alpha-chymotrypsin and silanediol

alpha-chymotrypsin has been researched along with silanediol* in 1 studies

Other Studies

1 other study(ies) available for alpha-chymotrypsin and silanediol

Article	Year
Serine protease inhibition by a silanediol peptidomimetic. Organic letters, 2012, Sep-07, Volume: 14, Issue:17 Silanediol peptidomimetics are demonstrated to inhibit a serine protease. Asymmetric synthesis of the inhibitor was accomplished using Brown hydroboration and CBS reduction of an acylsilane intermediate. The silanediol product was found to inhibit the serine protease chymotrypsin with a K(i) of 107 nM. Inhibition of the enzyme may involve exchange of a silane hydroxyl with the active site serine nucleophile, contrasting with previous silanediol protease inhibitors. Topics: Chymotrypsin; Molecular Structure; Peptidomimetics; Serine Proteinase Inhibitors; Silanes	2012

Article

Year

Serine protease inhibition by a silanediol peptidomimetic.

Organic letters, 2012, Sep-07, Volume: 14, Issue:17

Silanediol peptidomimetics are demonstrated to inhibit a serine protease. Asymmetric synthesis of the inhibitor was accomplished using Brown hydroboration and CBS reduction of an acylsilane intermediate. The silanediol product was found to inhibit the serine protease chymotrypsin with a K(i) of 107 nM. Inhibition of the enzyme may involve exchange of a silane hydroxyl with the active site serine nucleophile, contrasting with previous silanediol protease inhibitors.

Topics: Chymotrypsin; Molecular Structure; Peptidomimetics; Serine Proteinase Inhibitors; Silanes

2012