Compounds > alpha-methylhistamine

alpha-methylhistamine and clozapine

alpha-methylhistamine has been researched along with clozapine in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (33.33)18.2507
2000's5 (55.56)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jansen, FP; Leurs, R; Prell, GD; Rodrigues, AA; Timmerman, H1
Marr, I; Schlicker, E1
Arrang, JM; Morisset, S; Sahm, UG; Schwartz, JC; Tardivel-Lacombe, J; Traiffort, E1
Chang, H; Erlander, MG; Lovenberg, TW; Pyati, J; Wilson, SJ1
Blevitt, J; Carruthers, N; Chai, W; Hofstra, CL; Jiang, X; Li, X; Liu, C; Lovenberg, TW; Ma, X; Pyati, J; Wilson, SJ1
Alston, J; Ames, RS; Bergsma, DJ; Boyce, R; Davenport, CM; Dytko, GM; Fitzgerald, LR; Herrity, NC; Hieble, JP; Li, X; Mannan, IJ; Michalovich, D; Sarau, HM; Tan, KB; Tierney, LA; Vawter, L; Wilson, S; Wu, H; Zhu, Y1
Kuei, C; Liu, C; Lovenberg, TW; Wilson, SJ1
Bakker, RA; Leurs, R; Lim, HD; Ling, P; Thurmond, RL; van Rijn, RM1
Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K1

Other Studies

9 other study(ies) available for alpha-methylhistamine and clozapine

ArticleYear
Interaction of clozapine with the histamine H3 receptor in rat brain.
    British journal of pharmacology, 1995, Volume: 114, Issue:8

    Topics: Animals; Binding, Competitive; Cerebral Cortex; Clozapine; Haloperidol; Histamine Antagonists; Histamine Release; Imidazoles; Isothiuronium; Methylhistamines; Piperidines; Rats; Receptors, Histamine H3

1995
The moderate affinity of clozapine at H3 receptors is not shared by its two major metabolites and by structurally related and unrelated atypical neuroleptics.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 353, Issue:3

    Topics: Animals; Antipsychotic Agents; Benzodiazepines; Binding, Competitive; Clozapine; Dibenzothiepins; Dose-Response Relationship, Drug; Histamine Antagonists; Isotope Labeling; Male; Methylhistamines; Mice; Olanzapine; Pirenzepine; Rats; Rats, Wistar; Receptors, Histamine H3; Remoxipride; Risperidone; Structure-Activity Relationship; Thioridazine; Tritium

1996
Atypical neuroleptics enhance histamine turnover in brain via 5-Hydroxytryptamine2A receptor blockade.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2

    Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Catalepsy; Clozapine; Drug Interactions; Haloperidol; Histamine; Histamine Antagonists; Imidazoles; Male; Methylhistamines; Mice; Olanzapine; Pirenzepine; Receptor, Serotonin, 5-HT2A; Receptors, Histamine H3; Receptors, Serotonin; Serotonin Antagonists

1999
Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:3

    Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Animals; Cloning, Molecular; Dose-Response Relationship, Drug; Humans; Methylhistamines; Molecular Sequence Data; Rats; Receptors, Histamine H3; Recombinant Proteins; RNA, Messenger

2000
Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow.
    Molecular pharmacology, 2001, Volume: 59, Issue:3

    Topics: Adenylyl Cyclases; Amino Acid Sequence; Bone Marrow; Cloning, Molecular; Histamine; Humans; Methylhistamines; Molecular Sequence Data; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; RNA, Messenger; Sequence Homology, Amino Acid; Tissue Distribution; Tritium

2001
Cloning, expression, and pharmacological characterization of a novel human histamine receptor.
    Molecular pharmacology, 2001, Volume: 59, Issue:3

    Topics: Amino Acid Sequence; Animals; Calcium; Cloning, Molecular; Dose-Response Relationship, Drug; Gene Expression; Genes, Reporter; Histamine; Humans; Luciferases; Mice; Molecular Sequence Data; Radioligand Assay; Receptors, Histamine; Receptors, Histamine H3; Sequence Homology, Amino Acid; Tissue Distribution; Tritium

2001
Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:1

    Topics: Amino Acid Sequence; Animals; Calcium; Cell Line; Cloning, Molecular; COS Cells; Cyclic AMP; DNA Fragmentation; Guinea Pigs; Humans; Mice; Molecular Sequence Data; Radioligand Assay; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Transfection

2001
Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:3

    Topics: Cell Line; Histamine Agonists; Humans; Imidazoles; Indoles; Isothiuronium; Ligands; Methylhistamines; Piperazines; Radioligand Assay; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3; Receptors, Histamine H4

2005
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
    Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21

    Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship

2010