Page last updated: 2024-09-02

alpha-hydroxymetoprolol and metoprolol

alpha-hydroxymetoprolol has been researched along with metoprolol in 59 studies

Compound Research Comparison

Studies
(alpha-hydroxymetoprolol)
Trials
(alpha-hydroxymetoprolol)
Recent Studies (post-2010)
(alpha-hydroxymetoprolol)
Studies
(metoprolol)
Trials
(metoprolol)
Recent Studies (post-2010) (metoprolol)
596125,8211,7431,304

Protein Interaction Comparison

ProteinTaxonomyalpha-hydroxymetoprolol (IC50)metoprolol (IC50)
Beta-2 adrenergic receptorHomo sapiens (human)2.573
Beta-1 adrenergic receptorHomo sapiens (human)0.176
Cytochrome P450 2C9 Homo sapiens (human)4.87
Cytochrome P450 2J2Homo sapiens (human)4.87

Research

Studies (59)

TimeframeStudies, this research(%)All Research%
pre-199026 (44.07)18.7374
1990's9 (15.25)18.2507
2000's12 (20.34)29.6817
2010's8 (13.56)24.3611
2020's4 (6.78)2.80

Authors

AuthorsStudies
Chiba, K; Ishizaki, T; Jang, IJ; Kusaka, M; Shin, SG; Sohn, DR1
Noguchi, H; Shimizu, H; Uno, K1
Balmér, K; Lagerström, PO; Persson, A; Persson, BA; Schill, G1
John, VA; Lloyd, P; Signy, M; Smith, SE1
Fujita, K; Horai, Y; Ishizaki, T1
Avenant, J; Moncrieff, J; Sommers, DK1
Moncrieff, J; Simpson, D1
Garrick, C; Rutledge, DR1
Chak, W; Chan, MK; Ho, PW; Lin, HJ; Pun, KK; Yeung, CK; Yeung, RT1
Gyllenhaal, O; Hoffmann, KJ; Vessman, J1
Holm, B; Lindeberg, S; Lundborg, P; Regårdh, CG; Sandström, B1
Hashimoto, K; Horai, Y; Ishizaki, T; Kusaka, M; Tsujimoto, G1
Gengo, FM; Lalka, D; Modi, MW; Schuster, D1
Ervik, M; Johansson, L; Kylberg-Hanssen, K1
Carey, C; Ermer, JC; Gengo, FM; Kalonaros, GC; McHugh, WB1
Bernier, JJ; Duval, M; Evard, D; Godbillon, J; Hirtz, J; Schoeller, JP; Vidon, N1
Bernier, JJ; Bovet, M; Duval, M; Evard, D; Godbillon, J; Hirtz, J; Schoeller, JP; Vidon, N1
Abadie, F; Lecaillon, JB; Massias, P; Schoeller, JP1
Högstedt, S; Lindberg, B; Peng, DR; Rane, A; Regårdh, CG1
Gyllenhaal, O; König, WA; Vessman, J1
Gengo, FM; McHugh, WB; Ulatowski, JA1
Gengo, FM; Kinkel, WR; McHugh, WB; Ziemniak, MA1
Duval, M; Godbillon, J1
Landahl, S; Larsson, M; Lundborg, P; Regårdh, CG1
Jack, DB; Quarterman, CP; Wilkins, M1
Abadie, F; Godbillon, J; Gosset, G; Lecaillon, JB1
Hoffmann, KJ; Lagerström, PO; Landahl, S; Larsson, M; Lundborg, P; Regårdh, CG; Steen, B1
Lennard, MS; Silas, JH1
Jusko, WJ; Pautler, DB1
Jack, DB; Kendall, MJ; Quarterman, CP1
Tu, ZG; Zhao, LL1
Xie, HG; Zhou, HH1
Ackland, MJ; Ellis, SW; Lennard, MS; Rekka, E; Rowland, K; Simula, AP; Tucker, GT; Wolf, CR1
Abdon, NJ; Everts, B; Hedner, T; Herlitz, J; Karlson, BW1
Eddington, NE; Leslie, J; Mistry, B1
Arseneault, M; Hamelin, BA; Labbé, L; Pilote, S; Robitaille, NM; Sirois, C; Turgeon, J1
Eddington, ND; Leslie, JL; Mistry, B2
Eddington, ND; Sirisuth, N1
Bergmann, K; Eschenhagen, T; Feifel, N; Heide, R; Rau, T; Werner, U; Wuttke, H1
Bertucci, C; Bonato, PS; Cerqueira, PM; Cesarino, EJ; Lanchote, VL1
Boralli, VB; Cerqueira, PM; Coelho, EB; Lanchote, VL1
Delabar, U; Eichelbaum, M; Fux, R; Gleiter, CH; Kivistö, KT; Lorenz, G; Mörike, K; Pröhmer, AM; Schaeffeler, E; Schwab, M1
Ismail, R; Teh, LK1
Babak, S; Bergman, U; Bertilsson, L; Boldueva, S; Burbello, A; Goryachkina, K1
Bang, S; Chung, HJ; Chung, MW; Jin, SK; Kang, JH; Kim, JI; Lee, HJ; Lee, SH; Roh, J; Woo, SW1
Baranowska, I; Wilczek, A1
Barclay, VK; Johansson, IM; Pettersson, CE; Tyrefors, NL1
Antunes, Nde J; Cavalli, RC; Lanchote, VL; Marques, MP1
Gu, HW; Li, SS; Liu, YJ; Su, ZY; Wu, HL; Yin, XL; Yu, RQ1
Duricova, J; Grundmann, M; Jurckova, N; Kacirova, I; Perinova, I1
Cesarino, EJ; de Moraes, NV; de Souza, L; Hayashida, M; Lanchote, VL; Neves, DV; Nogueira, MS1
Bae, SH; Bae, SK; Cho, DY; Lee, JK1
Bae, SH; Bae, SK; Cho, DY; Kim, BT; Kim, YW; Lee, JK; Lee, S; Oh, E; Park, JB1
Ma, YR; Qin, HY; Rao, Z; Wang, XD; Wang, YF; Wei, YH; Wu, XA; Zhang, GQ; Zhou, Y1
Bourgogne, E; Delhotal-Landes, B; Gourlain, H; Labat, L; Leclercq, M; Mégarbane, B; Soichot, M1
Claw, KG; Dalton, R; Dunham, MJ; Fade, M; Fowler, DM; Gaedigk, A; Lee, SB; McDonald, MG; Nickerson, DA; Phillips, BR; Prasad, B; Rettie, AE; Schuetz, E; Shen, DD; Thornton, TA; Thummel, KE; Wong, LH; Woodahl, EL1
Zhang, WJ1
de Denus, S; Jutras, M; Leclair, G; Meloche, M; St-Jean, I1

Trials

6 trial(s) available for alpha-hydroxymetoprolol and metoprolol

ArticleYear
The relationship between serum concentrations and central nervous system actions of metoprolol.
    Journal of neurology, neurosurgery, and psychiatry, 1985, Volume: 48, Issue:2

    Topics: Adult; Brain; Double-Blind Method; Flicker Fusion; Humans; Kinetics; Male; Metoprolol; Psychomotor Performance; Random Allocation; Reaction Time

1985
Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: a prospective clinical study.
    Clinical pharmacology and therapeutics, 2005, Volume: 78, Issue:4

    Topics: Adrenergic beta-1 Receptor Antagonists; Cytochrome P-450 CYP2D6; Dose-Response Relationship, Drug; Female; Genotype; Humans; Hypertension; Male; Metoprolol; Middle Aged; Polymorphism, Genetic; Prospective Studies

2005
The relevance of CYP2D6 genetic polymorphism on chronic metoprolol therapy in cardiovascular patients.
    Journal of clinical pharmacy and therapeutics, 2006, Volume: 31, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Antihypertensive Agents; Cardiovascular Diseases; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Kidney Diseases; Male; Metoprolol; Middle Aged; Pharmacogenetics; Polymorphism, Genetic

2006
Inhibition of metoprolol metabolism and potentiation of its effects by paroxetine in routinely treated patients with acute myocardial infarction (AMI).
    European journal of clinical pharmacology, 2008, Volume: 64, Issue:3

    Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Area Under Curve; Bradycardia; Cytochrome P-450 CYP2D6; Depression; Dose-Response Relationship, Drug; Drug Interactions; Female; Genotype; Heart Rate; Humans; Hypotension, Orthostatic; Male; Metoprolol; Middle Aged; Myocardial Infarction; Paroxetine

2008
Influence of CYP2D6*10 on the pharmacokinetics of metoprolol in healthy Korean volunteers.
    Journal of clinical pharmacy and therapeutics, 2008, Volume: 33, Issue:5

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Alleles; Area Under Curve; Asian People; Cytochrome P-450 CYP2D6; Female; Half-Life; Humans; Korea; Male; Metoprolol; Pharmacogenetics; Polymorphism, Genetic; Young Adult

2008
Effect of the potent CYP2D6 inhibitor sarpogrelate on the pharmacokinetics and pharmacodynamics of metoprolol in healthy male Korean volunteers.
    Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:3

    Topics: Administration, Oral; Adult; Area Under Curve; Asian People; Cytochrome P-450 CYP2D6 Inhibitors; Healthy Volunteers; Humans; Male; Metoprolol; Middle Aged; Republic of Korea; Succinates; Young Adult

2015

Other Studies

53 other study(ies) available for alpha-hydroxymetoprolol and metoprolol

ArticleYear
Utility of a one-point (3-hour postdose) plasma metabolic ratio as a phenotyping test using metoprolol in two east Asian populations.
    Therapeutic drug monitoring, 1992, Volume: 14, Issue:3

    Topics: Adolescent; Adult; Asian People; Chromatography, High Pressure Liquid; Debrisoquin; Female; Humans; Japan; Korea; Male; Metoprolol; Middle Aged; Oxidation-Reduction; Phenotype

1992
Variation of pharmacokinetics after oral administration of slow-release metoprolol tablets and pharmacogenetic considerations.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:6

    Topics: Administration, Oral; Adult; Asian People; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Humans; Japan; Male; Metoprolol; Middle Aged; Pharmacogenetics; Phenotype; Tablets; United Kingdom; White People

1992
Liquid chromatographic separation of the enantiomers of metoprolol and its alpha-hydroxy metabolite on Chiralcel OD for determination in plasma and urine.
    Journal of chromatography, 1991, Aug-16, Volume: 553, Issue:1-2

    Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Humans; Metoprolol; Spectrometry, Fluorescence; Stereoisomerism

1991
The effect of impaired renal function on the pharmacokinetics of metoprolol after single administration of a 14/190 metoprolol OROS system.
    American heart journal, 1990, Volume: 120, Issue:2

    Topics: Administration, Oral; Delayed-Action Preparations; Humans; Kidney Diseases; Male; Metoprolol; Osmolar Concentration

1990
Genetically determined N-acetylation and oxidation capacities in Japanese patients with non-occupational urinary bladder cancer.
    European journal of clinical pharmacology, 1989, Volume: 37, Issue:6

    Topics: Acetylation; Adult; Aged; Aged, 80 and over; Chi-Square Distribution; Dapsone; Disease Susceptibility; Female; Humans; Japan; Male; Metoprolol; Middle Aged; Oxidation-Reduction; Phenotype; Urinary Bladder Neoplasms

1989
Metoprolol alpha-hydroxylation polymorphism in the San Bushmen of southern Africa.
    Human toxicology, 1989, Volume: 8, Issue:1

    Topics: Black People; Debrisoquin; Humans; Hydroxylation; Male; Metoprolol; Nigeria; Polymorphism, Genetic; South Africa; White People

1989
Determination of metoprolol and its alpha-hydroxy metabolite in urine by direct-injection reversed-phase high-performance liquid chromatography with fluorimetric detection.
    Journal of chromatography, 1989, Mar-24, Volume: 488, Issue:2

    Topics: Chromatography, High Pressure Liquid; Humans; Metoprolol; Spectrometry, Fluorescence

1989
Determination of metoprolol and its alpha-hydroxide metabolite in serum by reversed-phase high-performance liquid chromatography.
    Journal of chromatographic science, 1989, Volume: 27, Issue:9

    Topics: Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Injections, Intravenous; Metoprolol

1989
Effects of selective and non-selective beta-blockers on the alanine and free fatty acid responses to glucagon challenge in hemodialysis patients.
    Clinical nephrology, 1986, Volume: 26, Issue:5

    Topics: Adrenergic beta-Antagonists; Adult; Alanine; Blood Glucose; Fatty Acids, Nonesterified; Glucagon; Humans; Metoprolol; Middle Aged; Propranolol; Renal Dialysis

1986
Analysis of alpha-hydroxy metabolites of metoprolol in human urine after phosgene/trimethylsilyl derivatization.
    Biomedical & environmental mass spectrometry, 1987, Volume: 14, Issue:10

    Topics: Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Metoprolol; Phosgene; Trimethylsilyl Compounds

1987
The effect of hydralazine on steady-state plasma concentrations of metoprolol in pregnant hypertensive women.
    European journal of clinical pharmacology, 1988, Volume: 35, Issue:2

    Topics: Adult; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hydralazine; Hypertension; Metoprolol; Pregnancy; Pregnancy Complications, Cardiovascular; Time Factors

1988
Simultaneous determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by liquid chromatography with a preliminary observation on metoprolol oxidation in Japanese subjects.
    Therapeutic drug monitoring, 1988, Volume: 10, Issue:4

    Topics: Chromatography, Liquid; Humans; Japan; Metoprolol; Oxidation-Reduction; Phenotype; Reproducibility of Results

1988
Reversed-phase high-performance liquid chromatographic assay to quantitate diastereomeric derivatives of metoprolol enantiomers in plasma.
    Journal of chromatography, 1988, Dec-09, Volume: 433

    Topics: Animals; Chromatography, High Pressure Liquid; Male; Metoprolol; Microsomes, Liver; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Stereoisomerism

1988
Determination of metoprolol in plasma and urine using high-resolution gas chromatography and electron-capture detection.
    Journal of chromatography, 1986, Aug-22, Volume: 381, Issue:1

    Topics: Biotransformation; Chromatography, Gas; Electrochemistry; Humans; Indicators and Reagents; Metoprolol

1986
Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon.
    British journal of clinical pharmacology, 1985, Volume: 19 Suppl 2

    Topics: Adult; Colon; Female; Humans; Intestinal Absorption; Kinetics; Male; Metoprolol; Phenylacetates

1985
Investigation of drug absorption from the gastrointestinal tract of man. IV. Influence of food and digestive secretions on metoprolol jejunal absorption.
    British journal of clinical pharmacology, 1985, Volume: 19 Suppl 2

    Topics: Adult; Bile Acids and Salts; Body Water; Food; Half-Life; Humans; Intestinal Absorption; Intestinal Secretions; Jejunum; Kinetics; Male; Metoprolol; Phenylacetates

1985
Influence of food on the absorption of metoprolol administered as an Oros drug delivery system to man.
    British journal of clinical pharmacology, 1985, Volume: 19 Suppl 2

    Topics: Adult; Biological Availability; Biotransformation; Delayed-Action Preparations; Female; Food; Humans; Intestinal Absorption; Kinetics; Male; Metoprolol; Time Factors

1985
Pregnancy-induced increase in metoprolol metabolism.
    Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:6

    Topics: Adult; Blood Proteins; Female; Humans; Hypertension; Kinetics; Metoprolol; Pregnancy; Pregnancy Complications, Cardiovascular; Protein Binding; Time Factors

1985
Enantiomer separation of metoprolol and its analogues and metabolites by capillary column gas chromatography after derivatization with phosgene.
    Journal of chromatography, 1985, Dec-20, Volume: 350, Issue:1

    Topics: Chemical Phenomena; Chemistry; Chromatography, Gas; Indicators and Reagents; Metoprolol; Phosgene; Stereoisomerism

1985
Metoprolol and alpha-hydroxymetoprolol concentrations and reduction in essential tremor.
    Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:3

    Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Humans; Kinetics; Metoprolol; Middle Aged; Tremor

1984
High-performance liquid chromatographic determination of metoprolol and alpha-hydroxymetoprolol concentrations in human serum, urine, and cerebrospinal fluid.
    Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:7

    Topics: Chromatography, High Pressure Liquid; Drug Stability; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Metoprolol; Temperature

1984
Determination of two metoprolol metabolites in human urine by high-performance liquid chromatography.
    Journal of chromatography, 1984, Jul-13, Volume: 309, Issue:1

    Topics: Chromatography, High Pressure Liquid; Humans; Kinetics; Metoprolol

1984
Pharmacokinetics of metoprolol in healthy, elderly, non-smoking individuals after a single dose and two weeks of treatment.
    European journal of clinical pharmacology, 1984, Volume: 27, Issue:2

    Topics: Administration, Oral; Adult; Age Factors; Aged; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Metoprolol

1984
Lack of evidence for polymorphism in metoprolol metabolism.
    British journal of clinical pharmacology, 1983, Volume: 16, Issue:2

    Topics: Acebutolol; Adult; Biotransformation; Half-Life; Humans; Metoprolol; Polymorphism, Genetic

1983
Determination of metoprolol and its alpha-hydroxylated metabolite in human plasma by high-performance liquid chromatography.
    Journal of chromatography, 1984, Feb-10, Volume: 305, Issue:2

    Topics: Chromatography, High Pressure Liquid; Humans; Metoprolol; Molecular Weight

1984
Pharmacokinetics of metoprolol and its metabolite alpha-OH-metoprolol in healthy, non-smoking, elderly individuals.
    European journal of clinical pharmacology, 1983, Volume: 24, Issue:2

    Topics: Adult; Age Factors; Aged; Female; Humans; Kidney; Kinetics; Male; Metoprolol; Propanolamines

1983
Rapid determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by high-performance liquid chromatography.
    Journal of chromatography, 1983, Jan-14, Volume: 272, Issue:1

    Topics: Chromatography, High Pressure Liquid; Debrisoquin; Humans; Metoprolol; Propanolamines

1983
Determination of metoprolol and alpha-hydroxymetoprolol in plasma by high-performance liquid chromatography.
    Journal of chromatography, 1982, Mar-12, Volume: 228

    Topics: Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Metoprolol; Microchemistry; Propanolamines

1982
The effect of age on the pharmacokinetics of metoprolol and its metabolites.
    British journal of clinical pharmacology, 1981, Volume: 11, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Chemical Phenomena; Chemistry; Female; Humans; Kinetics; Metoprolol; Middle Aged; Propanolamines

1981
Metoprolol alpha-hydroxylation capacity in 96 Chinese Han volunteers.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1995, Volume: 16, Issue:4

    Topics: Asian People; China; Female; Humans; Hydroxylation; Male; Metabolic Clearance Rate; Metoprolol; Microsomes, Liver; Phenotype; Polymorphism, Genetic

1995
Assay of metoprolol and alpha-hydroxymetoprolol in human urine by reversed-phase liquid chromatography with direct-injection.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1995, Volume: 16, Issue:1

    Topics: Chromatography, High Pressure Liquid; Humans; Metoprolol

1995
Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol.
    The Biochemical journal, 1996, Jun-01, Volume: 316 ( Pt 2)

    Topics: Amino Acid Sequence; Binding Sites; Cloning, Molecular; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Humans; Kinetics; Metoprolol; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Conformation; Protein Structure, Secondary; Saccharomyces cerevisiae; Sequence Alignment; Spectrophotometry; Stereoisomerism

1996
Effects and pharmacokinetics of high dose metoprolol on chest pain in patients with suspected or definite acute myocardial infarction.
    European journal of clinical pharmacology, 1997, Volume: 53, Issue:1

    Topics: Aged; Aged, 80 and over; Analgesia; Antihypertensive Agents; Blood Pressure; Catecholamines; Chest Pain; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Pain Measurement; Respiration

1997
A sensitive assay of metoprolol and its major metabolite alpha-hydroxy metoprolol in human plasma and determination of dextromethorphan and its metabolite dextrorphan in urine with high performance liquid chromatography and fluorometric detection.
    Journal of pharmaceutical and biomedical analysis, 1998, Volume: 16, Issue:6

    Topics: Adrenergic beta-Antagonists; Antitussive Agents; Chromatography, High Pressure Liquid; Dextromethorphan; Dextrorphan; Humans; Indicators and Reagents; Metoprolol; Neuroprotective Agents; Quality Control; Reference Standards; Reproducibility of Results; Spectrometry, Fluorescence

1998
Effect of gender, sex hormones, time variables and physiological urinary pH on apparent CYP2D6 activity as assessed by metabolic ratios of marker substrates.
    Pharmacogenetics, 2000, Volume: 10, Issue:5

    Topics: Administration, Oral; Adult; Analysis of Variance; Biomarkers; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Enzyme Activation; Female; Gonadal Steroid Hormones; Humans; Hydrogen-Ion Concentration; Male; Menstrual Cycle; Metoprolol; Sex Characteristics; Sex Factors; Substrate Specificity; Time Factors; Urine

2000
Enantiomeric separation of metoprolol and alpha-hydroxymetoprolol by liquid chromatography and fluorescence detection using a chiral stationary phase.
    Journal of chromatography. B, Biomedical sciences and applications, 2001, Jul-15, Volume: 758, Issue:2

    Topics: Adrenergic beta-Antagonists; Biological Availability; Calibration; Chromatography, High Pressure Liquid; Metoprolol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Stereoisomerism

2001
Influence of input rate on the stereospecific and nonstereospecific first pass metabolism and pharmacokinetics of metoprolol extended release formulations.
    Chirality, 2002, May-05, Volume: 14, Issue:4

    Topics: Delayed-Action Preparations; Female; Humans; Male; Metoprolol; Stereoisomerism

2002
The influence of first pass metabolism on the development and validation of an IVIVC for metoprolol extended release tablets.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2002, Volume: 53, Issue:3

    Topics: Biological Availability; Delayed-Action Preparations; Female; Humans; Male; Metoprolol; Models, Biological; Reproducibility of Results; Solubility; Time Factors

2002
Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment.
    Pharmacogenetics, 2002, Volume: 12, Issue:6

    Topics: Adrenergic beta-Antagonists; Chromatography, High Pressure Liquid; Cohort Studies; Coronary Artery Disease; Cross-Sectional Studies; Cytochrome P-450 CYP2D6; DNA Primers; Drug Administration Schedule; Female; Gene Frequency; Genotype; Humans; Hypertension; Male; Metoprolol; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; White People

2002
Stereoselective metabolism of metoprolol: enantioselectivity of alpha-hydroxymetoprolol in plasma and urine.
    Chirality, 2003, Volume: 15, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Biotransformation; Chromatography, High Pressure Liquid; Circular Dichroism; Humans; Kinetics; Metoprolol; Middle Aged; Spectrophotometry, Ultraviolet; Stereoisomerism

2003
Stereoselective analysis of metoprolol and its metabolites in rat plasma with application to oxidative metabolism.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Sep-05, Volume: 823, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Circular Dichroism; Half-Life; Male; Metoprolol; Rats; Rats, Wistar; Reproducibility of Results; Stereoisomerism

2005
Simultaneous RP-HPLC determination of sotalol, metoprolol, alpha-hydroxymetoprolol, paracetamol and its glucuronide and sulfate metabolites in human urine.
    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2009, Volume: 25, Issue:6

    Topics: Chromatography, High Pressure Liquid; Glucuronides; Humans; Metoprolol; Molecular Structure; Reproducibility of Results; Sensitivity and Specificity; Sotalol; Sulfates

2009
Chiral analysis of metoprolol and two of its metabolites, α-hydroxymetoprolol and deaminated metoprolol, in wastewater using liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. A, 2012, Dec-21, Volume: 1269

    Topics: Adrenergic beta-Antagonists; Chromatography, Liquid; Deamination; Metoprolol; Solid Phase Extraction; Stereoisomerism; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical

2012
Stereoselective determination of metoprolol and its metabolite α-hydroxymetoprolol in plasma by LC-MS/MS: application to pharmacokinetics during pregnancy.
    Chirality, 2013, Volume: 25, Issue:1

    Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Chromatography, High Pressure Liquid; Female; Humans; Metoprolol; Pregnancy; Stereoisomerism; Tandem Mass Spectrometry

2013
Simultaneous determination of metoprolol and α-hydroxymetoprolol in human plasma using excitation-emission matrix fluorescence coupled with second-order calibration methods.
    Bioanalysis, 2012, Volume: 4, Issue:23

    Topics: Adrenergic beta-1 Receptor Antagonists; Algorithms; Blood Chemical Analysis; Calibration; Cardiovascular Diseases; Humans; Kinetics; Metoprolol; Oxidation-Reduction; Spectrometry, Fluorescence

2012
Clinically important interaction between metoprolol and propafenone.
    Canadian family physician Medecin de famille canadien, 2013, Volume: 59, Issue:4

    Topics: Aged; Anti-Arrhythmia Agents; Antihypertensive Agents; Atrial Fibrillation; Cytochrome P-450 CYP2D6; Diuretics; Drug Interactions; Dyspnea; Fatigue; Female; Humans; Hypertension; Medication Reconciliation; Metoprolol; Propafenone

2013
Metoprolol oxidation polymorphism in Brazilian elderly cardiac patients.
    The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:9

    Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Aged, 80 and over; Anthropometry; Black People; Brazil; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Female; Heart Diseases; Humans; Inactivation, Metabolic; Male; Metoprolol; Middle Aged; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Urinalysis; White People

2013
Simultaneous determination of metoprolol and its metabolites, α-hydroxymetoprolol and O-desmethylmetoprolol, in human plasma by liquid chromatography with tandem mass spectrometry: Application to the pharmacokinetics of metoprolol associated with CYP2D6 g
    Journal of separation science, 2014, Volume: 37, Issue:11

    Topics: Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Genotype; Humans; Male; Metoprolol; Polymorphism, Genetic; Tandem Mass Spectrometry; Young Adult

2014
Development of a LC-MS/MS method for simultaneous determination of metoprolol and its metabolites, α-hydroxymetoprolol and O-desmethylmetoprolol, in rat plasma: application to the herb-drug interaction study of metoprolol and breviscapine.
    Biomedical chromatography : BMC, 2015, Volume: 29, Issue:9

    Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Herb-Drug Interactions; Male; Metoprolol; Rats; Rats, Wistar; Tandem Mass Spectrometry

2015
False positive amphetamines and 3,4-methylenedioxymethamphetamine immunoassays in the presence of metoprolol-two cases reported in clinical toxicology.
    Journal of analytical toxicology, 2020, Mar-07, Volume: 44, Issue:2

    Topics: Adult; Amphetamine; Amphetamines; Cross Reactions; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Immunoassay; Immunoenzyme Techniques; Male; Methamphetamine; Metoprolol; Middle Aged; N-Methyl-3,4-methylenedioxyamphetamine; Substance Abuse Detection

2020
Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6-Mediated Metabolic Activity.
    Clinical and translational science, 2020, Volume: 13, Issue:1

    Topics: Alleles; Computational Biology; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Genetic Association Studies; Genetic Loci; Haplotypes; High-Throughput Nucleotide Sequencing; Humans; Metoprolol; Microsomes, Liver; Pharmacogenomic Testing; Polymorphism, Genetic; Practice Guidelines as Topic

2020
Simultaneous time-course measurements of metoprolol and α-hydroxyl metoprolol in fingermarks after oral administration by liquid chromatography tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020, Nov-01, Volume: 1156

    Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Female; Fingers; Humans; Limit of Detection; Linear Models; Male; Metoprolol; Middle Aged; Reproducibility of Results; Specimen Handling; Tandem Mass Spectrometry; Tissue Distribution; Young Adult

2020
Isocyanate derivatization coupled with phospholipid removal microelution-solid phase extraction for the simultaneous quantification of (S)-metoprolol and (S)-α-hydroxymetoprolol in human plasma with LC-MS/MS.
    Journal of pharmaceutical and biomedical analysis, 2021, Sep-10, Volume: 204

    Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Isocyanates; Metoprolol; Phospholipids; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry

2021