alpha-chymotrypsin and lodelaben

alpha-chymotrypsin has been researched along with lodelaben* in 1 studies

Other Studies

1 other study(ies) available for alpha-chymotrypsin and lodelaben

Article	Year
SC-39026, a specific human neutrophil elastase inhibitor. Biochemical and biophysical research communications, 1987, Sep-15, Volume: 147, Issue:2 SC-39026, (+/-) 2-chloro-4-(1-hydroxyoctadecyl)benzoic acid, inhibits human neutrophil elastase with an IC50 of 0.5 microM (KI of 1.5 microM). Its inhibition of elastase is reversible and noncompetitive at low concentrations (0.5-1.25 microM). Inhibition is "mixed" at higher inhibitor concentrations. SC-39026 is inactive against hog pancreatic elastase, bovine alpha-chymotrypsin and Pseudomonas aeruginosa elastase, but does inhibit human neutrophil cathepsin G with an IC50 of approximately 2.5 microM. Neutrophil elastases isolated from rat, hamster, rabbit and hog are also inhibited by SC-39026. Topics: Animals; Cathepsin G; Cathepsins; Cattle; Chlorobenzoates; Chymotrypsin; Cricetinae; Humans; Neutrophils; Pancreas; Pancreatic Elastase; Pseudomonas aeruginosa; Rabbits; Rats; Serine Endopeptidases; Swine	1987

Article

Year

SC-39026, a specific human neutrophil elastase inhibitor.

Biochemical and biophysical research communications, 1987, Sep-15, Volume: 147, Issue:2

SC-39026, (+/-) 2-chloro-4-(1-hydroxyoctadecyl)benzoic acid, inhibits human neutrophil elastase with an IC50 of 0.5 microM (KI of 1.5 microM). Its inhibition of elastase is reversible and noncompetitive at low concentrations (0.5-1.25 microM). Inhibition is "mixed" at higher inhibitor concentrations. SC-39026 is inactive against hog pancreatic elastase, bovine alpha-chymotrypsin and Pseudomonas aeruginosa elastase, but does inhibit human neutrophil cathepsin G with an IC50 of approximately 2.5 microM. Neutrophil elastases isolated from rat, hamster, rabbit and hog are also inhibited by SC-39026.

Topics: Animals; Cathepsin G; Cathepsins; Cattle; Chlorobenzoates; Chymotrypsin; Cricetinae; Humans; Neutrophils; Pancreas; Pancreatic Elastase; Pseudomonas aeruginosa; Rabbits; Rats; Serine Endopeptidases; Swine

1987