alpha-chymotrypsin and perfluorooctanoic-acid

alpha-chymotrypsin has been researched along with perfluorooctanoic-acid* in 1 studies

Other Studies

1 other study(ies) available for alpha-chymotrypsin and perfluorooctanoic-acid

Article	Year
Assessment of perfluorooctanoic acid toxicity in pancreatic cells. Toxicology in vitro : an international journal published in association with BIBRA, 2021, Volume: 72 Perfluorooctanoic acid (PFOA) was classified as a possible carcinogen for humans (Group 2B). The in vivo studies have reported that PFOA might lead to hepatic, testicular and pancreatic toxicities and cancers. However, its mechanisms in pancreatic tissue are still unclear and insufficiently discussed. Since inflammation is the most important mechanism leading to pancreatitis and ultimately cancer, we aimed to investigate the role of inflammation in PFOA-induced pancreatic toxicity. To this end, the effect of PFOA on cell viability, apoptosis, oxidative stress and inflammatory pathways, as well as levels of trypsin and chymotrypsin were assessed in the human pancreatic cell line (PANC-1). PFOA caused cell death in concentration dependent manner (IC Topics: Apoptosis; Caprylates; Catalase; Cell Line, Tumor; Cell Survival; Chymotrypsin; Fluorocarbons; Glutathione; Humans; Malondialdehyde; Oxidative Stress; Pancreas; Trypsin	2021

Article

Year

Assessment of perfluorooctanoic acid toxicity in pancreatic cells.

Toxicology in vitro : an international journal published in association with BIBRA, 2021, Volume: 72

Perfluorooctanoic acid (PFOA) was classified as a possible carcinogen for humans (Group 2B). The in vivo studies have reported that PFOA might lead to hepatic, testicular and pancreatic toxicities and cancers. However, its mechanisms in pancreatic tissue are still unclear and insufficiently discussed. Since inflammation is the most important mechanism leading to pancreatitis and ultimately cancer, we aimed to investigate the role of inflammation in PFOA-induced pancreatic toxicity. To this end, the effect of PFOA on cell viability, apoptosis, oxidative stress and inflammatory pathways, as well as levels of trypsin and chymotrypsin were assessed in the human pancreatic cell line (PANC-1). PFOA caused cell death in concentration dependent manner (IC

Topics: Apoptosis; Caprylates; Catalase; Cell Line, Tumor; Cell Survival; Chymotrypsin; Fluorocarbons; Glutathione; Humans; Malondialdehyde; Oxidative Stress; Pancreas; Trypsin

2021