alpha-hydroxymetoprolol has been researched along with metoprolol in 59 studies
| Studies (alpha-hydroxymetoprolol) | Trials (alpha-hydroxymetoprolol) | Recent Studies (post-2010) (alpha-hydroxymetoprolol) | Studies (metoprolol) | Trials (metoprolol) | Recent Studies (post-2010) (metoprolol) |
|---|---|---|---|---|---|
| 59 | 6 | 12 | 5,821 | 1,743 | 1,304 |
| Protein | Taxonomy | alpha-hydroxymetoprolol (IC50) | metoprolol (IC50) |
|---|---|---|---|
| Beta-2 adrenergic receptor | Homo sapiens (human) | 2.573 | |
| Beta-1 adrenergic receptor | Homo sapiens (human) | 0.176 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 4.87 | |
| Cytochrome P450 2J2 | Homo sapiens (human) | 4.87 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (44.07) | 18.7374 |
| 1990's | 9 (15.25) | 18.2507 |
| 2000's | 12 (20.34) | 29.6817 |
| 2010's | 8 (13.56) | 24.3611 |
| 2020's | 4 (6.78) | 2.80 |
| Authors | Studies |
|---|---|
| Chiba, K; Ishizaki, T; Jang, IJ; Kusaka, M; Shin, SG; Sohn, DR | 1 |
| Noguchi, H; Shimizu, H; Uno, K | 1 |
| Balmér, K; Lagerström, PO; Persson, A; Persson, BA; Schill, G | 1 |
| John, VA; Lloyd, P; Signy, M; Smith, SE | 1 |
| Fujita, K; Horai, Y; Ishizaki, T | 1 |
| Avenant, J; Moncrieff, J; Sommers, DK | 1 |
| Moncrieff, J; Simpson, D | 1 |
| Garrick, C; Rutledge, DR | 1 |
| Chak, W; Chan, MK; Ho, PW; Lin, HJ; Pun, KK; Yeung, CK; Yeung, RT | 1 |
| Gyllenhaal, O; Hoffmann, KJ; Vessman, J | 1 |
| Holm, B; Lindeberg, S; Lundborg, P; Regårdh, CG; Sandström, B | 1 |
| Hashimoto, K; Horai, Y; Ishizaki, T; Kusaka, M; Tsujimoto, G | 1 |
| Gengo, FM; Lalka, D; Modi, MW; Schuster, D | 1 |
| Ervik, M; Johansson, L; Kylberg-Hanssen, K | 1 |
| Carey, C; Ermer, JC; Gengo, FM; Kalonaros, GC; McHugh, WB | 1 |
| Bernier, JJ; Duval, M; Evard, D; Godbillon, J; Hirtz, J; Schoeller, JP; Vidon, N | 1 |
| Bernier, JJ; Bovet, M; Duval, M; Evard, D; Godbillon, J; Hirtz, J; Schoeller, JP; Vidon, N | 1 |
| Abadie, F; Lecaillon, JB; Massias, P; Schoeller, JP | 1 |
| Högstedt, S; Lindberg, B; Peng, DR; Rane, A; Regårdh, CG | 1 |
| Gyllenhaal, O; König, WA; Vessman, J | 1 |
| Gengo, FM; McHugh, WB; Ulatowski, JA | 1 |
| Gengo, FM; Kinkel, WR; McHugh, WB; Ziemniak, MA | 1 |
| Duval, M; Godbillon, J | 1 |
| Landahl, S; Larsson, M; Lundborg, P; Regårdh, CG | 1 |
| Jack, DB; Quarterman, CP; Wilkins, M | 1 |
| Abadie, F; Godbillon, J; Gosset, G; Lecaillon, JB | 1 |
| Hoffmann, KJ; Lagerström, PO; Landahl, S; Larsson, M; Lundborg, P; Regårdh, CG; Steen, B | 1 |
| Lennard, MS; Silas, JH | 1 |
| Jusko, WJ; Pautler, DB | 1 |
| Jack, DB; Kendall, MJ; Quarterman, CP | 1 |
| Tu, ZG; Zhao, LL | 1 |
| Xie, HG; Zhou, HH | 1 |
| Ackland, MJ; Ellis, SW; Lennard, MS; Rekka, E; Rowland, K; Simula, AP; Tucker, GT; Wolf, CR | 1 |
| Abdon, NJ; Everts, B; Hedner, T; Herlitz, J; Karlson, BW | 1 |
| Eddington, NE; Leslie, J; Mistry, B | 1 |
| Arseneault, M; Hamelin, BA; Labbé, L; Pilote, S; Robitaille, NM; Sirois, C; Turgeon, J | 1 |
| Eddington, ND; Leslie, JL; Mistry, B | 2 |
| Eddington, ND; Sirisuth, N | 1 |
| Bergmann, K; Eschenhagen, T; Feifel, N; Heide, R; Rau, T; Werner, U; Wuttke, H | 1 |
| Bertucci, C; Bonato, PS; Cerqueira, PM; Cesarino, EJ; Lanchote, VL | 1 |
| Boralli, VB; Cerqueira, PM; Coelho, EB; Lanchote, VL | 1 |
| Delabar, U; Eichelbaum, M; Fux, R; Gleiter, CH; Kivistö, KT; Lorenz, G; Mörike, K; Pröhmer, AM; Schaeffeler, E; Schwab, M | 1 |
| Ismail, R; Teh, LK | 1 |
| Babak, S; Bergman, U; Bertilsson, L; Boldueva, S; Burbello, A; Goryachkina, K | 1 |
| Bang, S; Chung, HJ; Chung, MW; Jin, SK; Kang, JH; Kim, JI; Lee, HJ; Lee, SH; Roh, J; Woo, SW | 1 |
| Baranowska, I; Wilczek, A | 1 |
| Barclay, VK; Johansson, IM; Pettersson, CE; Tyrefors, NL | 1 |
| Antunes, Nde J; Cavalli, RC; Lanchote, VL; Marques, MP | 1 |
| Gu, HW; Li, SS; Liu, YJ; Su, ZY; Wu, HL; Yin, XL; Yu, RQ | 1 |
| Duricova, J; Grundmann, M; Jurckova, N; Kacirova, I; Perinova, I | 1 |
| Cesarino, EJ; de Moraes, NV; de Souza, L; Hayashida, M; Lanchote, VL; Neves, DV; Nogueira, MS | 1 |
| Bae, SH; Bae, SK; Cho, DY; Lee, JK | 1 |
| Bae, SH; Bae, SK; Cho, DY; Kim, BT; Kim, YW; Lee, JK; Lee, S; Oh, E; Park, JB | 1 |
| Ma, YR; Qin, HY; Rao, Z; Wang, XD; Wang, YF; Wei, YH; Wu, XA; Zhang, GQ; Zhou, Y | 1 |
| Bourgogne, E; Delhotal-Landes, B; Gourlain, H; Labat, L; Leclercq, M; Mégarbane, B; Soichot, M | 1 |
| Claw, KG; Dalton, R; Dunham, MJ; Fade, M; Fowler, DM; Gaedigk, A; Lee, SB; McDonald, MG; Nickerson, DA; Phillips, BR; Prasad, B; Rettie, AE; Schuetz, E; Shen, DD; Thornton, TA; Thummel, KE; Wong, LH; Woodahl, EL | 1 |
| Zhang, WJ | 1 |
| de Denus, S; Jutras, M; Leclair, G; Meloche, M; St-Jean, I | 1 |
6 trial(s) available for alpha-hydroxymetoprolol and metoprolol
| Article | Year |
|---|---|
The relationship between serum concentrations and central nervous system actions of metoprolol.
Topics: Adult; Brain; Double-Blind Method; Flicker Fusion; Humans; Kinetics; Male; Metoprolol; Psychomotor Performance; Random Allocation; Reaction Time | 1985 |
Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: a prospective clinical study.
Topics: Adrenergic beta-1 Receptor Antagonists; Cytochrome P-450 CYP2D6; Dose-Response Relationship, Drug; Female; Genotype; Humans; Hypertension; Male; Metoprolol; Middle Aged; Polymorphism, Genetic; Prospective Studies | 2005 |
The relevance of CYP2D6 genetic polymorphism on chronic metoprolol therapy in cardiovascular patients.
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Antihypertensive Agents; Cardiovascular Diseases; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Kidney Diseases; Male; Metoprolol; Middle Aged; Pharmacogenetics; Polymorphism, Genetic | 2006 |
Inhibition of metoprolol metabolism and potentiation of its effects by paroxetine in routinely treated patients with acute myocardial infarction (AMI).
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Area Under Curve; Bradycardia; Cytochrome P-450 CYP2D6; Depression; Dose-Response Relationship, Drug; Drug Interactions; Female; Genotype; Heart Rate; Humans; Hypotension, Orthostatic; Male; Metoprolol; Middle Aged; Myocardial Infarction; Paroxetine | 2008 |
Influence of CYP2D6*10 on the pharmacokinetics of metoprolol in healthy Korean volunteers.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Alleles; Area Under Curve; Asian People; Cytochrome P-450 CYP2D6; Female; Half-Life; Humans; Korea; Male; Metoprolol; Pharmacogenetics; Polymorphism, Genetic; Young Adult | 2008 |
Effect of the potent CYP2D6 inhibitor sarpogrelate on the pharmacokinetics and pharmacodynamics of metoprolol in healthy male Korean volunteers.
Topics: Administration, Oral; Adult; Area Under Curve; Asian People; Cytochrome P-450 CYP2D6 Inhibitors; Healthy Volunteers; Humans; Male; Metoprolol; Middle Aged; Republic of Korea; Succinates; Young Adult | 2015 |
53 other study(ies) available for alpha-hydroxymetoprolol and metoprolol
| Article | Year |
|---|---|
Utility of a one-point (3-hour postdose) plasma metabolic ratio as a phenotyping test using metoprolol in two east Asian populations.
Topics: Adolescent; Adult; Asian People; Chromatography, High Pressure Liquid; Debrisoquin; Female; Humans; Japan; Korea; Male; Metoprolol; Middle Aged; Oxidation-Reduction; Phenotype | 1992 |
Variation of pharmacokinetics after oral administration of slow-release metoprolol tablets and pharmacogenetic considerations.
Topics: Administration, Oral; Adult; Asian People; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Humans; Japan; Male; Metoprolol; Middle Aged; Pharmacogenetics; Phenotype; Tablets; United Kingdom; White People | 1992 |
Liquid chromatographic separation of the enantiomers of metoprolol and its alpha-hydroxy metabolite on Chiralcel OD for determination in plasma and urine.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Humans; Metoprolol; Spectrometry, Fluorescence; Stereoisomerism | 1991 |
The effect of impaired renal function on the pharmacokinetics of metoprolol after single administration of a 14/190 metoprolol OROS system.
Topics: Administration, Oral; Delayed-Action Preparations; Humans; Kidney Diseases; Male; Metoprolol; Osmolar Concentration | 1990 |
Genetically determined N-acetylation and oxidation capacities in Japanese patients with non-occupational urinary bladder cancer.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Chi-Square Distribution; Dapsone; Disease Susceptibility; Female; Humans; Japan; Male; Metoprolol; Middle Aged; Oxidation-Reduction; Phenotype; Urinary Bladder Neoplasms | 1989 |
Metoprolol alpha-hydroxylation polymorphism in the San Bushmen of southern Africa.
Topics: Black People; Debrisoquin; Humans; Hydroxylation; Male; Metoprolol; Nigeria; Polymorphism, Genetic; South Africa; White People | 1989 |
Determination of metoprolol and its alpha-hydroxy metabolite in urine by direct-injection reversed-phase high-performance liquid chromatography with fluorimetric detection.
Topics: Chromatography, High Pressure Liquid; Humans; Metoprolol; Spectrometry, Fluorescence | 1989 |
Determination of metoprolol and its alpha-hydroxide metabolite in serum by reversed-phase high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Injections, Intravenous; Metoprolol | 1989 |
Effects of selective and non-selective beta-blockers on the alanine and free fatty acid responses to glucagon challenge in hemodialysis patients.
Topics: Adrenergic beta-Antagonists; Adult; Alanine; Blood Glucose; Fatty Acids, Nonesterified; Glucagon; Humans; Metoprolol; Middle Aged; Propranolol; Renal Dialysis | 1986 |
Analysis of alpha-hydroxy metabolites of metoprolol in human urine after phosgene/trimethylsilyl derivatization.
Topics: Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Metoprolol; Phosgene; Trimethylsilyl Compounds | 1987 |
The effect of hydralazine on steady-state plasma concentrations of metoprolol in pregnant hypertensive women.
Topics: Adult; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hydralazine; Hypertension; Metoprolol; Pregnancy; Pregnancy Complications, Cardiovascular; Time Factors | 1988 |
Simultaneous determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by liquid chromatography with a preliminary observation on metoprolol oxidation in Japanese subjects.
Topics: Chromatography, Liquid; Humans; Japan; Metoprolol; Oxidation-Reduction; Phenotype; Reproducibility of Results | 1988 |
Reversed-phase high-performance liquid chromatographic assay to quantitate diastereomeric derivatives of metoprolol enantiomers in plasma.
Topics: Animals; Chromatography, High Pressure Liquid; Male; Metoprolol; Microsomes, Liver; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Stereoisomerism | 1988 |
Determination of metoprolol in plasma and urine using high-resolution gas chromatography and electron-capture detection.
Topics: Biotransformation; Chromatography, Gas; Electrochemistry; Humans; Indicators and Reagents; Metoprolol | 1986 |
Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon.
Topics: Adult; Colon; Female; Humans; Intestinal Absorption; Kinetics; Male; Metoprolol; Phenylacetates | 1985 |
Investigation of drug absorption from the gastrointestinal tract of man. IV. Influence of food and digestive secretions on metoprolol jejunal absorption.
Topics: Adult; Bile Acids and Salts; Body Water; Food; Half-Life; Humans; Intestinal Absorption; Intestinal Secretions; Jejunum; Kinetics; Male; Metoprolol; Phenylacetates | 1985 |
Influence of food on the absorption of metoprolol administered as an Oros drug delivery system to man.
Topics: Adult; Biological Availability; Biotransformation; Delayed-Action Preparations; Female; Food; Humans; Intestinal Absorption; Kinetics; Male; Metoprolol; Time Factors | 1985 |
Pregnancy-induced increase in metoprolol metabolism.
Topics: Adult; Blood Proteins; Female; Humans; Hypertension; Kinetics; Metoprolol; Pregnancy; Pregnancy Complications, Cardiovascular; Protein Binding; Time Factors | 1985 |
Enantiomer separation of metoprolol and its analogues and metabolites by capillary column gas chromatography after derivatization with phosgene.
Topics: Chemical Phenomena; Chemistry; Chromatography, Gas; Indicators and Reagents; Metoprolol; Phosgene; Stereoisomerism | 1985 |
Metoprolol and alpha-hydroxymetoprolol concentrations and reduction in essential tremor.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Humans; Kinetics; Metoprolol; Middle Aged; Tremor | 1984 |
High-performance liquid chromatographic determination of metoprolol and alpha-hydroxymetoprolol concentrations in human serum, urine, and cerebrospinal fluid.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Metoprolol; Temperature | 1984 |
Determination of two metoprolol metabolites in human urine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Kinetics; Metoprolol | 1984 |
Pharmacokinetics of metoprolol in healthy, elderly, non-smoking individuals after a single dose and two weeks of treatment.
Topics: Administration, Oral; Adult; Age Factors; Aged; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Metoprolol | 1984 |
Lack of evidence for polymorphism in metoprolol metabolism.
Topics: Acebutolol; Adult; Biotransformation; Half-Life; Humans; Metoprolol; Polymorphism, Genetic | 1983 |
Determination of metoprolol and its alpha-hydroxylated metabolite in human plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Metoprolol; Molecular Weight | 1984 |
Pharmacokinetics of metoprolol and its metabolite alpha-OH-metoprolol in healthy, non-smoking, elderly individuals.
Topics: Adult; Age Factors; Aged; Female; Humans; Kidney; Kinetics; Male; Metoprolol; Propanolamines | 1983 |
Rapid determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Debrisoquin; Humans; Metoprolol; Propanolamines | 1983 |
Determination of metoprolol and alpha-hydroxymetoprolol in plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Metoprolol; Microchemistry; Propanolamines | 1982 |
The effect of age on the pharmacokinetics of metoprolol and its metabolites.
Topics: Adolescent; Adult; Aged; Aging; Chemical Phenomena; Chemistry; Female; Humans; Kinetics; Metoprolol; Middle Aged; Propanolamines | 1981 |
Metoprolol alpha-hydroxylation capacity in 96 Chinese Han volunteers.
Topics: Asian People; China; Female; Humans; Hydroxylation; Male; Metabolic Clearance Rate; Metoprolol; Microsomes, Liver; Phenotype; Polymorphism, Genetic | 1995 |
Assay of metoprolol and alpha-hydroxymetoprolol in human urine by reversed-phase liquid chromatography with direct-injection.
Topics: Chromatography, High Pressure Liquid; Humans; Metoprolol | 1995 |
Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol.
Topics: Amino Acid Sequence; Binding Sites; Cloning, Molecular; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Humans; Kinetics; Metoprolol; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Conformation; Protein Structure, Secondary; Saccharomyces cerevisiae; Sequence Alignment; Spectrophotometry; Stereoisomerism | 1996 |
Effects and pharmacokinetics of high dose metoprolol on chest pain in patients with suspected or definite acute myocardial infarction.
Topics: Aged; Aged, 80 and over; Analgesia; Antihypertensive Agents; Blood Pressure; Catecholamines; Chest Pain; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Pain Measurement; Respiration | 1997 |
A sensitive assay of metoprolol and its major metabolite alpha-hydroxy metoprolol in human plasma and determination of dextromethorphan and its metabolite dextrorphan in urine with high performance liquid chromatography and fluorometric detection.
Topics: Adrenergic beta-Antagonists; Antitussive Agents; Chromatography, High Pressure Liquid; Dextromethorphan; Dextrorphan; Humans; Indicators and Reagents; Metoprolol; Neuroprotective Agents; Quality Control; Reference Standards; Reproducibility of Results; Spectrometry, Fluorescence | 1998 |
Effect of gender, sex hormones, time variables and physiological urinary pH on apparent CYP2D6 activity as assessed by metabolic ratios of marker substrates.
Topics: Administration, Oral; Adult; Analysis of Variance; Biomarkers; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Enzyme Activation; Female; Gonadal Steroid Hormones; Humans; Hydrogen-Ion Concentration; Male; Menstrual Cycle; Metoprolol; Sex Characteristics; Sex Factors; Substrate Specificity; Time Factors; Urine | 2000 |
Enantiomeric separation of metoprolol and alpha-hydroxymetoprolol by liquid chromatography and fluorescence detection using a chiral stationary phase.
Topics: Adrenergic beta-Antagonists; Biological Availability; Calibration; Chromatography, High Pressure Liquid; Metoprolol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Stereoisomerism | 2001 |
Influence of input rate on the stereospecific and nonstereospecific first pass metabolism and pharmacokinetics of metoprolol extended release formulations.
Topics: Delayed-Action Preparations; Female; Humans; Male; Metoprolol; Stereoisomerism | 2002 |
The influence of first pass metabolism on the development and validation of an IVIVC for metoprolol extended release tablets.
Topics: Biological Availability; Delayed-Action Preparations; Female; Humans; Male; Metoprolol; Models, Biological; Reproducibility of Results; Solubility; Time Factors | 2002 |
Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment.
Topics: Adrenergic beta-Antagonists; Chromatography, High Pressure Liquid; Cohort Studies; Coronary Artery Disease; Cross-Sectional Studies; Cytochrome P-450 CYP2D6; DNA Primers; Drug Administration Schedule; Female; Gene Frequency; Genotype; Humans; Hypertension; Male; Metoprolol; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; White People | 2002 |
Stereoselective metabolism of metoprolol: enantioselectivity of alpha-hydroxymetoprolol in plasma and urine.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Biotransformation; Chromatography, High Pressure Liquid; Circular Dichroism; Humans; Kinetics; Metoprolol; Middle Aged; Spectrophotometry, Ultraviolet; Stereoisomerism | 2003 |
Stereoselective analysis of metoprolol and its metabolites in rat plasma with application to oxidative metabolism.
Topics: Adrenergic beta-Antagonists; Animals; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Circular Dichroism; Half-Life; Male; Metoprolol; Rats; Rats, Wistar; Reproducibility of Results; Stereoisomerism | 2005 |
Simultaneous RP-HPLC determination of sotalol, metoprolol, alpha-hydroxymetoprolol, paracetamol and its glucuronide and sulfate metabolites in human urine.
Topics: Chromatography, High Pressure Liquid; Glucuronides; Humans; Metoprolol; Molecular Structure; Reproducibility of Results; Sensitivity and Specificity; Sotalol; Sulfates | 2009 |
Chiral analysis of metoprolol and two of its metabolites, α-hydroxymetoprolol and deaminated metoprolol, in wastewater using liquid chromatography-tandem mass spectrometry.
Topics: Adrenergic beta-Antagonists; Chromatography, Liquid; Deamination; Metoprolol; Solid Phase Extraction; Stereoisomerism; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical | 2012 |
Stereoselective determination of metoprolol and its metabolite α-hydroxymetoprolol in plasma by LC-MS/MS: application to pharmacokinetics during pregnancy.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Chromatography, High Pressure Liquid; Female; Humans; Metoprolol; Pregnancy; Stereoisomerism; Tandem Mass Spectrometry | 2013 |
Simultaneous determination of metoprolol and α-hydroxymetoprolol in human plasma using excitation-emission matrix fluorescence coupled with second-order calibration methods.
Topics: Adrenergic beta-1 Receptor Antagonists; Algorithms; Blood Chemical Analysis; Calibration; Cardiovascular Diseases; Humans; Kinetics; Metoprolol; Oxidation-Reduction; Spectrometry, Fluorescence | 2012 |
Clinically important interaction between metoprolol and propafenone.
Topics: Aged; Anti-Arrhythmia Agents; Antihypertensive Agents; Atrial Fibrillation; Cytochrome P-450 CYP2D6; Diuretics; Drug Interactions; Dyspnea; Fatigue; Female; Humans; Hypertension; Medication Reconciliation; Metoprolol; Propafenone | 2013 |
Metoprolol oxidation polymorphism in Brazilian elderly cardiac patients.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Aged, 80 and over; Anthropometry; Black People; Brazil; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Female; Heart Diseases; Humans; Inactivation, Metabolic; Male; Metoprolol; Middle Aged; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Urinalysis; White People | 2013 |
Simultaneous determination of metoprolol and its metabolites, α-hydroxymetoprolol and O-desmethylmetoprolol, in human plasma by liquid chromatography with tandem mass spectrometry: Application to the pharmacokinetics of metoprolol associated with CYP2D6 g
Topics: Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Genotype; Humans; Male; Metoprolol; Polymorphism, Genetic; Tandem Mass Spectrometry; Young Adult | 2014 |
Development of a LC-MS/MS method for simultaneous determination of metoprolol and its metabolites, α-hydroxymetoprolol and O-desmethylmetoprolol, in rat plasma: application to the herb-drug interaction study of metoprolol and breviscapine.
Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Herb-Drug Interactions; Male; Metoprolol; Rats; Rats, Wistar; Tandem Mass Spectrometry | 2015 |
False positive amphetamines and 3,4-methylenedioxymethamphetamine immunoassays in the presence of metoprolol-two cases reported in clinical toxicology.
Topics: Adult; Amphetamine; Amphetamines; Cross Reactions; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Immunoassay; Immunoenzyme Techniques; Male; Methamphetamine; Metoprolol; Middle Aged; N-Methyl-3,4-methylenedioxyamphetamine; Substance Abuse Detection | 2020 |
Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6-Mediated Metabolic Activity.
Topics: Alleles; Computational Biology; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Genetic Association Studies; Genetic Loci; Haplotypes; High-Throughput Nucleotide Sequencing; Humans; Metoprolol; Microsomes, Liver; Pharmacogenomic Testing; Polymorphism, Genetic; Practice Guidelines as Topic | 2020 |
Simultaneous time-course measurements of metoprolol and α-hydroxyl metoprolol in fingermarks after oral administration by liquid chromatography tandem mass spectrometry.
Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Female; Fingers; Humans; Limit of Detection; Linear Models; Male; Metoprolol; Middle Aged; Reproducibility of Results; Specimen Handling; Tandem Mass Spectrometry; Tissue Distribution; Young Adult | 2020 |
Isocyanate derivatization coupled with phospholipid removal microelution-solid phase extraction for the simultaneous quantification of (S)-metoprolol and (S)-α-hydroxymetoprolol in human plasma with LC-MS/MS.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Isocyanates; Metoprolol; Phospholipids; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry | 2021 |