alpha-aminopyridine has been researched along with pyrimidinones in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 15 (68.18) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Balbi, A; Bongrani, S; Cadel, S; Di Braccio, M; Mazzei, M; Roma, G; Schiantarelli, P | 1 |
| Inaba, T; Shishikura, T; Shito, K; Uchida, M | 1 |
| Crescenzi, B; Di Marco, A; Donghi, M; Felock, PJ; Ferrara, M; Fiore, F; Fonsi, M; Gardelli, C; Gonzalez-Paz, O; Kinzel, O; Laufer, R; Monteagudo, E; Muraglia, E; Nizi, E; Orvieto, F; Pescatore, G; Rowley, M; Summa, V | 1 |
| Hong, S; Kim, J | 1 |
| Antonakos, B; Cooke, VG; Danial, NN; Flemming, D; Hurov, KE; Jones, MD; Korn, JM; Ledell, J; Lehár, J; Mishina, Y; Schoumacher, M; Sellers, WR; Shao, W; Sonkin, D; Steiger, J; Stump, MD; Yan-Neale, Y | 1 |
| Bedard, PL; Britten, CD; Carter, K; Csonka, D; Demanse, D; Janku, F; Le, N; Nauwelaerts, H; Paz-Ares, L; Pérez-García, J; Peters, M; Sessa, C; Stathis, A; Tabernero, J; Van Cutsem, E; Vansteenkiste, J; Wainberg, ZA; Zubel, A | 1 |
| Blank, C; Cornelissen-Steijger, PD; Geukes Foppen, MH; Goding, CR; Graeber, TG; Haanen, J; Hugo, W; Kemper, K; Kong, X; Krijgsman, O; Lo, RS; McDermott, U; Müller, J; Peeper, DS; Possik, PA; Ribas, A; Robert, L; Song, C; Tsoi, J | 1 |
| Debnath, J; Marsh, T | 1 |
| Avnet, S; Baldini, N; Di Pompo, G; Lattanzi, G; Mai, A; Rotili, D; Salerno, M; Valente, S; Zwergel, C | 1 |
| Akiyama, R; Anderson, JL; Denny, CT; Federman, N; Park, A; Tap, WD | 1 |
| Liu, P; Xu, B; Zhang, C | 1 |
| Chaire, V; Fourneaux, B; Italiano, A; Karanian, M; Laroche-Clary, A; Lucchesi, C; Pineau, R | 1 |
| Cho, BC; Choi, HM; Hong, MH; Joo, HS; Kang, HN; Kim, DH; Kim, HR; Lee, Y; Yoon, SO; Yun, MR | 1 |
| Baslan, T; Bott, MJ; Chen, CC; Chen, HA; de Stanchina, E; Fennell, M; Feucht, J; Ho, YJ; Kulick, A; Leibold, J; Lowe, SW; Manchado, E; Poirier, JT; Romesser, PB; Rudin, CM; Ruscetti, M; Salgado, NR; Sanchez-Rivera, FJ; Sherr, CJ; Tian, S | 1 |
| Acker, M; Bagdanoff, JT; Chan, H; Chen, YN; Chen, Z; Firestone, B; Fodor, M; Fortanet, J; Hao, H; Hentemann, M; Kato, M; Koenig, R; LaBonte, LR; LaMarche, MJ; Liu, C; Liu, G; Liu, S; McNeill, E; Mohseni, M; Sarver, P; Sendzik, M; Spence, S; Stams, T; Tamez, V; Tichkule, R; Towler, C; Wang, H; Wang, P; Williams, SL; Yu, B | 1 |
| Ellman, JA; Hoang, GL; Zoll, AJ | 1 |
| Arkenau, HT; Auger, KR; Blagden, SP; Fleming, RA; Gazzah, A; Greystoke, A; Mak, G; Mazumdar, J; Nebot, N; Plummer, R; Rizzuto, I; Rogan, D; Soria, JC; Tolson, J; Yan, L; Zhang, J | 1 |
| Aasen, SN; Bjerkvig, R; Feng, Z; Hoang, T; Knappskog, S; Parajuli, H; Roy, K; Stokke, K; Thorsen, F; Wang, J | 1 |
| Hanrahan, JW; Luo, Y; Thomas, DY; Turner, MJ | 1 |
| Adderley, T; Christopher, G; Irwin, MS; Kano, Y; Kee, L; Ladumor, Y; Ohh, M; Robinson, CM; Valencia-Sama, I | 1 |
| Abou Saleh, L; Aragon, IV; Boyd, A; Koloteva, A; McDonough, W; Murphy, JM; Rich, J; Richter, W | 1 |
| Lea, S; Mathioudakis, AG; Singh, D | 1 |
1 review(s) available for alpha-aminopyridine and pyrimidinones
| Article | Year |
|---|---|
Inhaled Phosphodiesterase Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease.
Topics: Administration, Inhalation; Aminopyridines; Animals; Benzamides; Cyclic AMP; Cyclopropanes; Humans; Inflammation; Isoquinolines; para-Aminobenzoates; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrimidinones; Sulfonamides | 2021 |
2 trial(s) available for alpha-aminopyridine and pyrimidinones
| Article | Year |
|---|---|
A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors.
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Morpholines; Neoplasms; Pyridones; Pyrimidinones | 2015 |
A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours.
Topics: Aged; Aminopyridines; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Female; Focal Adhesion Protein-Tyrosine Kinases; Humans; Hydroxamic Acids; Male; Mesothelioma; Middle Aged; Neoplasms; Progression-Free Survival; Pyridones; Pyrimidinones | 2019 |
19 other study(ies) available for alpha-aminopyridine and pyrimidinones
| Article | Year |
|---|---|
[Derivatives of pyrimidine 1,2-condensate. IV. Synthesis and pharmacological properties of the N,N-disubstituted 4-amino-2H-pyrido(1,2-a)pyrimidin- 2-ones and 2-amino-4H-pyrido(1,2-a)pyrmidin-4-ones].
Topics: Aminopyridines; Animals; Drug Evaluation, Preclinical; Passive Cutaneous Anaphylaxis; Pyrimidinones; Rats; Structure-Activity Relationship | 1988 |
A late cutaneous response in actively sensitized rats: a new method for evaluating the efficacy of antiallergic drugs.
Topics: Aminopyridines; Animals; Anti-Allergic Agents; Antigens; Cromolyn Sodium; Cyclosporine; Dinitrobenzenes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Edema; Haptens; Hindlimb; Hypersensitivity, Delayed; Male; ortho-Aminobenzoates; Ovalbumin; Passive Cutaneous Anaphylaxis; Promethazine; Pyridines; Pyrimidinones; Quinolones; Rats; Rats, Wistar | 2006 |
Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors.
Topics: Administration, Oral; Aminopyridines; Animals; Azepines; Biological Availability; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Dogs; HIV Integrase; HIV Integrase Inhibitors; HIV-1; Humans; Macaca mulatta; Microsomes, Liver; Pyrimidinones; Rats; Stereoisomerism; Structure-Activity Relationship | 2008 |
Discovery of new aminopyrimidine-based phosphoinositide 3-kinase beta (PI3Kβ) inhibitors with selectivity over PI3Kα.
Topics: Aminopyridines; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Drug Discovery; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Morpholines; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Pyrimidinones; Substrate Specificity | 2011 |
Inhibiting Tankyrases sensitizes KRAS-mutant cancer cells to MEK inhibitors via FGFR2 feedback signaling.
Topics: Acetamides; Aminopyridines; Aniline Compounds; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Drug Synergism; Erlotinib Hydrochloride; Feedback, Physiological; Female; Humans; MAP Kinase Kinase Kinases; Mice; Mice, Nude; Morpholines; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyrimidinones; Quinazolines; ras Proteins; Receptor, Fibroblast Growth Factor, Type 2; Signal Transduction; Sulfonamides; Tankyrases; Thiazoles; Xenograft Model Antitumor Assays | 2014 |
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Axl Receptor Tyrosine Kinase; Benzamides; Cell Line, Tumor; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Imatinib Mesylate; Imidazoles; Indoles; Melanoma; Mice; Microphthalmia-Associated Transcription Factor; Oximes; Piperazines; Prognosis; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidines; Pyrimidinones; Receptor Protein-Tyrosine Kinases; Signal Transduction; Skin Neoplasms; Sulfonamides; Vemurafenib; Xenograft Model Antitumor Assays | 2014 |
Ironing out VPS34 inhibition.
Topics: Aminopyridines; Autophagy; Cell Communication; Class III Phosphatidylinositol 3-Kinases; Humans; Intracellular Signaling Peptides and Proteins; Nuclear Receptor Coactivators; Proteins; Pyridines; Pyrimidines; Pyrimidinones | 2015 |
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.
Topics: Aminopyridines; Apoptosis; Bone Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Neoplastic Stem Cells; Osteogenesis; Osteosarcoma; Pyrimidinones; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Structure-Activity Relationship | 2015 |
Evaluation of In Vitro Activity of the Class I PI3K Inhibitor Buparlisib (BKM120) in Pediatric Bone and Soft Tissue Sarcomas.
Topics: Aminopyridines; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Class I Phosphatidylinositol 3-Kinases; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Humans; Mechanistic Target of Rapamycin Complex 1; Morpholines; Multiprotein Complexes; Mutation; Osteosarcoma; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyridones; Pyrimidines; Pyrimidinones; Pyrroles; Sarcoma; Signal Transduction; TOR Serine-Threonine Kinases | 2015 |
Addition of the p110α inhibitor BYL719 overcomes targeted therapy resistance in cells from Her2-positive-PTEN-loss breast cancer.
Topics: Aminopyridines; Animals; Antibodies; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Humans; Lapatinib; Mice; Morpholines; ortho-Aminobenzoates; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; PTEN Phosphohydrolase; Pyrimidinones; Quinazolines; Receptor, ErbB-2; Thiazoles; Xenograft Model Antitumor Assays | 2016 |
Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications.
Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Everolimus; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Leiomyosarcoma; MAP Kinase Kinase Kinases; Mechanistic Target of Rapamycin Complex 2; Mice; Morpholines; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridones; Pyrimidinones; Quinolines; Rapamycin-Insensitive Companion of mTOR Protein; RNA Interference; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases; Transfection; Tumor Burden; Xenograft Model Antitumor Assays | 2017 |
ERK-dependent IL-6 autocrine signaling mediates adaptive resistance to pan-PI3K inhibitor BKM120 in head and neck squamous cell carcinoma.
Topics: Aminopyridines; Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Autocrine Communication; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Female; Head and Neck Neoplasms; Humans; Interleukin-6; MAP Kinase Signaling System; Mice; Mice, Inbred NOD; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; Receptors, Interleukin-6; RNA, Small Interfering; Squamous Cell Carcinoma of Head and Neck; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2018 |
NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination.
Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzimidazoles; Cellular Senescence; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cytostatic Agents; Cytotoxicity, Immunologic; Humans; Immunologic Surveillance; Intercellular Adhesion Molecule-1; Killer Cells, Natural; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Molecular Targeted Therapy; Mutation; Piperazines; Proto-Oncogene Proteins p21(ras); Purines; Pyridines; Pyridones; Pyrimidinones; Retinoblastoma Protein; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays | 2018 |
6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.
Topics: Administration, Oral; Allosteric Regulation; Allosteric Site; Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Enzyme Inhibitors; Female; Humans; Male; Mice, Inbred C57BL; Molecular Structure; Neoplasms; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pyrimidinones; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2019 |
Three-Component Coupling of Aldehydes, 2-Aminopyridines, and Diazo Esters via Rhodium(III)-Catalyzed Imidoyl C-H Activation: Synthesis of Pyrido[1,2- a]pyrimidin-4-ones.
Topics: Aldehydes; Aminopyridines; Azo Compounds; Catalysis; Esters; Imides; Molecular Structure; Pyridines; Pyrimidinones; Rhodium | 2019 |
Effective Treatment of Metastatic Melanoma by Combining MAPK and PI3K Signaling Pathway Inhibitors.
Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Melanoma; Mice, Inbred NOD; Mice, SCID; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; Signal Transduction; Skin Neoplasms; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays | 2019 |
The dual phosphodiesterase 3/4 inhibitor RPL554 stimulates rare class III and IV CFTR mutants.
Topics: Aminopyridines; Animals; Benzodioxoles; Bronchi; Cell Line; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Isoquinolines; Mutation; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Primary Cell Culture; Pyrimidinones; Rats; Rats, Inbred F344; Thyroid Epithelial Cells; Transgenes | 2020 |
Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Genes, ras; Heterografts; Humans; Indoles; Male; MAP Kinase Signaling System; Mice, Inbred NOD; Mice, SCID; Mitogen-Activated Protein Kinase Kinases; Mutation; Neoplasm Recurrence, Local; Neuroblastoma; Piperidines; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pyridones; Pyrimidines; Pyrimidinones; Pyrroles; Triazoles; Vemurafenib | 2020 |
PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.
Topics: Aminopyridines; Animals; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Disease Models, Animal; Female; Gastroparesis; Mice; Mice, Nude; Phosphodiesterase 4 Inhibitors; Pyridines; Pyrimidinones; Rolipram | 2020 |