Page last updated: 2024-09-04

alpha-methylepinine and deoxyepinephrine

alpha-methylepinine has been researched along with deoxyepinephrine in 27 studies

Compound Research Comparison

Studies (alpha-methylepinine)	Trials (alpha-methylepinine)	Recent Studies (post-2010) (alpha-methylepinine)	Studies (deoxyepinephrine)	Trials (deoxyepinephrine)	Recent Studies (post-2010) (deoxyepinephrine)
28	3	6	502	91	33

Research

Studies (27)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (18.52)	18.2507
2000's	15 (55.56)	29.6817
2010's	7 (25.93)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Brewster, WK; Johnson, MP; Nichols, DE; Steele, TD; Yim, GK	1
Cho, AK; Chu, TY; Ellis, SW; Hiratsuka, A; Lennard, MS; Lin, LY; Schmitz, DA; Tucker, GT; Woods, HF	1
Elayan, I; Foltz, RL; Gibb, JW; Hanson, GR; Johnson, M; Lim, HK	1
Bourquin, D; Bracher, K; Brenneisen, R; Helmlin, HJ; Vonlanthen, D	1
Atterwill, CK; Davenport-Jones, JE; Fox, RM; Walker, TM	1
Brenneisen, R; Camí, J; de la Torre, R; Farré, M; Mas, M; Ortuño, J; Roset, PN; Segura, J	1
de La Torre, R; Farré, M; Joglar, J; Llebaria, A; McLure, JA; Ortuño, J; Pizarro, N; Pujadas, M; Roset, PN; Segura, J; Segura, M	1
de la Torre, R; Farré, M; Joglar, J; Llebaria, A; Pizarro, N; Segura, J	1
Camí, J; de la Torre, R; Farré, M; Hernández-López, C; Joglar, J; Llebaria, A; Mas, M; Ortuño, J; Pizarro, N; Pujadas, M; Roset, PN; Segura, J	1
de la Torre, R; Farré, M; Joglar, J; Llebaria, A; McLure, JA; Ortuño, J; Pizarro, N; Pujadas, M; Segura, J; Segura, M	1
de la Torre, R; Farré, M; Joglar, J; Peiró, AM; Pizarro, N; Pujadas, M; Roset, PN	1
Colado, MI; de la Torre, R; Escobedo, I; Farre, M; Green, AR; O'Shea, E; Orio, L; Sanchez, V; Segura, M	1
Banks, ML; Czoty, PW; Kisor, DF; Nader, MA; Nichols, DE; Sprague, JE	1
Maurer, HH; Mueller, M; Peters, FT; Ricaurte, GA	2
Maurer, HH; McCann, UD; Mueller, M; Peters, FT; Ricaurte, GA	1
Huestis, MA; Maurer, HH; Mueller, M; Peters, FT; Ricaurte, GA	1
Huestis, MA; Kolbrich-Spargo, EA; Maurer, HH; Mueller, M; Peters, FT; Ricaurte, GA	1
Blanco, M; Felim, A; Fleury, MB; Largeron, M; Monnet, FP; Neudörffer, A	1
Felim, A; Largeron, M; Maurer, HH; McCann, UD; Mueller, M; Neudörffer, A; Peters, FT; Ricaurte, GA; Yuan, J	1
Blanco, M; Felim, A; Herrera, G; Largeron, M; Neudörffer, A; O'Connor, JE	1
Maldonado Adrian, C; McCann, UD; Mueller, M; Ricaurte, GA; Yuan, J	1
Huestis, MA; Maurer, HH; Meyer, MR; Schwaninger, AE	1
Antolino-Lobo, I; Meulenbelt, J; Molendijk, J; Nijmeijer, SM; Scherpenisse, P; van den Berg, M; van Duursen, MB	1
Almeida, B; Barenys, M; Boix, N; Flick, B; Joglar, J; Klug, S; Llobet, JM	1
Baumann, MH; Blough, BE; Goldberg, SR; Schindler, CW; Tella, SR; Thorndike, EB	1
Maurer, HH; Meyer, MR; Richter, LH	1

Trials

3 trial(s) available for alpha-methylepinine and deoxyepinephrine

Article	Year
Analysis of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in plasma and urine by HPLC-DAD and GC-MS. Journal of analytical toxicology, 1996, Volume: 20, Issue:6 Topics: 3,4-Methylenedioxyamphetamine; Administration, Oral; Adolescent; Adult; Chromatography, High Pressure Liquid; Deoxyepinephrine; Female; Fluorocarbons; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Hydrolysis; Ion Exchange Resins; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Reference Standards	1996
Non-linear pharmacokinetics of MDMA ('ecstasy') in humans. British journal of clinical pharmacology, 2000, Volume: 49, Issue:2 Topics: 3,4-Methylenedioxyamphetamine; Adult; Area Under Curve; Blood Pressure; Cross-Over Studies; Deoxyepinephrine; Diastole; Dose-Response Relationship, Drug; Double-Blind Method; Hallucinogens; Humans; Hydrogen-Ion Concentration; Male; Metabolic Clearance Rate; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Pilot Projects; Time Factors	2000
Determination of MDMA and its metabolites in blood and urine by gas chromatography-mass spectrometry and analysis of enantiomers by capillary electrophoresis. Journal of analytical toxicology, 2002, Volume: 26, Issue:3 Topics: 3,4-Methylenedioxyamphetamine; Deoxyepinephrine; Electrophoresis, Capillary; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Substance Abuse Detection	2002

Other Studies

24 other study(ies) available for alpha-methylepinine and deoxyepinephrine

Article	Year
Assessment of the role of alpha-methylepinine in the neurotoxicity of MDMA. Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:2 Topics: 3,4-Methylenedioxyamphetamine; Animals; Biogenic Amines; Brain Chemistry; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Deoxyepinephrine; Electrochemistry; Injections, Intraventricular; Male; Mice; Microsomes, Liver; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Species Specificity	1991
The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6). Biochemical pharmacology, 1994, Mar-29, Volume: 47, Issue:7 Topics: 3,4-Methylenedioxyamphetamine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Deoxyepinephrine; Humans; Kinetics; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; N-Methyl-3,4-methylenedioxyamphetamine; NADP; Saccharomyces cerevisiae; Transfection	1994
Short-term effects of 2,4,5-trihydroxyamphetamine, 2,4,5-trihydroxymethamphetamine and 3,4-dihydroxymethamphetamine on central tryptophan hydroxylase activity. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2 Topics: 5,6-Dihydroxytryptamine; Amphetamines; Animals; Corpus Striatum; Deoxyepinephrine; Enzyme Activation; Hippocampus; In Vitro Techniques; Male; Methamphetamine; Oxidopamine; Rats; Rats, Sprague-Dawley; Tryptophan Hydroxylase	1993
The neurotoxic effects of methylenedioxymethamphetamine (MDMA) and its metabolites on rat brain spheroids in culture. Cell biology and toxicology, 1999, Volume: 15, Issue:3 Topics: 3,4-Methylenedioxyamphetamine; Animals; Biomarkers; Brain; Brain Diseases; Cytosol; Deoxyepinephrine; Dose-Response Relationship, Drug; Fetus; Glial Fibrillary Acidic Protein; Glutathione; L-Lactate Dehydrogenase; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Serotonin; Serotonin Agents; Spheroids, Cellular	1999
3,4-Dihydroxymethamphetamine (HHMA). A major in vivo 3,4-methylenedioxymethamphetamine (MDMA) metabolite in humans. Chemical research in toxicology, 2001, Volume: 14, Issue:9 Topics: Adult; Chromatography, High Pressure Liquid; Deoxyepinephrine; Hallucinogens; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Sensitivity and Specificity; Toxicity Tests	2001
Synthesis and capillary electrophoretic analysis of enantiomerically enriched reference standards of MDMA and its main metabolites. Bioorganic & medicinal chemistry, 2002, Volume: 10, Issue:4 Topics: Deoxyepinephrine; Electrophoresis, Capillary; Hallucinogens; Lactates; N-Methyl-3,4-methylenedioxyamphetamine; Reference Standards; Stereoisomerism	2002
High-performance liquid chromatography with electrochemical detection applied to the analysis of 3,4-dihydroxymethamphetamine in human plasma and urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002, Apr-05, Volume: 769, Issue:2 Topics: Calibration; Chromatography, High Pressure Liquid; Deoxyepinephrine; Electrochemistry; Reference Standards; Reproducibility of Results; Sensitivity and Specificity	2002
Stereochemical analysis of 3,4-methylenedioxymethamphetamine and its main metabolites in human samples including the catechol-type metabolite (3,4-dihydroxymethamphetamine). Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:9 Topics: 3,4-Methylenedioxyamphetamine; Administration, Oral; Area Under Curve; Catechol O-Methyltransferase; Cytochrome P-450 CYP2D6; Deoxyepinephrine; Half-Life; Humans; Male; Methamphetamine; Methods; Phenotype; Polymorphism, Genetic; Stereoisomerism	2004
A comparative study on the acute and long-term effects of MDMA and 3,4-dihydroxymethamphetamine (HHMA) on brain monoamine levels after i.p. or striatal administration in mice. British journal of pharmacology, 2005, Volume: 144, Issue:2 Topics: Animals; Biogenic Monoamines; Brain; Corpus Striatum; Deoxyepinephrine; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; N-Methyl-3,4-methylenedioxyamphetamine; Time Factors	2005
Ambient temperature effects on 3,4-methylenedioxymethamphetamine-induced thermodysregulation and pharmacokinetics in male monkeys. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:10 Topics: 3,4-Methylenedioxyamphetamine; Animals; Body Temperature; Deoxyepinephrine; Fever; Hallucinogens; Macaca fascicularis; Male; Serotonin Agents; Temperature	2007
Validated liquid chromatographic-electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-methoxym Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Aug-15, Volume: 855, Issue:2 Topics: 3,4-Methylenedioxyamphetamine; Animals; Calibration; Chromatography, Liquid; Deoxyepinephrine; Hallucinogens; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Saimiri; Spectrometry, Mass, Electrospray Ionization	2007
Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") and its major metabolites in squirrel monkeys at plasma concentrations of MDMA that develop after typical psychoactive doses. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:1 Topics: Animals; Area Under Curve; Deoxyepinephrine; Half-Life; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Saimiri; Species Specificity	2008
Liquid chromatographic-electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-methoxymethampheta Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Oct-15, Volume: 874, Issue:1-2 Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Brain Chemistry; Chromatography, Liquid; Deoxyepinephrine; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization	2008
Simultaneous liquid chromatographic-electrospray ionization mass spectrometric quantification of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) and its metabolites 3,4-dihydroxymethamphetamine, 4-hydroxy-3-methoxymethamphetamine and 3,4-methylenedioxya Forensic science international, 2009, Jan-30, Volume: 184, Issue:1-3 Topics: 3,4-Methylenedioxyamphetamine; Animals; Chromatography, Liquid; Deoxyepinephrine; Forensic Toxicology; Hallucinogens; Humans; Hydrolysis; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Saimiri; Spectrometry, Mass, Electrospray Ionization	2009
Hydrolysis of 3,4-methylenedioxymethamphetamine (MDMA) metabolite conjugates in human, squirrel monkey, and rat plasma. Analytical and bioanalytical chemistry, 2009, Volume: 393, Issue:6-7 Topics: Animals; Chromatography, Liquid; Deoxyepinephrine; Glucuronic Acid; Glucuronidase; Humans; Hydrolysis; Methamphetamine; Rats; Rats, Sprague-Dawley; Saimiri; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Sulfatases; Sulfuric Acids	2009
[Metabolites of ecstasy and cytotoxicity effects]. Annales pharmaceutiques francaises, 2009, Volume: 67, Issue:2 Topics: Animals; Biological Assay; Biotransformation; Cell Survival; Deoxyepinephrine; Escherichia coli; Hallucinogens; Hippocampus; Injections, Intraventricular; N-Methyl-3,4-methylenedioxyamphetamine; Pyramidal Cells; Rats; Reactive Oxygen Species	2009
Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicity. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:10 Topics: 3,4-Methylenedioxyamphetamine; Animals; Deoxyepinephrine; Disease Models, Animal; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Serotonin	2009
Synthesis and in vitro cytotoxicity profile of the R-enantiomer of 3,4-dihydroxymethamphetamine (R-(-)-HHMA): comparison with related catecholamines. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Catecholamines; Cell Line, Tumor; Deoxyepinephrine; Flow Cytometry; Humans; Levodopa; N-Methyl-3,4-methylenedioxyamphetamine; Stereoisomerism; Toxicity Tests	2010
Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: implications for mechanisms of neurotoxicity. Synapse (New York, N.Y.), 2011, Volume: 65, Issue:10 Topics: 3,4-Methylenedioxyamphetamine; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Deoxyepinephrine; Dextromethorphan; Excitatory Amino Acid Antagonists; Hydroxyindoleacetic Acid; Male; Neurotoxicity Syndromes; Neurotoxins; Rats; Rats, Sprague-Dawley; Serotonin; Sulfides	2011
Development and validation of LC-HRMS and GC-NICI-MS methods for stereoselective determination of MDMA and its phase I and II metabolites in human urine. Journal of mass spectrometry : JMS, 2011, Volume: 46, Issue:7 Topics: Chromatography, Liquid; Deoxyepinephrine; Drug Stability; Gas Chromatography-Mass Spectrometry; Glucuronides; Humans; Least-Squares Analysis; Mass Spectrometry; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Sulfates	2011
Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants. Toxicology, 2011, Nov-18, Volume: 289, Issue:2-3 Topics: Animals; Antioxidants; Cell Survival; Cells, Cultured; Deoxyepinephrine; Drug Interactions; Glutathione; Hepatocytes; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Protective Agents; Rats; Rats, Wistar	2011
Effects of MDMA (ecstasy) and two of its metabolites on rat embryos in vitro. Reproductive toxicology (Elmsford, N.Y.), 2012, Volume: 34, Issue:1 Topics: 3,4-Methylenedioxyamphetamine; Animals; Deoxyepinephrine; Embryo, Mammalian; Embryonic Development; Female; Hallucinogens; In Vitro Techniques; N-Methyl-3,4-methylenedioxyamphetamine; Pregnancy; Rats; Rats, Sprague-Dawley	2012
Effects of 3,4-methylenedioxymethamphetamine (MDMA) and its main metabolites on cardiovascular function in conscious rats. British journal of pharmacology, 2014, Volume: 171, Issue:1 Topics: 3,4-Methylenedioxyamphetamine; Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiovascular System; Consciousness; Deoxyepinephrine; Dopamine; Dose-Response Relationship, Drug; Hallucinogens; Heart Rate; Male; Metabolic Detoxication, Phase I; Methamphetamine; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Telemetry; Time Factors	2014
Methylenedioxy designer drugs: mass spectrometric characterization of their glutathione conjugates by means of liquid chromatography-high-resolution mass spectrometry/mass spectrometry and studies on their glutathionyl transferase inhibition potency. Analytica chimica acta, 2014, Apr-25, Volume: 822 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Deoxyepinephrine; Dinitrochlorobenzene; Enzyme Assays; Female; Glutathione; Glutathione Transferase; Humans; Isomerism; N-Methyl-3,4-methylenedioxyamphetamine; Placenta; Pregnancy; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry	2014