alpha-methyl-4-carboxyphenylglycine and quisqualic acid

alpha-methyl-4-carboxyphenylglycine has been researched along with quisqualic acid in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (52.63)18.2507
2000's8 (42.11)29.6817
2010's1 (5.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Costantino, G; Pellicciari, R1
Bräuner-Osborne, H; Egebjerg, J; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Adam, G; Bleuel, Z; Chaboz, S; Ellis, GJ; Faull, RL; Malherbe, P; Messer, J; Metzler, V; Mutel, V; Nilly, A; Richards, JG; Roughley, BS; Schlaeger, EJ1
Bischoff, F; Janssen, C; Langlois, X; Lavreysen, H; Lesage, AS; Leysen, JE1
Cavanni, P; Eistetter, H; Ferraguti, F; Ratti, E; Salvagno, C; Trist, DG1
Littman, L; Robinson, MB1
Burnett, JP; Kingston, AE; Lodge, D; Mayne, NG1
Choi, S; Lovinger, DM1
Burke, JP; Hablitz, JJ1
Deng, A; Growdon, JH; Nitsch, RM; Wurtman, RJ1
Deitmer, JW; Lohr, C1
Alger, BE; Kirov, SA; Morishita, W1
Blanc, EM; Guiramand, J; Jallageas, M; Recasens, M1
Croucher, MJ; Harris, JR; Jane, DE; Thomas, LS1
Chu, Z; Hablitz, JJ1
Challiss, RA; McIlhinney, RA; Rhodes, A; Selkirk, JV1
Foster, AC; Naeve, GS; Selkirk, JV1
Brown, EM; Conn, PJ; Hall, RA; Hamelberg, D; Jiang, JY; Meyer, RC; Nagaraju, M; Yang, JJ; Zhang, L1

Reviews

1 review(s) available for alpha-methyl-4-carboxyphenylglycine and quisqualic acid

ArticleYear
Ligands for glutamate receptors: design and therapeutic prospects.
    Journal of medicinal chemistry, 2000, Jul-13, Volume: 43, Issue:14

    Topics: Animals; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; N-Methylaspartate; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synapses

2000

Other Studies

18 other study(ies) available for alpha-methyl-4-carboxyphenylglycine and quisqualic acid

ArticleYear
Homology modeling of metabotropic glutamate receptors. (mGluRs) structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists.
    Journal of medicinal chemistry, 1996, Sep-27, Volume: 39, Issue:20

    Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Computer Simulation; Electrochemistry; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Conformation; Protein Structure, Secondary; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Sequence Homology

1996
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections.
    Journal of neurochemistry, 2000, Volume: 75, Issue:6

    Topics: Animals; Binding, Competitive; Brain; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Humans; Imidazoles; Indans; Intracellular Fluid; Kainic Acid; Male; Organ Specificity; Quinazolines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Recombinant Proteins; Spinal Cord; Transfection

2000
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
    Molecular pharmacology, 2003, Volume: 63, Issue:5

    Topics: Adamantane; Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Brain; Cell Line; Cell Membrane; CHO Cells; Chromones; Cricetinae; Humans; Naphthalenes; Pyrans; Quinolines; Quinoxalines; Quisqualic Acid; Radioligand Assay; Rats; Receptors, Metabotropic Glutamate; Transfection; Tritium

2003
Competitive antagonism by phenylglycine derivatives at type I metabotropic glutamate receptors.
    Molecular and cellular neurosciences, 1994, Volume: 5, Issue:3

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Benzoates; Binding, Competitive; Calcium; Cells, Cultured; CHO Cells; Cricetinae; Cycloleucine; Cytidine Diphosphate Diglycerides; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Kainic Acid; Neurons; Neurotoxins; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Quisqualic Acid; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Signal Transduction

1994
The effects of L-glutamate and trans-(+-)-1-amino-1,3-cyclopentanedicarboxylate on phosphoinositide hydrolysis can be pharmacologically differentiated.
    Journal of neurochemistry, 1994, Volume: 63, Issue:4

    Topics: Alanine; Animals; Animals, Newborn; Aspartic Acid; Benzoates; Brain; Cerebellum; Cycloleucine; Glutamic Acid; Glycine; Hippocampus; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kinetics; Neurotoxins; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Stereoisomerism

1994
Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1 alpha and mGluR5a subtypes.
    Neuropharmacology, 1995, Volume: 34, Issue:8

    Topics: Animals; Benzoates; Calcium; Cells, Cultured; Excitatory Amino Acid Antagonists; Glycine; Humans; Hydrolysis; Phosphatidylinositols; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Signal Transduction

1995
Metabotropic glutamate receptor modulation of voltage-gated Ca2+ channels involves multiple receptor subtypes in cortical neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, Volume: 16, Issue:1

    Topics: Animals; Benzoates; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Cycloleucine; Cyclopropanes; Electrophysiology; Ethylmaleimide; Excitatory Amino Acid Agonists; Glycine; Ion Channel Gating; Neurons; Neurotoxins; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spider Venoms

1996
G-protein activation by metabotropic glutamate receptors reduces spike frequency adaptation in neocortical neurons.
    Neuroscience, 1996, Volume: 75, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adult; Alanine; Amino Acids, Dicarboxylic; Animals; Benzoates; Cycloleucine; Enzyme Inhibitors; Frontal Lobe; Glycine; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Isoquinolines; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Protein Kinase Inhibitors; Protein Kinases; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction; Staurosporine; Sulfonamides; Thionucleotides

1996
Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain.
    Journal of neurochemistry, 1997, Volume: 69, Issue:2

    Topics: Amyloid beta-Protein Precursor; Benzoates; Cell Line; Cycloleucine; Enzyme Activation; Excitatory Amino Acid Antagonists; Gene Expression; Glutamic Acid; Glycine; GTP-Binding Proteins; Humans; Melitten; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Protein Kinases; Quisqualic Acid; Receptors, Metabotropic Glutamate; Transfection; Type C Phospholipases

1997
Intracellular Ca2+ release mediated by metabotropic glutamate receptor activation in the leech giant glial cell.
    The Journal of experimental biology, 1997, Volume: 200, Issue:Pt 19

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Calcium; Calcium-Transporting ATPases; Central Nervous System; Enzyme Inhibitors; Glutamic Acid; Glycine; Indoles; Intracellular Fluid; Ion Transport; Leeches; Ligands; Membrane Potentials; Neuroglia; Quisqualic Acid; Receptors, Metabotropic Glutamate

1997
Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA1.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Jul-01, Volume: 18, Issue:13

    Topics: 4-Aminopyridine; Amino Acids, Dicarboxylic; Animals; Benzoates; Calcium Channels; Cycloleucine; Cyclopropanes; Enzyme Inhibitors; Ethylmaleimide; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Male; Membrane Potentials; Neural Inhibition; Neuroprotective Agents; Patch-Clamp Techniques; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Signal Transduction; Synapses

1998
Potentiation of glutamatergic agonist-induced inositol phosphate formation by basic fibroblast growth factor is related to developmental features in hippocampal cultures: neuronal survival and glial cell proliferation.
    The European journal of neuroscience, 1999, Volume: 11, Issue:10

    Topics: Animals; Antimetabolites, Antineoplastic; Benzoates; Cell Division; Cell Survival; Cells, Cultured; Cellular Senescence; Cycloleucine; Cytarabine; Epidermal Growth Factor; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Fibroblast Growth Factor 2; Glutamic Acid; Glycine; Hippocampus; Inositol Phosphates; Neuroglia; Neurons; Neuroprotective Agents; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Type C Phospholipases

1999
Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro.
    Neuropharmacology, 2000, Jul-10, Volume: 39, Issue:9

    Topics: Animals; Aspartic Acid; Autoreceptors; Benzoates; Calcium; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; In Vitro Techniques; Indans; Male; Neurons; Phenylacetates; Prosencephalon; Quisqualic Acid; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Tetrodotoxin; Tritium

2000
Quisqualate induces an inward current via mGluR activation in neocortical pyramidal neurons.
    Brain research, 2000, Oct-06, Volume: 879, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Bicuculline; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Guanosine Diphosphate; In Vitro Techniques; Membrane Potentials; Neocortex; Patch-Clamp Techniques; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tetrodotoxin; Thionucleotides

2000
Characterization of an N-terminal secreted domain of the type-1 human metabotropic glutamate receptor produced by a mammalian cell line.
    Journal of neurochemistry, 2002, Volume: 80, Issue:2

    Topics: Amino Acid Sequence; Animals; Benzoates; Binding, Competitive; CHO Cells; Cricetinae; Dimerization; Excitatory Amino Acid Antagonists; Glycine; Glycoside Hydrolases; Glycosylation; GTP-Binding Proteins; Humans; Molecular Sequence Data; Peptide Fragments; Protein Structure, Tertiary; Quisqualic Acid; Receptors, Metabotropic Glutamate; Transfection; Tritium

2002
Blockade of excitatory amino acid transporters in the rat hippocampus results in enhanced activation of group I and group III metabotropic glutamate receptors.
    Neuropharmacology, 2003, Volume: 45, Issue:7

    Topics: Animals; Aspartic Acid; Benzoates; Colforsin; Cyclic AMP; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glycine; Hippocampus; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Methoxyhydroxyphenylglycol; Pyridines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate

2003
Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α.
    The Journal of biological chemistry, 2014, Jan-17, Volume: 289, Issue:3

    Topics: Allosteric Regulation; Amino Acid Substitution; Benzoates; Binding Sites; Calcium; Calcium Signaling; Carbamates; Excitatory Amino Acid Agonists; Glycine; HEK293 Cells; Humans; Mutation, Missense; Protein Structure, Tertiary; Quisqualic Acid; Receptors, Metabotropic Glutamate; Xanthenes

2014