alpha-methyl-4-carboxyphenylglycine and glutamic acid

alpha-methyl-4-carboxyphenylglycine has been researched along with glutamic acid in 47 studies

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's25 (53.19)18.2507
2000's21 (44.68)29.6817
2010's1 (2.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bräuner-Osborne, H; Egebjerg, J; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO1
Arnold, MB; Johnson, BG; Ornstein, PL; Schoepp, DD; Wheeler, WJ; Wright, RA1
Adam, G; Bleuel, Z; Chaboz, S; Ellis, GJ; Faull, RL; Malherbe, P; Messer, J; Metzler, V; Mutel, V; Nilly, A; Richards, JG; Roughley, BS; Schlaeger, EJ1
Arnold, MB; Ornstein, PL; Schoepp, DD; Wheeler, WJ; Wright, RA1
Bischoff, F; Janssen, C; Langlois, X; Lavreysen, H; Lesage, AS; Leysen, JE1
Cavanni, P; Eistetter, H; Ferraguti, F; Ratti, E; Salvagno, C; Trist, DG1
Haun, SE; Horrocks, LA; Lipscomb, DC; Segeleon, JE; Trapp, VL1
Bridges, RJ; Chamberlin, AR; Cotman, CW; Miller, S1
Littman, L; Robinson, MB1
Cardoso, LF; Martini, LH; Souza, DO; Tasca, CI; Vendite, D1
Berrino, L; D'Amico, M; de Novellis, V; Pizzirusso, A; Rossi, F1
Dichter, MA; Fitzsimonds, RM1
Forni, C; Kerkerian-Le Goff, L; Nieoullon, A; Pisano, P; Samuel, D1
Attwell, D; Sarantis, M; Takahashi, M1
Glitsch, M; Llano, I; Marty, A1
Deng, A; Growdon, JH; Nitsch, RM; Wurtman, RJ1
Attucci, S; Cozzi, A; Luneia, R; Marinozzi, M; Moroni, F; Pellicciari, R; Peruginelli, F1
Copenhagen, DR; Dixon, DB1
Deitmer, JW; Lohr, C1
Bear, MF; Huber, KM; Sawtell, NB1
Kennedy, RT; Lada, MW; Vickroy, TW1
Beart, PM; Jones, NM; Lawrence, AJ1
Behrens, MM; Canzoniero, LM; Choi, DW; Lobner, D; Strasser, U1
Foley, CM; Hasser, EM; Hay, M; Moffitt, JA1
Masgrau, R; Picatoste, F; Sarri, E; Servitja, JM1
Berthele, A; Biber, K; Boddeke, HW; Gebicke-Härter, PJ; Laurie, DJ; Sommer, B; Tölle, TR; van Calker, D1
Kato, BM; Rubel, EW1
Hanania, T; Johnson, KM1
Blanc, EM; Guiramand, J; Jallageas, M; Recasens, M1
Bianchin, MM; Izquierdo, I; McGaugh, JL; Roesler, R; Spanis, CW1
Croucher, MJ; Harris, JR; Jane, DE; Thomas, LS1
Chamberlain, M; Johnson, MP; Kelly, G1
Brasnjo, G; Otis, TS1
Bernardi, G; Bonsi, P; Calabresi, P; Centonze, D; Conquet, F; Gubellini, P; Picconi, B; Pisani, A1
Hirose, K; Iino, M; Kakizawa, S; Okubo, Y1
Jingami, H; Kamiya, N; Kunishima, N; Morikawa, K; Tsuchiya, D1
Gear, RW; Levine, JD; Tambeli, CH; Young, A1
Clinckers, R; Ebinger, G; Lindekens, H; Lodge, D; Meurs, A; Michotte, Y; O'Neill, MJ; Smolders, I1
Kelly, E; McIlhinney, RA; Mundell, SJ; Pula, G; Roberts, PJ1
Branco, LG; de Paula, PM1
Ennis, M; Hayar, A; Heinbockel, T; Zhu, M1
Chiocchetti, A; Dianzani, C; Dianzani, U; Fantozzi, R; Lombardi, G; Mesturini, R; Miglio, G; Mocellin, M; Orilieri, E; Varsaldi, F1
Croucher, MJ; Datla, KP; Dexter, DT; Vernon, AC; Zbarsky, V1
Dobrunz, LE; Speed, HE1
Jiang, ZZ; Liu, Y; Shang, J; Wang, S; Wang, W; Zhang, LY; Zhang, Z1
Faria, LC; Fuortes, MG; Merlin, LR1
Blazquez-Llorca, L; Freitag, SV; Herms, J; Ovsepian, SV; Rodrigues, EF1

Reviews

1 review(s) available for alpha-methyl-4-carboxyphenylglycine and glutamic acid

ArticleYear
Ligands for glutamate receptors: design and therapeutic prospects.
    Journal of medicinal chemistry, 2000, Jul-13, Volume: 43, Issue:14

    Topics: Animals; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; N-Methylaspartate; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synapses

2000

Other Studies

46 other study(ies) available for alpha-methyl-4-carboxyphenylglycine and glutamic acid

ArticleYear
[3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells.
    Neuropharmacology, 1999, Volume: 38, Issue:10

    Topics: Amino Acids; Animals; Binding, Competitive; Calcium; Cell Membrane; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Kinetics; Radioligand Assay; Receptors, Metabotropic Glutamate; Recombinant Proteins; Transfection; Tritium; Xanthenes

1999
Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections.
    Journal of neurochemistry, 2000, Volume: 75, Issue:6

    Topics: Animals; Binding, Competitive; Brain; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Humans; Imidazoles; Indans; Intracellular Fluid; Kainic Acid; Male; Organ Specificity; Quinazolines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Recombinant Proteins; Spinal Cord; Transfection

2000
Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes.
    Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 362, Issue:6

    Topics: Amino Acids; Binding, Competitive; Cell Membrane; Excitatory Amino Acid Antagonists; Humans; Kinetics; Radioligand Assay; Receptors, Metabotropic Glutamate; Recombinant Proteins; Substrate Specificity; Tritium; Xanthenes

2000
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
    Molecular pharmacology, 2003, Volume: 63, Issue:5

    Topics: Adamantane; Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Brain; Cell Line; Cell Membrane; CHO Cells; Chromones; Cricetinae; Humans; Naphthalenes; Pyrans; Quinolines; Quinoxalines; Quisqualic Acid; Radioligand Assay; Rats; Receptors, Metabotropic Glutamate; Transfection; Tritium

2003
Competitive antagonism by phenylglycine derivatives at type I metabotropic glutamate receptors.
    Molecular and cellular neurosciences, 1994, Volume: 5, Issue:3

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Benzoates; Binding, Competitive; Calcium; Cells, Cultured; CHO Cells; Cricetinae; Cycloleucine; Cytidine Diphosphate Diglycerides; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Kainic Acid; Neurons; Neurotoxins; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Quisqualic Acid; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Signal Transduction

1994
Astroglial phosphoinositide hydrolysis during combined glucose-oxygen deprivation: role of the metabotropic glutamate receptor.
    Journal of neurochemistry, 1995, Volume: 65, Issue:3

    Topics: Alanine; Animals; Animals, Newborn; Astrocytes; Benzoates; Cells, Cultured; Glucose; Glutamic Acid; Glycine; Hydrolysis; Inositol Phosphates; L-Lactate Dehydrogenase; Lithium Chloride; Oxygen; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tritium

1995
Pharmacological dissociation of glutamatergic metabotropic signal transduction pathways in cortical astrocytes.
    European journal of pharmacology, 1994, Oct-14, Volume: 269, Issue:2

    Topics: Animals; Astrocytes; Benzoates; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cycloleucine; Dicarboxylic Acids; Glutamic Acid; Glycine; Isoproterenol; Neuroglia; Neurotoxins; Phosphatidylinositols; Pyrrolidines; Rats; Receptors, Metabotropic Glutamate; Signal Transduction

1994
The effects of L-glutamate and trans-(+-)-1-amino-1,3-cyclopentanedicarboxylate on phosphoinositide hydrolysis can be pharmacologically differentiated.
    Journal of neurochemistry, 1994, Volume: 63, Issue:4

    Topics: Alanine; Animals; Animals, Newborn; Aspartic Acid; Benzoates; Brain; Cerebellum; Cycloleucine; Glutamic Acid; Glycine; Hippocampus; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kinetics; Neurotoxins; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Stereoisomerism

1994
Modulation of adenosine-induced cAMP accumulation via metabotropic glutamate receptors in chick optic tectum.
    Neurochemical research, 1995, Volume: 20, Issue:9

    Topics: Adenosine; Alanine; Animals; Benzoates; Chickens; Cyclic AMP; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; In Vitro Techniques; Male; Quinoxalines; Receptors, Metabotropic Glutamate; Superior Colliculi

1995
Opposing effects on blood pressure following the activation of metabotropic and ionotropic glutamate receptors in raphe obscurus in the anaesthetized rat.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 353, Issue:3

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Benzoates; Blood Pressure; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hypertension; Male; Microinjections; N-Methylaspartate; Neurotoxins; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Valine

1996
Heterologous modulation of inhibitory synaptic transmission by metabotropic glutamate receptors in cultured hippocampal neurons.
    Journal of neurophysiology, 1996, Volume: 75, Issue:2

    Topics: Animals; Benzoates; Cells, Cultured; Cycloleucine; Dicarboxylic Acids; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Neural Inhibition; Neurons; Neurotransmitter Uptake Inhibitors; Patch-Clamp Techniques; Pyrrolidines; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission

1996
Involvement of the glutamatergic metabotropic receptors in the regulation of glutamate uptake and extracellular excitatory amino acid levels in the striatum of chloral hydrate-anesthetized rats.
    Brain research, 1996, Nov-11, Volume: 739, Issue:1-2

    Topics: Amino Acids, Dicarboxylic; Anesthetics, Intravenous; Animals; Benzoates; Chloral Hydrate; Corpus Striatum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Female; Glutamic Acid; Glycine; Potassium; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate

1996
Postsynaptic glutamate uptake in rat cerebellar Purkinje cells.
    The Journal of physiology, 1996, Dec-01, Volume: 497 ( Pt 2)

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Benzoates; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ion Channel Gating; Kynurenic Acid; Membrane Potentials; Monosaccharide Transport Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrodotoxin

1996
Glutamate as a candidate retrograde messenger at interneurone-Purkinje cell synapses of rat cerebellum.
    The Journal of physiology, 1996, Dec-01, Volume: 497 ( Pt 2)

    Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Benzoates; Colforsin; Cyclopropanes; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Interneurons; Kinetics; Presynaptic Terminals; Purkinje Cells; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission; Tetrodotoxin

1996
Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain.
    Journal of neurochemistry, 1997, Volume: 69, Issue:2

    Topics: Amyloid beta-Protein Precursor; Benzoates; Cell Line; Cycloleucine; Enzyme Activation; Excitatory Amino Acid Antagonists; Gene Expression; Glutamic Acid; Glycine; GTP-Binding Proteins; Humans; Melitten; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Protein Kinases; Quisqualic Acid; Receptors, Metabotropic Glutamate; Transfection; Type C Phospholipases

1997
Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist.
    The European journal of neuroscience, 1997, Volume: 9, Issue:7

    Topics: Animals; Benzoates; Caudate Nucleus; Corpus Striatum; Cyclic AMP; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate

1997
Metabotropic glutamate receptor-mediated suppression of an inward rectifier current is linked via a cGMP cascade.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Dec-01, Volume: 17, Issue:23

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Aminobutyrates; Animals; Atrial Natriuretic Factor; Benzoates; Cyclic GMP; Enzyme Inhibitors; Glutamic Acid; Glycine; Ictaluridae; Ion Channel Gating; Isoquinolines; Models, Neurological; Patch-Clamp Techniques; Photoreceptor Cells; Potassium Channels; Receptors, Metabotropic Glutamate; Second Messenger Systems; Thionucleotides

1997
Intracellular Ca2+ release mediated by metabotropic glutamate receptor activation in the leech giant glial cell.
    The Journal of experimental biology, 1997, Volume: 200, Issue:Pt 19

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Calcium; Calcium-Transporting ATPases; Central Nervous System; Enzyme Inhibitors; Glutamic Acid; Glycine; Indoles; Intracellular Fluid; Ion Transport; Leeches; Ligands; Membrane Potentials; Neuroglia; Quisqualic Acid; Receptors, Metabotropic Glutamate

1997
Effects of the metabotropic glutamate receptor antagonist MCPG on phosphoinositide turnover and synaptic plasticity in visual cortex.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Jan-01, Volume: 18, Issue:1

    Topics: Action Potentials; Age Factors; Animals; Benzoates; Binding, Competitive; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Long-Term Potentiation; Neuronal Plasticity; Neuroprotective Agents; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Metabotropic Glutamate; Synapses; Visual Cortex

1998
Evidence for neuronal origin and metabotropic receptor-mediated regulation of extracellular glutamate and aspartate in rat striatum in vivo following electrical stimulation of the prefrontal cortex.
    Journal of neurochemistry, 1998, Volume: 70, Issue:2

    Topics: Animals; Aspartic Acid; Benzoates; Calcium; Corpus Striatum; Cycloleucine; Dicarboxylic Acids; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Glycine; Male; Neurons; Neurotransmitter Uptake Inhibitors; Prefrontal Cortex; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tetrodotoxin; Time Factors

1998
In vivo microdialysis reveals facilitatory metabotropic glutamate receptors regulating excitatory amino acid release in rat nucleus tractus solitarius.
    Neurochemistry international, 1998, Volume: 32, Issue:1

    Topics: Animals; Aspartic Acid; Benzoates; Calcium; Chromatography, High Pressure Liquid; Cycloleucine; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Glycine; Kinetics; Male; Microdialysis; Neurotoxins; Rats; Rats, Inbred WKY; Receptors, Metabotropic Glutamate; Solitary Nucleus; Tetrodotoxin

1998
Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures.
    The European journal of neuroscience, 1998, Volume: 10, Issue:9

    Topics: Animals; Astrocytes; Benzoates; Cell Death; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Indans; Mice; N-Methylaspartate; Neurons; Neurotransmitter Agents; Protein Binding; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate

1998
Glutamate in the nucleus of the solitary tract activates both ionotropic and metabotropic glutamate receptors.
    The American journal of physiology, 1998, Volume: 275, Issue:6

    Topics: Animals; Benzoates; Blood Pressure; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Heart Rate; Kynurenic Acid; Lumbosacral Region; Male; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Solitary Nucleus; Sympathetic Nervous System

1998
Group I metabotropic glutamate receptors mediate phospholipase D stimulation in rat cultured astrocytes.
    Journal of neurochemistry, 1999, Volume: 72, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Astrocytes; Benzoates; Carcinogens; Cerebellum; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Enzyme Activation; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Neurons; Neuroprotective Agents; Norepinephrine; Phospholipase D; Phosphorus Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sympathomimetics; Tetradecanoylphorbol Acetate; Type C Phospholipases

1999
Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia.
    Journal of neurochemistry, 1999, Volume: 72, Issue:4

    Topics: Animals; Astrocytes; Benzoates; Brain; Brain Chemistry; Calcium; Cells, Cultured; Cycloleucine; DNA Primers; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gene Expression; Glutamic Acid; Glycine; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Microglia; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction

1999
Glutamate regulates IP3-type and CICR stores in the avian cochlear nucleus.
    Journal of neurophysiology, 1999, Volume: 81, Issue:4

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alanine; Animals; Benzoates; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Chelating Agents; Chick Embryo; Cochlear Nucleus; Cyclic AMP; Cycloleucine; Cysteine; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Gallic Acid; Glutamic Acid; Glycine; Ibotenic Acid; Inositol 1,4,5-Trisphosphate Receptors; Ion Channel Gating; Neurons; Neuroprotective Agents; Neurotransmitter Agents; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Receptors, Cytoplasmic and Nuclear; Ryanodine; Second Messenger Systems; Thionucleotides

1999
Regulation of NMDA-stimulated [14C]GABA and [3H]acetylcholine release by striatal glutamate and dopamine receptors.
    Brain research, 1999, Oct-09, Volume: 844, Issue:1-2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Carbon Radioisotopes; Corpus Striatum; Cycloleucine; Dopamine Agonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; N-Methylaspartate; Proline; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tritium

1999
Potentiation of glutamatergic agonist-induced inositol phosphate formation by basic fibroblast growth factor is related to developmental features in hippocampal cultures: neuronal survival and glial cell proliferation.
    The European journal of neuroscience, 1999, Volume: 11, Issue:10

    Topics: Animals; Antimetabolites, Antineoplastic; Benzoates; Cell Division; Cell Survival; Cells, Cultured; Cellular Senescence; Cycloleucine; Cytarabine; Epidermal Growth Factor; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Fibroblast Growth Factor 2; Glutamic Acid; Glycine; Hippocampus; Inositol Phosphates; Neuroglia; Neurons; Neuroprotective Agents; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Type C Phospholipases

1999
(+/-)-Alpha-methyl-4-carboxyphenylglycine, a metabotropic glutamate receptor blocker, impairs retention of an inhibitory avoidance task in rats when infused into the basolateral nucleus of the amygdala.
    Brain research, 2000, Jan-10, Volume: 852, Issue:2

    Topics: Amygdala; Animals; Avoidance Learning; Benzoates; Electroshock; Emotions; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Microinjections; Neural Inhibition; Nociceptors; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Retention, Psychology

2000
Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro.
    Neuropharmacology, 2000, Jul-10, Volume: 39, Issue:9

    Topics: Animals; Aspartic Acid; Autoreceptors; Benzoates; Calcium; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; In Vitro Techniques; Indans; Male; Neurons; Phenylacetates; Prosencephalon; Quisqualic Acid; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Tetrodotoxin; Tritium

2000
Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists.
    Journal of neuroendocrinology, 2001, Volume: 13, Issue:8

    Topics: Adrenalectomy; Adrenocorticotropic Hormone; Amino Acids; Animals; Benzoates; Bridged Bicyclo Compounds; Corticosterone; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Neuroprotective Agents; Paraventricular Hypothalamic Nucleus; Phenylacetates; Propionates; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Xanthenes

2001
Neuronal glutamate transporters control activation of postsynaptic metabotropic glutamate receptors and influence cerebellar long-term depression.
    Neuron, 2001, Aug-30, Volume: 31, Issue:4

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Benzoates; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Glycine; Long-Term Potentiation; Nerve Fibers; Neural Inhibition; Organ Culture Techniques; Picrotoxin; Purkinje Cells; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Synapses; Tetrodotoxin

2001
Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.
    Neuroscience, 2001, Volume: 106, Issue:3

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Action Potentials; Animals; Anticonvulsants; Benzoates; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Mice; Mice, Knockout; Muscarine; Muscarinic Agonists; N-Methylaspartate; Neostriatum; Neurons; Phenylacetates; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Synaptic Transmission

2001
Visualization of IP(3) dynamics reveals a novel AMPA receptor-triggered IP(3) production pathway mediated by voltage-dependent Ca(2+) influx in Purkinje cells.
    Neuron, 2001, Oct-11, Volume: 32, Issue:1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Blood Proteins; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Cycloleucine; Cytoplasm; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Genetic Vectors; Glutamic Acid; Glycine; Green Fluorescent Proteins; Indicators and Reagents; Inositol 1,4,5-Trisphosphate; Luminescent Proteins; Membrane Potentials; Mice; Mice, Inbred ICR; Neuroprotective Agents; Patch-Clamp Techniques; Phosphoproteins; Purkinje Cells; Receptors, AMPA; Receptors, Metabotropic Glutamate; Sindbis Virus

2001
Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Mar-05, Volume: 99, Issue:5

    Topics: Benzoates; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Antagonists; Gadolinium; Glutamic Acid; Glycine; Ligands; Models, Molecular; Molecular Structure; Protein Structure, Tertiary; Receptors, Glutamate

2002
Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Animals; Benzoates; Capsaicin; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Isoquinolines; Male; Nociceptors; Pyridines; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Stimulation, Chemical; Substance P

2003
In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands.
    Journal of neurochemistry, 2004, Volume: 88, Issue:5

    Topics: Amino Acids; Animals; Anticonvulsants; Benzoates; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Ligands; Limbic System; Male; Microdialysis; Pilocarpine; Pyridines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures

2004
Desensitization and internalization of metabotropic glutamate receptor 1a following activation of heterologous Gq/11-coupled receptors.
    Biochemistry, 2004, Jun-15, Volume: 43, Issue:23

    Topics: Arrestins; Benzoates; beta-Adrenergic Receptor Kinases; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Line; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Endocytosis; Glutamic Acid; Glycine; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Phosphoproteins; Protein Binding; Protein Kinase C; Receptors, G-Protein-Coupled; Receptors, Metabotropic Glutamate

2004
Glutamatergic neurotransmission modulates hypoxia-induced hyperventilation but not anapyrexia.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2004, Volume: 37, Issue:10

    Topics: Animals; Benzoates; Body Temperature; Body Temperature Regulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hyperventilation; Hypoxia; Injections, Intraventricular; Kynurenic Acid; Male; Rats; Rats, Wistar

2004
Olfactory nerve-evoked, metabotropic glutamate receptor-mediated synaptic responses in rat olfactory bulb mitral cells.
    Journal of neurophysiology, 2006, Volume: 95, Issue:4

    Topics: Amino Acids; Animals; Aspartic Acid; Benzoates; Dopamine D2 Receptor Antagonists; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA-B Receptor Antagonists; Glutamic Acid; Glycine; In Vitro Techniques; Male; Neuronal Plasticity; Neurons, Afferent; Odorants; Olfactory Bulb; Olfactory Nerve; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, GABA-B; Receptors, Metabotropic Glutamate; Synapses; Tacrine; Xanthenes

2006
Group I mGlu receptor stimulation inhibits activation-induced cell death of human T lymphocytes.
    British journal of pharmacology, 2006, Volume: 148, Issue:6

    Topics: Apoptosis; Benzoates; Cells, Cultured; Fas Ligand Protein; Glutamic Acid; Glycine; Humans; Lymphocyte Activation; Receptors, Metabotropic Glutamate; RNA, Messenger; T-Lymphocytes

2006
Subtype selective antagonism of substantia nigra pars compacta Group I metabotropic glutamate receptors protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo.
    Journal of neurochemistry, 2007, Volume: 103, Issue:3

    Topics: Animals; Benzoates; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Molecular Structure; Nerve Degeneration; Neural Pathways; Neuroprotective Agents; Neurotoxins; Oxidopamine; Parkinsonian Disorders; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Substantia Nigra; Treatment Outcome; Tyrosine 3-Monooxygenase

2007
Developmental decrease in short-term facilitation at Schaffer collateral synapses in hippocampus is mGluR1 sensitive.
    Journal of neurophysiology, 2008, Volume: 99, Issue:2

    Topics: Action Potentials; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Benzoates; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Phosphinic Acids; Piperidines; Propanolamines; Pyrazoles; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Synapses; Temperature

2008
Activation of group I metabotropic glutamate receptors induces long-term depression in the hippocampal CA1 region of adult rats in vitro.
    Neuroscience research, 2008, Volume: 62, Issue:1

    Topics: Age Factors; Aging; Animals; Axons; Benzoates; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Long-Term Synaptic Depression; Neural Inhibition; Neural Pathways; Neurons; Organ Culture Techniques; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Synaptic Membranes; Synaptic Transmission

2008
Impact of protein kinase C activation on epileptiform activity in the hippocampal slice.
    Epilepsy research, 2008, Volume: 82, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; Animals; Atropine; Benzoates; Benzophenanthridines; Enzyme Activation; Epilepsy; Glutamic Acid; Glycine; Guinea Pigs; Hippocampus; In Vitro Techniques; Neurotransmitter Agents; Phorbol 12,13-Dibutyrate; Picrotoxin; Protein Kinase C; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Signal Transduction

2008
Ambient Glutamate Promotes Paroxysmal Hyperactivity in Cortical Pyramidal Neurons at Amyloid Plaques via Presynaptic mGluR1 Receptors.
    Cerebral cortex (New York, N.Y. : 1991), 2017, 10-01, Volume: 27, Issue:10

    Topics: Animals; Benzoates; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Mice, Inbred C57BL; Neurons; Plaque, Amyloid; Pyramidal Cells; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Synaptic Transmission

2017