alpha-cyclodextrin and titanium-dioxide

Photocatalytic properties of titanium dioxide nanoparticles (TiO

Topics: alpha-Cyclodextrins; Anti-Infective Agents; Benzoic Acid; beta-Cyclodextrins; Diffusion; Food Packaging; Food Preservation; Food Preservatives; Kinetics; Metal Nanoparticles; Sorbic Acid; Surface Properties; Titanium

This study describes a new means to conduct molecular recognition-based analysis using mass spectrometry. Taking advantage of the unique characteristic of the absorption capacity of the TiO(2) sol-gel material in the UV region, a TiO(2) sol-gel-deposited thin film was employed as the sample substrate to assist in UV laser desorption/ionization of analytes. Sol-gels are polymeric materials that are easy to prepare and modify at low temperatures. Molecularly imprinted TiO(2) sol-gels were generated for molecular recognition-based analysis. alpha-Cyclodextrin (CD) was selected as the template molecule and doped into TiO(2) in a sol-gel reaction. The molecularly imprinted TiO(2) sol was spin-coated on a glass slide, and appropriate template cavities in the TiO(2) sol-gel material were formed after the template molecules were removed. We demonstrate that this modified glass slide can be used to select alpha-CD from a sample solution containing equal amounts of alpha-, beta-, and gamma-CD (50 ppb each, 18 mL); alpha-CD was directly detected from the modified glass slide by matrix-assisted laser desorption/ionization mass spectrometry without the addition of extra matrix. This approach provides a new detection method for molecular recognition-based analysis.

Topics: alpha-Cyclodextrins; Bradykinin; Cyclodextrins; Cytochromes c; Insulin; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry; Titanium