Page last updated: 2024-09-02

alpha-hydroxymetoprolol and dextromethorphan

alpha-hydroxymetoprolol has been researched along with dextromethorphan in 3 studies

Compound Research Comparison

Studies
(alpha-hydroxymetoprolol)
Trials
(alpha-hydroxymetoprolol)
Recent Studies (post-2010)
(alpha-hydroxymetoprolol)
Studies
(dextromethorphan)
Trials
(dextromethorphan)
Recent Studies (post-2010) (dextromethorphan)
596122,020342593

Protein Interaction Comparison

ProteinTaxonomyalpha-hydroxymetoprolol (IC50)dextromethorphan (IC50)
Sodium channel protein type 1 subunit alphaRattus norvegicus (Norway rat)1.3
Sodium channel protein type 2 subunit alphaRattus norvegicus (Norway rat)1.3
Sodium channel protein type 3 subunit alphaRattus norvegicus (Norway rat)1.3
Cytochrome P450 2D26Rattus norvegicus (Norway rat)5.6
Cytochrome P450 2D6Homo sapiens (human)2.1768
Sodium-dependent serotonin transporterHomo sapiens (human)0.0027
Sigma non-opioid intracellular receptor 1Cavia porcellus (domestic guinea pig)0.1236

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Eddington, NE; Leslie, J; Mistry, B1
Arseneault, M; Hamelin, BA; Labbé, L; Pilote, S; Robitaille, NM; Sirois, C; Turgeon, J1
Claw, KG; Dalton, R; Dunham, MJ; Fade, M; Fowler, DM; Gaedigk, A; Lee, SB; McDonald, MG; Nickerson, DA; Phillips, BR; Prasad, B; Rettie, AE; Schuetz, E; Shen, DD; Thornton, TA; Thummel, KE; Wong, LH; Woodahl, EL1

Other Studies

3 other study(ies) available for alpha-hydroxymetoprolol and dextromethorphan

ArticleYear
A sensitive assay of metoprolol and its major metabolite alpha-hydroxy metoprolol in human plasma and determination of dextromethorphan and its metabolite dextrorphan in urine with high performance liquid chromatography and fluorometric detection.
    Journal of pharmaceutical and biomedical analysis, 1998, Volume: 16, Issue:6

    Topics: Adrenergic beta-Antagonists; Antitussive Agents; Chromatography, High Pressure Liquid; Dextromethorphan; Dextrorphan; Humans; Indicators and Reagents; Metoprolol; Neuroprotective Agents; Quality Control; Reference Standards; Reproducibility of Results; Spectrometry, Fluorescence

1998
Effect of gender, sex hormones, time variables and physiological urinary pH on apparent CYP2D6 activity as assessed by metabolic ratios of marker substrates.
    Pharmacogenetics, 2000, Volume: 10, Issue:5

    Topics: Administration, Oral; Adult; Analysis of Variance; Biomarkers; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Enzyme Activation; Female; Gonadal Steroid Hormones; Humans; Hydrogen-Ion Concentration; Male; Menstrual Cycle; Metoprolol; Sex Characteristics; Sex Factors; Substrate Specificity; Time Factors; Urine

2000
Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6-Mediated Metabolic Activity.
    Clinical and translational science, 2020, Volume: 13, Issue:1

    Topics: Alleles; Computational Biology; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Genetic Association Studies; Genetic Loci; Haplotypes; High-Throughput Nucleotide Sequencing; Humans; Metoprolol; Microsomes, Liver; Pharmacogenomic Testing; Polymorphism, Genetic; Practice Guidelines as Topic

2020