alpha-cyclodextrin and tetraborate

In this study, a large volume sample stacking (LVSS) with polarity switching (PS) and cyclodextrin electrokinetic chromatography (CDEKC) method has been developed for the simultaneous separation and determination of 8 preservatives: methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP), isobutylparaben (IBP), sorbic acid (SA), benzoic acid (BA), p-hydroxybenzoic acid (PHBA) in pharmaceuticals. The effects of some typical parameters such as sample volume, applied voltage, composition and pH of the running buffer and organic modifier concentration were examined and optimized. Moreover, the impact of type and concentration of cyclodextrin as electrolyte modifiers was also investigated. The detection limits of analytes for the elaborated LVSS-PS-CDEKC method were found to be in 0.8-5 ng mL

Topics: alpha-Cyclodextrins; Ambroxol; Benzoic Acid; Borates; Chromatography, Micellar Electrokinetic Capillary; Electrophoresis; Hydroxybenzoates; Ketotifen; Parabens; Phenylbutyrates; Preservatives, Pharmaceutical; Sorbic Acid