Page last updated: 2024-08-21

alpha-naphthoflavone and proadifen

alpha-naphthoflavone has been researched along with proadifen in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199019 (61.29)18.7374
1990's6 (19.35)18.2507
2000's2 (6.45)29.6817
2010's4 (12.90)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hirobe, M; Ohi, H; Ohta, S; Takahara, E1
Daniels, JM; Massey, TE1
Giri, SN; Siegel, DM1
Bender, PE; Eckardt, RD; Leonard, TB; Newton, JF; Romano, MC; Straub, KM1
Hayashi, S; Ishikawa, T; Murakami, K; Noshiro, M; Okuda, K; Shimosato, T1
Beyerinck, RA; Brass, EP; Garrity, MJ1
Numazawa, M; Satoh, S1
Flory, W; Henk, WG; Turk, MA1
Buhler, DR; Carpenter, HM; Williams, DE1
Kuwahara, S; Mannering, GJ1
Ahokas, JT; Pelkonen, O; Sotaniemi, EA1
Finnen, MJ; Shuster, S1
Kasuya, Y; Kawanishi, T; Ohno, Y; Omori, Y; Takahashi, A; Takanaka, A1
Nagata, K; Yoshihara, S; Yoshimura, H1
Hall, ST; Houston, JB; Rhodes, JC1
Cazer, FD; Hart, RW; Sheikh, YM; Witiak, DT1
Della Porta, G; Dragani, TA; Sozzi, G1
DePierre, JW; Meijer, J1
Ishidate, M; Miyata, R; Nohmi, T; Yoshikawa, K1
Grafstöm, R; Stohs, SJ1
Ahokas, JT; Kärki, NT; Pelkonen, O; Saarni, H; Sotaniemi, EA1
Benford, DJ; Bridges, JW1
Huang, H; Jurima-Romet, M; Paul, CJ; Solomonraj, G; Thomas, BH1
Black, KA; Novicki, DL; Smith, GJ; Vincent, JL1
Melancon, MJ; Renauld, AE; Sordillo, LM1
Burnstein, KL; Hayakawa, K; Kizu, R; Klinge, CM; Mizokami, A; Okamura, K; Toriba, A1
Akao, T; Hattori, M; Nakamura, N; Sasahara, M; Takagawa, K; Tang, J; Wang, ZT1
Greenhaw, J; Salminen, WF; Shi, Q; Yang, X1
Beltrán-Ramírez, O; Pérez, RM; Sierra-Santoyo, A; Villa-Treviño, S1
Kubickova, B; Martinkova, M; Stiborova, M1
Greenhaw, J; Salminen, WF; Shi, Q1

Other Studies

31 other study(ies) available for alpha-naphthoflavone and proadifen

ArticleYear
Effects of oxygen concentration on the metabolism of anisole homologues by rat liver microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:11

    Topics: Animals; Anisoles; Benzoflavones; In Vitro Techniques; Male; Microsomes, Liver; Oxygen; Phenobarbital; Phenyl Ethers; Proadifen; Rats; Rats, Wistar

1992
Modulation of aflatoxin B1 biotransformation in rabbit pulmonary and hepatic microsomes.
    Toxicology, 1992, Volume: 74, Issue:1

    Topics: Aflatoxin B1; Aflatoxin M1; Aflatoxins; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Isoenzymes; Kinetics; Lung; Male; Microsomes; Microsomes, Liver; NADP; Oxidoreductases; Proadifen; Rabbits

1992
Characterization of covalent binding of [14C]-2-chloro-4-acetotoluidide to microsomes of starling liver and kidney.
    Journal of biochemical toxicology, 1991,Summer, Volume: 6, Issue:2

    Topics: Animals; Benzoflavones; Birds; Cysteine; Cytochrome P-450 Enzyme Inhibitors; Glutathione; In Vitro Techniques; Kidney; Kinetics; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proadifen; Protein Binding; Sulfhydryl Compounds; Toluidines

1991
Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases.
    The Journal of biological chemistry, 1987, Feb-05, Volume: 262, Issue:4

    Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Kinetics; Leukotriene B4; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proadifen; Pyrimidines; Rats; Rats, Inbred F344; Temperature

1987
Aryl hydrocarbon hydroxylase activity in rat submandibular glands.
    Journal of dental research, 1986, Volume: 65, Issue:1

    Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Carbon Monoxide; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Metyrapone; NADH Dehydrogenase; NADPH-Ferrihemoprotein Reductase; Oxygenases; Proadifen; Rats; Rats, Inbred Strains; Submandibular Gland; Time Factors

1986
Inhibition of prostaglandin E2 catabolism and potentiation of hepatic prostaglandin E2 action in rat hepatocytes by inhibitors of oxidative metabolism.
    Biochemical pharmacology, 1988, Apr-01, Volume: 37, Issue:7

    Topics: Aminopyrine; Animals; Benzoflavones; Dinoprostone; Glucagon; Glycogen; Liver; Male; Metyrapone; Oxidation-Reduction; Proadifen; Prostaglandins E; Rats; Rats, Inbred Strains

1988
Kinetic studies of inhibition of estradiol 2- and 16 alpha-hydroxylases in rat liver microsomes with various cytochrome P-450 inhibitors.
    Journal of steroid biochemistry, 1988, Volume: 29, Issue:2

    Topics: Aminoglutethimide; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P450 Family 2; Hydroxylation; Kinetics; Male; Metyrapone; Microsomes, Liver; Proadifen; Rats; Rats, Inbred Strains; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases

1988
Chemical modulation of 3-methylindole toxicosis in mice: effect on bronchiolar and olfactory mucosal injury.
    Veterinary pathology, 1986, Volume: 23, Issue:5

    Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bronchi; Epithelium; Female; Flavonoids; Glutathione; Indoles; Male; Maleates; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Nasal Mucosa; Phenobarbital; Piperonyl Butoxide; Proadifen; Sex Factors; Skatole

1986
Hexachlorobenzene-induced porphyria in Japanese quail: an in vitro study of changes in cytochrome P-450 and monooxygenases.
    Journal of toxicology and environmental health, 1985, Volume: 16, Issue:2

    Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; Chlorobenzenes; Coturnix; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Female; Hexachlorobenzene; Metyrapone; Microsomes, Liver; Oxidoreductases; Oxygenases; Porphyrias; Proadifen

1985
Evidence for a predominantly NADH-dependent O-dealkylating system in rat hepatic microsomes.
    Biochemical pharmacology, 1985, Dec-15, Volume: 34, Issue:24

    Topics: Animals; Antibodies; Benzoflavones; Carbon Monoxide; Cobalt; Cyanides; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Dealkylation; Electron Transport; Ethylmorphine; In Vitro Techniques; Linoleic Acids; Lipid Peroxides; Male; Manganese; Methylcholanthrene; Microsomes, Liver; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Nitrobenzenes; Oxygen; Partial Pressure; Phenobarbital; Proadifen; Rats

1985
Coumarin 7-hydroxylase activity in human liver microsomes. Properties of the enzyme and interspecies comparisons.
    British journal of clinical pharmacology, 1985, Volume: 19, Issue:1

    Topics: Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Guinea Pigs; Humans; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Proadifen; Rats; Rats, Inbred Strains; Species Specificity

1985
Phase 1 and Phase 2 drug metabolism in isolated epidermal cells from adult hairless mice and in whole human hair follicles.
    Biochemical pharmacology, 1985, Oct-01, Volume: 34, Issue:19

    Topics: Animals; Benzoflavones; Carbon Monoxide; Coumarins; Cytochrome P-450 Enzyme System; Epidermis; Female; Hair; Humans; Kinetics; Male; Mice; Mice, Hairless; Proadifen; Spectrometry, Fluorescence; Umbelliferones

1985
Nature of N-nitrosodimethylamine demethylase in hepatic microsomes of rats.
    Archives of toxicology, 1984, Volume: 56, Issue:1

    Topics: Aminoacetonitrile; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzoflavones; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Imidazoles; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Monoamine Oxidase; Niacinamide; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Inbred Strains; Tranylcypromine

1984
Different responsiveness of hepatic and pulmonary microsomal mixed function oxidases to phenobarbital-type and 3-methylcholanthrene-type polychlorinated biphenyls in rats.
    Journal of pharmacobio-dynamics, 1983, Volume: 6, Issue:12

    Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Enzyme Induction; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Proadifen; Rats; Rats, Inbred Strains

1983
Inhibition of antipyrine metabolite formation in rats in vivo.
    Xenobiotica; the fate of foreign compounds in biological systems, 1984, Volume: 14, Issue:9

    Topics: Animals; Antipyrine; Benzoflavones; Cimetidine; Cytochrome P-450 Enzyme System; Male; Metyrapone; Proadifen; Rats; Rats, Inbred Strains

1984
Biotransformation of 7, 12-dimethylbenz(a)anthracene(DMBA): on the genesis of DMBA-trans-dihydrodiols and DMBA-7- and 12-methylhydroxylated metabolites.
    Biochemical and biophysical research communications, 1980, Apr-14, Volume: 93, Issue:3

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzoflavones; beta-Naphthoflavone; Carbon Disulfide; Flavonoids; Liver; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Phenobarbital; Proadifen; Rats; Structure-Activity Relationship

1980
Effect of enzymatic induction and inhibition on cyclophosphamide-induced sister chromatid exchange in vivo.
    Carcinogenesis, 1983, Volume: 4, Issue:1

    Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bromodeoxyuridine; Crossing Over, Genetic; Cyclophosphamide; Enzyme Induction; Male; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Pentobarbital; Proadifen; Sister Chromatid Exchange; Zoxazolamine

1983
Comparison of trans-stilbene oxide, phenobarbital and 3-methylcholanthrene as inducers of steroid metabolism by the rat liver microsomal cytochrome P-450 system.
    Journal of steroid biochemistry, 1983, Volume: 18, Issue:4

    Topics: Androstenedione; Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Hydroxylation; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Stilbenes; Testosterone

1983
Effects of 7, 8-benzoflavone and SKF 525-A on the enzyme-mediated mutagenicity of phenylenediamines.
    The Journal of toxicological sciences, 1982, Volume: 7, Issue:1

    Topics: Animals; Benzoflavones; Flavonoids; Male; Microsomes; Mixed Function Oxygenases; Mutagens; Phenylenediamines; Proadifen; Rats; Rats, Inbred Strains; Salmonella typhimurium

1982
Inhibitors of 7-ethoxyresorufin and 7-ethoxycoumarin de-ethylases in rat small intestinal microsomes and cells.
    Drug and chemical toxicology, 1981, Volume: 4, Issue:2

    Topics: Animals; Benzoflavones; Benzopyrenes; Coumarins; Cytochrome P-450 CYP1A1; Female; Intestine, Small; Methylcholanthrene; Metyrapone; Microsomes; Oxidoreductases; Proadifen; Rats; Rats, Inbred Strains; Rotenone

1981
Dose-dependent effects of medrozyprogesterone acetate on the hepatic drug-metabolizing enzyme system in rats.
    Biochemical pharmacology, 1980, Apr-15, Volume: 29, Issue:8

    Topics: Animals; Benzoflavones; Benzopyrene Hydroxylase; Dose-Response Relationship, Drug; Enzyme Induction; Female; Flavonoids; In Vitro Techniques; Male; Medroxyprogesterone; Microsomes, Liver; Mixed Function Oxygenases; Proadifen; Rats; Sex Factors

1980
Characterization of the activation of hepatic microsomal hydroxylation by betamethasone and alpha naphthoflavone.
    Biochemical pharmacology, 1980, Sep-01, Volume: 29, Issue:17

    Topics: Animals; Benzoflavones; Betamethasone; Enzyme Activation; Flavonoids; Hydroxylation; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; Proadifen; Rats

1980
Metabolism of phenazopyridine by isolated rat hepatocytes.
    Biopharmaceutics & drug disposition, 1993, Volume: 14, Issue:2

    Topics: Animals; Benzoflavones; Detergents; Enzyme Induction; In Vitro Techniques; Indomethacin; Liver; Male; Metyrapone; Octoxynol; Phenazopyridine; Polyethylene Glycols; Proadifen; Rats; Rats, Wistar

1993
Flow cytometric analysis of xenobiotic metabolism activity in isolated rat hepatocytes.
    Cytometry, 1993, Volume: 14, Issue:3

    Topics: Animals; Benzoflavones; Flow Cytometry; Fluoresceins; Light; Liver; Male; Metyrapone; Mixed Function Oxygenases; Proadifen; Rats; Xenobiotics

1993
Identification of in vitro cytochrome P450 modulators to detect induction by prototype inducers in the mallard duckling (Anas platyrhynchos).
    Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1999, Volume: 122, Issue:2

    Topics: Animals; Benzimidazoles; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Ducks; Enzyme Induction; Microsomes, Liver; Oxazines; Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls; Proadifen

1999
Antiandrogenic activities of diesel exhaust particle extracts in PC3/AR human prostate carcinoma cells.
    Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 76, Issue:2

    Topics: Adenocarcinoma; Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anilides; Benzoflavones; beta-Galactosidase; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Luciferases; Male; Nitriles; Polycyclic Aromatic Hydrocarbons; Proadifen; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Receptors, Aryl Hydrocarbon; Saccharomyces cerevisiae; Tosyl Compounds; Vehicle Emissions

2003
In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:10

    Topics: Alanine Transaminase; Animals; Antitussive Agents; Aspartate Aminotransferases; Asteraceae; Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Drugs, Chinese Herbal; Esterases; Expectorants; Liver; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Monocrotaline; Phenylmethylsulfonyl Fluoride; Proadifen; Pyrrolizidine Alkaloids; Rats; Rats, Sprague-Dawley; Tritolyl Phosphates

2007
Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 122, Issue:2

    Topics: Aniline Compounds; Animals; Benzoflavones; Biomarkers; Cell Survival; Cells, Cultured; Crotonates; Cytochrome P-450 Enzyme System; Hepatocytes; Hydroxybutyrates; Inactivation, Metabolic; Isoxazoles; Ketoconazole; Leflunomide; Liver; Male; Nitriles; Primary Cell Culture; Proadifen; Rats; Rats, Sprague-Dawley; Ticlopidine; Toluidines; Triazoles

2011
Cancer prevention mediated by caffeic acid phenethyl ester involves cyp2b1/2 modulation in hepatocarcinogenesis.
    Toxicologic pathology, 2012, Volume: 40, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Caffeic Acids; Carcinogenicity Tests; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochromes; Diethylnitrosamine; Disease Models, Animal; Liver Neoplasms, Experimental; Male; Phenylethyl Alcohol; Proadifen; Rats; Rats, Inbred F344; Steroid Hydroxylases

2012
Effects of cytochrome P450 inhibitors on peroxidase activity.
    Neuro endocrinology letters, 2012, Volume: 33 Suppl 3

    Topics: Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Ellipticines; Enzyme Activation; Enzyme Inhibitors; Horseradish Peroxidase; Humans; Ketoconazole; Metyrapone; Piperonyl Butoxide; Proadifen; Quinidine; Structure-Activity Relationship; Substrate Specificity; Sulfaphenazole; Triazoles; Troleandomycin

2012
Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes.
    Journal of applied toxicology : JAT, 2014, Volume: 34, Issue:8

    Topics: Animals; Benzoflavones; Benzofurans; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dietary Supplements; Enzyme Inhibitors; Hepatocytes; Ketoconazole; Liver; Male; Mitochondria; Proadifen; Rats; Rats, Sprague-Dawley; Ticlopidine

2014