alpha-aminopyridine has been researched along with rolipram in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (42.31) | 29.6817 |
| 2010's | 12 (46.15) | 24.3611 |
| 2020's | 3 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| Vignola, AM | 1 |
| Belleguic, C; Cupif, JF; David, M; Depince, A; Gouault, N; Martin-Chouly, CA; Pinel, B | 1 |
| Beume, R; Bundschuh, DS; Marx, D; Wohlsen, A; Wollin, L | 1 |
| Aggarwal, N; Arya, R; Bora, RS; Dastidar, S; Gupta, D; Malik, R; Ray, A; Saini, KS; Singh, V | 1 |
| Chaves, J; Lerner, A; Makkinje, A; Meyers, JA; Taverna, J | 1 |
| Barone, FC; Barton, ME; Kikkawa, H; Kinoshita, M; Kuratani, K; Legos, JJ; Shimamura, M; White, RF | 1 |
| Choi, HE; Chung, KS; Kwak, HJ; Lim, HJ; Park, HY; Park, KM | 1 |
| Harada, D; Ikeda, Y; Kobayashi, K; Manabe, H; Nosaka, Y | 1 |
| Angell, TD; Ballantine, SP; Cook, CM; Cooper, AW; Dawson, J; Delves, CJ; Hamblin, JN; Jones, PS; Lindvall, M; Lucas, FS; Mitchell, CJ; Neu, MY; Ranshaw, LE; Solanke, YE; Somers, DO; Wiseman, JO | 1 |
| Ahn, Y; Ertl, RF; Fredriksson, K; Holz, O; Kamio, K; Kawasaki, S; Kobayashi, T; Liu, X; Magnussen, H; Rennard, SI; Skold, CM; Sugiura, H; Togo, S; Wang, X | 1 |
| Ball, D; Barnette, MS; Capper-Spudich, EA; Davis, TG; Ferrari, L; Knowles, RG; Kou, JP; Lucas, FS; Nials, AT; Peterson, JJ; Podolin, PL; Solanke, YE; Williamson, RA; Wiseman, J; Wren, P | 1 |
| Beume, R; Hirrle, A; Marx, D; Tenor, H; Wohlsen, A | 1 |
| Germer, CT; Roewer, N; Schick, MA; Schlegel, N; Waschke, J; Wollborn, J; Wunder, C | 1 |
| Basma, H; Fahrid, M; Gunji, Y; Holz, O; Kanaji, N; Liu, X; Magnussen, H; Michalski, J; Muller, KC; Nakanishi, M; Nelson, A; Nogel, S; Rabe, KF; Rennard, SI; Sato, T; Toews, ML; Wang, X | 1 |
| Krug, O; Schänzer, W; Thevis, M | 1 |
| Arban, R; Cavallini, P; Davies, CH; Davis, TG; Gray, FA; Montanari, D; Negri, M; Poffe, A; Rutter, AR; Schneck, J; Vicentini, E; Wren, PB | 1 |
| Babu, CS; Jabaris, SG; Kumar, RS; Narayanan, S; Sumathy, H; Thanikachalam, S | 1 |
| Bury, A; Konrad, FM; Ngamsri, KC; Reutershan, J; Schick, MA | 1 |
| Girish, R; Jabaris, SS; Narayanan, S; Saravana Babu, C; Sugumar, M; Sumathy, H; Thanikachalam, M; Thanikachalam, S | 1 |
| Akkerman, S; Blokland, A; Creemers, P; De Vry, J; Prickaerts, J; Sambeth, A; Uz, T; van Duinen, M; Vanmierlo, T | 1 |
| Fan, CD; Hao, PD; Li, DW; Liu, X; Mao, LL; Sun, BL; Sun, JY; Yang, MF; Yang, XY; Zhang, HT; Zhang, ZY | 1 |
| Barnes, PJ; Davies, CM; Donnelly, LE; Dunne, AE; Fenwick, PS; Kawamatawong, T; Tullett, H | 1 |
| An, B; Hu, J; Huang, L; Li, X; Li, Z; Pan, T | 1 |
| Chen, Z; Gao, Y; Guo, L; He, X; Huang, L; Huang, YY; Li, Z; Liang, J; Liang, SH; Luo, HB; Wu, D; Wu, R; Yu, S; Zhou, Q | 1 |
| Abou Saleh, L; Aragon, IV; Boyd, A; Koloteva, A; McDonough, W; Murphy, JM; Rich, J; Richter, W | 1 |
| Aguiar, JA; Ask, K; Cao, Q; Doxey, AC; Hirota, JA; Hou, V; Huff, RD; Inman, MD; Kim, Y; Miller, MS; Revill, S; Tiessen, N | 1 |
1 review(s) available for alpha-aminopyridine and rolipram
| Article | Year |
|---|---|
PDE4 inhibitors in COPD--a more selective approach to treatment.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Benzamides; Bronchodilator Agents; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Nitriles; Phosphodiesterase Inhibitors; Pneumonia; Pulmonary Disease, Chronic Obstructive; Rolipram; Theophylline; Treatment Outcome | 2004 |
25 other study(ies) available for alpha-aminopyridine and rolipram
| Article | Year |
|---|---|
Synthesis and potential anti-inflammatory activity of some tetrahydrophthalazinones.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Design; Drug Evaluation, Preclinical; Humans; Lipopolysaccharides; Molecular Structure; Phosphodiesterase Inhibitors; Phthalazines; Pulmonary Disease, Chronic Obstructive; Rolipram; Stereoisomerism; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2004 |
Inhibition of airway hyperresponsiveness and pulmonary inflammation by roflumilast and other PDE4 inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Aminopyridines; Animals; Benzamides; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Disease Models, Animal; Immunization; Male; Neutrophils; Nitriles; Ovalbumin; Phosphodiesterase Inhibitors; Pneumonia; Pyridines; Rats; Respiratory Hypersensitivity; Rolipram; Serotonin; Treatment Outcome; Tumor Necrosis Factor-alpha | 2006 |
A reporter gene assay for screening of PDE4 subtype selective inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Benzamides; Cell Line; Cloning, Molecular; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Cytoplasm; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Isoenzymes; Kinetics; Luciferases; Phosphodiesterase Inhibitors; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Rolipram; Transfection; U937 Cells | 2007 |
Phosphodiesterase 4 inhibitors augment levels of glucocorticoid receptor in B cell chronic lymphocytic leukemia but not in normal circulating hematopoietic cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Apoptosis; Benzamides; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Dexamethasone; Gene Expression Regulation, Leukemic; Hematopoietic System; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Nitriles; Phosphodiesterase Inhibitors; Receptors, Glucocorticoid; Rolipram | 2007 |
Inhibition of phosphodiesterase type 4 decreases stress-induced defecation in rats and mice.
Topics: Aminopyridines; Animals; Antidiarrheals; Benzamides; Cold Temperature; Cyclopropanes; Defecation; Gastrointestinal Motility; Irritable Bowel Syndrome; Loperamide; Male; Mice; Mice, Inbred C57BL; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Restraint, Physical; Rolipram; Stress, Psychological | 2008 |
PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways.
Topics: Aminopyridines; Animals; Apoptosis; Base Sequence; Benzamides; Cell Line; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclopropanes; Guanine Nucleotide Exchange Factors; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; rap1 GTP-Binding Proteins; Rats; RNA, Small Interfering; Rolipram; Signal Transduction | 2008 |
Curative effects of phosphodiesterase 4 inhibitors cilomilast, roflumilast, and rolipram in dermatitis mouse model.
Topics: Aminopyridines; Animals; Benzamides; Carboxylic Acids; Cyclohexanecarboxylic Acids; Cyclopropanes; Dermatitis; Dermatitis, Contact; Disease Models, Animal; Eosinophil Peroxidase; Interleukin-4; Male; Mice; Mice, Inbred BALB C; Nitriles; Peroxidase; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Picryl Chloride; Rolipram | 2008 |
Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors.
Topics: Aminopyridines; Animals; Benzamides; Chemistry, Pharmaceutical; Crystallography, X-Ray; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Design; Humans; Leukocytes, Mononuclear; Models, Biological; Models, Chemical; Phosphodiesterase 4 Inhibitors; Pyrazoles; Pyridines; Pyrrolidinones; Rats; Rolipram; Tumor Necrosis Factor-alpha | 2008 |
PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts.
Topics: Adult; Aminopyridines; Benzamides; Cells, Cultured; Chemotaxis; Collagen; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclooxygenase 1; Cyclooxygenase 2; Cyclopropanes; Dinoprostone; Drug Synergism; Fibroblasts; Fibronectins; Humans; Lung; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Fibrosis; Rolipram; Transforming Growth Factor beta1 | 2009 |
The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in
Topics: Aminopyridines; Animals; Benzamides; Carboxylic Acids; Cyclohexanecarboxylic Acids; Cyclopropanes; Ferrets; Humans; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Neutrophils; Nitriles; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pica; Piperazines; Pyridines; Rats; Rats, Inbred Lew; Receptors, Adrenergic, alpha-2; Rolipram; Tumor Necrosis Factor-alpha; Vomiting | 2009 |
Effect of cyclic AMP-elevating agents on airway ciliary beat frequency in central and lateral airways in rat precision-cut lung slices.
Topics: Aminopyridines; Animals; Benzamides; Colforsin; Cyclic AMP; Cyclopropanes; Dissection; Enzyme Inhibitors; Female; In Vitro Techniques; Lung; Mucociliary Clearance; Phosphodiesterase 4 Inhibitors; Prostaglandins; Rats; Rats, Wistar; Rolipram; Terbutaline; Time Factors | 2010 |
Phosphodiesterase-4 inhibition as a therapeutic approach to treat capillary leakage in systemic inflammation.
Topics: Aminopyridines; Animals; Benzamides; Capillaries; Capillary Permeability; Cyclic AMP; Cyclopropanes; Endothelium, Vascular; Inflammation; Lipopolysaccharides; Male; Microcirculation; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Vascular Diseases | 2012 |
Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4.
Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Aminopyridines; Benzamides; Cells, Cultured; Chemotaxis; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Dinoprostone; Fibroblasts; Fibronectins; Gene Expression; Humans; Iloprost; Isoenzymes; Lung; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Receptors, Epoprostenol; Receptors, Prostaglandin; Receptors, Prostaglandin E, EP2 Subtype; Rolipram; Second Messenger Systems | 2012 |
Monitoring phosphodiesterase-4 inhibitors using liquid chromatography/(tandem) mass spectrometry in sports drug testing.
Topics: Aminopyridines; Benzamides; Chromatography, Liquid; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Limit of Detection; Nitriles; Phosphodiesterase 4 Inhibitors; Rolipram; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry | 2013 |
GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 inhibitor that demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in preclinical species.
Topics: Aminopyridines; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzamides; Callithrix; Cerebral Cortex; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Evaluation, Preclinical; Ferrets; Inflammation; Isoenzymes; Macaca fascicularis; Male; Nootropic Agents; Oxadiazoles; Phosphodiesterase 4 Inhibitors; Pica; Rats; Rolipram; Thiazoles | 2014 |
Effects of rolipram and roflumilast, phosphodiesterase-4 inhibitors, on hypertension-induced defects in memory function in rats.
Topics: Aminopyridines; Animals; Benzamides; Blood Pressure; Brain; Cognition; Corticosterone; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Gene Expression Regulation, Enzymologic; Hypertension; Male; Maze Learning; Memory; Phosphodiesterase 4 Inhibitors; Rats; Rats, Wistar; Recognition, Psychology; RNA, Messenger; Rolipram | 2015 |
The unrecognized effects of phosphodiesterase 4 on epithelial cells in pulmonary inflammation.
Topics: Aminopyridines; Animals; Benzamides; Capillary Permeability; Chemokines; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Cytoskeleton; Disease Models, Animal; Enzyme Activation; Epithelial Cells; Gene Expression; Male; Mice; Neutrophil Infiltration; Neutrophils; Phosphodiesterase 4 Inhibitors; Pneumonia; Protein Transport; Rolipram; Time Factors | 2015 |
Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system.
Topics: Adrenergic alpha-2 Receptor Agonists; Aminopyridines; Animals; Antihypertensive Agents; Benzamides; Brain-Derived Neurotrophic Factor; Clonidine; Cognition Disorders; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclopropanes; Desoxycorticosterone Acetate; Disease Models, Animal; Hippocampus; Hypertension; Male; Memory; Nootropic Agents; Phosphodiesterase 4 Inhibitors; Rats; Rats, Wistar; Rolipram | 2015 |
The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses.
Topics: Aminopyridines; Animals; Benzamides; Cyclopropanes; Donepezil; Indans; Male; Memory; Mice; Mice, Inbred C57BL; Nootropic Agents; Phosphodiesterase 4 Inhibitors; Piperidines; Rats, Wistar; Recognition, Psychology; Rolipram; Scopolamine; Spatial Memory; Vomiting | 2016 |
The phosphodiesterase-4 inhibitor roflumilast decreases ethanol consumption in C57BL/6J mice.
Topics: Alcohol Drinking; Aminopyridines; Animals; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Ethanol; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phosphodiesterase 4 Inhibitors; Rolipram | 2017 |
Direct Inhibitory Effect of the PDE4 Inhibitor Roflumilast on Neutrophil Migration in Chronic Obstructive Pulmonary Disease.
Topics: Aminopyridines; Benzamides; Calcium; CD11b Antigen; Chemokine CXCL1; Chemotaxis, Leukocyte; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Guanine Nucleotide Exchange Factors; Humans; Leukotriene B4; Neutrophils; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Rolipram | 2019 |
Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Aminopyridines; Animals; Benzamides; Clioquinol; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Design; Humans; Ligands; Mice; Rats; Rolipram | 2019 |
Discovery and Optimization of α-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia.
Topics: Aminopyridines; Animals; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Dementia, Vascular; Dogs; Drug Design; Humans; Male; Mice, Inbred C57BL; Molecular Structure; Phosphodiesterase 4 Inhibitors; Protein Binding; Rolipram; Structure-Activity Relationship; Vomiting; Xanthones | 2020 |
PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.
Topics: Aminopyridines; Animals; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Disease Models, Animal; Female; Gastroparesis; Mice; Mice, Nude; Phosphodiesterase 4 Inhibitors; Pyridines; Pyrimidinones; Rolipram | 2020 |
Potentiation of long-acting β
Topics: Adrenergic beta-2 Receptor Agonists; Aminopyridines; Benzamides; Benzothiazoles; Budesonide; Cell Line; Chemokines; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Drug Synergism; Drug Therapy, Combination; Epithelial Cells; Formoterol Fumarate; Glucocorticoids; Humans; Lung; Multidrug Resistance-Associated Proteins; Nitriles; Phosphodiesterase 4 Inhibitors; Rolipram; Second Messenger Systems; Triazoles | 2021 |