alpha-chymotrypsin and carbetocin

alpha-chymotrypsin has been researched along with carbetocin* in 1 studies

Other Studies

1 other study(ies) available for alpha-chymotrypsin and carbetocin

Article	Year
Interaction of chymotrypsin with carbetocin ([1-deamino-1-monocarba-2-O-methyltyrosine]-oxytocin). Pharmacology & toxicology, 1997, Volume: 81, Issue:3 The results of the present study describe the course of reaction and the products following chymotrypsin treatment of the oxytocin analogue carbetocin ([1-deamino-1-monocarba-2-O-methyltyrosine]-oxytocin). The metabolites were analyzed and identified through TLC, HPLC and mass spectrometry. The main product emerging after treatment of carbetocin with chymotrypsin is 9-desglycineamide carbetocin indicating preferential hydrolysis of the peptide bond between leucine at position 8 and carboxyterminal glycineamide. At the same time the stability of the bond between tyrosine at position 2 and isoleucine at position 3 appears significantly enhanced through the alkylation of the hydroxyl group of tyrosine. Topics: Chromatography, High Pressure Liquid; Chymotrypsin; Delayed-Action Preparations; Drug Interactions; Glycine; Injections, Intravenous; Oxytocics; Oxytocin; Tyrosine	1997

Article

Year

Interaction of chymotrypsin with carbetocin ([1-deamino-1-monocarba-2-O-methyltyrosine]-oxytocin).

Pharmacology & toxicology, 1997, Volume: 81, Issue:3

The results of the present study describe the course of reaction and the products following chymotrypsin treatment of the oxytocin analogue carbetocin ([1-deamino-1-monocarba-2-O-methyltyrosine]-oxytocin). The metabolites were analyzed and identified through TLC, HPLC and mass spectrometry. The main product emerging after treatment of carbetocin with chymotrypsin is 9-desglycineamide carbetocin indicating preferential hydrolysis of the peptide bond between leucine at position 8 and carboxyterminal glycineamide. At the same time the stability of the bond between tyrosine at position 2 and isoleucine at position 3 appears significantly enhanced through the alkylation of the hydroxyl group of tyrosine.

Topics: Chromatography, High Pressure Liquid; Chymotrypsin; Delayed-Action Preparations; Drug Interactions; Glycine; Injections, Intravenous; Oxytocics; Oxytocin; Tyrosine

1997