; Mice, Transgenic; Neurons; Osmolar Concentration; Patch-Clamp Techniques; Picrotoxin; Pregnanediones; Protein Isoforms; Receptors, GABA-A; Retina; Sesterterpenes; Triazoles; Zinc | 2000 |
Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors.
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; Male; Nociceptors; Pain Measurement; Pregnanediones; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Reference Values; Spinal Cord; Steroids; Time Factors | 2000 |
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Isoxazoles; Kindling, Neurologic; Ligands; Mice; Pentylenetetrazole; Pregnanediones; Receptors, GABA-A | 2004 |
5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain.
Topics: Anesthetics; Animals; Behavior, Animal; Bicuculline; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Estranes; Female; GABA Antagonists; Hot Temperature; Hyperalgesia; Neuralgia; Nitriles; Oxidation-Reduction; Pain Measurement; Pain Threshold; Pregnanediones; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Steroids; Time Factors; Touch; Treatment Outcome | 2005 |