Page last updated: 2024-08-21

alpha-aminopyridine and ym 201636

alpha-aminopyridine has been researched along with ym 201636 in 24 studies

Research

Studies (24)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (8.33)	29.6817
2010's	21 (87.50)	24.3611
2020's	1 (4.17)	2.80

Authors

Authors	Studies
Boucheron, C; Cooke, FT; Hayakawa, M; Jat, P; Jefferies, HB; Kaizawa, H; Koizumi, T; Ohishi, T; Parker, PJ; Waterfield, MD; Workman, P	1
Ikonomov, OC; Sbrissa, D; Shisheva, A	2
Brown, DL; Brown, NF; Castro, NA; Hamilton, NA; Kerr, MC; Meunier, FA; Stow, JL; Teasdale, RD; Town, L; Wang, JT	1
Carter, CA; Chen, K; Chen, MH; Donaldson, J; Ehrlich, LS; Fernandes, F; Jin, J; Medina, GN; Montelaro, R; Symons, M; Tjandra, N	1
Bolino, A; Cerri, F; Chicanne, G; Dina, G; Kaufman, E; Meisler, MH; Payrastre, B; Quattrini, A; Tronchère, H; Vaccari, I; Weisman, LS; Wrabetz, L	1
Chalmers, AD; Dukes, JD; Whitley, P	1
Hill, EV; Hollmann, M; Lang, F; Manahan-Vaughan, D; Neumann, S; Novkovic, T; Seebohm, G; Strutz-Seebohm, N; Tavaré, JM; Theiss, C	1
Delvecchio, K; Filios, C; Ikonomov, OC; Sbrissa, D; Shisheva, A	1
Hazeki, K; Hazeki, O; Ishikawa, Y; Kubota, K; Masuda, A; Nigorikawa, K; Nukuda, A; Segawa, T; Takaba, Y; Takasuga, S	1
Coulson, EJ; Harper, CB; Martin, S; May, LM; Meunier, FA; Osborne, SL	1
Bak, G; Hwang, JU; Kato, M; Lee, EJ; Lee, Y; Maeshima, M; Segami, S; Sze, H	1
Hazeki, K; Hazeki, O; Nigorikawa, K; Uehara, M	1
Botelho, RJ; Dayam, RM; Kim, GH; Prashar, A; Terebiznik, M	1
Eguchi, T; Ichikawa, S; Iwabuchi, Y; Iwasaki, H; Kanoh, N; Kazami, S; Kudo, F; Mano, K; Nagumo, Y; Nishiyama, Y; Ohmichi, T; Osada, H; Usui, T	1
Compton, LM; Garg, P; Ikonomov, OC; Sbrissa, D; Shisheva, A	1
Hirano, T; Munnik, T; Sato, MH	1
Bauer, A; Bernardino, A; Brennan, D; Cook, B; Farrow, N; Fogarty, K; Kashem, M; Molinaro, T; Nelson, R	1
Becker, L; Biel, M; Butz, ES; Chao, YK; Chen, CC; Grimm, C; Grishchuk, Y; Heller, S; Slaugenhaupt, SA; Wahl-Schott, C	1
Botelho, RJ; Choy, CH; Dayam, RM; Glogauer, M; Mancuso, G; Sun, CX	1
Guo, YK; Hirano, T; Li, E; Li, S; Ma, T; Sato, MH; Wan, ZY; Yu, SX; Zhang, WT; Zhang, Y	1
Fang, D; Hou, JZ; Li, W; Liang, C; Niu, J; Sun, H; Wang, X; Xi, ZQ; Xie, SQ	1
Ask, EH; Brech, A; Clancy, T; Clement, D; Goodridge, JP; Grimm, C; Hammer, Q; Jacobs, B; Kjällquist, U; Landskron, J; Linnarsson, S; Liu, LL; Lorenz, S; Louch, WE; Malmberg, KJ; Meza-Zepeda, L; Oei, VYS; Patel, S; Pfefferle, A; Saetersmoen, ML; Skarpen, E; Stenmark, H; Taskén, K; Wiiger, MT	1
Huang, YW; Qin, P; Zhao, Z	1

Reviews

2 review(s) available for alpha-aminopyridine and ym 201636

Article	Year
Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations. Toxicology and applied pharmacology, 2019, 11-15, Volume: 383 Topics: Aminopyridines; Animals; Antineoplastic Agents; Heterocyclic Compounds, 3-Ring; Humans; Neoplasms; Phosphatidylinositol 3-Kinases; Protein Binding; Translational Research, Biomedical	2019
Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2. Cell calcium, 2021, Volume: 94 Topics: Aminopyridines; Antiviral Agents; COVID-19; Drug Design; Endocytosis; Endosomes; Heterocyclic Compounds, 3-Ring; Humans; Hydrazones; Ion Channels; Lysosomes; Models, Biological; Morpholines; Pyrimidines; SARS-CoV-2; Vacuolar Proton-Translocating ATPases; Viral Envelope; Virus Internalization; Virus Uncoating	2021

Article

Year

Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations.

Toxicology and applied pharmacology, 2019, 11-15, Volume: 383

Topics: Aminopyridines; Animals; Antineoplastic Agents; Heterocyclic Compounds, 3-Ring; Humans; Neoplasms; Phosphatidylinositol 3-Kinases; Protein Binding; Translational Research, Biomedical

2019

Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2.

Cell calcium, 2021, Volume: 94

Topics: Aminopyridines; Antiviral Agents; COVID-19; Drug Design; Endocytosis; Endosomes; Heterocyclic Compounds, 3-Ring; Humans; Hydrazones; Ion Channels; Lysosomes; Models, Biological; Morpholines; Pyrimidines; SARS-CoV-2; Vacuolar Proton-Translocating ATPases; Viral Envelope; Virus Internalization; Virus Uncoating

2021

Other Studies

22 other study(ies) available for alpha-aminopyridine and ym 201636

Article	Year
A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO reports, 2008, Volume: 9, Issue:2 Topics: Aminopyridines; Animals; Biological Transport; Biomarkers; Cell Membrane; Endosomes; Enzyme Inhibitors; Heterocyclic Compounds, 3-Ring; Lysosomes; Mice; NIH 3T3 Cells; Phosphatidylinositol Phosphates; Phosphotransferases (Alcohol Group Acceptor); Retroviridae	2008
YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes. Biochemical and biophysical research communications, 2009, May-08, Volume: 382, Issue:3 Topics: Adipocytes; Aminopyridines; Animals; Antiviral Agents; Glucose; Glucose Transporter Type 4; Heterocyclic Compounds, 3-Ring; Insulin; Insulin Antagonists; Mice; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Protein Transport; Retroviridae; Virus Replication	2009
Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella. The EMBO journal, 2010, Apr-21, Volume: 29, Issue:8 Topics: Aminopyridines; Animals; Bacterial Proteins; Cell Line; Endocytosis; Endosomes; Heterocyclic Compounds, 3-Ring; Humans; Lysosomes; Macrophages; Membrane Proteins; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pinocytosis; rab GTP-Binding Proteins; rab7 GTP-Binding Proteins; RNA Interference; Salmonella typhimurium; Vacuoles	2010
Phosphoinositides direct equine infectious anemia virus gag trafficking and release. Traffic (Copenhagen, Denmark), 2011, Volume: 12, Issue:4 Topics: Acid Anhydride Hydrolases; Aminopyridines; Animals; Antiviral Agents; Cell Membrane; Cells, Cultured; Chlorocebus aethiops; COS Cells; Gene Products, gag; Heterocyclic Compounds, 3-Ring; HIV-1; Horses; Humans; Infectious Anemia Virus, Equine; Mutation; Phosphatidylinositol Phosphates; Protein Binding; Protein Transport; Transfection; Virus Assembly	2011
Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies. PLoS genetics, 2011, Volume: 7, Issue:10 Topics: Aminopyridines; Animals; Axons; Charcot-Marie-Tooth Disease; Flavoproteins; Heterocyclic Compounds, 3-Ring; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Myelin Sheath; Neurons; Peripheral Nerves; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide Phosphatases; Phospholipids; Protein Tyrosine Phosphatases, Non-Receptor; Rats; Schwann Cells	2011
The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PloS one, 2012, Volume: 7, Issue:3 Topics: Aminopyridines; Animals; Calcium; Claudin-1; Claudins; Cycloheximide; Dogs; Endocytosis; Endosomal Sorting Complexes Required for Transport; Epithelium; Heterocyclic Compounds, 3-Ring; Membrane Proteins; Microscopy, Fluorescence; Permeability; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Protein Transport; Tight Junctions	2012
Identification of a novel signaling pathway and its relevance for GluA1 recycling. PloS one, 2012, Volume: 7, Issue:3 Topics: Aminopyridines; Animals; Animals, Newborn; Enzyme Inhibitors; Heterocyclic Compounds, 3-Ring; Hippocampus; Immediate-Early Proteins; Mice; Mice, Inbred C57BL; Oocytes; Phosphatidylinositol Phosphates; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; rab GTP-Binding Proteins; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Signal Transduction; Up-Regulation; Xenopus	2012
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636. American journal of physiology. Cell physiology, 2012, Aug-15, Volume: 303, Issue:4 Topics: 3T3-L1 Cells; Aminopyridines; Animals; CHO Cells; Cricetinae; DNA-Binding Proteins; HEK293 Cells; Heterocyclic Compounds, 3-Ring; Humans; Insulin; Mice; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; RNA-Binding Proteins	2012
Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics. FEBS letters, 2012, Nov-16, Volume: 586, Issue:22 Topics: Aminopyridines; Animals; Cell Line; Female; Heterocyclic Compounds, 3-Ring; Macrophages; Mice; Microscopy, Fluorescence; Phagosomes; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; PTEN Phosphohydrolase; RNA Interference	2012
Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death. PloS one, 2013, Volume: 8, Issue:3 Topics: Aminopyridines; Animals; Apoptosis; Autophagy; Endocytosis; Endosomes; Heterocyclic Compounds, 3-Ring; Hippocampus; Immunohistochemistry; Lysosomes; Mice; Mice, Inbred C57BL; Neuroendocrine Cells; Neurons; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Transport; Rats; Vacuoles	2013
Rapid structural changes and acidification of guard cell vacuoles during stomatal closure require phosphatidylinositol 3,5-bisphosphate. The Plant cell, 2013, Volume: 25, Issue:6 Topics: Abscisic Acid; Aminopyridines; Arabidopsis; Arabidopsis Proteins; Butyrates; Gene Expression Regulation, Plant; Green Fluorescent Proteins; Heterocyclic Compounds, 3-Ring; Hydrogen-Ion Concentration; Inorganic Pyrophosphatase; Microscopy, Confocal; Mutation; Phosphatidylinositol Phosphates; Phosphotransferases (Alcohol Group Acceptor); Plant Growth Regulators; Plant Stomata; Plants, Genetically Modified; Reverse Transcriptase Polymerase Chain Reaction; Vacuolar Proton-Translocating ATPases; Vacuoles; Vicia faba	2013
PIKfyve regulates the endosomal localization of CpG oligodeoxynucleotides to elicit TLR9-dependent cellular responses. PloS one, 2013, Volume: 8, Issue:9 Topics: Aminopyridines; Animals; Biological Transport; Cell Line; Cytokines; Endosomes; Female; Gene Expression Regulation; Gene Knockdown Techniques; Heterocyclic Compounds, 3-Ring; Macrophages, Peritoneal; Mice; Oligodeoxyribonucleotides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; RNA, Messenger; Signal Transduction; Toll-Like Receptor 9	2013
PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages. Traffic (Copenhagen, Denmark), 2014, Volume: 15, Issue:10 Topics: Aminopyridines; Animals; Cathepsin D; Cell Line; Endosomes; Enzyme Inhibitors; Heterocyclic Compounds, 3-Ring; Lysosomal-Associated Membrane Protein 1; Macrophages; Mice; Phagocytosis; Phagosomes; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Protein Transport; Receptors, IgG	2014
Vicenistatin induces early endosome-derived vacuole formation in mammalian cells. Bioscience, biotechnology, and biochemistry, 2016, Volume: 80, Issue:5 Topics: Aminoglycosides; Aminopyridines; Animals; Anti-Bacterial Agents; Cell Line; Cholesterol; Endocytosis; Endosomes; Fibroblasts; Flavoproteins; Gene Expression Regulation; HEK293 Cells; HeLa Cells; Heterocyclic Compounds, 3-Ring; Humans; Intracellular Signaling Peptides and Proteins; Lactams; Liposomes; Macrolides; Membrane Fusion; Membrane Proteins; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoric Monoester Hydrolases; Protein Transport; rab5 GTP-Binding Proteins; Rats; Signal Transduction; Transport Vesicles; Vacuoles	2016
Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency. American journal of physiology. Cell physiology, 2016, 09-01, Volume: 311, Issue:3 Topics: Aminopyridines; Animals; Cell Line; Cell Membrane; Chlorocebus aethiops; Class III Phosphatidylinositol 3-Kinases; COS Cells; Endocytosis; Endosomes; Heterocyclic Compounds, 3-Ring; Macrolides; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphatidylinositols; rab5 GTP-Binding Proteins; Vacuolar Proton-Translocating ATPases; Vacuoles	2016
Inhibition of phosphatidylinositol 3,5-bisphosphate production has pleiotropic effects on various membrane trafficking routes in Arabidopsis. Plant & cell physiology, 2017, 01-01, Volume: 58, Issue:1 Topics: Aminopyridines; Antiporters; Arabidopsis; Arabidopsis Proteins; Cell Membrane; Endosomes; Gene Expression Regulation, Plant; Genetic Pleiotropy; Golgi Apparatus; Green Fluorescent Proteins; Heterocyclic Compounds, 3-Ring; Membrane Transport Proteins; Microscopy, Confocal; Mutation; Phosphatidylinositol Phosphates; Phosphotransferases (Alcohol Group Acceptor); Plant Roots; Plants, Genetically Modified; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; Vacuoles	2017
Development of Three Orthogonal Assays Suitable for the Identification and Qualification of PIKfyve Inhibitors. Assay and drug development technologies, 2017, Volume: 15, Issue:5 Topics: Aminopyridines; Animals; Dose-Response Relationship, Drug; Electrophoresis, Gel, Pulsed-Field; Enzyme Inhibitors; HEK293 Cells; Heterocyclic Compounds, 3-Ring; Humans; Microfluidic Analytical Techniques; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Sf9 Cells	2017
Small Molecules for Early Endosome-Specific Patch Clamping. Cell chemical biology, 2017, Jul-20, Volume: 24, Issue:7 Topics: Action Potentials; Aminopyridines; Androstadienes; Bridged Bicyclo Compounds, Heterocyclic; CD11b Antigen; Endosomes; HEK293 Cells; Heterocyclic Compounds, 3-Ring; Humans; Lung; Lysosomal-Associated Membrane Protein 1; Lysosomes; Macrophages; Macrophages, Peritoneal; Patch-Clamp Techniques; rab GTP-Binding Proteins; rab5 GTP-Binding Proteins; rab7 GTP-Binding Proteins; Thiazolidines; Transient Receptor Potential Channels; Wortmannin	2017
The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase. Journal of immunology (Baltimore, Md. : 1950), 2017, 09-15, Volume: 199, Issue:6 Topics: Aminopyridines; Animals; Cell Degranulation; Cells, Cultured; Chemotaxis; GTP Phosphohydrolases; Heterocyclic Compounds, 3-Ring; Humans; Hydrazones; Lysosomal-Associated Membrane Protein 1; Lysosomes; Membrane Fusion; Mice; Mice, Inbred Strains; Morpholines; Neutrophils; Phagocytosis; Phagosomes; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Reactive Oxygen Species; Transient Receptor Potential Channels; Triazines	2017
Arabidopsis Plant physiology, 2018, Volume: 177, Issue:4 Topics: Aminopyridines; Arabidopsis; Arabidopsis Proteins; Flowers; Gene Expression Regulation, Plant; Heterocyclic Compounds, 3-Ring; Membrane Proteins; Mutation; Phosphatidylinositol Phosphates; Plants, Genetically Modified; Pollen; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Vacuoles	2018
Inhibition of PIKfyve using YM201636 suppresses the growth of liver cancer via the induction of autophagy. Oncology reports, 2019, Volume: 41, Issue:3 Topics: Adult; Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Heterocyclic Compounds, 3-Ring; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Xenograft Model Antitumor Assays	2019
Remodeling of secretory lysosomes during education tunes functional potential in NK cells. Nature communications, 2019, 01-31, Volume: 10, Issue:1 Topics: Aminopyridines; Animals; Granzymes; Heterocyclic Compounds, 3-Ring; Humans; K562 Cells; Killer Cells, Natural; Lysosomal-Associated Membrane Protein 1; Lysosomes; Mice; Receptors, KIR; Signal Transduction	2019