alpha-ketoisovalerate has been researched along with 2-oxo-3-methylvalerate in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (50.00) | 18.7374 |
| 1990's | 7 (13.46) | 18.2507 |
| 2000's | 17 (32.69) | 29.6817 |
| 2010's | 2 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grieben, K; Kramer, P; Langenbeck, U; Matthaei, D; Mench-Hoinowski, A; Schauder, P; Scheler, F | 1 |
| Cox, RP; Dancis, J; Sullivan, SG | 1 |
| Beck, K; Schadewaldt, P; Wendel, U | 1 |
| Kind, KL; Owens, JA; Robinson, JS; Smeaton, TC | 1 |
| Baker, DH; Funk, MA; Lowry, KR | 1 |
| Herbertz, L; Langer, K; Schauder, P | 1 |
| Herbertz, L; Langer, K; Schauder, P; Zavelberg, D | 1 |
| Brown, OR; Smyk-Randall, EM | 1 |
| Kolsaker, P; Nesbakken, T; Ormerod, J | 1 |
| Goodwin, GW; Han, AC; Harris, RA; Paxton, R | 1 |
| Alexander, V; Swain, LM; Walser, M | 1 |
| Demigné, C; Fafournoux, P; Rémésy, C | 1 |
| Bode, JC | 1 |
| Schauder, P | 1 |
| Henning, HV; Langenbeck, U; Matthaei, D; Schauder, P; Schröder, K | 1 |
| Chantler, C; Dalton, RN | 2 |
| Block, KP; Harper, AE; Miller, RH | 1 |
| Harper, AE; Miller, RH | 1 |
| Hashizume, I; Hayashi, T; Takagi, N; Tatsumi, M; Tokunaga, T; Tsuchiya, H | 1 |
| Sano, K; Shin, M; Umezawa, C; Yamada, O | 1 |
| Henning, HV; Langenbeck, U; Matthaei, D; Schauder, P; Scheler, F | 1 |
| Baker, DH; Boebel, KP | 1 |
| Harper, AE; Hutson, SM | 1 |
| Bier, DM; Karl, IE; Schwarz, HP | 1 |
| Cordewener, JH; van Hinsbergh, VW; Veerkamp, JH | 1 |
| Ckless, K; Schlottfeldt, JL; Wajner, M; Wannmacher, CM | 1 |
| Encke, J; Fuchs, M; Gerlach, J; Neuhaus, P; Nündel, M; Riedel, E; Smith, M; Unger, J | 1 |
| Dawes, IW; Dickinson, JR; Sinclair, DA | 1 |
| Hoffer, LJ; Mamer, OA; Reimer, ML; Robitaille, L; Taveroff, A | 1 |
| Matsuo, Y; Walser, M; Yagi, M | 1 |
| Adelmeyer, F; Schadewaldt, P | 1 |
| Hammen, HW; Ott, AC; Schadewaldt, P; Wendel, U | 1 |
| Claiborne, A; Snoep, JL; van Der Merwe, MJ; van Der Weijden, CC; Ward, DE; Westerhoff, HV | 1 |
| Farage, M; Reis, M; Wolosker, H | 1 |
| Dutra-Filho, CS; Santos, CE; Souza, DO; Tasca, CI; Tavares, RG; Wajner, M | 1 |
| Coitinho, AS; de Bastiani, J; de Mello, CF; Fighera, MR; Lima, TT; Wajner, M | 1 |
| de Freitas Miranda, R; de Lima Pelaez, P; Funchal, C; Oliveira Loureiro, S; Pessoa-Pureur, R; Vivian, L; Wajner, M | 1 |
| Blanchard, JS; Sugantino, M; Yu, M; Zheng, R | 1 |
| Dutra-Filho, CS; Ribeiro, CA; Rosa, RB; Schuck, PF; Sgaravatti, AM; Wajner, M; Wannmacher, CM; Wyse, AT | 1 |
| Dall Bello Pessutto, F; de Almeida, LM; de Lima Pelaez, P; Funchal, C; Loureiro, SO; Pessoa-Pureur, R; Vivian, L; Wajner, M | 1 |
| Brinco, F; de Boer, MA; de Castro Vasques, V; Diligenti, F; Mallmann, F; Mello, CF; Wajner, M | 1 |
| Beck, HC; Hansen, AM; Lauritsen, FR | 1 |
| Erikson, O; Hertzberg, M; Näsholm, T | 1 |
| De Almeida, LM; Funchal, C; Gottfried, C; Pessoa-Pureur, R; Wajner, M | 1 |
| Braun, CA; Bridi, R; Dutra-Filho, CS; Lissi, EG; Wajner, M; Wannmacher, CM; Zorzi, GK | 1 |
| Dos Santos, AQ; Funchal, C; Gottfried, C; Jacques-Silva, MC; Pessoa-Pureur, R; Wajner, M; Zamoner, A | 1 |
| Eggeling, L; Kennerknecht, N; Marienhagen, J; Sahm, H | 1 |
| Funchal, C; Gottfried, C; Jacques-Silva, MC; Pessoa-Pureur, R; Santos, AQ; Schuck, PF; Wajner, M | 1 |
| Bürger, C; de Souza Wyse, AT; Dutra-Filho, CS; Wajner, A; Wajner, M; Wannmacher, CM | 1 |
| Boulangé, CL; Chou, CJ; Claus, SP; Collino, S; Dumas, ME; Holmes, E; Kochhar, S; Martin, FP; Montoliu, I; Nicholson, JK; Rezzi, S | 1 |
| Shibata, K | 1 |
1 review(s) available for alpha-ketoisovalerate and 2-oxo-3-methylvalerate
| Article | Year |
|---|---|
Branched-chain amino acid metabolism.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Amino Acids, Branched-Chain; Animals; Chemical Phenomena; Chemistry, Physical; Cytosol; Dietary Proteins; Enzyme Activation; Hemiterpenes; Hormones; Humans; Isoenzymes; Isoleucine; Keto Acids; Ketone Oxidoreductases; Kinetics; Leucine; Liver; Mitochondria; Multienzyme Complexes; Nitrogen; Oxidation-Reduction; Substrate Specificity; Tissue Distribution; Transaminases; Valine | 1984 |
1 trial(s) available for alpha-ketoisovalerate and 2-oxo-3-methylvalerate
| Article | Year |
|---|---|
Metabolism of orally administered branched-chain alpha-keto acids.
Topics: Administration, Oral; Adult; Amino Acids, Branched-Chain; Amino Acids, Essential; Blood Glucose; Calcium; Cysteine; Female; Hemiterpenes; Humans; Insulin; Keto Acids; Male; Random Allocation; Time Factors; Tyrosine | 1983 |
50 other study(ies) available for alpha-ketoisovalerate and 2-oxo-3-methylvalerate
| Article | Year |
|---|---|
Plasma keto-analogues in uraemic patients.
Topics: Amino Acids; Creatinine; Hemiterpenes; Humans; Keto Acids; Kidney Failure, Chronic; Renal Dialysis; Urea; Uremia | 1979 |
Transient and long-term differential modulations of branched-chain alpha-keto acid decarboxylase activity in hypophysectomized rats.
Topics: Animals; Caproates; Carboxy-Lyases; Hemiterpenes; Hypophysectomy; Keto Acids; Ketoglutaric Acids; Mitochondria, Liver; Pentanoic Acids; Rats | 1978 |
Analysis of maple syrup urine disease in cell culture: use of substrates.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Cells, Cultured; Fibroblasts; Hemiterpenes; Humans; Isoleucine; Keto Acids; Ketone Oxidoreductases; Leucine; Maple Syrup Urine Disease; Multienzyme Complexes; Substrate Specificity; Valine | 1989 |
The placenta releases branched-chain keto acids into the umbilical and uterine circulations in the pregnant sheep.
Topics: Animals; Blood Circulation; Female; Fetal Blood; Fetus; Hemiterpenes; Keto Acids; Maternal-Fetal Exchange; Placenta; Pregnancy; Sheep; Uterus | 1989 |
Utilization of the L- and DL-isomers of alpha-keto-beta-methylvaleric acid by rats and comparative efficacy of the keto analogs of branched-chain amino acids provided as ornithine, lysine and histidine salts.
Topics: Amino Acids, Branched-Chain; Animals; Body Weight; Eating; Hemiterpenes; Histidine; Isoleucine; Keto Acids; Leucine; Lysine; Male; Ornithine; Rats; Rats, Inbred Strains; Salts; Stereoisomerism; Valine | 1987 |
[Plasma level of branched-chain amino and keto acids in healthy subjects after an intravenous dose of MCT/LCT or LCT].
Topics: Adult; Amino Acids, Branched-Chain; Caproates; Fasting; Fat Emulsions, Intravenous; Female; Hemiterpenes; Humans; Infusions, Intravenous; Insulin; Isoleucine; Keto Acids; Leucine; Male; Middle Aged; Random Allocation; Triglycerides; Valerates; Valine | 1988 |
Sex-specific differences in plasma branched-chain keto acid levels in obesity.
Topics: Blood Glucose; Body Composition; Female; Hemiterpenes; Humans; Insulin; Insulin Resistance; Isoleucine; Keto Acids; Leucine; Male; Middle Aged; Obesity; Sex Characteristics; Valine | 1987 |
A reverse-phase high-performance liquid chromatography assay for dihydroxy-acid dehydratase.
Topics: Chromatography, High Pressure Liquid; Escherichia coli; Hemiterpenes; Hydrazones; Hydro-Lyases; Keto Acids | 1987 |
Mechanism of biosynthesis of 2-oxo-3-methylvalerate in Chlorobium vibrioforme.
Topics: Acetyl Coenzyme A; Bacteria; Chemical Phenomena; Chemistry; Hemiterpenes; Keto Acids; Magnetic Resonance Spectroscopy | 1988 |
Activation of branched-chain alpha-ketoacid dehydrogenase in isolated hepatocytes by branched-chain alpha-ketoacids.
Topics: 3-Hydroxybutyric Acid; 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Animals; Caproates; Enzyme Activation; Hemiterpenes; Hydrocarbons, Chlorinated; Hydroxybutyrates; Keto Acids; Ketone Oxidoreductases; Liver; Multienzyme Complexes; Rats; Sodium Fluoride | 1987 |
Measurement of branched-chain ketoacids in plasma by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Hemiterpenes; Humans; Keto Acids; Male; Rats; Rats, Inbred Strains; Reference Values | 1987 |
Respective contribution of plasma branched-chain amino acids and 2-keto acids to the hepatic metabolism of the carbon moiety of branched-chain amino acids in fed rats.
Topics: Amino Acids, Branched-Chain; Animals; Caseins; Dietary Proteins; Hemiterpenes; Hepatic Veins; Keto Acids; Liver; Male; Portal Vein; Rats; Rats, Inbred Strains | 1986 |
[Branched-chain amino acids and their ketoanalogs: therapeutic uses in patients with chronic liver or kidney failure].
Topics: Administration, Oral; Amino Acids; Amino Acids, Branched-Chain; Amino Acids, Essential; Blood-Brain Barrier; Dietary Proteins; Hemiterpenes; Hepatic Encephalopathy; Humans; Keto Acids; Kidney Failure, Chronic; Liver Cirrhosis; Renal Dialysis | 1985 |
Pharmacokinetic and metabolic interrelationships among branched-chain keto and amino acids in humans.
Topics: Adult; Amino Acids, Branched-Chain; Drug Interactions; Female; Half-Life; Hemiterpenes; Humans; Isoleucine; Keto Acids; Kinetics; Leucine; Male; Reference Values; Time Factors; Valine | 1985 |
Influence of insulin on blood levels of branched chain keto and amino acids in man.
Topics: Adult; Amino Acids, Branched-Chain; Blood Glucose; Female; Hemiterpenes; Hormones; Humans; Insulin; Isoleucine; Keto Acids; Leucine; Male; Valine | 1983 |
Metabolism of valine and 3-methyl-2-oxobutanoate by the isolated perfused rat kidney.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Animals; Hemiterpenes; In Vitro Techniques; Isoleucine; Keto Acids; Ketone Oxidoreductases; Kidney; Leucine; Male; Multienzyme Complexes; Oxidation-Reduction; Perfusion; Rats; Valine | 1984 |
High-performance liquid chromatography of alpha-keto acids in human saliva.
Topics: Adult; Chromatography, High Pressure Liquid; Hemiterpenes; Humans; Keto Acids; Ketoglutaric Acids; Pyruvates; Pyruvic Acid; Saliva | 1983 |
The relationship between branched-chain amino acids and alpha-keto acids in blood in uremia.
Topics: Adolescent; Adult; Amino Acids, Branched-Chain; Female; Glutamates; Hemiterpenes; Humans; Intracellular Fluid; Keto Acids; Male; Pyruvates; Renal Dialysis; Uremia | 1983 |
Effect of dietary excess leucine on the levels of branched chain alpha-keto acids and ketone bodies in blood and the liver of rats.
Topics: Animals; Body Weight; Diet; Hemiterpenes; Keto Acids; Ketone Bodies; Leucine; Liver; Male; NAD; Rats; Rats, Inbred Strains | 1983 |
Blood levels of branched-chain alpha-keto acids in uremia: effect of an oral glucose tolerance test.
Topics: Adult; Blood Glucose; C-Peptide; Female; Glucose Tolerance Test; Hemiterpenes; Humans; Insulin; Keto Acids; Kidney Failure, Chronic; Male; Middle Aged; Uremia | 1981 |
Comparative utilization of the alpha-keto and D- and L-alpha-hydroxy analogs of leucine, isoleucine and valine by chicks and rats.
Topics: Animals; Caproates; Chickens; Hemiterpenes; Isoleucine; Keto Acids; Leucine; Male; Pentanoic Acids; Rats; Species Specificity; Structure-Activity Relationship; Valerates; Valine | 1982 |
Blood and tissue branched-chain amino and alpha-keto acid concentrations: effect of diet, starvation, and disease.
Topics: Amino Acids, Branched-Chain; Animals; Diabetes Mellitus, Experimental; Diet; Hemiterpenes; Humans; Isoleucine; Keto Acids; Leucine; Male; Maple Syrup Urine Disease; Rats; Starvation; Valine | 1981 |
The alpha-keto acids of branched-chain amino acids: simplified derivatization for physiological samples and complete separation as quinoxalinols by packed column gas chromatography.
Topics: Amino Acids, Branched-Chain; Animals; Chromatography, Gas; Hemiterpenes; Keto Acids; Muscles; Pyruvates; Quinoxalines; Rats | 1980 |
Degradation of branched-chain amino acids and 2-oxo acids in human and rat muscle.
Topics: Amino Acids, Branched-Chain; Animals; Carnitine; Hemiterpenes; Humans; Keto Acids; Leucine; Liver; Male; Mitochondria, Muscle; Muscles; Oxidation-Reduction; Rats; Valine | 1980 |
Immunosuppressive effects of organic acids accumulating in patients with maple syrup urine disease.
Topics: Caproates; Cells, Cultured; Hemiterpenes; Humans; Keto Acids; Lymphocyte Activation; Maple Syrup Urine Disease; Mitogens; Pentanoic Acids; Phytohemagglutinins; Valerates | 1995 |
Alpha-keto acid metabolism by hepatocytes cultured in a hybrid liver support bioreactor.
Topics: Animals; Artificial Organs; Cells, Cultured; Cytochrome P-450 Enzyme System; Hemiterpenes; Keto Acids; Ketoglutaric Acids; Liver; Liver Function Tests; Perfusion; Potassium; Protein Biosynthesis; Pyruvates; Pyruvic Acid; Swine | 1994 |
Purification and characterization of the branched chain alpha-ketoacid dehydrogenase complex from Saccharomyces cerevisiae.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Hemiterpenes; Keto Acids; Ketone Oxidoreductases; Kinetics; Molecular Weight; Multienzyme Complexes; Saccharomyces cerevisiae; Spectrophotometry, Ultraviolet; Substrate Specificity | 1993 |
Alpha-keto and alpha-hydroxy branched-chain acid interrelationships in normal humans.
Topics: Adult; Amino Acids, Branched-Chain; Dietary Proteins; Evaluation Studies as Topic; Fasting; Female; Hemiterpenes; Humans; Isoleucine; Keto Acids; Leucine; Male; Mass Spectrometry; Oxidation-Reduction; Protein Binding; Time Factors; Valerates; Valine | 1993 |
Arteriovenous differences and tissue concentrations of branched-chain ketoacids.
Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Dogs; Hemiterpenes; Keto Acids; Kidney; Liver; Male; Muscles; Myocardium; Rats; Rats, Sprague-Dawley | 1993 |
Coupled enzymatic assay for estimation of branched-chain L-amino acid aminotransferase activity with 2-Oxo acid substrates.
Topics: Animals; Cattle; Cell-Free System; Cells, Cultured; Endothelium, Vascular; Hemiterpenes; Isoenzymes; Keto Acids; Linear Models; Mitochondria, Heart; Rats; Substrate Specificity; Temperature; Transaminases | 1996 |
Renal clearance of branched-chain L-amino and 2-oxo acids in maple syrup urine disease.
Topics: Adolescent; Adult; Amino Acids, Branched-Chain; Child; Child, Preschool; Hemiterpenes; Humans; Isoleucine; Keto Acids; Leucine; Male; Maple Syrup Urine Disease; Metabolic Clearance Rate; Middle Aged; Valine | 1999 |
Branched-chain alpha-keto acid catabolism via the gene products of the bkd operon in Enterococcus faecalis: a new, secreted metabolite serving as a temporary redox sink.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Adenosine Triphosphate; Aerobiosis; Amino Acid Sequence; Anaerobiosis; Base Sequence; Enterococcus faecalis; Genes, Bacterial; Hemiterpenes; Keto Acids; Ketone Oxidoreductases; Models, Biological; Molecular Sequence Data; Multienzyme Complexes; Multigene Family; Operon; Oxidation-Reduction; Promoter Regions, Genetic; Pyruvates; Response Elements; Transcription, Genetic | 2000 |
Chloride-dependent inhibition of vesicular glutamate uptake by alpha-keto acids accumulated in maple syrup urine disease.
Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Biological Transport; Brain; Cell Membrane; Chlorides; Electrochemistry; Glutamic Acid; Hemiterpenes; Hydrogen-Ion Concentration; In Vitro Techniques; Keto Acids; Maple Syrup Urine Disease; Membrane Potentials; Rats; Synaptic Vesicles | 2000 |
Inhibition of glutamate uptake into synaptic vesicles of rat brain by the metabolites accumulating in maple syrup urine disease.
Topics: Animals; Brain; Glutamic Acid; Hemiterpenes; Isoleucine; Keto Acids; Leucine; Male; Maple Syrup Urine Disease; Neurons; Rats; Rats, Wistar; Synaptic Vesicles; Synaptosomes; Valine | 2000 |
Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats.
Topics: Animals; Corpus Striatum; Excitatory Amino Acid Antagonists; GABA Agonists; Hemiterpenes; Keto Acids; Male; Maple Syrup Urine Disease; Rats; Rats, Wistar; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Seizures | 2001 |
Effect of the branched-chain alpha-ketoacids accumulating in maple syrup urine disease on the high molecular weight neurofilament subunit (NF-H) in rat cerebral cortex.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Cytoskeleton; Dose-Response Relationship, Drug; Hemiterpenes; Immunohistochemistry; Keto Acids; Maple Syrup Urine Disease; Nerve Degeneration; Neurofilament Proteins; Neurons; Rats; Rats, Wistar; Subcellular Fractions | 2002 |
Mycobacterium tuberculosis ketopantoate hydroxymethyltransferase: tetrahydrofolate-independent hydroxymethyltransferase and enolization reactions with alpha-keto acids.
Topics: Amino Acids; Bacterial Proteins; Catalysis; Deuterium; Enzyme Activation; Hemiterpenes; Hydrogen-Ion Concentration; Hydroxymethyl and Formyl Transferases; Keto Acids; Metals; Molecular Conformation; Mycobacterium tuberculosis; Nuclear Magnetic Resonance, Biomolecular; Pantothenic Acid; Protons; Pyruvic Acid; Recombinant Proteins; Spectrophotometry; Substrate Specificity; Tetrahydrofolates | 2003 |
Inhibition of brain energy metabolism by the alpha-keto acids accumulating in maple syrup urine disease.
Topics: Animals; Biological Transport; Brain; Carbon Dioxide; Disease Models, Animal; Energy Metabolism; Glucose; Hemiterpenes; Humans; Keto Acids; Lactates; Maple Syrup Urine Disease; Rats; Rats, Wistar; Succinate Cytochrome c Oxidoreductase | 2003 |
Alpha-keto-beta-methylvaleric acid increases the in vitro phosphorylation of intermediate filaments in cerebral cortex of young rats through the gabaergic system.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Benzylamines; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; GABA Antagonists; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Hemiterpenes; In Vitro Techniques; Intermediate Filaments; Isoquinolines; Keto Acids; Phosphorus Isotopes; Phosphorylation; Radiochemistry; Rats; Rats, Wistar; Sulfonamides; Vimentin | 2004 |
Intrahippocampal administration of the alpha-keto acids accumulating in maple syrup urine disease provokes learning deficits in rats.
Topics: Animals; Avoidance Learning; Behavior, Animal; Hemiterpenes; Hippocampus; Injections, Intraventricular; Keto Acids; Male; Maple Syrup Urine Disease; Rats; Rats, Wistar; Reaction Time | 2004 |
Catabolism of leucine to branched-chain fatty acids in Staphylococcus xylosus.
Topics: Cell Membrane; Chromatography; Culture Media; Fatty Acids; Flavoring Agents; Food Microbiology; Glucose; Hemiterpenes; Isoleucine; Keto Acids; Leucine; Meat Products; Oxidation-Reduction; Pentanoic Acids; Pyruvic Acid; Staphylococcus; Valine | 2004 |
A conditional marker gene allowing both positive and negative selection in plants.
Topics: Alanine; Arabidopsis; Catalysis; D-Amino-Acid Oxidase; DNA; Dose-Response Relationship, Drug; Genetic Markers; Genetic Techniques; Genetic Vectors; Hemiterpenes; Isoleucine; Keto Acids; Oxygen; Plants; Plants, Genetically Modified; RNA; Serine; Transgenes; Valine | 2004 |
Evidence that the branched-chain alpha-keto acids accumulating in maple syrup urine disease induce morphological alterations and death in cultured astrocytes from rat cerebral cortex.
Topics: Actins; Animals; Animals, Newborn; Astrocytes; Brain; Cell Death; Cell Shape; Cells, Cultured; Cerebral Cortex; Creatine; Creatine Kinase; Cytoskeleton; Dose-Response Relationship, Drug; Energy Metabolism; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hemiterpenes; Keto Acids; Lysophospholipids; Maple Syrup Urine Disease; Rats; Rats, Wistar; rhoA GTP-Binding Protein | 2004 |
alpha-keto acids accumulating in maple syrup urine disease stimulate lipid peroxidation and reduce antioxidant defences in cerebral cortex from young rats.
Topics: Animals; Antioxidants; Catalase; Cerebral Cortex; Disease Models, Animal; Free Radicals; Glutathione Peroxidase; Hemiterpenes; Keto Acids; Lipid Peroxidation; Male; Maple Syrup Urine Disease; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2005 |
Branched-chain alpha-keto acids accumulating in maple syrup urine disease induce reorganization of phosphorylated GFAP in C6-glioma cells.
Topics: Animals; Cell Line, Tumor; Cytoskeleton; Glial Fibrillary Acidic Protein; Glioma; Hemiterpenes; Keto Acids; Maple Syrup Urine Disease; Phosphorylation; Rats | 2005 |
Functional analysis of all aminotransferase proteins inferred from the genome sequence of Corynebacterium glutamicum.
Topics: Alanine; Aspartic Acid; Bacterial Proteins; Butyrates; Carbon-Sulfur Lyases; Corynebacterium glutamicum; Gene Deletion; Glutamic Acid; Hemiterpenes; Keto Acids; Phenylpyruvic Acids; Pyruvic Acid; Substrate Specificity; Transaminases | 2005 |
Creatine and antioxidant treatment prevent the inhibition of creatine kinase activity and the morphological alterations of C6 glioma cells induced by the branched-chain alpha-keto acids accumulating in maple syrup urine disease.
Topics: Animals; Antioxidants; Cell Line, Tumor; Cell Shape; Creatine; Creatine Kinase; Glioma; Hemiterpenes; Humans; Keto Acids; Maple Syrup Urine Disease; Rats | 2006 |
Synaptic plasma membrane Na(+), K (+)-ATPase activity is significantly reduced by the alpha-keto acids accumulating in maple syrup urine disease in rat cerebral cortex.
Topics: Alanine; Animals; Cell Membrane; Cerebral Cortex; Enzyme Activation; Hemiterpenes; Keto Acids; Maple Syrup Urine Disease; Phenylalanine; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Synapses | 2007 |
Early metabolic adaptation in C57BL/6 mice resistant to high fat diet induced weight gain involves an activation of mitochondrial oxidative pathways.
Topics: Adaptation, Physiological; Animals; Diet, High-Fat; Female; Hemiterpenes; Keto Acids; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mitochondria; NAD; Obesity; Oxidation-Reduction; Succinic Acid; Urine; Weight Gain | 2013 |
Urinary Excretion of 2-Oxo Acids Is Greater in Rats with Streptozotocin-Induced Diabetes.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Energy Intake; Energy Metabolism; Hemiterpenes; Isoleucine; Keto Acids; Male; Rats, Wistar; Renal Elimination; Streptozocin; Valine; Weight Gain | 2018 |