alpha-asarone and tetramethylpyrazine

alpha-asarone has been researched along with tetramethylpyrazine* in 1 studies

Other Studies

1 other study(ies) available for alpha-asarone and tetramethylpyrazine

Article	Year
Borneol and Α-asarone as adjuvant agents for improving blood-brain barrier permeability of puerarin and tetramethylpyrazine by activating adenosine receptors. Drug delivery, 2018, Volume: 25, Issue:1 Puerarin (PUE) and tetramethylpyrazine (TMP) are central nervous system (CNS) drugs used in cerebrovascular diseases. Poor brain-blood barrier (BBB) permeability limited their clinical application. Borneol and α-asarone have been proposed as an oral brain-targeting enhancer. In this study, we aimed to first evaluate the 'orifice-opening' effect of borneol and α-asarone, both aromatic resuscitation drugs, on improvement of brain delivery of PUE and TMP and second to investigate whether the enhancing effects were associated with adenosine receptors (ARs)-mediated trans-BBB pathway. In vitro BBB model was established and borneol and α-asarone significantly increased the cumulative amount of permeated PUE and TMP and the enhancing effects could be counteracted by AR inhibitors. Borneol and α-asarone could decrease expression of ZO-1, an important BBB junction protein, but inversely increase the expression of A Topics: Adjuvants, Pharmaceutic; Allylbenzene Derivatives; Animals; Anisoles; Biological Transport; Blood-Brain Barrier; Camphanes; Cell Line; Humans; Isoflavones; Male; Mice; Permeability; Pyrazines; Rats, Sprague-Dawley; Receptors, Purinergic P1	2018

Article

Year

Borneol and Α-asarone as adjuvant agents for improving blood-brain barrier permeability of puerarin and tetramethylpyrazine by activating adenosine receptors.

Drug delivery, 2018, Volume: 25, Issue:1

Puerarin (PUE) and tetramethylpyrazine (TMP) are central nervous system (CNS) drugs used in cerebrovascular diseases. Poor brain-blood barrier (BBB) permeability limited their clinical application. Borneol and α-asarone have been proposed as an oral brain-targeting enhancer. In this study, we aimed to first evaluate the 'orifice-opening' effect of borneol and α-asarone, both aromatic resuscitation drugs, on improvement of brain delivery of PUE and TMP and second to investigate whether the enhancing effects were associated with adenosine receptors (ARs)-mediated trans-BBB pathway. In vitro BBB model was established and borneol and α-asarone significantly increased the cumulative amount of permeated PUE and TMP and the enhancing effects could be counteracted by AR inhibitors. Borneol and α-asarone could decrease expression of ZO-1, an important BBB junction protein, but inversely increase the expression of A

Topics: Adjuvants, Pharmaceutic; Allylbenzene Derivatives; Animals; Anisoles; Biological Transport; Blood-Brain Barrier; Camphanes; Cell Line; Humans; Isoflavones; Male; Mice; Permeability; Pyrazines; Rats, Sprague-Dawley; Receptors, Purinergic P1

2018