alpha-fluoro-beta-alanine has been researched along with beta-alanine in 67 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (16.42) | 18.7374 |
| 1990's | 27 (40.30) | 18.2507 |
| 2000's | 16 (23.88) | 29.6817 |
| 2010's | 10 (14.93) | 24.3611 |
| 2020's | 3 (4.48) | 2.80 |
| Authors | Studies |
|---|---|
| Kaneko, M; Kikugawa, M; Kontani, Y; Tamaki, N | 1 |
| Carton, M; de Forni, M; Lemaire, L; Longo, S; Malet-Martino, MC; Martino, R | 1 |
| Harada, M; Koga, K; Miura, I; Nishitani, H; Shirahama, T | 1 |
| Barnes, S; Diasio, RB; Zhang, RW | 1 |
| Bachert, P; Port, RE; Semmler, W | 1 |
| Baldwin, NJ; Ng, TC; Sijens, PE | 1 |
| Croisy, A; Guerquin-Kern, JL; Leteurtre, F; Lhoste, JM | 1 |
| Bachert-Baumann, P; Ermark, F; Gückel, F; Lorenz, WJ; Schlag, P; Semmler, W; van Kaick, G | 1 |
| Barnes, S; Diasio, RB; Johnson, MR; Sweeny, DJ | 1 |
| Kuroiwa, T; Matsuo, T; Okeda, R; Shibutani, M; Shimokawa, R; Tajima, T | 1 |
| Griffiths, JR; Maxwell, RJ; Prior, MJ | 1 |
| Foth, H; Kahl, GF; Kunellis, EM; Müseler, T | 1 |
| Furusawa, M; Hara, Y; Kono, A | 1 |
| Armand, JP; Bernadou, J; Béteille, JP; Bon, M; Lopez, A; Malet-Martino, MC; Martino, R | 1 |
| Barnes, S; Diasio, RB; Sweeny, DJ | 1 |
| Britsch, B; Herrmann, R; Hull, WE; Kunz, W; Port, RE | 1 |
| Bon, M; Cabanac, S; Dimicoli, JL; Malet-Martino, MC; Martino, R; Nedelec, JF | 1 |
| Armand, JP; Bernadou, J; Lopez, A; Malet-Martino, MC; Martino, R | 1 |
| Diasio, RB; Schuetz, JD; Sommadossi, JP; Wallace, HJ | 1 |
| Haruno, A; Kunimune, Y; Morita, K; Unemi, N; Yamamoto, J; Yamashita, K; Yoshimura, Y | 1 |
| Cano, JP; Diasio, RB; Mentre, F; Sommadossi, JP; Steimer, JL | 1 |
| Hoshi, A; Iigo, M; Kuretani, K; Nakamura, A | 1 |
| Almond, MR; Chestnut, WG; Harrington, JA; Porter, DJ; Spector, T; Tanoury, G | 1 |
| Bachert, P; Krems, B; Lorenz, WJ; Zabel, HJ | 1 |
| Bastian, G; Compagnon, P; Dominique, S; Hellot, MF; Kannass, MM; Moore, N; Richard, MO; Thiberville, L; Thuillez, C; Vincent, C | 1 |
| Barnes, S; Crawford, JM; Godleski, JJ; Hastings, CL; Stearns, RC | 1 |
| Baccanari, DP; Davis, ST; Joyner, SS; Spector, T | 1 |
| Anzion, RB; Bos, RP; Sessink, PJ; Timmersmans, JL | 1 |
| Bachert, P; Bellemann, ME; Brix, G; Lorenz, WJ; Zabel, HJ | 1 |
| Havinga, R; Kuipers, F; Scherphof, GL; van Borssum Waalkes, M | 1 |
| Diasio, RB; Liu, T; Soong, SJ; Zhang, R | 1 |
| Anderson, D; Blesing, C; Kerr, DJ; Seymour, LW | 1 |
| Brown, TR; He, L; Li, CW; Murphy-Boesch, J; Negendank, W; Padavic-Shaller, KA | 1 |
| Hirai, N; Lee, YS; Okuno, K; Tarabar, D; Ueno, H; Yasutomi, M | 1 |
| Beigelman, L; Handschumacher, RE; Liu, M; Pizzorno, G; Russell, RL | 1 |
| Bachert, P; Becker, M; Dietz, A; Knopp, MV; Rudat, V; Schlemmer, HP; van Kaick, G; Vanselow, B; Wannenmacher, M; Weidauer, H; Wollensack, P; Zuna, I | 1 |
| Bellemann, ME; Brix, G; Haberkorn, U | 1 |
| Baccanari, DP; Cao, S; Davis, ST; Porter, DJ; Rustum, YM; Spector, T; Tansik, RL | 1 |
| Hirakawa, Y; Kawaguchi, Y; Kuwata, K; Matsushima, E; Nagayama, S | 1 |
| Collins, DJ; Dzik-Jurasz, AS; Leach, MO; Rowland, IJ | 1 |
| Dankert, J; Guchelaar, HJ; van Kuilenburg, AB; Vermes, A | 1 |
| Blesch, KS; Burger, HU; Gieschke, R; Reigner, B; Steimer, JL | 1 |
| Bridgewater, J; Grange, S; Kimura, M; Kuranami, M; Lucraft, H; McAleer, J; Monkhouse, J; Poole, C; Reigner, B; Saeki, T; Sasaki, Y; Schüller, J; Watanabe, T; Weidekamm, E; Yorulmaz, C | 1 |
| Heerschap, A; Kentgens, AP; Klomp, DW; Van Laarhoven, HW | 1 |
| BERGMAN, ED; WINNICK, RE; WINNICK, T | 1 |
| Ariyoshi, T; Yada, H; Yamashita, K | 1 |
| Ciccolini, J; Etienne-Grimaldi, MC; Fischel, JL; Formento, P; Milano, G | 1 |
| Brambilla, G; Buratti, M; Campo, L; Colombi, A; Fustinoni, S; Giglio, M; Iavicoli, S; Omodeo-Salè, E; Rubino, FM; Verduci, C | 1 |
| Hatakeyama, K; Muneoka, K; Shirai, Y; Wakai, T; Yokoyama, N | 1 |
| Creten, O; Spileers, W; Stalmans, P | 1 |
| Yamada, Y | 1 |
| Hirakawa, K; Kim, WY; Nakata, B | 1 |
| Hanauske, A; Hilger, RA; Krauss, J; Kredtke, S; Makris, L; Mende, B; Scheulen, ME; Scigalla, P; Strumberg, D; Thyssen, D; Urrea, PD | 1 |
| Bowen, C; Licea-Perez, H; Wang, S | 1 |
| d'Almeida, A; Denis, F; Marsan, P; Ndaw, S; Robert, A | 1 |
| Black, ME; Darnell, JL; Davies, NM; Serve, KM; Takemoto, JK | 1 |
| Blaha, L; Dott, W; Kovalova, L; Zounkova, R | 1 |
| Amidon, GL; Provoda, CJ; Tsume, Y | 1 |
| Bussières, JF; Caron, N; Gagné, S; Plante, C; Poupeau, C; Tanguay, C | 1 |
| Hasebe, M; Ishii, N; Kikuchi, Y; Kudoh, Y; Sasaki, M; Sugiyama, R | 1 |
| Funakoshi, T; Horimatsu, T; Matsubara, K; Matsubara, T; Miyamoto, S; Muto, M; Nakagawa, S; Nishikawa, Y; Yanagita, M; Yonezawa, A | 1 |
| Atgé, B; Canal-Raffin, M; Dhersin, A; Martinez, B; Molimard, M; Rousset, M; Sidatt Cheikh El Moustaph, M; Titier, K; Verdun-Esquer, C; Villa, A | 1 |
| Cottica, D; Grignani, E; Locatelli, CA; Lonati, D; Negri, S; Pastoris, O; Santorelli, D; Sottani, C; Studioso, E; Zaratin, L | 1 |
| Chen, J; Chen, W; Gao, S; Jiang, W; Li, M; Man, H; Wang, Z; Yang, Y; Zhang, F; Zhang, R | 1 |
| Funakoshi, T; Horimatsu, T; Ikeda, A; Imamaki, H; Kataoka, S; Matsubara, T; Muto, M; Nakagawa, S; Nishikawa, Y; Oura, M; Ozaki, Y; Watanabe, N; Yanagita, M; Yonezawa, A | 1 |
| Beijnen, JH; Dorlo, TPC; Huitema, ADR; Jacobs, BAW; Kurk, SA; May, AM; Molenaar-Kuijsten, L; Steeghs, N | 1 |
| Beijnen, JH; Cats, A; de Vries, N; Guchelaar, HJ; Knikman, JE; Rosing, H | 1 |
4 trial(s) available for alpha-fluoro-beta-alanine and beta-alanine
| Article | Year |
|---|---|
Plasma 5-fluorouracil and alpha-fluoro-beta-alanin accumulation in lung cancer patients treated with continuous infusion of cisplatin and 5-fluorouracil.
Topics: Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Carcinoma, Non-Small-Cell Lung; Cisplatin; Fluorouracil; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Time Factors | 1994 |
5-fluorocytosine-related bone-marrow depression and conversion to fluorouracil: a pilot study.
Topics: Adult; Aged; beta-Alanine; Biotransformation; Bone Marrow; Candidiasis; Female; Flucytosine; Fluorouracil; Humans; Injections, Intravenous; Leukocyte Count; Leukopenia; Male; Meningitis, Cryptococcal; Middle Aged; Models, Theoretical; Pilot Projects; Platelet Count; Thrombocytopenia | 2002 |
Population pharmacokinetics and concentration-effect relationships of capecitabine metabolites in colorectal cancer patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged | 2003 |
Pharmacokinetics of capecitabine (Xeloda) in Japanese and Caucasian patients with breast cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; beta-Alanine; Biotransformation; Breast Neoplasms; Capecitabine; Deoxycytidine; Female; Fluorouracil; Half-Life; Humans; Japan; Metabolic Clearance Rate; Middle Aged; Tissue Distribution; White People | 2003 |
63 other study(ies) available for alpha-fluoro-beta-alanine and beta-alanine
| Article | Year |
|---|---|
Inhibition of D-3-aminoisobutyrate-pyruvate aminotransferase by 5-fluorouracil and alpha-fluoro-beta-alanine.
Topics: Alanine Transaminase; Animals; beta-Alanine; Fluorouracil; Kinetics; Liver; Rats; Thymine; Transaminases | 1992 |
Fluoroacetaldehyde as cardiotoxic impurity in fluorouracil (Roche)
Topics: Acetaldehyde; Animals; beta-Alanine; Drug Contamination; Fluoroacetates; Fluorouracil; Heart; Humans; In Vitro Techniques; Rabbits; Rats | 1991 |
[In-vivo 19F-MRS study of 5-fluorouracil (5-FU) metabolism on tumors].
Topics: Animals; beta-Alanine; Fluorine; Fluorouracil; Liver; Liver Neoplasms, Experimental; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred F344; Rats, Inbred Strains; Sarcoma, Yoshida; Tissue Distribution; Uridine Triphosphate | 1991 |
Disposition and metabolism of 2-fluoro-beta-alanine conjugates of bile acids following secretion into bile.
Topics: Animals; beta-Alanine; Bile; Bile Acids and Salts; Chromatography, High Pressure Liquid; Intestinal Absorption; Liver; Male; Microtubule-Associated Proteins; Models, Biological; Pyrimidines; Rats; Rats, Inbred Strains; Secretory Rate; Ursodeoxycholic Acid | 1991 |
Kinetic modeling of in vivo--nuclear magnetic resonance spectroscopy data: 5-fluorouracil in liver and liver tumors.
Topics: Adult; Aged; beta-Alanine; Female; Fluorine; Fluorouracil; Humans; Least-Squares Analysis; Liver; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Middle Aged; Urea | 1991 |
Multinuclear MR investigation of the metabolic response of the murine RIF-1 tumor to 5-fluorouracil chemotherapy.
Topics: Animals; beta-Alanine; Female; Fibrosarcoma; Fluorine; Fluorouracil; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Phosphates; Phosphocreatine; Phosphorus; Regression Analysis; Remission Induction; Skin Neoplasms | 1991 |
pH dependence of 5-fluorouracil uptake observed by in vivo 31P and 19F nuclear magnetic resonance spectroscopy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta-Alanine; Fibrosarcoma; Fluorine; Fluorouracil; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Phosphorus; Rats; Rats, Inbred Strains; Urea | 1991 |
Real-time follow-up of 5-fluorouracil metabolism in the liver of tumor patients by means of F-19 MR spectroscopy.
Topics: Adult; Aged; beta-Alanine; Female; Fluorine; Fluorouracil; Humans; Liver; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Middle Aged; Time Factors | 1990 |
2-Fluoro-beta-alanine, a previously unrecognized substrate for bile acid coenzyme A:amino acid:N-acyltransferase from human liver.
Topics: Acyltransferases; Alanine; Amidohydrolases; beta-Alanine; Bile Acids and Salts; Cholic Acids; Chromatography, High Pressure Liquid; Culture Techniques; Glycine; Humans; Kinetics; Liver; Substrate Specificity; Taurine | 1990 |
Experimental neurotoxicity of 5-fluorouracil and its derivatives is due to poisoning by the monofluorinated organic metabolites, monofluoroacetic acid and alpha-fluoro-beta-alanine.
Topics: Animals; Axons; beta-Alanine; Brain; Cats; Fluoroacetates; Fluorouracil; Microscopy, Electron; Neurotoxins; Organ Specificity; Vacuoles | 1990 |
In vivo 19F NMR spectroscopy of the antimetabolite 5-fluorouracil and its analogues. An assessment of drug metabolism.
Topics: Animals; Antineoplastic Agents; beta-Alanine; Carcinoid Tumor; Female; Floxuridine; Fluorouracil; Infusions, Intravenous; Liver; Magnetic Resonance Spectroscopy; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Tegafur | 1990 |
Nonlinear elimination kinetics of 5-fluoro-2'-deoxyuridine in isolated perfused rat liver and isolated hepatocytes.
Topics: Animals; beta-Alanine; Chromatography, Thin Layer; Floxuridine; Fluorouracil; Half-Life; Liver; Male; Rats; Rats, Inbred Strains | 1990 |
[Effect of uracil on the both reactions, 5-fluorouracil degradation into 2-fluoro-beta-alanine and 5-fluorouracil splitting from tegafur in human tumor].
Topics: Adenocarcinoma, Papillary; Alanine; beta-Alanine; Fluorouracil; Humans; Lung Neoplasms; Tegafur; Tumor Cells, Cultured; Uracil | 1989 |
Evidence for the importance of 5'-deoxy-5-fluorouridine catabolism in humans from 19F nuclear magnetic resonance spectrometry.
Topics: Aged; Antineoplastic Agents; beta-Alanine; Female; Floxuridine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Urea | 1986 |
Formation of conjugates of 2-fluoro-beta-alanine and bile acids during the metabolism of 5-fluorouracil and 5-fluoro-2-deoxyuridine in the isolated perfused rat liver.
Topics: Alanine; Animals; beta-Alanine; Bile; Bile Acids and Salts; Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Liver; Male; Perfusion; Rats | 1988 |
Metabolites of 5-fluorouracil in plasma and urine, as monitored by 19F nuclear magnetic resonance spectroscopy, for patients receiving chemotherapy with or without methotrexate pretreatment.
Topics: Aged; beta-Alanine; Blood Proteins; Chromatography, High Pressure Liquid; Female; Fluorides; Fluorouracil; Humans; Kinetics; Magnetic Resonance Spectroscopy; Male; Methotrexate; Middle Aged; Neoplasms; Protein Binding | 1988 |
Direct 19F NMR spectroscopic observation of 5-fluorouracil metabolism in the isolated perfused mouse liver model.
Topics: Animals; beta-Alanine; Fluorouracil; In Vitro Techniques; Liver; Magnetic Resonance Spectroscopy; Mice; Urea | 1988 |
Complete urinary excretion profile of 5-fluorouracil during a six-day chemotherapeutic schedule, as resolved by 19F nuclear magnetic resonance.
Topics: beta-Alanine; Fluorine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Radioisotopes; Urea | 1985 |
Dihydrofluorouracil, a fluorouracil catabolite with antitumor activity in murine and human cells.
Topics: Animals; Antineoplastic Agents; beta-Alanine; Breast Neoplasms; Carcinoma, Ehrlich Tumor; Cell Line; Cell Survival; Female; Fluorouracil; Humans; Male; Mice; Mice, Inbred Strains; Thymidylate Synthase | 1985 |
Effect of coadministration of uracil on the toxicity of tegafur.
Topics: Animals; beta-Alanine; Cats; Dogs; Female; Fluorouracil; Heart Diseases; Lethal Dose 50; Male; Mice; Nervous System Diseases; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Tegafur; Uracil | 1984 |
A mathematical model of the kinetics of 5-fluorouracil and its catabolites in freshly isolated rat hepatocytes.
Topics: Animals; beta-Alanine; Biological Transport; Fluorouracil; In Vitro Techniques; Kinetics; Liver; Mathematics; Models, Biological; Rats | 1984 |
Excretion of 1-hexylcarbamoyl-5-fluorouracil in urine of mice.
Topics: Animals; beta-Alanine; Female; Fluorouracil; Mice; Mice, Inbred Strains | 1981 |
Enzymatic elimination of fluoride from alpha-fluoro-beta-alanine.
Topics: Alanine; Alanine Transaminase; Amino Acid Sequence; Animals; Antimetabolites, Antineoplastic; beta-Alanine; Catalysis; Chemical Phenomena; Chemistry, Physical; Enzyme Activation; Enzyme Inhibitors; Fluorides; Fluorouracil; Glyoxylates; Kinetics; Liver; Malondialdehyde; Molecular Sequence Data; Rats; Stereoisomerism; Substrate Specificity; Transaminases | 1995 |
19F-[1H] nuclear Overhauser effect and proton decoupling of 5-fluorouracil and alpha-fluoro-beta-alanine.
Topics: beta-Alanine; Fluorouracil; Humans; Liver; Magnetic Resonance Spectroscopy | 1995 |
Ultrastructural localization of a fluorinated bile salt in hepatocytes.
Topics: Animals; beta-Alanine; Bile Acids and Salts; Cholic Acid; Cholic Acids; Fluorine; Liver; Male; Microscopy, Electron; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1994 |
5-Ethynyluracil (776C85): protection from 5-fluorouracil-induced neurotoxicity in dogs.
Topics: Animals; beta-Alanine; Central Nervous System Diseases; Dihydrouracil Dehydrogenase (NADP); Dogs; Dose-Response Relationship, Drug; Fluorouracil; Infusions, Intravenous; Male; Oxidoreductases; Uracil | 1994 |
Assessment of occupational exposure of pharmaceutical plant workers to 5-fluorouracil. Determination of alpha-fluoro-beta-alanine in urine.
Topics: Air Pollutants, Occupational; beta-Alanine; Drug Compounding; Drug Industry; Environmental Monitoring; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Metabolic Clearance Rate; Occupational Exposure; Protective Clothing | 1994 |
Selective 19F MR imaging of 5-fluorouracil and alpha-fluoro-beta-alanine.
Topics: Artifacts; beta-Alanine; Fluorouracil; Humans; Liver Neoplasms; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Models, Structural; Signal Processing, Computer-Assisted | 1993 |
Conversion of liposomal 5-fluoro-2'-deoxyuridine and its dipalmitoyl derivative to bile acid conjugates of alpha-fluoro-beta-alanine and their excretion into rat bile.
Topics: Animals; beta-Alanine; Bile; Bile Acids and Salts; Floxuridine; Liposomes; Male; Rats; Rats, Wistar; Tritium | 1993 |
A mathematical model of the kinetics and tissue distribution of 2-fluoro-beta-alanine, the major catabolite of 5-fluorouracil.
Topics: Animals; beta-Alanine; Body Fluid Compartments; Enterohepatic Circulation; Fluorouracil; Humans; Injections, Intravenous; Kinetics; Mathematical Computing; Models, Biological; Rats; Regression Analysis; Tissue Distribution | 1993 |
Simultaneous gas chromatographic-mass spectrophotometric determination of alpha-fluoro-beta-alanine and 5-fluorouracil in plasma.
Topics: Antimetabolites, Antineoplastic; beta-Alanine; Blood Proteins; Fluorobenzenes; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Linear Models; Osmolar Concentration; Reproducibility of Results | 1997 |
Proton-decoupled 19F spectroscopy of 5-FU catabolites in human liver.
Topics: beta-Alanine; Fluorouracil; Humans; Liver; Magnetic Resonance Spectroscopy; Phantoms, Imaging | 1997 |
Superiority of hepatic arterial infusion in preventing catabolism of 5-FU compared with portal vein infusion revealed by an in vivo 19F NMR study.
Topics: Animals; Antimetabolites, Antineoplastic; beta-Alanine; Fluorine; Fluorouracil; Hepatic Artery; Infusions, Intra-Arterial; Infusions, Intravenous; Isotopes; Magnetic Resonance Spectroscopy; Male; Portal Vein; Rats; Rats, Wistar; Tail | 1998 |
beta-alanine and alpha-fluoro-beta-alanine concentrative transport in rat hepatocytes is mediated by GABA transporter GAT-2.
Topics: Animals; beta-Alanine; Biological Transport; Carrier Proteins; Cell Line; Chlorides; Dogs; GABA Plasma Membrane Transport Proteins; Kidney; Liver; Male; Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Sodium; Uridine | 1999 |
Alterations of intratumoral pharmacokinetics of 5-fluorouracil in head and neck carcinoma during simultaneous radiochemotherapy.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Biotransformation; Carboplatin; Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorine; Fluorouracil; Head and Neck Neoplasms; Humans; Isotopes; Lymphatic Metastasis; Magnetic Resonance Imaging; Male; Middle Aged | 1999 |
Biochemical modulation of the catabolism and tissue uptake of the anticancer drug 5-fluorouracil by 5-bromovinyluracil: assessment with metabolic (19)F MR imaging.
Topics: Animals; Antimetabolites, Antineoplastic; beta-Alanine; Biotransformation; Bromouracil; Cell Division; Dose-Response Relationship, Drug; Fluorouracil; Immunologic Factors; Liver; Liver Neoplasms, Experimental; Magnetic Resonance Imaging; Male; Muscle, Skeletal; Neoplasm Transplantation; Rats; Rats, Inbred ACI; Tissue Distribution; Tumor Cells, Cultured | 1999 |
alpha-fluoro-beta-alanine: effects on the antitumor activity and toxicity of 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; beta-Alanine; Colonic Neoplasms; Colorectal Neoplasms; Drug Interactions; Female; Fluorouracil; Mice; Multiple Myeloma; Neoplasm Transplantation; Rats; Rats, Inbred F344; Tumor Cells, Cultured | 2000 |
[Comparison of pharmacokinetics of 5-FU and alpha-fluoro-beta-alanine, a metabolite of 5-FU, in plasma after administration of UFT, tegafur, 5-FU or doxifluridine to rats].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Floxuridine; Fluorouracil; Male; Rats; Rats, Sprague-Dawley; Tegafur; Uracil | 2000 |
Gallbladder localization of (19)F MRS catabolite signals in patients receiving bolus and protracted venous infusional 5-fluorouracil.
Topics: Aged; Antimetabolites, Antineoplastic; beta-Alanine; Female; Fluorouracil; Gallbladder; Humans; Liver; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male | 2000 |
Optimization of localized 19F magnetic resonance spectroscopy for the detection of fluorinated drugs in the human liver.
Topics: Antimetabolites, Antineoplastic; beta-Alanine; Fluorine Radioisotopes; Fluorouracil; Humans; Liver; Liver Neoplasms; Magnetic Resonance Spectroscopy; Phantoms, Imaging | 2003 |
Some metabolic and enzymic experiments with alpha-fluoro-beta-alanine.
Topics: Alanine; beta-Alanine; Biochemical Phenomena; Fluorides; Humans | 1963 |
Neurotoxic effects of alpha-fluoro-beta-alanine (FBAL) and fluoroacetic acid (FA) on dogs.
Topics: Administration, Oral; Animals; beta-Alanine; Dogs; Fluoroacetates; Fluorouracil; Hyperesthesia; Male; Neurotoxicity Syndromes; Rodenticides; Seizures; Telencephalon; Toxicity Tests; Vacuoles | 2004 |
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
Topics: Antineoplastic Agents; beta-Alanine; Cell Line, Tumor; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Foot Dermatoses; Hand Dermatoses; Humans; Inhibitory Concentration 50; Keratinocytes; Syndrome; Thymidine Phosphorylase | 2004 |
Assay of urinary alpha-fluoro-beta-alanine by gas chromatography-mass spectrometry for the biological monitoring of occupational exposure to 5-fluorouracil in oncology nurses and pharmacy technicians.
Topics: Antimetabolites, Antineoplastic; beta-Alanine; Environmental Monitoring; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Occupational Exposure; Oncology Nursing; Technology, Pharmaceutical; Workforce | 2006 |
5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine.
Topics: Aged; Antimetabolites, Antineoplastic; beta-Alanine; Cardiovascular Diseases; Colonic Neoplasms; Drug Combinations; Electrocardiography; Fluorouracil; Heart; Humans; Liver Neoplasms; Lung Neoplasms; Male; Oxonic Acid; Tegafur | 2005 |
Systemic absorption of 5-fluorouracil during vitrectomy.
Topics: Absorption; Antimetabolites; beta-Alanine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Vitrectomy; Vitreoretinopathy, Proliferative; Vitreous Body | 2006 |
[Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil].
Topics: beta-Alanine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fluorouracil; Humans; Infusions, Intravenous; Kidney; Oxonic Acid; Stomach Neoplasms; Tegafur; Uracil | 2006 |
Alternative pharmacokinetics of S-1 components, 5-fluorouracil, dihydrofluorouracil and alpha-fluoro-beta-alanine after oral administration of S-1 following total gastrectomy.
Topics: Administration, Oral; Adult; Aged; Area Under Curve; beta-Alanine; Drug Combinations; Fluorouracil; Gastrectomy; Humans; Middle Aged; Oxonic Acid; Stomach Neoplasms; Tegafur | 2007 |
Pharmacokinetic study of S-1.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Area Under Curve; beta-Alanine; Biological Availability; Clinical Trials as Topic; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fasting; Fluorouracil; Food; Gastric Acidity Determination; Half-Life; Humans; Hydrogen-Ion Concentration; Oxonic Acid; Pantoprazole; Pyridines; Tegafur; Triazines; Uracil | 2009 |
Development of a sensitive and selective LC-MS/MS method for the determination of alpha-fluoro-beta-alanine, 5-fluorouracil and capecitabine in human plasma.
Topics: Antimetabolites, Antineoplastic; beta-Alanine; Capecitabine; Dansyl Compounds; Deoxycytidine; Fluorouracil; Humans; Indicators and Reagents; Mass Spectrometry; Methyl Ethers; Quality Control; Reference Standards; Reproducibility of Results; Specimen Handling | 2009 |
Biological monitoring of occupational exposure to 5-fluorouracil: urinary α-fluoro-β-alanine assay by high performance liquid chromatography tandem mass spectrometry in health care personnel.
Topics: Antimetabolites, Antineoplastic; beta-Alanine; Chromatography, High Pressure Liquid; Environmental Monitoring; Fluorouracil; Health Personnel; Humans; Limit of Detection; Occupational Exposure; Tandem Mass Spectrometry | 2010 |
Validation of an isocratic HPLC method to detect 2-fluoro-beta-alanine for the analysis of dihydropyrimidine dehydrogenase activity.
Topics: beta-Alanine; Cell Line, Tumor; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Dihydrouracil Dehydrogenase (NADP); Drug Stability; Fluorouracil; Humans; o-Phthalaldehyde; Reproducibility of Results; Sensitivity and Specificity; Sulfhydryl Compounds | 2010 |
Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites.
Topics: Animals; Antineoplastic Agents; Arabinofuranosyluracil; beta-Alanine; Chlorophyta; Cytarabine; Daphnia; Deoxycytidine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fluorouracil; Gemcitabine; Growth Inhibitors; Mutagenicity Tests; Mutagens; Pseudomonas; Salmonella; Toxicity Tests | 2010 |
The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC-MS.
Topics: Analysis of Variance; Antimetabolites, Antineoplastic; beta-Alanine; Cell Extracts; Cell Line, Tumor; Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Humans; Linear Models; Mass Spectrometry; Reproducibility of Results; Uracil; Urea | 2011 |
Pilot study of biological monitoring of four antineoplastic drugs among Canadian healthcare workers.
Topics: Adult; Antineoplastic Agents; beta-Alanine; Canada; Cross-Sectional Studies; Cyclophosphamide; Drug Monitoring; Environmental Monitoring; Female; Health Personnel; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Occupational Exposure; Personal Protective Equipment; Pilot Projects; Tandem Mass Spectrometry; Young Adult | 2017 |
Occupational exposures among nurses caring for chemotherapy patients -Quantitative analysis of cyclophosphamide and α-fluoro-β-alanine in urine.
Topics: Adult; Antineoplastic Agents; beta-Alanine; Cyclophosphamide; Female; Humans; Male; Middle Aged; Nurses; Occupational Exposure; Occupational Health; Protective Devices; Time Factors; Young Adult | 2016 |
Accumulation of alpha-fluoro-beta-alanine and fluoro mono acetate in a patient with 5-fluorouracil-associated hyperammonemia.
Topics: Aged; Ammonia; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Colorectal Neoplasms; Combined Modality Therapy; Diabetic Nephropathies; Fluoroacetates; Fluorouracil; Humans; Hyperammonemia; Male; Renal Dialysis | 2017 |
Biomonitoring of occupational exposure to 5-FU by assaying α-fluoro-β-alanine in urine with a highly sensitive UHPLC-MS/MS method.
Topics: beta-Alanine; Chromatography, High Pressure Liquid; Environmental Monitoring; Fluorouracil; Humans; Limit of Detection; Occupational Exposure; Sensitivity and Specificity; Tandem Mass Spectrometry | 2018 |
A new, sensitive and versatile assay for quantitative determination of α-fluoro-β-alanine (AFBA) in human urine by using the reversed-phase ultrahigh performance-tandem mass spectrometry (rp-UHPLC-MS/MS) system.
Topics: Antineoplastic Agents; beta-Alanine; Biotransformation; Calibration; Capecitabine; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Fluorouracil; Health Personnel; Humans; Occupational Exposure; Occupational Health; Reference Standards; Reproducibility of Results; Risk Assessment; Tandem Mass Spectrometry; Urinalysis | 2018 |
A direct, sensitive and efficient method for determination of alpha-fluoro-beta-alanine in urine: Evaluating the influence of magnesium isoglycyrrhizinate on excretion in rat model.
Topics: Animals; beta-Alanine; Chromatography, High Pressure Liquid; Limit of Detection; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Tandem Mass Spectrometry; Triterpenes | 2018 |
Successful management of hyperammonemia with hemodialysis on day 2 during 5-fluorouracil treatment in a patient with gastric cancer: a case report with 5-fluorouracil metabolite analyses.
Topics: Aged, 80 and over; Ammonia; Antimetabolites, Antineoplastic; beta-Alanine; Drug Administration Schedule; Fluoroacetates; Fluorouracil; Humans; Hyperammonemia; Male; Renal Dialysis; Stomach Neoplasms; Time Factors; Treatment Outcome | 2020 |
Worse capecitabine treatment outcome in patients with a low skeletal muscle mass is not explained by altered pharmacokinetics.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; beta-Alanine; Capecitabine; Female; Fluorouracil; Humans; Male; Middle Aged; Muscle, Skeletal; Neoplasms; Prodrugs; Sex Factors; Tomography, X-Ray Computed; Treatment Outcome | 2021 |
Development of a UPLC-MS/MS Assay for the Quantitative Determination of Capecitabine, 5'-deoxy-5-fluorocytidine (5'-dFCR), 5'-deoxy-5-fluorouridine (5'-dFUR), 5'-fluorouracil (5-FU), and α-fluoro-β-alanine (FBAL).
Topics: beta-Alanine; Capecitabine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Fluorouracil; Humans; Lithium; Prodrugs; Tandem Mass Spectrometry | 2023 |