alpha-monofluoromethyldopa has been researched along with methyldopa in 26 studies
| Studies (alpha-monofluoromethyldopa) | Trials (alpha-monofluoromethyldopa) | Recent Studies (post-2010) (alpha-monofluoromethyldopa) | Studies (methyldopa) | Trials (methyldopa) | Recent Studies (post-2010) (methyldopa) |
|---|---|---|---|---|---|
| 29 | 0 | 0 | 3,719 | 420 | 143 |
| Protein | Taxonomy | alpha-monofluoromethyldopa (IC50) | methyldopa (IC50) |
|---|---|---|---|
| Epidermal growth factor receptor | Homo sapiens (human) | 5.228 | |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | 5.176 | |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | 2.126 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (76.92) | 18.7374 |
| 1990's | 5 (19.23) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bey, P; Jung, MJ; Koch-Weser, J; Palfreyman, MG; Ribereau-Gayon, G; Wagner, J; Zraïka, M | 1 |
| Head, GA; Howe, PR; Lungershausen, YK; Rogers, PF | 1 |
| Bonaventure, N; Kempf, E; Rudolf, G; Wioland, N | 1 |
| Eisenhofer, G; Hoffman, PL; Szabo, G | 1 |
| Bradbury, AJ; Giddins, RE; Smith, JA | 1 |
| Kilbinger, H; Racké, K; Schwörer, H | 1 |
| Bradbury, AJ; Costall, B; Gunning, SJ; Naylor, RJ | 1 |
| Juorio, AV; Sloley, BD | 1 |
| Endo, Y | 1 |
| Dyck, LE | 1 |
| Parkinson, D; Rando, RR | 1 |
| Fozard, JR; Koch-Weser, J; Möhring, J; Palfreyman, MG; Spedding, M; Wagner, J | 1 |
| Gardner, CR; Richards, MH | 1 |
| Curzon, G; Hutson, PH; Kantamaneni, BD; Sarna, GS | 1 |
| Curzon, G; Hutson, PH; Sarna, GS | 1 |
| Arbogast, R; Palfreyman, MG; Wagner, J; Zreika, M | 1 |
| Baylin, SB; Maneckjee, R | 1 |
| Gerhart, F; Hornsperger, JM; Jung, MJ; Wagner, J | 1 |
| Baughman, R; Masland, RH; Parkinson, D; Rando, RR | 1 |
| Boulton, AA; Juorio, AV | 1 |
| Henning, M; Johansson, P | 1 |
| Aster, SD; Maycock, AL; Patchett, AA | 1 |
| Bey, P; Jung, MJ; Koch-Weser, J; Palfreyman, MG; Sjoerdsma, A; Wagner, J; Zraïka, M | 1 |
| Henry, DP; Van Huysse, JW; Willis, LR | 1 |
| Boulton, AA; Durden, DA; Dyck, LE | 1 |
| Andrews, AM; Holmes, A; Huang, SJ; Kim, DK; Lesch, KP; Martin, BJ; Murphy, DL; Tolliver, TJ; Wichems, C | 1 |
26 other study(ies) available for alpha-monofluoromethyldopa and methyldopa
| Article | Year |
|---|---|
Inhibition of monoamine synthesis by irreversible blockade of aromatic aminoacid decarboxylase with alpha-monofluoromethyldopa.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Biogenic Amines; Brain; Kidney; Male; Methyldopa; Mice; Myocardium; Swine; Time Factors | 1979 |
Effects of depleting central and peripheral adrenaline stores on blood pressure in stroke-prone spontaneously hypertensive rats.
Topics: Analysis of Variance; Animals; Blood Pressure; Brain; Dopamine Antagonists; Electric Stimulation; Epinephrine; Male; Medulla Oblongata; Methyldopa; Norepinephrine; Phenylethanolamine N-Methyltransferase; Rats; Rats, Inbred SHR | 1991 |
EOG and ERG modifications induced in the chicken eye after blockade of catecholamine and 5-hydroxytryptamine biosynthesis.
Topics: Animals; Chickens; Dark Adaptation; Dopamine; Dopamine Antagonists; Electrooculography; Electroretinography; Light; Melatonin; Methyldopa; Serotonin; Vitreous Body | 1990 |
Opposite changes in turnover of noradrenaline and dopamine in the CNS of ethanol-dependent mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alcoholism; Animals; Brain; Catecholamines; Dopamine; Heart; Male; Methoxyhydroxyphenylglycol; Methyldopa; Mice; Mice, Inbred C57BL; Myocardium; Norepinephrine | 1990 |
Inhibition of serum melatonin concentration and synthesis of brain indolealkylamines by monofluoromethyldopa in the rat.
Topics: 5-Hydroxytryptophan; Animals; Aromatic-L-Amino-Acid Decarboxylases; Brain; Cerebral Cortex; Hydroxyindoleacetic Acid; Hypothalamus; Indoles; Male; Melatonin; Methyldopa; Pineal Gland; Rats; Rats, Inbred Strains; Serotonin | 1985 |
Spontaneous release of endogenous 5-hydroxytryptamine and 5-hydroxyindoleacetic acid from the isolated vascularly perfused ileum of the guinea-pig.
Topics: Animals; Calcium; Guinea Pigs; Hydroxyindoleacetic Acid; Ileum; Imipramine; In Vitro Techniques; Male; Methyldopa; Myenteric Plexus; Pargyline; Perfusion; Portal Vein; Serotonin; Tetrodotoxin; Tryptophan | 1987 |
Evidence that 5-hydroxytryptamine may exert both facilitatory and inhibitory control of electrical field stimulation-evoked contractions in longitudinal muscle taken from the body of guinea-pig stomach.
Topics: 5-Hydroxytryptophan; Animals; Electric Stimulation; Fenclonine; Guinea Pigs; In Vitro Techniques; Male; Methyldopa; Metoclopramide; Muscle Contraction; Muscle, Smooth; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Stomach; Tropanes | 1986 |
The presence of tyramine and related monoamines in the nerve cord and some other tissues of the lobster, Homarus americanus.
Topics: Animals; Biogenic Amines; Chromatography, High Pressure Liquid; Female; Male; Methyldopa; Nephropidae; Nervous System; Osmolar Concentration; Tissue Distribution; Tyramine | 1988 |
Suppression and potentiation of 5-hydroxytryptophan-induced hypoglycaemia by alpha-monofluoromethyldopa: correlation with the accumulation of 5-hydroxytryptamine in the liver.
Topics: 5-Hydroxytryptophan; Animals; Blood Glucose; Brain; Carbidopa; Carboxy-Lyases; Kidney; Lipopolysaccharides; Liver; Male; Methyldopa; Mice; Serotonin | 1987 |
Effect of monofluoromethyldopa (MFMD) on trace amine levels.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Isomerism; Kidney; Male; Methyldopa; Phenethylamines; Rats; Rats, Inbred Strains; Tryptamines; Tyramine | 1987 |
Evidence for a neurotransmitter role for 5-hydroxytryptamine in chick retina.
Topics: 5-Hydroxytryptophan; Animals; Chickens; Darkness; Dihydroxyphenylalanine; Dopamine; Kinetics; Light; Methyldopa; Neurotransmitter Agents; Pargyline; Retina; Serotonin | 1981 |
Depression of sympathetic nervous function by DL-alpha-monofluoromethyldopa, an enzyme-activated, irreversible inhibitor of L-aromatic amino acid decarboxylase.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Blood Pressure; Dopamine; Hypertension; Male; Methyldopa; Neurotransmitter Agents; Rats; Reserpine; Spinal Cord; Sympathetic Nervous System | 1980 |
Use of D,L-alpha-monofluoromethyldopa to distinguish subcellular pools of aromatic amino acid decarboxylase in mouse brain.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Axonal Transport; Brain; Male; Methyldopa; Mice; Neurotransmitter Agents; Subcellular Fractions; Synaptosomes | 1981 |
Concurrent determination of brain dopamine and 5-hydroxytryptamine turnovers in individual freely moving rats using repeated sampling of cerebrospinal fluid.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Methyldopa; Probenecid; Rats; Rats, Inbred Strains; Serotonin | 1984 |
Effect of alpha-methyl fluorodopa on dopamine metabolites: importance of conjugation and egress.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Methyldopa; Probenecid; Rats; Rats, Inbred Strains | 1984 |
A method for measuring monoamine turnover in animals using an irreversible inhibitor of aromatic L-amino acid decarboxylase, DL-alpha-mono fluoromethyldopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Biogenic Amines; Brain Chemistry; Dopamine; Haloperidol; Hydroxyindoleacetic Acid; Male; Methyldopa; Mice; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Species Specificity; Tetrahydronaphthalenes; Time Factors | 1984 |
Use of radiolabeled monofluoromethyl-Dopa to define the subunit structure of human L-Dopa decarboxylase.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Dopa Decarboxylase; Humans; Methyldopa; Mice; Protein Conformation; Rats; Species Specificity; Tissue Distribution | 1983 |
Inhibition of aromatic amino acid decarboxylase and depletion of biogenic amines in brain of rats treated with alpha-monofluoromethyl p-tyrosine: similitudes and differences with the effects of alpha-monofluoromethyldopa.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Biogenic Amines; Brain Chemistry; Kidney; Male; Methyldopa; Methyltyrosines; Rats; Rats, Inbred Strains; Swine; Tyrosine | 1984 |
Dopamine metabolism following irreversible inactivation of aromatic amino acid decarboxylase in retina.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Chickens; Darkness; Dihydroxyphenylalanine; Dopamine; Kinetics; Light; Methyldopa; Rabbits; Retina | 1981 |
Cerebral decarboxylation of meta- and para-tyrosine.
Topics: Animals; Carboxy-Lyases; Corpus Striatum; Dose-Response Relationship, Drug; Homovanillic Acid; Male; Methyldopa; Mice; Tyramine; Tyrosine | 1983 |
Alpha-Monofluoromethyldopa (MFMD) in combination with L-DOPA Effects on tissue catecholamines and blood pressure in rats.
Topics: Animals; Blood Pressure; Catecholamines; Drug Interactions; Levodopa; Male; Methyldopa; Rats; Rats, Inbred Strains; Sodium Chloride | 1982 |
Inactivation of 3-(3,4-dihydroxyphenyl)alanine decarboxylase by 2-(fluoromethyl)-3-(3,4-dihydroxyphenyl)alanine.
Topics: Alanine; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Carbon Radioisotopes; Kidney; Kinetics; Liver; Male; Methyldopa; Rats; Substrate Specificity; Swine; Tritium | 1980 |
Further studies on the inhibition of monoamine synthesis by monofluoromethyldopa.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain Chemistry; Catecholamines; Dopamine; Male; Methyldopa; Mice; Serotonin; Time Factors; Tryptophan | 1980 |
In vivo renal production and tubular secretion of tyramine.
Topics: Animals; Blood Pressure; Kidney; Kidney Tubules; Male; Methyldopa; Norepinephrine; p-Aminohippuric Acid; Quinolinium Compounds; Rabbits; Tyramine | 1995 |
Effects of monoamine oxidase inhibitors on the acid metabolites of some trace amines and of dopamine in the rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amines; Animals; Corpus Striatum; Dopamine; Male; Methyldopa; Monoamine Oxidase Inhibitors; Phenylacetates; Piperidines; Rats; Rats, Wistar; Selegiline | 1993 |
Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter.
Topics: Animals; Aorta; Blotting, Northern; Brain; Chromatography, High Pressure Liquid; Dopamine; Female; Gene Expression Regulation; Hydroxyindoleacetic Acid; Kidney; Levodopa; Liver; Lung; Male; Methyldopa; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Myocardium; Nonlinear Dynamics; Norethandrolone; Pancreas; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sex Factors; Spleen; Time Factors; Tryptophan Hydroxylase | 2005 |