alpha-aminopyridine has been researched along with thiophenes in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.13) | 18.7374 |
| 1990's | 4 (12.50) | 18.2507 |
| 2000's | 9 (28.13) | 29.6817 |
| 2010's | 15 (46.88) | 24.3611 |
| 2020's | 3 (9.38) | 2.80 |
| Authors | Studies |
|---|---|
| Kammerer, RC; Schmitz, DA | 1 |
| Benham, CD; Harries, MH; Meadows, HJ; Thompson, M | 1 |
| Benham, CD; Blackburn, TP; Kumar, CS; Meadows, HJ; Pritchett, DB | 1 |
| Bright, F; Kennett, GA; Trail, B | 1 |
| Dekeyne, A; Girardon, S; Millan, MJ | 1 |
| Hutcheon, B; Morley, P; Poulter, MO | 1 |
| Bernardino, AM; Borges, JC; Carvalho, JM; Castro, HC; da Silva Pinheiro, LC; Ferreira, VF; Frugulhetti, IC; Lanfredi-Rangel, A; Loureiro, NI; Rodrigues, CR; Romeiro, GA; Sabatini-Lopes, J; Vannier-Santos, MA | 1 |
| Bertaina-Anglade, V; Boyer, PA; la Rochelle, CD; Mocaër, E | 1 |
| Burón, E; Martín-López, M; Navarro, JF | 2 |
| Ing, T; Poulter, MO | 1 |
| Adler, M; Arnaiz, DO; Cheeseman, S; Chou, YL; Dole, WP; Ewing, J; Fitch, R; Griedel, BD; Karanjawala, R; Kochanny, MJ; Lee, W; Lentz, D; Liang, A; Light, D; Morrissey, MM; Morser, J; Post, J; Rumennik, G; Sacchi, KL; Sakata, ST; Shaw, KJ; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Wu, SC; Ye, B; Zhao, Z | 1 |
| Asaka, M; Hattori, T; Katsurada, T; Nagai, K; Ohkawara, T; Sadakane, C; Takeda, H | 1 |
| Coutinho, OP; Moreno, AJ; Pinto-Basto, D; Queiroz, MJ; Silva, JP | 1 |
| Long, BC; Miller, BH; Pletcher, MT; Schultz, LE | 1 |
| Altun, M; Dianov, GL; Fischer, R; Goldenberg, SJ; Kessler, BM; Khoronenkova, SV; Kogan, E; Konietzny, R; Kramer, HB; Kumar, KG; Leach, CA; Mackeen, MM; McDermott, JL; McGouran, J; Nicholson, B; Parsons, JL; Willems, LI | 1 |
| Cho, JU; Jung, SH; Kim, SY; Lee, H; Park, TK; Phan, TN; Sun, X; Woo, SH; Yang, BS | 1 |
| Aliagas, I; Alicke, B; Boggs, JW; Buckmelter, AJ; Choo, EF; Dinkel, V; Gloor, SL; Gould, SE; Gradl, SN; Grina, J; Gunzner-Toste, J; Hansen, JD; Hastings, G; Hatzivassiliou, G; Laird, ER; Lee, W; Mathieu, S; Moreno, D; Pulk, R; Ran, Y; Ren, L; Rudolph, J; Voegtli, WC; Wen, Z; Wenglowsky, S; Zhao, G | 1 |
| Aherne, GW; Baxter, JE; Bayliss, R; Boxall, K; Cheung, KM; Fry, AM; Hardy, T; Hoelder, S; Innocenti, P; Mas-Droux, C; Pickard, L; Rowan, F; Solanki, S; Westlake, M; Yeoh, S | 1 |
| Jung, SH; Ryu, WS; Sun, X; Yang, BS | 1 |
| Fisher, JL; Heidelberg, LS; Warren, JW | 1 |
| Chen, S; Holden, JK; Hollingsworth, SA; Huang, H; Kang, S; Li, H; Lim, N; Poulos, TL; Silverman, RB; Tang, W; Xue, F | 1 |
| Cho, JU; Choi, S; Cui, M; Kim, BH; Kim, SY; Kim, TY; Kwon, YG; Lee, H; Lee, S; Lee, Y; Yang, BS; Yoo, H | 1 |
| Anzaldi, M; Galietta, LJ; Mazzei, M; Mazzei, MT; Nieddu, E; Pedemonte, N; Pollarolo, B; Schenone, S | 1 |
| Ahmad, S; Ali, A; Banerjea, AC; Farooqui, SR; Raja, R | 1 |
| Fraedrich, K; Friedrich, M; Matthaei, A; Rauch, P; Schubert, U; Setz, C; Traxdorf, M | 1 |
| Al-Horani, RA; Clemons Bankston, P | 1 |
| Barquissau, V; Castillo-Armengol, J; Dergai, O; Fajas, L; Giralt, A; Leal-Esteban, LC; Lopez-Mejia, IC; Martínez-Carreres, L; Moret, C; Nasrallah, A; Orpinell, M; Pabois, A; Puyal, J; Romero, P; Zhang, L | 1 |
| Cooper, SL; Hill, SJ; Jörg, M; March, J; Sabbatini, AR; Scammells, PJ; Woolard, J | 1 |
| Hussar, DA | 1 |
| Allegra, A; Caserta, S; Innao, V; Musolino, C; Zaccuri, AM | 1 |
| Balbin, A; Cresta, S; Crystal, A; Curigliano, G; De Vita, S; Duhoux, FP; He, W; Huober, J; Jhaveri, K; Ji, Y; Juric, D; Kundamal, N; Layman, RM; Sheng, Q; Takahashi, S; Terret, C; Yap, YS | 1 |
2 review(s) available for alpha-aminopyridine and thiophenes
| Article | Year |
|---|---|
New Small Molecule Drugs for Thrombocytopenia: Chemical, Pharmacological, and Therapeutic Use Considerations.
Topics: Aminopyridines; Animals; Cinnamates; Drug Development; Humans; Morpholines; Oxazines; Pyridines; Pyrimidines; Receptors, Thrombopoietin; Small Molecule Libraries; Syk Kinase; Thiazoles; Thiophenes; Thrombocytopenia | 2019 |
Immune thrombocytopenia: options and new perspectives.
Topics: Aminopyridines; Antibodies, Monoclonal, Humanized; COVID-19; Histocompatibility Antigens Class I; Humans; Immunosuppressive Agents; Morpholines; Protein Kinase Inhibitors; Purpura, Thrombocytopenic, Idiopathic; Pyrimidines; Receptors, Fc; Receptors, Thrombopoietin; SARS-CoV-2; Syk Kinase; Thiazoles; Thiophenes | 2021 |
30 other study(ies) available for alpha-aminopyridine and thiophenes
| Article | Year |
|---|---|
Metabolism of methapyrilene by rat-liver homogenate.
Topics: Aminopyridines; Animals; Gas Chromatography-Mass Spectrometry; Liver; Male; Methapyrilene; Rats; Rats, Inbred Strains; Thiophenes | 1986 |
Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum.
Topics: Aminopyridines; Animals; Cells, Cultured; Cerebellum; Chloride Channels; GABA Modulators; gamma-Aminobutyric Acid; Rats; Receptors, GABA-A; Thiophenes | 1997 |
SB-205384: a GABA(A) receptor modulator with novel mechanism of action that shows subunit selectivity.
Topics: Aminopyridines; Animals; Female; GABA Modulators; Humans; Pyridines; Rats; Receptors, GABA-A; Recombinant Proteins; Thiophenes; Xenopus laevis; Zolpidem | 1998 |
Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated.
Topics: Aminopyridines; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Dose-Response Relationship, Drug; Indoles; Male; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes | 1998 |
Discriminative stimulus properties of the novel serotonin (5-HT)2C receptor agonist, RO 60-0175: a pharmacological analysis.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Conditioning, Operant; Ethylamines; Fluorobenzenes; Indoles; Male; Mianserin; Piperazines; Piperidines; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Reinforcement, Psychology; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes | 1999 |
Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons.
Topics: Aminopyridines; Animals; Cells, Cultured; Cellular Senescence; Cerebral Cortex; Electric Conductivity; Electrophysiology; Embryo, Mammalian; GABA Modulators; Kinetics; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synapses; Thiophenes | 2000 |
Design, synthesis, SAR, and biological evaluation of new 4-(phenylamino)thieno[2,3-b]pyridine derivatives.
Topics: Aminopyridines; Animals; Antiprotozoal Agents; Giardia lamblia; Hominidae; Magnetic Resonance Spectroscopy; Mass Spectrometry; Structure-Activity Relationship; Thiophenes | 2006 |
Antidepressant-like effects of agomelatine (S 20098) in the learned helplessness model.
Topics: Acetamides; Aminopyridines; Animals; Antidepressive Agents; Avoidance Learning; Helplessness, Learned; Imipramine; Indoles; Male; Melatonin; Rats; Rats, Wistar; Receptors, Melatonin; Serotonin 5-HT2 Receptor Antagonists; Thiophenes | 2006 |
Anxiolytic-like activity of SB-205384 in the elevated plus-maze test in mice.
Topics: Aminopyridines; Animals; Anti-Anxiety Agents; Drug Evaluation, Preclinical; Exploratory Behavior; GABA Agonists; GABA-A Receptor Agonists; Male; Maze Learning; Mice; Random Allocation; Receptors, GABA-A; Stress, Psychological; Thiophenes | 2006 |
Diversity of GABA(A) receptor synaptic currents on individual pyramidal cortical neurons.
Topics: Aminopyridines; Animals; Cells, Cultured; Cerebral Cortex; Female; Furosemide; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Imidazoles; Inhibitory Postsynaptic Potentials; Pregnancy; Pyramidal Cells; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sodium Potassium Chloride Symporter Inhibitors; Synapses; Thiophenes; Zolpidem | 2007 |
Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors.
Topics: Amides; Aminopyridines; Animals; Anticoagulants; Crystallography, X-Ray; Dogs; Factor Xa Inhibitors; Humans; In Vitro Techniques; Male; Models, Molecular; ortho-Aminobenzoates; Prothrombin Time; Rats; Rats, Wistar; Structure-Activity Relationship; Thiophenes; Venous Thrombosis | 2007 |
Effects of SB-205384, a positive modulator of alpha3-subunit-containing GABA-A receptors, on isolation-induced aggression in male mice.
Topics: Aggression; Aminopyridines; Animals; Behavior, Animal; Male; Mice; Olfaction Disorders; Random Allocation; Receptors, GABA-A; Social Isolation; Thiophenes; Videotape Recording; Zinc Sulfate | 2008 |
Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.
Topics: Acylation; Aminopyridines; Animals; Anorexia; Antineoplastic Agents; Body Weight; Chalcones; Cisplatin; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Eating; Flavones; Gastric Mucosa; Gastrointestinal Agents; Ghrelin; Hesperidin; Indoles; Male; Oligopeptides; Piperazines; Protein Binding; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, Ghrelin; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Receptor Agonists; Stomach; Thiophenes; Vagotomy | 2008 |
Antioxidant activity of synthetic diarylamines: a mitochondrial and cellular approach.
Topics: Amines; Aminopyridines; Aniline Compounds; Animals; Antioxidants; Cell Survival; Chromans; Female; Lipid Peroxidation; Male; Membrane Potentials; Mitochondria; Mitochondria, Liver; Oxygen Consumption; PC12 Cells; Rats; Rats, Wistar; Thiophenes | 2009 |
Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice.
Topics: Aminopyridines; Animals; Behavior, Animal; Crosses, Genetic; Depression; Genotype; Hindlimb Suspension; Mice; Mice, Inbred C57BL; Mice, Inbred NZB; Quantitative Trait Loci; Receptors, GABA-A; Thiophenes | 2010 |
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Topics: Aminopyridines; Antibodies; Cell Line; Chromatography, High Pressure Liquid; Enzyme Activation; Enzyme Inhibitors; Humans; Proteomics; RNA Interference; Tandem Mass Spectrometry; Thiocyanates; Thiophenes; Ubiquitin Thiolesterase; Ubiquitin-Specific Peptidase 7 | 2011 |
LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation.
Topics: Aminopyridines; Animals; Cells, Cultured; Cicatrix; Discoidin Domain Receptors; Female; Fibroblasts; Humans; Macrophage Activation; Macrophages; Mice; Rabbits; Receptor Protein-Tyrosine Kinases; Receptors, Mitogen; src-Family Kinases; Thiophenes; Wound Healing | 2012 |
Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Mice; Models, Molecular; Molecular Structure; Neoplasm Transplantation; Proto-Oncogene Proteins B-raf; Quinazolines; Rats; Solubility; Structure-Activity Relationship; Thiophenes; Transplantation, Heterologous | 2012 |
Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity.
Topics: Alkenes; Aminopyridines; Antineoplastic Agents; Benzamides; Benzene Derivatives; Crystallography, X-Ray; Drug Design; Humans; Mitosis; Molecular Structure; NIMA-Related Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Stereoisomerism; Structure-Activity Relationship; Thiophenes | 2012 |
Topical administration of the pan-Src kinase inhibitors, dasatinib and LCB 03-0110, prevents allergic contact dermatitis in mice.
Topics: Adjuvants, Immunologic; Administration, Cutaneous; Aminopyridines; Animals; Anti-Inflammatory Agents; Atrophy; Dasatinib; Dermatitis, Allergic Contact; Drug Evaluation; Female; Mice; Mice, Hairless; Mice, Inbred BALB C; Oxazolone; Protein Kinase Inhibitors; Pyrimidines; Skin; Thiazoles; Thiophenes | 2013 |
SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits.
Topics: Allosteric Regulation; Aminopyridines; Animals; Gene Expression Regulation; HEK293 Cells; Humans; Rats; Receptors, GABA-A; Recombinant Proteins; Thiophenes | 2013 |
Structure-based design of bacterial nitric oxide synthase inhibitors.
Topics: Aminopyridines; Anti-Bacterial Agents; Bacteria; Binding Sites; Drug Design; Enzyme Inhibitors; Molecular Dynamics Simulation; Nitric Oxide Synthase; Structure-Activity Relationship; Thiophenes | 2015 |
Anti-angiogenic activity of thienopyridine derivative LCB03-0110 by targeting VEGFR-2 and JAK/STAT3 Signalling.
Topics: Adenosine Triphosphate; Aminopyridines; Angiogenesis Inhibitors; Animals; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cell Survival; CSK Tyrosine-Protein Kinase; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Janus Kinases; Lung Neoplasms; Male; Mice; Mice, Hairless; Mice, Inbred BALB C; Mice, Nude; Models, Molecular; Protein Structure, Secondary; Rats; Receptor, TIE-2; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Thiophenes; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2015 |
Phenylhydrazones as Correctors of a Mutant Cystic Fibrosis Transmembrane Conductance Regulator.
Topics: Aminopyridines; Benzodioxoles; Cell Line; Cystic Fibrosis Transmembrane Conductance Regulator; Furans; Humans; Hydrazones; Mutation; Structure-Activity Relationship; Thiophenes | 2016 |
USP7 deubiquitinase controls HIV-1 production by stabilizing Tat protein.
Topics: Aminopyridines; Anti-HIV Agents; Cell Line; CRISPR-Cas Systems; Enzyme Induction; Enzyme Inhibitors; Genes, Reporter; HEK293 Cells; HIV-1; Host-Pathogen Interactions; Humans; Jurkat Cells; Protein Stability; Recombinant Fusion Proteins; T-Lymphocytes; tat Gene Products, Human Immunodeficiency Virus; Thiocyanates; Thiophenes; Ubiquitin Thiolesterase; Ubiquitin-Specific Peptidase 7; Ubiquitination; Virus Replication | 2017 |
Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes.
Topics: Aminopyridines; Anti-HIV Agents; Deubiquitinating Enzymes; gag Gene Products, Human Immunodeficiency Virus; Genes, MHC Class I; HIV Infections; HIV-1; Humans; Thiocyanates; Thiophenes; Ubiquitination; Virus Replication | 2017 |
CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival.
Topics: Adenylate Kinase; Aminopyridines; Animals; Autophagosomes; Autophagy; Benzimidazoles; Biphenyl Compounds; Cell Line, Tumor; Cellular Senescence; Cyclin-Dependent Kinase 4; Drug Synergism; Female; Gene Knockout Techniques; Humans; Insulin; Lysosomes; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred NOD; Molecular Targeted Therapy; Neoplasm Proteins; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins; Pyrones; Recombinant Fusion Proteins; Signal Transduction; Thiophenes; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2019 |
The effect of two selective A
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Aminopyridines; Animals; Cardiovascular System; Consciousness; Drug Partial Agonism; Heart Rate; Hemodynamics; Ligands; Male; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Regional Blood Flow; Thiazoles; Thiophenes | 2020 |
New Drugs 2019, part 4.
Topics: Aminopyridines; Cinnamates; Drug Approval; Factor Xa; Humans; Macrolides; Morpholines; Oligonucleotides; Oxazines; Pyridines; Pyrimidines; Recombinant Proteins; RNA, Small Interfering; Sisomicin; Tetracyclines; Thiazoles; Thiophenes; United States; United States Food and Drug Administration | 2019 |
A Phase I Study of LSZ102, an Oral Selective Estrogen Receptor Degrader, with or without Ribociclib or Alpelisib, in Patients with Estrogen Receptor-Positive Breast Cancer.
Topics: Adult; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Purines; Receptors, Estrogen; Thiazoles; Thiophenes | 2021 |