Page last updated: 2024-08-21

alpha-aminopyridine and pyrazines

alpha-aminopyridine has been researched along with pyrazines in 52 studies

Research

Studies (52)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (7.69)	18.7374
1990's	4 (7.69)	18.2507
2000's	14 (26.92)	29.6817
2010's	21 (40.38)	24.3611
2020's	9 (17.31)	2.80

Authors

Authors	Studies
Blinks, JR; Endoh, M; Taira, N; Yanagisawa, T	1
Hosokawa, T; Kojima, M; Mori, T; Yabuuchi, Y; Yamashita, S	1
Korkushko, AO; Kryshtal', OA	1
Hashimoto, K; Mori, T; Yabuuchi, Y; Yamashita, S	1
Liu, SY; Sylvester, DM	1
Chen, IW; Chen, Z; Cook, JJ; Cooper, CM; Cutrona, KJ; Dorsey, BD; Dyer, DL; Gardell, SJ; Hare, TR; Krueger, JA; Lewis, SD; Lin, JH; Lucas, BJ; Lyle, EA; Lyle, TA; Lynch, JJ; McDonough, CM; Naylor-Olsen, AM; Sanderson, PE; Shafer, JA; Stranieri, MT; Vacca, JP; Vastag, K; Yan, Y	1
Dekeyne, A; Girardon, S; Millan, MJ	1
Di Giovanni, G; Di Mascio, M; Di Matteo, V; Esposito, E	1
Almarsson, O; Chen, X; Gier, L; Loper, AE; Ostovic, D; Wu, Y	1
Daud, A; Munster, P; Spriggs, DR	1
Greenshaw, A; Hayes, D; Mosher, T	1
Beall, L; Chen, X; Connolly, PJ; Deangelis, A; Emanuel, S; Fuentes-Pesquera, A; Gruninger, RH; Jolliffe, L; Karnachi, P; Kuo, GH; Middleton, SA; Murray, WV; Prouty, C; Sechler, J; Song, F; Wang, A; Zhang, Y	1
Boothman, L; Denk, F; Hirani, E; Raley, J; Sharp, T	1
Asiri, AM; Badahdah, KO	1
Acosta, JI; Neisewander, JL	1
Egashira, N; Fujiwara, M; Iwasaki, K; Koushi, E; Mishima, K; Oishi, R	1
Greenshaw, AJ; Hayes, DJ; Mosher, TM	1
Fleshner, M; Greenwood, BN; Strong, PV	1
Alton, G; Chau, F; Christensen, JG; Cui, J; Karlicek, S; McTigue, MA; Murray, BW; Ryan, K; Timofeevski, SL; Zhu, JX; Zou, HY	1
Fletcher, PJ; Higgins, GA; Isaac, M; Sinyard, J; Slassi, A; Tampakeras, M	1
Acker, BA; Benson, AG; Blevis-Bal, RM; Bond, BR; Brown, DL; Cubbage, JW; Fobian, YM; Freskos, JN; Heasley, SE; Hughes, RO; Jacobsen, EJ; Macinnes, A; Maddux, TM; Mischke, BV; Molyneaux, JM; Moon, JB; Owen, DR; Rogier, DJ; Rumsey, JM; Stallings, WC; Tollefson, MB; Walker, JK; Williams, JM; Yu, Y; Zheng, Y	1
Baraldi, PG; Kalla, RV; Tabrizi, MA; Zablocki, J	1
Brown, BS; Brown, KK; Choudhry, AE; Donovan, BT; Heerding, DA; Kahana, JA; Kumar, R; Lafrance, L; Lai, Z; Leber, J; Levy, D; Li, M; Lin, H; Luengo, JI; Minthorn, EA; Robell, KA; Safonov, IG; Schaber, M; Takata, D; Venslavsky, J; Verma, S; Wang, W; Xie, R; Yamashita, DS; Zeng, J; Zhang, S	1
Duke, FD; Hamilton, EC; Neisewander, JL; Pentkowski, NS; Pockros, LA; Teer, AP; Thiel, KJ; Weber, SM	1
Benaliouad, F; Rompré, PP; Zhornitsky, S	1
Vicente, MA; Zangrossi, H	1
Bronson, JJ; Grace, J; Hartz, R; Healy, F; Lelas, S; Li, YW; Lodge, NJ; Macor, JE; Molski, T; Post-Munson, D; Sivarao, DV; Zaczek, R	1
Hammarström, LG; Lundbäck, T; Rottenberg, ME; Sjöberg, B; Svensson, R; Vodnala, SK	1
Bunch, RT; Euler, C; Haines, E; He, A; Peden, WM; Sanderson, T; Simic, D; Van Vleet, T	1
Axel, U; Baska, F; Greff, Z; Gyulavári, P; Ibolya, K; Kéri, G; Orfi, L; Peták, I; Szántai, KC; Szokol, B; Vantus, T; Zoltán, O	1
Der-Ghazarian, T; Neisewander, JL; Pentkowski, NS; Pockros-Burgess, LA	1
Hattori, T; Nahata, M; Nakagawa, K; Ohnishi, S; Okubo, N; Sadakane, C; Saegusa, Y; Takeda, H; Yamada, C	1
Bourke, CH; Goodman, MM; Kilts, CD; Owens, MJ; Stehouwer, JS; Voll, RJ	1
Beeson, CC; Demireva, EY; Gingrich, JA; Harmon, JL; McOmish, CE; Schnellmann, RG; Wills, LP	1
Sheridan, C	1
Baptista-de-Souza, D; Canto-de-Souza, A; Canto-de-Souza, L; Nunes-de-Souza, RL; Pelarin, V	1
Bartfeld, S; Chan, AKW; Chan, AS; Chan, ASY; Chan, D; Cheng, PSW; Clevers, H; Fan, X; Ho, SL; Kwong, DLW; Lam, KO; Law, S; Lee, BCH; Leung, SY; Ma, S; Mak, TW; Man, AHY; Shi, J; Siu, HC; Tsui, WY; Wong, JWH; Yan, HHN; Yue, SSK; Yuen, ST; Zhang, J	1
Azab, AK; Azab, F; Buggio, M; de la Puente, P; Fiala, M; Muz, B; Pachter, JA; Padval, MV; Vij, R; Weaver, DT	1
de Andrade, TGCS; Hernandes, PM; Sant'Ana, AB; Vicente, MA; Vilela-Costa, HH; Zangrossi, H	1
Tiong, IS; Wei, AH	1
Hua, Y; Huo, T; Kneubehl, AR; Lin, YL; Nie, S; Rico-Hesse, R; Song, Y; Vogt, MB; Wu, F; Wu, J; Yao, Y	1
Estey, EH; Percival, MM	1
DiNardo, CD; Wei, AH	1
Accordi, B; Basso, G; Bresolin, S; Cortese, G; Mariotto, E; Porcù, E; Serafin, V; Veltri, G	1
Naoe, T	1
Xia, X	1
Balamurali, MM; Chanda, K; Maiti, B; Rao, RN; Saikia, AA	1
Adachi, J; Araki, M; Friboulet, L; Fujita, N; Katayama, K; Katayama, R; Kukimoto-Niino, M; Kutkowska, J; Ma, B; Maruyama, K; Mizuta, H; Nishio, M; Oh-Hara, T; Okada, K; Okuno, Y; Sagae, Y; Sasakura, Y; Shirouzu, M; Simizu, S; Takagi, S; Takemoto, A; Tamai, K; Watanabe, K; Yanagitani, N	1
Ambarkhane, A; Bellenie, BR; Bracher, M; Bruce, I; Chinn, C; Coote, J; Cullen, E; Culshaw, A; Hall, E; Hollingworth, GJ; Lal, A; Marshall, S; McDonald, S; Neef, J; Nicklin, P; Rosner, E; Spendiff, M; Tessier, C; Thomas, M; Wallis, G; Wuersch, K	1
Geng, X; He, J; Huang, H; Jenny Lu, HA; Jia, Y; Jin, W; Li, M; Li, X; Meng, J; Qiu, Z; Shao, G; Wang, L; Wang, S; Xu, Y; Yang, B; Zhang, S; Zhou, H	1
Chen, W; Guo, G; Ou, H; Shi, M; Tang, J; Yang, C	1
Thol, F	1

Reviews

5 review(s) available for alpha-aminopyridine and pyrazines

Article	Year
New drugs in gynecologic cancer. Current treatment options in oncology, 2001, Volume: 2, Issue:2 Topics: Aminopyridines; Anti-Bacterial Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Boronic Acids; Bortezomib; Cisplatin; Female; Gefitinib; Genital Neoplasms, Female; Humans; Hydroxamic Acids; Lactams, Macrocyclic; Organoplatinum Compounds; Paclitaxel; Protein-Tyrosine Kinases; Pyrazines; Quinazolines; Trastuzumab	2001
Recent developments in A2B adenosine receptor ligands. Handbook of experimental pharmacology, 2009, Issue:193 Topics: Adenine; Adenosine A2 Receptor Antagonists; Aminopyridines; Animals; Asthma; Drug Discovery; Humans; Pyrazines; Pyrimidines; Receptor, Adenosine A2B; Xanthines	2009
New drugs creating new challenges in acute myeloid leukemia. Genes, chromosomes & cancer, 2019, Volume: 58, Issue:12 Topics: Aminopyridines; Aniline Compounds; Cytarabine; Daunorubicin; fms-Like Tyrosine Kinase 3; Gemtuzumab; Glycine; Humans; Leukemia, Myeloid, Acute; Pyrazines; Pyridines; Staurosporine; Triazines; United States; United States Food and Drug Administration	2019
Current treatment strategies for measurable residual disease in patients with acute myeloid leukemia. Cancer, 2019, Sep-15, Volume: 125, Issue:18 Topics: Aminopyridines; Aniline Compounds; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Immunological; Azacitidine; Cytogenetic Analysis; Decitabine; Enzyme Inhibitors; Flow Cytometry; Hematopoietic Stem Cell Transplantation; Humans; Hydrazines; Immunologic Factors; In Situ Hybridization, Fluorescence; Lenalidomide; Leukemia, Myeloid, Acute; Molecular Diagnostic Techniques; Neoplasm, Residual; Nivolumab; para-Aminobenzoates; Protein Kinase Inhibitors; Pyrazines; Pyrrolidines; Recombinant Fusion Proteins; Remission Induction; Transplantation, Homologous; Triazines; Triazoles	2019
＜Editors' Choice＞ How to improve outcomes of elderly patients with acute myeloid leukemia: era of excitement. Nagoya journal of medical science, 2020, Volume: 82, Issue:2 Topics: Aged; Aged, 80 and over; Aminopyridines; Aniline Compounds; Antineoplastic Agents; Arsenic Trioxide; Azacitidine; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Decitabine; fms-Like Tyrosine Kinase 3; Humans; Isocitrate Dehydrogenase; Leukemia, Myeloid, Acute; Molecular Targeted Therapy; Phenylurea Compounds; Precision Medicine; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Smoothened Receptor; Staurosporine; Sulfonamides; Survival Rate; Tretinoin; Triazines	2020

Other Studies

47 other study(ies) available for alpha-aminopyridine and pyrazines

Article	Year
Effects of new inotropic agents on cyclic nucleotide metabolism and calcium transients in canine ventricular muscle. Circulation, 1986, Volume: 73, Issue:3 Pt 2 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aequorin; Aminopyridines; Amrinone; Animals; Calcium; Carbachol; Cardiotonic Agents; Colforsin; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Enoximone; Female; Imidazoles; Male; Milrinone; Myocardial Contraction; Myocardium; Nifedipine; Nucleotides, Cyclic; Pyrazines; Pyridones; Quinolines; Time Factors	1986
In vitro and in vivo studies of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (OPC-8212), a novel positive inotropic drug, in various animals. Arzneimittel-Forschung, 1984, Volume: 34, Issue:3A Topics: Aminopyridines; Amrinone; Animals; Blood Pressure; Cardiotonic Agents; Cardiovascular System; Cats; Dobutamine; Dogs; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Phentolamine; Pindolol; Pyrazines; Quinolines; Rabbits; Rats; Sodium-Potassium-Exchanging ATPase; Theophylline	1984
[Blocking of proton-activated sodium permeability of the membranes of trigeminal ganglion neurons in the rat by organic cations]. Neirofiziologiia = Neurophysiology, 1984, Volume: 16, Issue:4 Topics: Amiloride; Aminopyridines; Animals; Calcium; Cell Membrane Permeability; Guanidine; Guanidines; Hydrogen-Ion Concentration; Magnesium; Pyrazines; Rats; Sodium; Tetraethylammonium; Tetraethylammonium Compounds; Trigeminal Ganglion; Trigeminal Nerve	1984
Positive inotropic effect of 3, 4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-qu inolinone (OPC-8212) in the dog with experimentally-induced right-sided heart failure. Arzneimittel-Forschung, 1984, Volume: 34, Issue:3A Topics: Administration, Oral; Aminopyridines; Amrinone; Animals; Blood Pressure; Cardiotonic Agents; Dobutamine; Dogs; Dose-Response Relationship, Drug; Heart Failure; Heart Rate; Injections, Intravenous; Male; Myocardial Contraction; Pyrazines; Quinolines	1984
Antiplatelet structure-activity relationship of tetramethylpyrazine. Life sciences, 1994, Volume: 55, Issue:17 Topics: Aminopyridines; Humans; Molecular Structure; Nitrogen; Platelet Aggregation Inhibitors; Pyrazines; Structure-Activity Relationship	1994
Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates. Journal of medicinal chemistry, 1998, Nov-05, Volume: 41, Issue:23 Topics: Aminopyridines; Animals; Biological Availability; Crystallography, X-Ray; Dogs; Macaca mulatta; Models, Molecular; Molecular Mimicry; Peptides; Pyrazines; Pyridones; Rats; Structure-Activity Relationship; Thrombin	1998
Discriminative stimulus properties of the novel serotonin (5-HT)2C receptor agonist, RO 60-0175: a pharmacological analysis. Neuropharmacology, 1999, Volume: 38, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Conditioning, Operant; Ethylamines; Fluorobenzenes; Indoles; Male; Mianserin; Piperazines; Piperidines; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Reinforcement, Psychology; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes	1999
Preferential modulation of mesolimbic vs. nigrostriatal dopaminergic function by serotonin(2C/2B) receptor agonists: a combined in vivo electrophysiological and microdialysis study. Synapse (New York, N.Y.), 2000, Volume: 35, Issue:1 Topics: Aminopyridines; Animals; Dopamine; Indoles; Male; Neostriatum; Neurons; Nucleus Accumbens; Piperazines; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substantia Nigra; Ventral Tegmental Area	2000
Identification of oxidative degradates of the thrombin inhibitor, 3-(2-phenethylamino)-6-methyl-1-(2-amino-6-methyl-5-methyleneca rboxamidomethylpyridinyl)pyrazinone, using liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spec Journal of pharmaceutical and biomedical analysis, 1999, Volume: 20, Issue:3 Topics: Amides; Aminopyridines; Chromatography, High Pressure Liquid; Diamide; Drug Contamination; Drug Stability; Hydrogen Peroxide; Hydroxylation; Mass Spectrometry; Molecular Weight; Oxidation-Reduction; Pyrazines; Reproducibility of Results; Solutions; Spectrophotometry, Ultraviolet; Tablets; Thrombin	1999
Differential effects of 5-HT2C receptor ligands on place conditioning and locomotor activity in rats. European journal of pharmacology, 2005, May-16, Volume: 515, Issue:1-3 Topics: Aminopyridines; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Indoles; Ligands; Male; Motor Activity; Oxadiazoles; Piperazines; Pyrazines; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Time Factors	2005
Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors. Journal of medicinal chemistry, 2005, Jul-28, Volume: 48, Issue:15 Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Endothelium, Vascular; Female; Humans; Mice; Mice, Nude; Models, Molecular; Pyrazines; Pyridines; Quantitative Structure-Activity Relationship; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays	2005
In vivo evidence that 5-HT(2C) receptors inhibit 5-HT neuronal activity via a GABAergic mechanism. British journal of pharmacology, 2006, Volume: 149, Issue:7 Topics: Action Potentials; Aminopyridines; Animals; Brain Chemistry; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunohistochemistry; Indoles; Male; Neural Inhibition; Neurons; Picrotoxin; Piperazines; Positron-Emission Tomography; Proto-Oncogene Proteins c-fos; Pyrazines; Pyridines; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Ritanserin; Serotonin	2006
Synthesis of some new anils: part 1. Reaction of 2-hydroxy-benzaldehyde and 2-hydroxynaphthaldehyde with 2-aminopyridene and 2-aminopyrazine. Molecules (Basel, Switzerland), 2007, Aug-13, Volume: 12, Issue:8 Topics: Acetonitriles; Aldehydes; Aminopyridines; Aniline Compounds; Magnetic Resonance Spectroscopy; Naphthalenes; Pyrazines; Schiff Bases; Solvents; Spectrophotometry, Infrared; Stereoisomerism; Toluene	2007
Stimulation of 5-HT2C receptors attenuates cue and cocaine-primed reinstatement of cocaine-seeking behavior in rats. Behavioural pharmacology, 2007, Volume: 18, Issue:8 Topics: Aminopyridines; Animals; Behavior, Addictive; Cocaine; Cues; Dose-Response Relationship, Drug; Extinction, Psychological; Indoles; Male; Motor Activity; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Self Administration	2007
2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice. Journal of pharmacological sciences, 2007, Volume: 105, Issue:4 Topics: Aminopyridines; Amphetamines; Analysis of Variance; Animals; Animals, Outbred Strains; Behavior, Animal; Dose-Response Relationship, Drug; Dronabinol; Freezing Reaction, Cataleptic; Indoles; Injections, Intraperitoneal; Ketanserin; Male; Mice; Pyrazines; Quinoxalines; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists; Time Factors	2007
Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats. Behavioural brain research, 2009, Feb-11, Volume: 197, Issue:2 Topics: Aminopyridines; Amphetamine; Animals; Conditioning, Operant; Dopamine Agents; Dose-Response Relationship, Drug; Indoles; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Motor Activity; Nicotine; Nicotinic Agonists; Pyrazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists	2009
The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats. Psychopharmacology, 2009, Volume: 203, Issue:4 Topics: Aminopyridines; Animals; Anxiety; Escape Reaction; Freezing Reaction, Cataleptic; Helplessness, Learned; Indoles; Injections, Intraperitoneal; Male; Piperazines; Pyrazines; Rats; Rats, Inbred F344; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Stress, Psychological	2009
Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry, 2009, Jun-16, Volume: 48, Issue:23 Topics: Aminopyridines; Binding Sites; Catalysis; Humans; Kinetics; Mutation; Phosphorylation; Protein Conformation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrazines	2009
Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice. Neuropharmacology, 2009, Volume: 57, Issue:3 Topics: Aminopyridines; Animals; Benzazepines; Dexfenfluramine; Eating; Ethylamines; Feeding Behavior; Indoles; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naphthyridines; Piperazines; Pyrazines; Quinoxalines; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists	2009
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system. Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15 Topics: Administration, Oral; Aminopyridines; Animals; Chemistry, Pharmaceutical; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Design; Humans; Hydrogen-Ion Concentration; Hypertension; Microsomes; Models, Chemical; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Solubility	2009
Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines. Bioorganic & medicinal chemistry letters, 2010, Jan-15, Volume: 20, Issue:2 Topics: Aminopyridines; Animals; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Dogs; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Haplorhini; Humans; Mice; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; Pyridines; Rats; Structure-Activity Relationship; Xenograft Model Antitumor Assays	2010
Stimulation of medial prefrontal cortex serotonin 2C (5-HT(2C)) receptors attenuates cocaine-seeking behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:10 Topics: Aminopyridines; Animals; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Extinction, Psychological; Indoles; Male; Prefrontal Cortex; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Reinforcement, Psychology; Self Administration; Serotonin Antagonists; Serotonin Receptor Agonists	2010
Evidence that the reward attenuating effect of the D1-like antagonist, SCH-23390, is not mediated by its agonist action at the 5-HT2c receptors. Behavioural brain research, 2011, Mar-01, Volume: 217, Issue:2 Topics: Aminopyridines; Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Conditioning, Operant; Dopamine Antagonists; Dose-Response Relationship, Drug; Indoles; Male; Piperazines; Pyrazines; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT2C; Reward; Serotonin Receptor Agonists	2011
Serotonin-2C receptors in the basolateral nucleus of the amygdala mediate the anxiogenic effect of acute imipramine and fluoxetine administration. The international journal of neuropsychopharmacology, 2012, Volume: 15, Issue:3 Topics: Aminopyridines; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Anxiety Disorders; Avoidance Learning; Basolateral Nuclear Complex; Exploratory Behavior; Fluoxetine; Imipramine; Indoles; Male; Maze Learning; Neuropsychological Tests; Pyrazines; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists	2012
Pharmacological and behavioral characterization of the novel CRF1 antagonist BMS-763534. Neuropharmacology, 2013, Volume: 67 Topics: Aminopyridines; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Male; Motor Activity; Protein Binding; Pyrazines; Rats; Rats, Inbred SHR; Receptors, Corticotropin-Releasing Hormone; Sheep; Swine	2013
In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:2 Topics: Aminopyridines; Animals; Benzopyrans; Cell Line; Humans; Mice; Mice, Inbred C57BL; Piperidines; Pyrazines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2013
MicroRNA changes associated with atypical CYP1A1 inducer BMS-764459. Toxicology, 2013, Sep-15, Volume: 311, Issue:3 Topics: Aminopyridines; Animals; Cytochrome P-450 CYP1A1; Enzyme Induction; Female; Formaldehyde; Gene Expression Profiling; Liver; MicroRNAs; Oligonucleotide Array Sequence Analysis; Paraffin Embedding; Pyrazines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger	2013
[Development and biochemical characterization of EGFR/c-Met dual inhibitors]. Acta pharmaceutica Hungarica, 2013, Volume: 83, Issue:4 Topics: Afatinib; Aminopyridines; Anilides; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Computer Simulation; Crizotinib; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Imidazoles; Lapatinib; Lung Neoplasms; Molecular Structure; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-met; Pyrazines; Pyrazoles; Pyridines; Pyridones; Quinazolines; Quinolines	2013
Effects of the 5-HT2C receptor agonist CP809101 in the amygdala on reinstatement of cocaine-seeking behavior and anxiety-like behavior. The international journal of neuropsychopharmacology, 2014, Volume: 17, Issue:11 Topics: Aminopyridines; Amygdala; Animals; Anxiety; Cocaine; Conditioning, Operant; Cues; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug-Seeking Behavior; Extinction, Psychological; Indoles; Male; Maze Learning; Piperazines; Pyrazines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Serotonin 5-HT2 Receptor Agonists	2014
Serotonin 2C receptor contributes to gender differences in stress-induced hypophagia in aged mice. Psychoneuroendocrinology, 2015, Volume: 55 Topics: Age Factors; Aminopyridines; Animals; Anorexia; Aromatase Inhibitors; Brain; Corticosterone; ERRalpha Estrogen-Related Receptor; Feeding Behavior; Female; Ghrelin; Indoles; Letrozole; Male; Mice; Nitriles; Paraventricular Hypothalamic Nucleus; Phenols; Piperazines; Pyrazines; Pyrazoles; Receptor, Serotonin, 5-HT2C; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Sex Factors; Stress, Psychological; Triazoles	2015
Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-ones as ligands for brain corticotropin-releasing factor type-1 (CRF1) rec Bioorganic & medicinal chemistry letters, 2015, Nov-15, Volume: 25, Issue:22 Topics: Aminopyridines; Animals; Brain; Cell Line; Fluorine Radioisotopes; Heterocyclic Compounds, 2-Ring; Humans; Ligands; Macaca fascicularis; Male; Peptide Fragments; Positron-Emission Tomography; Pyrazines; Radiopharmaceuticals; Receptors, Corticotropin-Releasing Hormone	2015
5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists. The Journal of pharmacology and experimental therapeutics, 2016, Volume: 357, Issue:1 Topics: Aminopyridines; Animals; Electron Transport Complex I; Female; Gene Expression Regulation; Gene Knockdown Techniques; Indoles; Kidney Tubules, Proximal; Male; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Oxidation-Reduction; Oxygen Consumption; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Piperazines; Pyrazines; Rabbits; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Transcription Factors	2016
First new drug approval for AML in 15 years. Nature biotechnology, 2017, 08-08, Volume: 35, Issue:8 Topics: Aminoglycosides; Aminopyridines; Aniline Compounds; Antibodies, Monoclonal, Humanized; Drug Approval; fms-Like Tyrosine Kinase 3; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Mutation; Pyrazines; Staurosporine; Triazines	2017
Interplay between 5-HT Neuropharmacology, 2018, 09-15, Volume: 140 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Dose-Response Relationship, Drug; Drug Interactions; Fear; Indoles; Male; Mice; Microinjections; Nociception; Pain Measurement; Periaqueductal Gray; Pyrazines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists	2018
A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening. Cell stem cell, 2018, 12-06, Volume: 23, Issue:6 Topics: Aminopyridines; Antineoplastic Agents; Benzimidazoles; Benzofurans; Biological Specimen Banks; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Humans; Isoxazoles; Male; Naphthoquinones; Organoids; Precision Medicine; Pyrazines; Stomach Neoplasms	2018
PYK2/FAK inhibitors reverse hypoxia-induced drug resistance in multiple myeloma. Haematologica, 2019, Volume: 104, Issue:7 Topics: Aminopyridines; Benzamides; Drug Resistance, Neoplasm; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Humans; Hypoxia; Multiple Myeloma; Proteasome Inhibitors; Pyrazines; Sulfonamides; Tumor Cells, Cultured	2019
Role of 5-HT2C receptors of the dorsal hippocampus in the modulation of anxiety- and panic-related defensive responses in rats. Neuropharmacology, 2019, Volume: 148 Topics: Aminopyridines; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Ethylamines; Hippocampus; Imipramine; Indoles; Male; Maze Learning; Microinjections; Panic; Piperazines; Punishment; Pyrazines; Rats; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists	2019
Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease. Journal of the American Chemical Society, 2019, 05-01, Volume: 141, Issue:17 Topics: Allosteric Site; Aminopyridines; Animals; Antiviral Agents; Cell Line, Tumor; Chlorocebus aethiops; Crystallography, X-Ray; Dengue Virus; Drug Discovery; Female; Humans; Male; Mice, Inbred C57BL; Protease Inhibitors; Protein Binding; Pyrazines; Serine Endopeptidases; Vero Cells; Viral Nonstructural Proteins; Viral Proteins; West Nile virus; Zika Virus; Zika Virus Infection	2019
How I treat acute myeloid leukemia in the era of new drugs. Blood, 2020, 01-09, Volume: 135, Issue:2 Topics: Adult; Aged; Aminopyridines; Aniline Compounds; Antineoplastic Agents; Biomarkers, Tumor; Bridged Bicyclo Compounds, Heterocyclic; Cytarabine; Daunorubicin; Female; fms-Like Tyrosine Kinase 3; Glycine; Humans; Isocitrate Dehydrogenase; Leukemia, Myeloid, Acute; Male; Molecular Targeted Therapy; Mutation; Prognosis; Pyrazines; Pyridines; Sialic Acid Binding Ig-like Lectin 3; Staurosporine; Sulfonamides; Triazines	2020
SYK Targeting Represents a Potential Therapeutic Option for Relapsed Resistant Pediatric International journal of molecular sciences, 2019, Dec-07, Volume: 20, Issue:24 Topics: Aminopyridines; Cell Proliferation; Child; Core Binding Factor Alpha 2 Subunit; Cyclohexylamines; Drug Resistance, Neoplasm; Humans; Indazoles; Morpholines; Neoplasm Recurrence, Local; Oncogene Proteins, Fusion; Oxazines; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrazines; Pyridines; Pyrimidines; Syk Kinase; Tumor Cells, Cultured	2019
Drug efficacy and toxicity prediction: an innovative application of transcriptomic data. Cell biology and toxicology, 2020, Volume: 36, Issue:6 Topics: Aminophenols; Aminopyridines; Animals; Antineoplastic Agents; Benzodioxoles; Cell Death; Cystic Fibrosis; Dose-Response Relationship, Drug; Drug Combinations; Drug Development; Epithelial Cells; Gene Expression Profiling; Gene Regulatory Networks; Humans; Leukemia, Myeloid, Acute; Pyrazines; Pyrazoles; Quinolones; Toxicity Tests; Transcriptome	2020
Diversity-Oriented Synthesis of Thiazolidine-2-imines via Microwave-Assisted One-Pot, Telescopic Approach and Its Interaction with Biomacromolecules. ACS combinatorial science, 2020, 11-09, Volume: 22, Issue:11 Topics: Acetylcholinesterase; Aminopyridines; Anticonvulsants; Antineoplastic Agents; Antitubercular Agents; Catalysis; Cholinesterase Inhibitors; Ethylene Dibromide; Humans; Imines; Isothiocyanates; Microwaves; Pyrazines; Pyrimidines; Small Molecule Libraries; Structure-Activity Relationship; Thiazolidines; Thiourea	2020
Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer. Nature communications, 2021, 02-24, Volume: 12, Issue:1 Topics: Aminopyridines; Aniline Compounds; Animals; Apoptosis; Benzamides; Carbazoles; Cell Line; Cell Survival; Crizotinib; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Immunoblotting; Indazoles; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Mice; Mice, Inbred BALB C; Molecular Dynamics Simulation; Neoplasm Recurrence, Local; Piperidines; Proto-Oncogene Proteins; Pyrazines; Pyrazoles; Receptor Protein-Tyrosine Kinases	2021
Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ. Journal of medicinal chemistry, 2021, 08-26, Volume: 64, Issue:16 Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Class Ib Phosphatidylinositol 3-Kinase; Female; Humans; Inflammation; Molecular Structure; No-Observed-Adverse-Effect Level; Protein Kinase Inhibitors; Pyrazines; Rats, Sprague-Dawley; Structure-Activity Relationship	2021
Inhibiting Focal Adhesion Kinase Ameliorates Cyst Development in Polycystin-1-Deficient Polycystic Kidney Disease in Animal Model. Journal of the American Society of Nephrology : JASN, 2021, Volume: 32, Issue:9 Topics: Aminopyridines; Animals; Benzamides; Cell Culture Techniques; Cell Proliferation; Disease Models, Animal; Dogs; Epithelial Cells; Focal Adhesion Protein-Tyrosine Kinases; Humans; Hydroxamic Acids; Mice; Mice, Inbred C57BL; Polycystic Kidney, Autosomal Dominant; Pyrazines; Signal Transduction; Sulfonamides	2021
MK212, a 5-hydroxytryptamine 2C receptor agonist, reverses prepulse inhibition deficits in the medial prefrontal cortex and ventral hippocampus. Progress in neuro-psychopharmacology & biological psychiatry, 2022, 03-08, Volume: 113 Topics: Aminopyridines; Animals; Brain; Dizocilpine Maleate; Hippocampus; Indoles; Mice; Prefrontal Cortex; Prepulse Inhibition; Pyrazines; Receptor, Serotonin, 5-HT2C; Receptors, N-Methyl-D-Aspartate	2022
What to use to treat AML: the role of emerging therapies. Hematology. American Society of Hematology. Education Program, 2021, 12-10, Volume: 2021, Issue:1 Topics: Aged; Aminopyridines; Aniline Compounds; Antineoplastic Agents; Cytarabine; Daunorubicin; Drug Approval; Drug Discovery; Glycine; Humans; Leukemia, Myeloid, Acute; Male; Neoplasm Recurrence, Local; Pyrazines; Pyridines; Triazines	2021