alpha-chymotrypsin and icatibant

alpha-chymotrypsin has been researched along with icatibant* in 1 studies

Other Studies

1 other study(ies) available for alpha-chymotrypsin and icatibant

Article	Year
Potentiation of the effects of bradykinin on its receptor in the isolated guinea pig ileum. Peptides, 2000, Volume: 21, Issue:8 Angiotensin I-converting enzyme (ACE/kininase II) inhibitors potentiated guinea pig ileum's isotonic contractions to bradykinin (BK) and its analogues, shifting the BK dose-response curve to the left. ACE inhibitors added at the peak of the contraction immediately enhanced it further (343 +/- 40%), although the ileum inactivated BK slowly (t(1/2) = 12-16 min). Chymotrypsin and cathepsin G also augmented the activity of BK up to three- or four-fold, but in a manner slower than that of ACE inhibitors. The BK B(2) receptor blocker HOE 140 inhibited all effects. Histamine and angiotensin II were not potentiated. ACE inhibitors potentiate BK independent of blocking its inactivation by inducing crosstalk between ACE and the BK B(2) receptor; proteases activate the receptor by different mechanism. Topics: Animals; Bradykinin; Cathepsin G; Cathepsins; Chymotrypsin; Dose-Response Relationship, Drug; Drug Synergism; Enalaprilat; Guinea Pigs; Hydrolysis; Ileum; Peptidyl-Dipeptidase A; Radioimmunoassay; Receptors, Bradykinin; Serine Endopeptidases	2000

Article

Year

Potentiation of the effects of bradykinin on its receptor in the isolated guinea pig ileum.

Peptides, 2000, Volume: 21, Issue:8

Angiotensin I-converting enzyme (ACE/kininase II) inhibitors potentiated guinea pig ileum's isotonic contractions to bradykinin (BK) and its analogues, shifting the BK dose-response curve to the left. ACE inhibitors added at the peak of the contraction immediately enhanced it further (343 +/- 40%), although the ileum inactivated BK slowly (t(1/2) = 12-16 min). Chymotrypsin and cathepsin G also augmented the activity of BK up to three- or four-fold, but in a manner slower than that of ACE inhibitors. The BK B(2) receptor blocker HOE 140 inhibited all effects. Histamine and angiotensin II were not potentiated. ACE inhibitors potentiate BK independent of blocking its inactivation by inducing crosstalk between ACE and the BK B(2) receptor; proteases activate the receptor by different mechanism.

Topics: Animals; Bradykinin; Cathepsin G; Cathepsins; Chymotrypsin; Dose-Response Relationship, Drug; Drug Synergism; Enalaprilat; Guinea Pigs; Hydrolysis; Ileum; Peptidyl-Dipeptidase A; Radioimmunoassay; Receptors, Bradykinin; Serine Endopeptidases

2000