alpha-chymotrypsin and diphenyl

alpha-chymotrypsin has been researched along with diphenyl* in 1 studies

Other Studies

1 other study(ies) available for alpha-chymotrypsin and diphenyl

Article	Year
Novel diphenyl esters of peptidyl alpha-aminoalkylphosphonates as inhibitors of chymotrypsin and subtilisin. Journal of enzyme inhibition and medicinal chemistry, 2009, Volume: 24, Issue:6 The activities of novel Cbz-N-protected alpha-aminophosphonic phenyl esters, analogs of leucine (1-15) and phenylalanine (17-29), which are substituted at the phenyl ester rings, as well as of their peptidic derivatives (31-43), were investigated for their inhibitory effects on chymotrypsin and subtilisin. The chemical nature and position of the examined substituents clearly demonstrated a strong structure-activity relationship. Among all synthesized compounds the most potent phosphonic-type inhibitors of subtilisin and chymotrypsin were identified, with k(2)/K(i) values 114,380 M(-1)s(-1) and 307,380 M(-1)s(-1), respectively. Topics: Alkylation; Amines; Biphenyl Compounds; Chymotrypsin; Esters; Kinetics; Organophosphonates; Organophosphorus Compounds; Peptides; Serine Proteinase Inhibitors; Structure-Activity Relationship; Subtilisins	2009

Article

Year

Novel diphenyl esters of peptidyl alpha-aminoalkylphosphonates as inhibitors of chymotrypsin and subtilisin.

Journal of enzyme inhibition and medicinal chemistry, 2009, Volume: 24, Issue:6

The activities of novel Cbz-N-protected alpha-aminophosphonic phenyl esters, analogs of leucine (1-15) and phenylalanine (17-29), which are substituted at the phenyl ester rings, as well as of their peptidic derivatives (31-43), were investigated for their inhibitory effects on chymotrypsin and subtilisin. The chemical nature and position of the examined substituents clearly demonstrated a strong structure-activity relationship. Among all synthesized compounds the most potent phosphonic-type inhibitors of subtilisin and chymotrypsin were identified, with k(2)/K(i) values 114,380 M(-1)s(-1) and 307,380 M(-1)s(-1), respectively.

Topics: Alkylation; Amines; Biphenyl Compounds; Chymotrypsin; Esters; Kinetics; Organophosphonates; Organophosphorus Compounds; Peptides; Serine Proteinase Inhibitors; Structure-Activity Relationship; Subtilisins

2009