alpha-chymotrypsin has been researched along with sulfuryl-fluoride* in 3 studies
3 other study(ies) available for alpha-chymotrypsin and sulfuryl-fluoride
| Article | Year |
|---|---|
Synthesis and biological evaluation of novel irreversible serine protease inhibitors using amino acid based sulfonyl fluorides as an electrophilic trap.
We have designed and synthesized novel irreversible serine protease inhibitors containing aliphatic sulfonyl fluorides as an electrophilic trap. These substituted taurine sulfonyl fluorides derived from taurine or protected amino acids were conveniently synthesized from β-aminoethanesulfonyl chlorides using KF/18-crown-6 or from β-aminoethanesulfonates using DAST. Their potency of irreversible inhibition of serine proteases is described in different enzyme assays using chymotrypsin leading to binding affinities up to 22 μM. Topics: Amino Acids; Binding Sites; Chymotrypsin; Kinetics; Serine Proteinase Inhibitors; Structure-Activity Relationship; Sulfinic Acids; Taurine | 2011 |
SULFONYL FLUORIDES AS INHIBITORS OF ESTERASES. 3. IDENTIFICATION OF SERINE AS THE SITE OF SULFONYLATION IN PHENYLMETHANESULFONYL ALPHA-CHYMOTRYPSIN.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Cysteine; Enzyme Inhibitors; Esterases; Hydrogen-Ion Concentration; Research; Serine; Sulfinic Acids; Sulfonic Acids | 1965 |
SULFONYL FLUORIDES AS INHIBITORS OF ESTERASES. II. FORMATION AND REACTIONS OF PHENYLMETHANESULFONYL ALPHA-CHYMOTRYPSIN.
Topics: Carbon Isotopes; Catalysis; Chymotrypsin; Dialysis; Dinitrophenols; Enzyme Inhibitors; Esterases; Fluorides; Hydrogen-Ion Concentration; Kinetics; Renal Dialysis; Research; Sulfinic Acids; Urea | 1964 |