alpha-aminopyridine has been researched along with piperidines in 140 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (4.29) | 18.7374 |
| 1990's | 14 (10.00) | 18.2507 |
| 2000's | 28 (20.00) | 29.6817 |
| 2010's | 65 (46.43) | 24.3611 |
| 2020's | 27 (19.29) | 2.80 |
| Authors | Studies |
|---|---|
| Izushi, K; Kamei, C; Tasaka, K | 1 |
| Maeno, T; Shibuya, Y | 1 |
| Ahn, HS; Barnett, A | 1 |
| Araujo, DM; Collier, B; Rícný, J; Welner, SA | 1 |
| Bevan, J; Heptinstall, S | 2 |
| Janssen, M; Janssen, PA; Janssens, F; Luyckx, M; Stokbroekx, RA; Torremans, J | 1 |
| Dinh, DM; Duncan, JN; Lajiness, ME; Lawson, CF; Poel, TJ; Rees, SA; Romero, AG; Schlachter, SK; Smith, MW | 1 |
| Bakthavachalam, V; Baldessarini, RJ; Kebabian, JW; Kula, NS; Xu, L | 1 |
| Hsu, SF; Jackson, MB; Wilke, RA | 1 |
| Cook, DF; Wirtshafter, D | 1 |
| Bobirnac, I; Bruinvels, AT; Danzeisen, M; Gazi, L; Geisse, S; Hoyer, D; Schoeffter, P; Schüpbach, E; Sommer, B; Tricklebank, M | 1 |
| Bakthavachalam, V; Baldessarini, RJ; Kula, NS; Pounds, S; Tarazi, FI; True, CD; Xu, L | 1 |
| Dekeyne, A; Girardon, S; Millan, MJ | 1 |
| Assié, MB; Bonnaud, B; Cosi, C; Funes, P; Jubault, N; Kleven, M; Koek, W; Vacher, B | 1 |
| Helmeste, DM; Mitsuhashi, M; Shioiri, T; Tang, SW | 1 |
| Heron-Maxwell, CL; O'Neill, MF; Shaw, G | 1 |
| Chari, S; Deth, RC; DuRand, CJ; Kotb, M; Kramer, ML; Liu, D; Nagata, M; Ouellette, D; Sharma, A; Shim, S; Tan, W; Wick, PF | 1 |
| Adams, WJ; Friis, JM; Genin, MJ; Kopta, LA; May, PD; Olmsted, RA; Poel, TJ; Romero, DL; Thomas, RC; Voorman, RL; Yagi, Y | 1 |
| Bobirnac, I; Danzeisen, M; Gazi, L; Hoyer, D; Langenegger, D; Schoeffter, P; Schüpbach, E; Sommer, B; Tricklebank, M | 1 |
| De La Garza, R; Madras, BK | 1 |
| Griebel, G; Perrault, G; Rodgers, RJ; Sanger, DJ | 1 |
| Hezky, P; Krejcí, I; Proska, J; Rádl, S | 1 |
| Asproni, B; Boatto, G; Cerri, R; Falcone, G; Filippelli, W; Palomba, M; Pau, A; Rimoli, MG | 1 |
| Assié, MB; Colpaert, FC; Cosi, C; Koek, W; Patoiseau, JF; Pauwels, PJ; Vacher, B | 1 |
| Evans, DC; Hemrick-Luecke, SK | 1 |
| Fletcher, PJ; Grottick, AJ; Higgins, GA | 1 |
| Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Adriaensen, H; Colpaert, FC; Deseure, K; Koek, W | 1 |
| Barrett, RJ; Sanders-Bush, E; Smith, RL | 1 |
| Carrasco, GA; D'Souza, DN; Damjanoska, KJ; Garcia, F; Haskins, KA; Kindel, GH; Muma, NA; Petersen, BR; Shankaran, M; Van De Kar, LD; Zhang, Y | 1 |
| Gray, K; Newson, M; Pei, Q; Sharp, T; Sprakes, M; Tordera, R | 1 |
| Enderlin, M; Fletcher, PJ; Haman, M; Higgins, GA | 1 |
| Adell, A; Amargós-Bosch, M; Artigas, F; Bortolozzi, A; Díaz-Mataix, L; Pons, S; Serrats, J | 1 |
| Dalley, JW; Glennon, JC; Robbins, TW; Theobald, DE; Winstanley, CA | 1 |
| Adriaensen, HF; Colpaert, FC; Deseure, KR | 1 |
| Cosi, C; Newman-Tancredi, A; Rollet, K; Tesori, V; Waget, A | 1 |
| Auclair, AL; Besnard, J; Depoortère, R; Kleven, MS; Newman-Tancredi, A | 1 |
| Assié, MB; Faucillon, V; Lomenech, H; Newman-Tancredi, A; Ravailhe, V | 1 |
| Filip, M; McCreary, AC; Przegaliński, E; Zaniewska, M | 1 |
| Fletcher, PJ; Higgins, GA; Sinyard, J; Tampakeras, M | 1 |
| Boulougouris, V; Glennon, JC; Robbins, TW | 1 |
| Dalley, JW; Glennon, JC; Murphy, ER; Pezze, MA; Robbins, TW; Robinson, ES; Theobald, DE | 1 |
| Al-Shamma, H; Behan, D; Chalmers, D; Chen, W; Espitia, S; Grottick, AJ; Martin, M; Menzaghi, F; Morgan, M; Reyes-Saldana, H; Smith, B; Thomsen, WJ; Whelan, K; Yuskin, D | 1 |
| Cai, L; Hertz, L; Li, B; Nu, W; Peng, L; Zhang, H; Zhang, S | 1 |
| Assié, MB; Bruins Slot, L; Buritova, J; Colpaert, FC; Cosi, C; Cussac, D; Heusler, P; Lauressergues, E; Martel, JC; Newman-Tancredi, A; Vacher, B | 1 |
| Filip, M; McCreary, AC; Zaniewska, M | 1 |
| Brennum, LT; Cremers, TI; Folgering, JH; Hertel, P; Hogg, S; Mørk, A; Sotty, F | 1 |
| Osterkamp, F; Scharn, D; Stragies, R; Vossmeyer, D; Zahn, G; Zischinsky, G; Zwintscher, A | 1 |
| France, CP; Koek, W; Li, JX; Rice, KC | 1 |
| Assié, MB; Auclair, AL; Bardin, L; Carilla-Durand, E; Colpaert, F; Depoortère, R; Kleven, MS; Koek, W; Newman-Tancredi, A; Vacher, B | 1 |
| Boulougouris, V; Robbins, TW | 1 |
| Filip, M; McCreary, AC; Wydra, K; Zaniewska, M | 1 |
| Opar, A | 1 |
| Auclair, AL; Bardin, L; Colpaert, FC; Depoortère, R; Newman-Tancredi, A; Vacher, B | 1 |
| Estrada-González, V; Márquez-Diosdado, MI; Montes-Rodríguez, CJ; Prospéro-García, O; Soria-Gómez, E | 1 |
| Lominac, KD; McCreary, AC; McIver, G; Szumlinski, KK; Valdivia, PN; Zayara, AE | 1 |
| Ding, WG; Kawai, H; Maeda, K; Maegawa, H; Matsuura, H; Nakamura, H; Sanada, M | 1 |
| Cohen, MS; Fantegrossi, WE; Henson, CM; Rice, KC; Simoneau, J; Woods, JH; Zimmerman, SM | 1 |
| Creed-Carson, M; Nobrega, JN; Oraha, A | 1 |
| Amantini, D; Antolini, M; Bifone, A; Cesari, N; Corsi, M; Gozzi, A; Martinelli, P; Massagrande, M; Montanari, D; Piccoli, L; Tessari, M; Turrini, G | 1 |
| Che, CT; Huang, Z; Ip, SP; Mao, QQ; Xian, YF | 1 |
| Regens, AL; Yazici, Y | 1 |
| Burger, JA | 1 |
| Fleischmann, R | 1 |
| Kimura, M; Tanaka, M; Watanabe, Y; Yoshimoto, K | 1 |
| Becker, G; Billard, T; Lancelot, S; Lemoine, L; Newman-Tancredi, A; Vacher, B; Zimmer, L | 1 |
| Wiestner, A | 2 |
| Chioua, M; Estrada, M; Iriepa, I; Marco-Contelles, J; Moraleda, I; Pérez, C; Rodríguez-Franco, MI; Samadi, A | 1 |
| Hayano, Y; Hosokawa-Muto, J; Kamatari, YO; Kuwata, K; Yamaguchi, K | 1 |
| Hammarström, LG; Lundbäck, T; Rottenberg, ME; Sjöberg, B; Svensson, R; Vodnala, SK | 1 |
| Steiger, B; Yazici, Y | 1 |
| Burmester, GR; Feist, E | 1 |
| Bifone, A; Gozzi, A; Lepore, S; Merlo-Pich, E; Vicentini, E | 1 |
| Ai, J; Geng, M; Ji, Y; Li, Y; Liu, J; Peng, X; Shi, D; Zhang, W | 1 |
| Cailly, T; Charnay, Y; Dumas, N; Fabis, F; Ginovart, N; Millet, P; Moulin-Sallanon, M; Rault, S; Suzanne, P; Tournier, BB | 1 |
| Bezzina, G; Body, S; Bradshaw, CM; Cheung, TH; Glennon, JC; Hampson, CL; Szabadi, E | 1 |
| Niemann, CU | 1 |
| Baran-Marszak, F; Bernard, S; Cymbalista, F; Danglade, D; Gardano, L; Gribben, J; Laguillier, C; Lazarian, G; Ledoux, D; Marzec, J; Roger, C; Thieblemont, C; Varin-Blank, N | 1 |
| Newman-Tancredi, A; Prickaerts, J; Schreiber, R; van Goethem, NP; Varney, M | 1 |
| Bonaventure, P; Carruthers, N; Dugovic, C; Fitz, SD; Johnson, PL; Lebold, TP; Lord, B; Lovenberg, T; Nepomuceno, D; Shekhar, A; Shelton, J; Shireman, BT; Wennerholm, M; Yun, S | 1 |
| Pettitt, AR; Slupsky, JR; Till, KJ | 1 |
| Borges, S; Dumpit, R; Hendershot, S; Hesk, D; Koharski, D; Lavey, C; McNamara, P; Voronin, K | 1 |
| Dickler, MN; Murphy, CG | 1 |
| Chai, Z; Feng, L; Li, YH; Liu, JC; Ma, CG; Xiao, BG; Xin, YL; Yu, JZ; Zhang, GX; Zhang, HZ | 1 |
| Ichinose, Y; Seto, T; Takenoyama, M; Toyokawa, G | 1 |
| de Boer, SF; Newman-Tancredi, A | 1 |
| Akkerman, S; Blokland, A; Creemers, P; De Vry, J; Prickaerts, J; Sambeth, A; Uz, T; van Duinen, M; Vanmierlo, T | 1 |
| Aston-Jones, G; Becker, HC; Lopez, MF; Moorman, DE | 1 |
| Chen, Y; Huang, G; Liao, L; Mao, X; Tang, Q; Wang, W; Wu, R | 1 |
| Liu, D; Savooji, J; Wu, J | 1 |
| Bojanowska, E; Drobnik, J; Juszczak, M; Wierucka-Rybak, M; Wolak, M | 1 |
| Doi, H; Kawasaki, A; Mawatari, A; Newman-Tancredi, A; Onoe, H; Onoe, K; Takeda, C; Yokoyama, C; Zimmer, L | 1 |
| Bria, E; Brunelli, M; Caccese, M; Caliò, A; Carbognin, L; Cuppone, F; Ferrara, R; Grizzi, G; Petraglia, S; Pilotto, S; Scarpa, A; Tortora, G | 1 |
| Browne, CJ; Fletcher, PJ; Higgins, GA; Soko, AD; Zeeb, FD | 1 |
| Aga, MA; Kumar, B; Nagaraju, PVVS; Rayees, S; Rouf, A; Sharma, A; Singh, G; Taneja, SC | 1 |
| Lücking, U; Sirvent, JA | 1 |
| Dholakia, S; Fildes, JE; Friend, PJ | 1 |
| Chow, LQM; Crino, L; De Pas, T; Felip, E; Mok, TSK; Salgia, R; Tan, DSW | 1 |
| Casellato, A; Macaccaro, P; Mandato, E; Nunes, SC; Piazza, F; Semenzato, G; Trentin, L; Tubi, LQ; Visentin, A; Zaffino, F | 1 |
| Barrett, AC; Butler, P; Caine, SB; Negus, SS; Thomsen, M | 1 |
| Chang, S; Hou, T; Kong, X; Li, D; Li, Y; Pan, P; Sun, H; Xu, L; Zhu, F | 1 |
| Hayashi, S; Hibino, Y; Kitada, M; Minami, Y; Miyokawa, N; Ohsaki, Y; Okumura, S; Sado, M; Sasaki, T; Yoshida, R | 1 |
| Bonnel, D; Eriksson, AH; Legouffe, R; Mortensen, RW; Nielsen, KT; Pamelard, F; Stauber, J | 1 |
| Beijnen, JH; Li, W; Schellens, JHM; Schinkel, AH; Sparidans, RW | 1 |
| Elkon, JM; Millett, RL; Tabbara, IA | 1 |
| Batchelor, TT; Grommes, C; Nayak, L; Tun, HW | 1 |
| Bagdy, G; Bogáthy, E; Kostyalik, D; Petschner, P; Vas, S | 1 |
| Amancio-Belmont, O; Estrada-González, V; Méndez-Díaz, M; Prospéro-García, O; Ruiz-Contreras, AE | 1 |
| Bjune, K; Naderi, S; Wierød, L | 1 |
| Higo, H; Hotta, K; Ichihara, E; Kano, H; Kayatani, H; Kiura, K; Kubo, T; Maeda, Y; Makimoto, G; Matsubara, T; Ninomiya, K; Ninomiya, T; Nishii, K; Ohashi, K; Rai, K; Sato, A; Tabata, M; Takata, M; Tomida, S; Toyooka, S; Watanabe, H | 1 |
| El Zein, N; Hachem, R; Hilal, G; Raad, I; Sarkis, R; Tahtouh, R; Wardi, L | 1 |
| Fujita, N; Horiike, A; Katayama, R; Kitazono, S; Koike, S; Nishikawa, S; Nishio, M; Ohyanagi, F; Tambo, Y; Tsukahara, M; Uchibori, K; Yanagitani, N; Yoshizawa, T | 1 |
| Brunac, AC; Castex, MP; Gomez-Brouchet, A; Guillemot, D; Karanian, M; Laprie, A; Laurent, C; Le Guellec, S; Le Loarer, F; Pierron, G | 1 |
| Adderley, T; Christopher, G; Irwin, MS; Kano, Y; Kee, L; Ladumor, Y; Ohh, M; Robinson, CM; Valencia-Sama, I | 1 |
| Chen, Z; Li, Y; Tian, C | 1 |
| Fan, L; Kong, YL; Li, JY; Liang, JH; Pan, BH; Wang, L; Wu, JZ; Xia, Y; Xu, W; Zhu, HY | 1 |
| Auclair, AL; Bardin, L; Bruins Slot, LA; Depoortere, R; Newman-Tancredi, A | 1 |
| Feng, X; Xu, ES | 1 |
| Beauchamp, E; Berthiaume, LG; Dong, WF; Gamma, JM; Gray, DW; Iyer, A; Lakshmanan, M; Lim, ST; Mackey, JR; Perinpanayagam, MA; Postovit, LM; Raju, A; Read, KD; Tan, SY; Tergaonkar, V; Vincent, KM; Wyatt, PG; Yap, MC | 1 |
| Bridges, A; Gleue, CA; Shah, K; Wentworth, A | 1 |
| Eisenstein, M | 1 |
| Andreasen, JT; Kristensen, JL; Odland, AU | 1 |
| Adachi, J; Araki, M; Friboulet, L; Fujita, N; Katayama, K; Katayama, R; Kukimoto-Niino, M; Kutkowska, J; Ma, B; Maruyama, K; Mizuta, H; Nishio, M; Oh-Hara, T; Okada, K; Okuno, Y; Sagae, Y; Sasakura, Y; Shirouzu, M; Simizu, S; Takagi, S; Takemoto, A; Tamai, K; Watanabe, K; Yanagitani, N | 1 |
| Baran, N; Bellvert, F; Boet, E; Bories, P; Bosc, C; Broin, N; Carroll, M; Cassan, C; Castellano, R; Castelli, FA; Cazals, G; Chu-Van, E; Cissé, MY; Cognet, G; Collette, Y; Conti, M; DiNardo, CD; Farge, T; Fenaille, F; Fernando, L; Gales, L; Gibon, Y; Gotanègre, M; Hosseini, M; Hucteau, A; Jourdan, F; Kaoma, T; Konopleva, M; Larrue, C; Le Cam, L; Linares, LK; Loric, S; Marszalek, JR; Montersino, C; Mouchel, PL; Nicolay, B; Pancaldi, V; Portais, JC; Poupin, N; Récher, C; Ronseaux, S; Sabatier, M; Sahal, A; Saland, E; Sarry, JE; Selak, MA; Stuani, L; Takahashi, K; Turtoi, A; Turtoi, E; Vey, N; Wang, F; Zavoriti, A | 1 |
| Hara, M; Iwakami, SI; Matsuda, H; Takahashi, K | 1 |
| Gawalska, A; Głuch-Lutwin, M; Jamrozik, M; Kołaczkowski, M; Newman-Tancredi, A; Pytka, K; Sałaciak, K; Sniecikowska, J | 1 |
| He, X; Jiao, XD; Ling, Y; Liu, J; Liu, K; Qin, BD; Song, K; Wu, Y; Xu, AQ; Zang, YS | 1 |
| Li, B; Li, Q; Liu, L; Sheng, Z; Song, J; Teng, L; Wang, B; Wang, L; Zhang, J | 1 |
| Fukushima, T; Kanda, S; Kobayashi, T; Koizumi, T; Noguchi, T; Sekiguchi, N | 1 |
| Anthonydhason, V; Fuchs, J; Guan, J; Hallberg, B; Palmer, RH; Siaw, JT; Uçkun, E; Wolfstetter, G | 1 |
| Chiang, CL; Chiang, TS; Chiu, CH; Chung, HP; Hung, JY; Ku, WH; Lee, KY; Lee, MH; Lin, CB; Lin, YT; Shih, JY; Su, J; Su, WC; Tseng, YH; Wei, YF; Wu, SY | 1 |
| Akai, M; Demura, Y; Ishizuka, T; Jikuya, N; Kurokawa, K; Nakashima, K; Oi, M; Tada, T; Takeda, T | 1 |
| Batlevi, CL; De Frank, S; Drullinsky, P; Gerecitano, JF; Hamilton, A; Hamlin, PA; Horwitz, SM; Kumar, A; Matasar, MJ; Michaud, L; Moskowitz, A; Moskowitz, CH; Nakajima, R; Nichols, C; Rademaker, J; Salles, G; Schöder, H; Seshan, V; Stewart, CM; Straus, D; Tsui, DWY; Whiting, K; Younes, A; Zelenetz, AD | 1 |
| Lé, AM; Torres, T | 1 |
| Broadbear, JH; Depoortere, RY; Newman-Tancredi, A; Ralph, D; Tunstall, BJ; Vacy, K | 1 |
| Chang, XS; Chen, YD; Ding, KL; Liu, YF; Liu, YH; Ma, HC; Xiao, ZZ; Yu, YY; Zhang, HB; Zhao, WJ; Zhou, R; Zhu, YJ | 1 |
| Kashizaki, F; Sekido, Y; Tanaka, A | 1 |
| Liu, Q; Luo, X; Peng, L; Zeng, X; Zhou, Z | 1 |
19 review(s) available for alpha-aminopyridine and piperidines
| Article | Year |
|---|---|
Promising new treatments for rheumatoid arthritis - the kinase inhibitors.
Topics: Aminopyridines; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Intracellular Signaling Peptides and Proteins; Janus Kinases; Morpholines; Oxazines; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Pyrroles; Syk Kinase; Treatment Outcome | 2011 |
Inhibiting B-cell receptor signaling pathways in chronic lymphocytic leukemia.
Topics: Adenine; Aminopyridines; Antineoplastic Agents; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Morpholines; Oxazines; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyridines; Pyrimidines; Quinazolinones; Receptors, Antigen, B-Cell; Risk Factors; Signal Transduction | 2012 |
Novel small-molecular therapeutics for rheumatoid arthritis.
Topics: Aminopyridines; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Janus Kinases; Molecular Targeted Therapy; Morpholines; Oxazines; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Pyrroles | 2012 |
Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia.
Topics: Adenine; Aminopyridines; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Models, Biological; Morpholines; Oxazines; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Pyrimidines; Receptors, Antigen, B-Cell; Signal Transduction | 2012 |
Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia.
Topics: Adenine; Aminopyridines; Antineoplastic Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocyte Count; Medical Oncology; Morpholines; Mutation; NF-kappa B; Oxazines; Phosphatidylinositol 3-Kinases; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Quinazolinones; Receptors, Antigen, B-Cell; Signal Transduction; src-Family Kinases | 2012 |
Kinase inhibitors for the treatment of rheumatoid arthritis.
Topics: Aminopyridines; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Morpholines; Oxazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Signal Transduction; Treatment Outcome | 2012 |
Small molecules targeting JAKs--a new approach in the treatment of rheumatoid arthritis.
Topics: Administration, Oral; Aminopyridines; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Forecasting; Germany; Humans; Janus Kinases; Male; Maximum Tolerated Dose; Molecular Targeted Therapy; Morpholines; Oxazines; Piperidines; Prognosis; Pyridines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome | 2013 |
[Targeted treatment of chronic lymphocytic leukaemia].
Topics: Adenine; Aminopyridines; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Morpholines; Oxazines; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Quinazolinones; Receptors, Antigen, B-Cell; Signal Transduction; Sulfonamides | 2014 |
The Role of CDK4/6 Inhibition in Breast Cancer.
Topics: Aminopyridines; Breast Neoplasms; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; DNA Breaks, Double-Stranded; Estrogen Receptor alpha; Female; Flavonoids; Humans; Piperazines; Piperidines; Protein Kinase Inhibitors; Purines; Pyridines | 2015 |
Insights into brain metastasis in patients with ALK+ lung cancer: is the brain truly a sanctuary?
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Brain; Brain Neoplasms; Carbazoles; Carcinoma, Non-Small-Cell Lung; Crizotinib; Humans; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Organophosphorus Compounds; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Receptor Protein-Tyrosine Kinases; Sulfones | 2015 |
Second- and third-generation ALK inhibitors for non-small cell lung cancer.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Carbazoles; Carcinoma, Non-Small-Cell Lung; Humans; Kaplan-Meier Estimate; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Organophosphorus Compounds; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Receptor Protein-Tyrosine Kinases; Sulfones | 2016 |
Current and developing therapies for the treatment of non-small cell lung cancer with ALK abnormalities: update and perspectives for clinical practice.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Carbazoles; Carcinoma, Non-Small-Cell Lung; Crizotinib; Drug Resistance, Neoplasm; Humans; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Piperidines; Precision Medicine; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Receptor Protein-Tyrosine Kinases | 2016 |
The use of kinase inhibitors in solid organ transplantation.
Topics: Aminopyridines; Humans; Immunosuppressive Agents; Indoles; Morpholines; Organ Transplantation; Oxazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Sunitinib; Syk Kinase | 2017 |
The accelerated path of ceritinib: Translating pre-clinical development into clinical efficacy.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Carbazoles; Carcinoma, Non-Small-Cell Lung; Humans; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Organophosphorus Compounds; Piperidines; Pyrazoles; Pyrimidines; Receptor Protein-Tyrosine Kinases; Sulfones | 2017 |
Directed Therapies in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung Cancer.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Carbazoles; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Crizotinib; Drug Resistance, Neoplasm; Humans; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Mutation; Organophosphorus Compounds; Piperidines; Pyrazoles; Pyridines; Pyrimidines; Receptor Protein-Tyrosine Kinases; Small Molecule Libraries | 2018 |
Introduction of novel agents in the treatment of primary CNS lymphoma.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Aminopyridines; Antineoplastic Agents, Immunological; Burkitt Lymphoma; Central Nervous System Neoplasms; Humans; Immunologic Factors; Lenalidomide; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rituximab; Salvage Therapy; Thalidomide; Toll-Like Receptors; TOR Serine-Threonine Kinases; Tumor Escape | 2019 |
Comparison of lorlatinib, alectinib and brigatinib in ALK inhibitor-naive/untreated ALK-positive advanced non-small-cell lung cancer: a systematic review and network meta-analysis.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Carbazoles; Carcinoma, Non-Small-Cell Lung; Humans; Lactams; Lung Neoplasms; Network Meta-Analysis; Organophosphorus Compounds; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines | 2022 |
New Topical Therapies for Psoriasis.
Topics: Administration, Topical; Aminopyridines; Amygdalin; Benzamides; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Dermatologic Agents; Humans; Interleukin-2; MicroRNAs; Nitriles; Phosphodiesterase 4 Inhibitors; Piperidines; Psoriasis; Pyrazoles; Pyrimidines; Resorcinols; Stilbenes | 2022 |
Comparative efficacy and safety of first-line treatments for advanced non-small cell lung cancer with ALK-rearranged: a meta-analysis of clinical trials.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Carbazoles; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Gene Rearrangement; Humans; Lactams; Lung Neoplasms; Network Meta-Analysis; Organophosphorus Compounds; Piperazines; Piperidines; Progression-Free Survival; Protein Kinase Inhibitors; Pyrazoles; Pyridazines; Pyrimidines; Randomized Controlled Trials as Topic; Treatment Outcome | 2021 |
1 trial(s) available for alpha-aminopyridine and piperidines
| Article | Year |
|---|---|
Phase I/Ib Study of the Efficacy and Safety of Buparlisib and Ibrutinib Therapy in MCL, FL, and DLBCL with Serial Cell-Free DNA Monitoring.
Topics: Adenine; Adult; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Cell-Free Nucleic Acids; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Morpholines; Phosphatidylinositol 3-Kinases; Piperidines; Pyrazoles; Pyrimidines | 2022 |
120 other study(ies) available for alpha-aminopyridine and piperidines
| Article | Year |
|---|---|
Inhibitory effect of levocabastine on experimental allergic conjunctivitis in guinea pigs.
Topics: Aminopyridines; Animals; Antigens; Capillary Permeability; Conjunctivitis, Allergic; Cromolyn Sodium; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; Histidine Decarboxylase; Male; Piperidines; SRS-A | 1991 |
Effects of 2-(4-phenylpiperidino)cyclohexanol (AH5183) and barium ions on frog neuromuscular transmission.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Animals; Barium; Calcium; In Vitro Techniques; Magnesium; Motor Endplate; Neuromuscular Depolarizing Agents; Neuromuscular Junction; Phencyclidine; Piperidines; Ranidae; Strontium; Synaptic Transmission | 1988 |
Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine.
Topics: Aminopyridines; Animals; Binding, Competitive; Cerebral Cortex; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Kinetics; Loratadine; Lung; Male; Piperidines; Pyrilamine; Receptors, Cell Surface | 1986 |
Acetylcholine synthesis and release by a sympathetic ganglion in the presence of 2-(4-phenylpiperidino) cyclohexanol (AH5183).
Topics: 4-Aminopyridine; Acetylcholine; Aminopyridines; Animals; Calcium; Cats; Electric Stimulation; Female; Ganglia, Sympathetic; Kinetics; Male; Phencyclidine; Physostigmine; Piperidines | 1986 |
Serotonin-induced platelet aggregation in whole blood and the effects of ketanserin and mepyramine.
Topics: Aminopyridines; Dose-Response Relationship, Drug; Humans; Ketanserin; Piperidines; Platelet Aggregation; Pyrilamine; Serotonin; Time Factors | 1985 |
New antihistaminic N-heterocyclic 4-piperidinamines. 3. Synthesis and antihistaminic activity of N-(4-piperidinyl)-3H-imidazo[4,5-b]pyridin-2-amines.
Topics: Administration, Oral; Aminopyridines; Animals; Astemizole; Benzimidazoles; Guinea Pigs; Histamine; Histamine Antagonists; Imidazoles; Male; p-Methoxy-N-methylphenethylamine; Piperidines; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1985 |
Effects of ketanserin and mepyramine on platelet aggregation and on the uptake of 5-hydroxytryptamine into platelets.
Topics: Adenosine Diphosphate; Aminopyridines; Blood Platelets; Humans; Ketanserin; Piperidines; Platelet Aggregation; Pyrilamine; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1983 |
Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D4 receptor.
Topics: Aminopyridines; Animals; CHO Cells; Cricetinae; Humans; Mitosis; Piperidines; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Signal Transduction | 1997 |
RBI-257: a highly potent dopamine D4 receptor-selective ligand.
Topics: Aminopyridines; Animals; Brain Chemistry; Cricetinae; Dopamine Agents; Guinea Pigs; Humans; In Vitro Techniques; Isomerism; Ligands; Membranes; Piperidines; Radioligand Assay; Rats; Receptors, Dopamine D2; Receptors, Dopamine D4 | 1997 |
Dopamine D4 receptor mediated inhibition of potassium current in neurohypophysial nerve terminals.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aminopyridines; Animals; Dopamine Agonists; Dopamine Antagonists; Electric Conductivity; Female; Kinetics; Male; Membrane Potentials; Nerve Endings; Patch-Clamp Techniques; Phenethylamines; Piperidines; Pituitary Gland, Posterior; Potassium; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4; Salicylamides | 1998 |
Serotonin-1B agonists induce compartmentally organized striatal Fos expression in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Corpus Striatum; Immunohistochemistry; Indoles; Male; Nerve Tissue Proteins; Piperazines; Piperidines; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Serotonin Receptor Agonists | 1998 |
The agonist activities of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor.
Topics: Aminopyridines; Antipsychotic Agents; Cell Line; Clozapine; Colforsin; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Humans; Kidney; Piperidines; Pyridines; Pyrroles; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone | 1998 |
Neuropharmacological assessment of potential dopamine D4 receptor-selective radioligands.
Topics: Aminopyridines; Animals; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Dopamine Agents; Dopamine Antagonists; Haloperidol; Humans; In Vitro Techniques; Ligands; Male; Piperidines; Prosencephalon; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4; Spiperone; Tritium | 1999 |
Discriminative stimulus properties of the novel serotonin (5-HT)2C receptor agonist, RO 60-0175: a pharmacological analysis.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Conditioning, Operant; Ethylamines; Fluorobenzenes; Indoles; Male; Mianserin; Piperazines; Piperidines; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Reinforcement, Psychology; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes | 1999 |
Novel derivatives of 2-pyridinemethylamine as selective, potent, and orally active agonists at 5-HT1A receptors.
Topics: Administration, Oral; Aminopyridines; Animals; Antidepressive Agents; Binding, Competitive; Cell Line; Cyclic AMP; Drug Evaluation, Preclinical; HeLa Cells; Humans; Ligands; Male; Motor Activity; Piperidines; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Structure-Activity Relationship | 1999 |
Binding of [3H]U-101958 to sigma1 receptor-like sites in human cerebellum and neuroblastoma cells.
Topics: Aminopyridines; Binding, Competitive; Cerebellum; Culture Techniques; Dopamine Agents; Humans; Neuroblastoma; Piperidines; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D4; Receptors, sigma; Reverse Transcriptase Polymerase Chain Reaction; Sigma-1 Receptor | 1999 |
5-HT2 receptor antagonism reduces hyperactivity induced by amphetamine, cocaine, and MK-801 but not D1 agonist C-APB.
Topics: Aminopyridines; Amphetamine; Animals; Benzazepines; Cocaine; Dizocilpine Maleate; Dopamine Agonists; Drug Interactions; Female; Fluorobenzenes; Indoles; Mice; Motor Activity; Piperidines; Ritanserin; Serotonin Antagonists | 1999 |
D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia.
Topics: Amino Acid Sequence; Aminopyridines; Animals; Benzazepines; Binding Sites; Carbon Radioisotopes; CHO Cells; Clozapine; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Formates; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Methionine; Mutagenesis, Site-Directed; Neuroblastoma; Phospholipids; Phosphorylation; Piperidines; Psychotic Disorders; Pyridines; Pyrroles; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; S-Adenosylmethionine; Salicylamides; Schizophrenia; Transfection; Tumor Cells, Cultured | 1999 |
Synthesis and structure-activity relationships of the (alkylamino)piperidine-containing BHAP class of non-nucleoside reverse transcriptase inhibitors: effect of 3-alkylpyridine ring substitution.
Topics: Administration, Oral; Aminopyridines; Animals; Anti-HIV Agents; Biological Availability; Cells, Cultured; In Vitro Techniques; Injections, Intravenous; Male; Microsomes, Liver; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Sulfonamides | 1999 |
Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L-745,870 and U-101958 at human recombinant D4.4 receptors expressed in CHO cells.
Topics: Aminopyridines; Animals; Butyrates; CHO Cells; Cricetinae; Cyclic AMP; Dopamine Agents; Humans; Ligands; Piperidines; Pyridines; Pyrroles; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Spiperone | 1999 |
[(3)H]PNU-101958, a D(4) dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brain.
Topics: Aminopyridines; Animals; Autoradiography; Brain; Hippocampus; Macaca mulatta; Molecular Probes; Piperidines; Prefrontal Cortex; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D4; Tissue Distribution; Tritium | 2000 |
The effects of compounds varying in selectivity as 5-HT(1A) receptor antagonists in three rat models of anxiety.
Topics: Aminopyridines; Animals; Anxiety; Cyclohexane Monoterpenes; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Isoquinolines; Male; Maze Learning; Motor Activity; Pindolol; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Succinimides | 2000 |
Synthesis and analgesic activity of some quinazoline analogs of anpirtoline.
Topics: Aminopyridines; Analgesics; Animals; Hot Temperature; Male; Mice; Mice, Inbred Strains; Molecular Structure; Pain; Piperidines; Pyridines; Quinazolines; Reaction Time; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Structure-Activity Relationship; Tramadol | 2000 |
Synthesis of substituted N-(4-piperidyl)-N-(3-pyridyl)amides with antiarrhythmic activity. Note 1.
Topics: Aconitine; Aminopyridines; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chromatography, Thin Layer; Female; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Male; Piperidines; Rats; Spectrophotometry, Infrared | 2000 |
5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Antidepressive Agents; Binding, Competitive; Buspirone; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Male; Motor Activity; Piperazines; Piperidines; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming | 2001 |
Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis.
Topics: Aminopyridines; Amphetamines; Animals; Corticosterone; Dose-Response Relationship, Drug; Ethylamines; Fluorobenzenes; Hypothalamo-Hypophyseal System; Indoles; Male; Piperazines; Piperidines; Quipazine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2002 |
Differential effects of the 5-HT(2A) receptor antagonist M100907 and the 5-HT(2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding.
Topics: Aminopyridines; Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Fluorobenzenes; Indoles; Male; Motor Activity; Neural Pathways; Piperidines; Quinolines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Self Administration; Serotonin; Serotonin Antagonists | 2002 |
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cells, Cultured; CHO Cells; Cricetinae; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Synergism; Female; Fentanyl; Gabapentin; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Imipramine; Ketamine; Male; Morphine; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Time Factors; Transfection | 2002 |
The 5-HT(1A) receptor agonist F 13640 attenuates mechanical allodynia in a rat model of trigeminal neuropathic pain.
Topics: Aminopyridines; Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Morphine; Muscle Relaxants, Central; Narcotics; Pain; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Stress, Mechanical; Trigeminal Neuralgia | 2002 |
Discriminative stimulus properties of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(+/-)DOI] in C57BL/6J mice.
Topics: Aminopyridines; Animals; Conditioning, Operant; Discrimination Learning; DOM 2,5-Dimethoxy-4-Methylamphetamine; Dose-Response Relationship, Drug; Fluorobenzenes; Indoles; Indophenol; Lysergic Acid Diethylamide; Male; Mice; Mice, Inbred C57BL; Piperazines; Piperidines; Pyridines; Reaction Time; Reinforcement Schedule; Serotonin Antagonists; Serotonin Receptor Agonists | 2003 |
Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol- l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine(2C) receptor agonist.
Topics: Aminopyridines; Animals; Drug Interactions; Ethylamines; Fluorobenzenes; Indoles; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors | 2003 |
Effect of different 5-HT1A receptor antagonists in combination with paroxetine on expression of the immediate-early gene Arc in rat brain.
Topics: Aminopyridines; Animals; Apoptosis Regulatory Proteins; Benzopyrans; Brain Chemistry; Gene Expression; Male; Muscle Proteins; Paroxetine; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists | 2003 |
The 5-HT2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism.
Topics: Aminopyridines; Animals; Dizocilpine Maleate; Drug Interactions; Fluorobenzenes; Impulsive Behavior; Indoles; Male; Motor Activity; Neuroprotective Agents; Piperidines; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; Serotonin Antagonists | 2003 |
In vivo modulation of 5-hydroxytryptamine release in mouse prefrontal cortex by local 5-HT(2A) receptors: effect of antipsychotic drugs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminopyridines; Anesthetics, Local; Animals; Antipsychotic Agents; Benzopyrans; Blotting, Western; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Fluorobenzenes; Immunohistochemistry; In Situ Hybridization; Indoles; Indophenol; Male; Mice; Mice, Inbred C57BL; Microdialysis; Piperidines; Prazosin; Prefrontal Cortex; Quinoxalines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrodotoxin; Thiazoles; Time Factors | 2003 |
5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion.
Topics: 5,7-Dihydroxytryptamine; Aminopyridines; Animals; Conditioning, Operant; Fluorobenzenes; Impulsive Behavior; Indoles; Injections, Intraventricular; Male; Piperidines; Psychomotor Performance; Rats; Reaction Time; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin Agents; Serotonin Antagonists | 2004 |
Effects of the combined continuous administration of morphine and the high-efficacy 5-HT1A agonist, F 13640 in a rat model of trigeminal neuropathic pain.
Topics: Aminopyridines; Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug Tolerance; Infusion Pumps, Implantable; Male; Morphine; Pain Measurement; Physical Stimulation; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin Receptor Agonists; Trigeminal Neuralgia | 2004 |
Clozapine, ziprasidone and aripiprazole but not haloperidol protect against kainic acid-induced lesion of the striatum in mice, in vivo: role of 5-HT1A receptor activation.
Topics: Aminopyridines; Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Agonists; Haloperidol; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Piperazines; Piperidines; Pyridines; Quinolones; Receptor, Serotonin, 5-HT1A; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Thiazoles | 2005 |
Actions of novel antipsychotic agents on apomorphine-induced PPI disruption: influence of combined serotonin 5-HT1A receptor activation and dopamine D2 receptor blockade.
Topics: Aminopyridines; Animals; Antipsychotic Agents; Apomorphine; Dioxanes; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Serotonin Receptor Agonists; Tropanes | 2006 |
Rapid desensitization of somatodendritic 5-HT1A receptors by chronic administration of the high-efficacy 5-HT1A agonist, F13714: a microdialysis study in the rat.
Topics: Aminopyridines; Animals; Buspirone; Hippocampus; Male; Microdialysis; Piperazines; Piperidines; Protein Binding; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists | 2006 |
Effects of the serotonin 5-HT2A and 5-HT2C receptor ligands on the discriminative stimulus effects of nicotine in rats.
Topics: Aminopyridines; Amphetamines; Animals; Azepines; Azetidines; Behavior, Animal; Brain; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethylamines; Fluorobenzenes; Indoles; Ligands; Male; Nicotine; Nicotinic Agonists; Piperidines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Nicotinic; Serotonin 5-HT2 Receptor Agonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2007 |
Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test.
Topics: Aminopyridines; Amphetamines; Animals; Conditioning, Operant; Ethylamines; Fluorobenzenes; Impulsive Behavior; Indoles; Ketanserin; Male; Mice; Mice, Inbred C57BL; Piperidines; Quinolines; Rats; Reaction Time; Serial Learning; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Species Specificity | 2007 |
Dissociable effects of selective 5-HT2A and 5-HT2C receptor antagonists on serial spatial reversal learning in rats.
Topics: Aminopyridines; Animals; Cognition; Conditioning, Operant; Discrimination Learning; Fluorobenzenes; Indoles; Male; Piperidines; Psychomotor Performance; Rats; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Reinforcement Schedule; Reversal Learning; Serotonin Antagonists; Space Perception | 2008 |
Opposing roles for 5-HT2A and 5-HT2C receptors in the nucleus accumbens on inhibitory response control in the 5-choice serial reaction time task.
Topics: Aminopyridines; Animals; Attention; Brain Chemistry; Cerebral Cortex; Choice Behavior; Dose-Response Relationship, Drug; Fluorobenzenes; Impulsive Behavior; Indoles; Limbic System; Male; Neural Inhibition; Neuropsychological Tests; Nucleus Accumbens; Piperidines; Rats; Reaction Time; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin Antagonists; Synaptic Transmission | 2008 |
Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization.
Topics: Aminopyridines; Animals; Behavior, Animal; Benzazepines; Body Weight; Brain; Cell Line; Dopamine; Eating; Fluorobenzenes; Humans; Indoles; Male; Norepinephrine; Obesity; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Transfection | 2008 |
Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation.
Topics: Aminopyridines; Animals; Antidepressive Agents, Second-Generation; Astrocytes; Butadienes; Calcium; Cells, Cultured; Chelating Agents; Dipeptides; Dose-Response Relationship, Drug; Egtazic Acid; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fluorobenzenes; Fluoxetine; Gene Expression; Indoles; Maleimides; Mice; Nitriles; Phosphorylation; Piperidines; Protein Kinase C; Proto-Oncogene Proteins c-fos; Quinazolines; Receptor, Serotonin, 5-HT2B; RNA, Messenger; Signal Transduction; Substrate Specificity; Transcriptional Activation; Tyrphostins; Up-Regulation; Urea | 2008 |
Signal transduction and functional selectivity of F15599, a preferential post-synaptic 5-HT1A receptor agonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Autoradiography; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Extracellular Signal-Regulated MAP Kinases; In Vitro Techniques; Male; Phosphorylation; Piperidines; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Signal Transduction | 2009 |
Interactions of serotonin (5-HT)2 receptor-targeting ligands and nicotine: locomotor activity studies in rats.
Topics: Aminopyridines; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Fluorobenzenes; Indoles; Male; Motor Activity; Nicotine; Nicotinic Agonists; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT2; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors | 2009 |
Relevance of dorsal raphe nucleus firing in serotonin 5-HT(2C) receptor blockade-induced augmentation of SSRIs effects.
Topics: Action Potentials; Aminopyridines; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Synergism; Fluorobenzenes; Indoles; Male; Microdialysis; Neurons; Piperidines; Protein Binding; Raphe Nuclei; Rats; Receptor, Serotonin, 5-HT2C; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Tritium | 2009 |
SAR of N-phenyl piperidine based oral integrin alpha5beta1 antagonists.
Topics: Administration, Oral; Aminopyridines; Animals; Dogs; Drug Design; Integrin alpha5beta1; Male; Phenylalanine; Piperidines; Rats; Stereoisomerism; Structure-Activity Relationship | 2010 |
Differential effects of serotonin 5-HT1A receptor agonists on the discriminative stimulus effects of the 5-HT2A receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rats and rhesus monkeys.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Discrimination, Psychological; DOM 2,5-Dimethoxy-4-Methylamphetamine; Drug Interactions; Macaca mulatta; Male; Phenethylamines; Piperidines; Rats; Rats, Sprague-Dawley; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Agonists; Tryptamines | 2010 |
F15599, a highly selective post-synaptic 5-HT(1A) receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity.
Topics: Aminopyridines; Animals; Antidepressive Agents; Corticosterone; Depression; Hypothermia; Male; Models, Animal; Molecular Targeted Therapy; Motor Activity; Piperidines; Prefrontal Cortex; Pyrimidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Serotonin; Serotonin 5-HT1 Receptor Agonists; Stress, Physiological; Swimming | 2010 |
Enhancement of spatial reversal learning by 5-HT2C receptor antagonism is neuroanatomically specific.
Topics: Aminopyridines; Analysis of Variance; Animals; Brain; Brain Mapping; Conditioning, Operant; Dose-Response Relationship, Drug; Fluorobenzenes; Indoles; Male; Piperidines; Rats; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Reinforcement Schedule; Reversal Learning; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Space Perception; Time Factors | 2010 |
Differential effects of serotonin (5-HT)2 receptor-targeting ligands on locomotor responses to nicotine-repeated treatment.
Topics: Aminopyridines; Amphetamines; Animals; Azepines; Ethylamines; Fluorobenzenes; Indoles; Male; Motor Activity; Nicotine; Nicotinic Agonists; Piperidines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors | 2010 |
Kinase inhibitors attract attention as oral rheumatoid arthritis drugs.
Topics: Administration, Oral; Aminopyridines; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Delivery Systems; Drug Design; Humans; Morpholines; Oxazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles | 2010 |
F15599, a preferential post-synaptic 5-HT1A receptor agonist: activity in models of cognition in comparison with reference 5-HT1A receptor agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Cognition; Disease Models, Animal; Enzyme Inhibitors; Male; Memory, Short-Term; Phencyclidine; Piperidines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Reflex, Startle; Serotonin 5-HT1 Receptor Agonists; Signal Transduction | 2010 |
Oleamide administered into the nucleus accumbens shell regulates feeding behaviour via CB1 and 5-HT2C receptors.
Topics: Aminopyridines; Animals; Eating; Feeding Behavior; Hyperphagia; Hypothalamus; Indoles; Ketanserin; Male; Motor Activity; Nucleus Accumbens; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Antagonists | 2010 |
Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats.
Topics: Aminopyridines; Animals; Behavior, Animal; Cocaine; Dopamine; Dose-Response Relationship, Drug; Fluorobenzenes; Glutamic Acid; Indoles; Male; Microdialysis; Neuronal Plasticity; Nucleus Accumbens; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Antagonists | 2011 |
Presence and functional role of the rapidly activating delayed rectifier K(+) current in left and right atria of adult mice.
Topics: Action Potentials; Aminopyridines; Animals; Atrial Function; Cells, Cultured; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Heart Atria; Kinetics; Kv1.5 Potassium Channel; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Organ Specificity; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyridines | 2010 |
Interaction of 5-HT2A and 5-HT2C receptors in R(-)-2,5-dimethoxy-4-iodoamphetamine-elicited head twitch behavior in mice.
Topics: Aminopyridines; Amphetamines; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Ethylamines; Fluorobenzenes; Hallucinogens; Head; Indoles; Ketanserin; Male; Mice; Mice, Inbred Strains; Movement; Piperidines; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Spiro Compounds; Sulfonamides | 2010 |
Effects of 5-HT(2A) and 5-HT(2C) receptor antagonists on acute and chronic dyskinetic effects induced by haloperidol in rats.
Topics: Aminopyridines; Animals; Antipsychotic Agents; Brain Chemistry; Catalepsy; Dyskinesia, Drug-Induced; Fluorobenzenes; Gene Expression Regulation; Haloperidol; Immunohistochemistry; In Situ Hybridization; Indoles; Ketanserin; Male; Mouth; Piperidines; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; RNA, Messenger; Serotonin Antagonists | 2011 |
Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonists.
Topics: Activity Cycles; Aminopyridines; Amphetamine; Animals; Behavior, Animal; Brain Mapping; Dioxanes; Magnetic Resonance Imaging; Motivation; Orexin Receptors; Phenylurea Compounds; Piperidines; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reward | 2011 |
Role of 5-HT(1A) and 5-HT(1B) receptors in the antidepressant-like effect of piperine in the forced swim test.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alkaloids; Aminopyridines; Animals; Antidepressive Agents; Benzodioxoles; Data Interpretation, Statistical; Male; Methiothepin; Mice; Mice, Inbred ICR; Motor Activity; Piperazines; Piperidines; Polyunsaturated Alkamides; Propanolamines; Pyridines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Swimming | 2011 |
Serotonin2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior.
Topics: Alcohol Drinking; Aminopyridines; Analysis of Variance; Animals; Biogenic Monoamines; Central Nervous System Depressants; Chromatography, High Pressure Liquid; Disease Models, Animal; Ethanol; Gene Expression Regulation; Indoles; Male; Mice; Mice, Inbred C57BL; Microdialysis; Microinjections; Nucleus Accumbens; Piperidines; Raphe Nuclei; Receptor, Serotonin, 5-HT2C; Receptors, Dopamine; RNA, Messenger; Serotonin Agents; Sulfonamides | 2012 |
Radiosynthesis and preclinical evaluation of 18F-F13714 as a fluorinated 5-HT1A receptor agonist radioligand for PET neuroimaging.
Topics: Aminopyridines; Animals; Brain; Cats; Fluorine Radioisotopes; Isotope Labeling; Male; Piperidines; Positron-Emission Tomography; Radioligand Assay; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists | 2012 |
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminopyridines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Enzyme Assays; Humans; Indans; Models, Biological; Models, Molecular; Nitriles; Permeability; Piperidines; Protein Binding; Pyridines; Structure-Activity Relationship | 2012 |
Characterizing antiprion compounds based on their binding properties to prion proteins: implications as medical chaperones.
Topics: Amides; Aminopyridines; Animals; Binding Sites; Carbazoles; Catechin; Congo Red; Magnetic Resonance Spectroscopy; Mice; Molecular Chaperones; Molecular Structure; Nitriles; Pentosan Sulfuric Polyester; Piperidines; Prions; Protein Conformation; Quinacrine; Surface Plasmon Resonance | 2013 |
In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis.
Topics: Aminopyridines; Animals; Benzopyrans; Cell Line; Humans; Mice; Mice, Inbred C57BL; Piperidines; Pyrazines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2013 |
Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Aminopyridines; Amygdala; Animals; Benzazepines; Corpus Striatum; Corticosterone; Dopamine Antagonists; Functional Neuroimaging; Gyrus Cinguli; Male; Medetomidine; Neural Pathways; Orexin Receptor Antagonists; Piperidines; Pyrimidines; Pyrroles; Rats; Receptors, Corticotropin-Releasing Hormone; Stress, Psychological; Yohimbine | 2013 |
Discovery of novel c-Met inhibitors bearing a 3-carboxyl piperidin-2-one scaffold.
Topics: Aminopyridines; Cell Line, Tumor; Cell Proliferation; Drug Design; Humans; Molecular Structure; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridones; Structure-Activity Relationship | 2014 |
Small-animal single-photon emission computed tomographic imaging of the brain serotoninergic systems in wild-type and mdr1a knockout rats.
Topics: Aminopyridines; Animals; ATP Binding Cassette Transporter, Subfamily B; Brain; Cinanserin; Gene Knockout Techniques; Iodine Radioisotopes; Male; Organ Specificity; Piperazines; Piperidines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2014 |
Evidence for a role of 5-HT2C receptors in the motor aspects of performance, but not the efficacy of food reinforcers, in a progressive ratio schedule.
Topics: Aminopyridines; Animals; Ethylamines; Fluorobenzenes; Food; Indoles; Male; Motivation; Piperidines; Rats; Rats, Wistar; Reaction Time; Receptor, Serotonin, 5-HT2C; Reinforcement, Psychology; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists | 2015 |
Inhibitors of BCR signalling interrupt the survival signal mediated by the micro-environment in mantle cell lymphoma.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Aged; Aged, 80 and over; Aminopyridines; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Cells, Cultured; Coculture Techniques; Cytokines; Female; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Lymphoma, Mantle-Cell; Male; Middle Aged; Morpholines; Oxazines; Phosphorylation; Piperidines; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Pyrimidines; Receptors, Antigen, B-Cell; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Syk Kinase; Tumor Cells, Cultured | 2015 |
Divergent effects of the 'biased' 5-HT1 A receptor agonists F15599 and F13714 in a novel object pattern separation task.
Topics: Aminopyridines; Animals; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Indans; Male; Pattern Recognition, Visual; Piperazines; Piperidines; Pyridines; Pyrimidines; Rats; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists | 2015 |
A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects.
Topics: Aminopyridines; Animals; Arousal; CHO Cells; Cricetinae; Cricetulus; HEK293 Cells; Humans; Hypnotics and Sedatives; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Protein Binding; Rats; Rats, Sprague-Dawley; Stress, Psychological | 2015 |
Expression of functional sphingosine-1 phosphate receptor-1 is reduced by B cell receptor signaling and increased by inhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukemia cells.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Aminopyridines; Antineoplastic Agents; B-Lymphocytes; Case-Control Studies; Cell Movement; Class I Phosphatidylinositol 3-Kinases; Gene Expression Regulation, Leukemic; Germinal Center; Human Umbilical Vein Endothelial Cells; Humans; Integrins; Intracellular Signaling Peptides and Proteins; Leukemia, Lymphocytic, Chronic, B-Cell; Lymph Nodes; Lysophospholipids; Morpholines; Oxazines; Piperidines; Primary Cell Culture; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Purines; Pyrazoles; Pyridines; Pyrimidines; Quinazolinones; Receptors, Antigen, B-Cell; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Syk Kinase | 2015 |
Synthesis of 3H, 13C,2H3,15N and 14C-labelled SCH 466036, a histamine 3 receptor antagonist.
Topics: Aminopyridines; Carbon Radioisotopes; Deuterium; Histamine H3 Antagonists; Nitrogen Isotopes; Piperidines; Radiopharmaceuticals; Tritium | 2015 |
Protective effect of a novel Rho kinase inhibitor WAR-5 in experimental autoimmune encephalomyelitis by modulating inflammatory response and neurotrophic factors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Aminopyridines; Animals; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Female; Immunoblotting; Immunoenzyme Techniques; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Nerve Growth Factors; Piperidines; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; T-Lymphocytes, Regulatory | 2015 |
Anti-aggressive effects of the selective high-efficacy 'biased' 5-HT₁A receptor agonists F15599 and F13714 in male WTG rats.
Topics: Aggression; Aminopyridines; Animals; Dose-Response Relationship, Drug; Male; Neurons; Piperazines; Piperidines; Pyridines; Pyrimidines; Raphe Nuclei; Rats; Serotonin 5-HT1 Receptor Agonists | 2016 |
The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses.
Topics: Aminopyridines; Animals; Benzamides; Cyclopropanes; Donepezil; Indans; Male; Memory; Mice; Mice, Inbred C57BL; Nootropic Agents; Phosphodiesterase 4 Inhibitors; Piperidines; Rats, Wistar; Recognition, Psychology; Rolipram; Scopolamine; Spatial Memory; Vomiting | 2016 |
The highly selective orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice.
Topics: Alcohol Drinking; Aminopyridines; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drinking Behavior; Ethanol; Male; Mice; Mice, Inbred C57BL; Orexin Receptor Antagonists; Piperidines; Sucrose | 2016 |
Endothelin‑1 induces oncostatin M expression in osteoarthritis osteoblasts by trans‑activating the oncostatin M gene promoter via Ets‑1.
Topics: Aminopyridines; Base Sequence; Binding Sites; Cells, Cultured; Endothelin-1; Genes, Reporter; Humans; Molecular Sequence Data; Morpholines; Oligopeptides; Oncostatin M; Osteoarthritis; Osteoblasts; Peptides, Cyclic; Piperidines; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Protein c-ets-1; RNA Interference; RNA, Messenger; RNA, Small Interfering; Transcriptional Activation | 2016 |
The inhibitory effect of combination treatment with leptin and cannabinoid CB1 receptor agonist on food intake and body weight gain is mediated by serotonin 1B and 2C receptors.
Topics: Aminopyridines; Animals; Cannabinoid Receptor Agonists; Drug Synergism; Eating; Indoles; Leptin; Male; Oxadiazoles; Piperazines; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Weight Gain | 2016 |
Marmoset Serotonin 5-HT1A Receptor Mapping with a Biased Agonist PET Probe 18F-F13714: Comparison with an Antagonist Tracer 18F-MPPF in Awake and Anesthetized States.
Topics: Aminopyridines; Anesthesia, General; Animals; Brain; Callithrix; Consciousness; Fluorine Radioisotopes; Male; Molecular Imaging; Piperazines; Piperidines; Positron-Emission Tomography; Predictive Value of Tests; Protein Binding; Pyridines; Radiopharmaceuticals; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Tissue Distribution | 2016 |
Effects of 5-HT
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Amphetamines; Animals; Conditioning, Operant; Fluorobenzenes; Indoles; Male; Methylphenidate; Piperazines; Piperidines; Pyridines; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Reinforcement, Psychology; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2017 |
Synthesis of Ofornine mimics from natural product l-vasicine as anti-hypertensive agents.
Topics: Alkaloids; Aminopyridines; Animals; Antihypertensive Agents; Biological Products; Blood Pressure; Dose-Response Relationship, Drug; Female; Hypertension; Injections, Intravenous; Mice; Molecular Structure; Piperidines; Quinazolines; Rats; Rats, Wistar; Structure-Activity Relationship | 2017 |
Novel Pieces for the Emerging Picture of Sulfoximines in Drug Discovery: Synthesis and Evaluation of Sulfoximine Analogues of Marketed Drugs and Advanced Clinical Candidates.
Topics: Aminopyridines; Ataxia Telangiectasia Mutated Proteins; Cyclin-Dependent Kinases; Drug Design; Estradiol; Fulvestrant; Imatinib Mesylate; Piperazines; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyridines; Sulfoxides; Vardenafil Dihydrochloride | 2017 |
CX-4945, a Selective Inhibitor of Casein Kinase 2, Synergizes with B Cell Receptor Signaling Inhibitors in Inducing Diffuse Large B Cell Lymphoma Cell Death.
Topics: Adenine; Aminopyridines; Apoptosis; Casein Kinase II; Cell Proliferation; Drug Synergism; Humans; Lymphoma, Large B-Cell, Diffuse; Morpholines; Naphthyridines; Oxazines; Phenazines; Piperidines; Pyrazoles; Pyridines; Pyrimidines; Receptors, Antigen, B-Cell; Tumor Cells, Cultured | 2018 |
Effects of Acute and Chronic Treatments with Dopamine D
Topics: Aminopyridines; Animals; Benzamides; Choice Behavior; Cocaine; Conditioning, Operant; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Tolerance; Food; Indoles; Ligands; Male; Morpholines; Piperidines; Pyridines; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Reinforcement, Psychology | 2017 |
How Does the L884P Mutation Confer Resistance to Type-II Inhibitors of JAK2 Kinase: A Comprehensive Molecular Modeling Study.
Topics: Allosteric Site; Aminopyridines; Benzimidazoles; Drug Resistance, Neoplasm; Entropy; Humans; Janus Kinase 2; Models, Molecular; Molecular Dynamics Simulation; Mutation; Piperidines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Protein Structure, Secondary; Pyrimidines | 2017 |
Activation of Src signaling mediates acquired resistance to ALK inhibition in lung cancer.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Animals; Antineoplastic Combined Chemotherapy Protocols; Carbazoles; Carcinoma, Non-Small-Cell Lung; Crizotinib; Drug Resistance, Neoplasm; Humans; Lactams; Lactams, Macrocyclic; Mice; Piperidines; Pyrazoles; Pyridines; Pyrimidines; Receptor Protein-Tyrosine Kinases; Signal Transduction; src-Family Kinases; Sulfones; Xenograft Model Antitumor Assays | 2017 |
MALDI imaging facilitates new topical drug development process by determining quantitative skin distribution profiles.
Topics: Acetamides; Administration, Topical; Aminopyridines; Benzamides; Cyclopropanes; Drug Discovery; Humans; Nitriles; Phosphodiesterase 4 Inhibitors; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Skin; Skin Absorption; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2018 |
Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates.
Topics: Aminopyridines; Animals; Carbazoles; Chromatography, Liquid; Drug Stability; Humans; Lactams; Lactams, Macrocyclic; Male; Mice; Organophosphorus Compounds; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Tandem Mass Spectrometry; Tissue Distribution | 2018 |
Blockade of Serotonin 2C Receptors with SB-242084 Moderates Reduced Locomotor Activity and Rearing by Cannabinoid 1 Receptor Antagonist AM-251.
Topics: Aminopyridines; Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Exploratory Behavior; Indoles; Locomotion; Male; Maze Learning; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Antagonists; Social Behavior | 2019 |
CB1R mediates oleamide's reward while 5HT2cR mediates aversion in the nucleus accumbens shell of rats.
Topics: Aminopyridines; Animals; Conditioning, Operant; Extinction, Psychological; Indoles; Male; Nucleus Accumbens; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT2C; Reward; Serotonin 5-HT2 Receptor Antagonists | 2019 |
Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms.
Topics: Aminopyridines; Animals; Benzimidazoles; CHO Cells; Cricetinae; Cricetulus; Hep G2 Cells; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Phosphorylcholine; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Pyrroles; Quinoxalines; Receptors, LDL; Ribonucleosides; RNA Stability; RNA, Messenger; Transcriptional Activation | 2019 |
Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Animals; Antineoplastic Combined Chemotherapy Protocols; Carbazoles; Cell Line, Tumor; Crizotinib; Drug Resistance, Neoplasm; Erlotinib Hydrochloride; Humans; Kidney Neoplasms; Lactams; Lactams, Macrocyclic; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred NOD; Middle Aged; Mutation; Piperidines; Pyrazoles; Xenograft Model Antitumor Assays | 2019 |
Glucose restriction reverses the Warburg effect and modulates PKM2 and mTOR expression in breast cancer cell lines.
Topics: Adenosine Triphosphate; Aminopyridines; Blotting, Western; Breast Neoplasms; Carrier Proteins; Cell Line, Tumor; Colorimetry; Down-Regulation; Flow Cytometry; Glucose; Humans; Lactic Acid; MCF-7 Cells; Membrane Proteins; Piperidines; Thyroid Hormone-Binding Proteins; Thyroid Hormones; TOR Serine-Threonine Kinases | 2019 |
Drug resistance mechanisms in Japanese anaplastic lymphoma kinase-positive non-small cell lung cancer and the clinical responses based on the resistant mechanisms.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Asian People; Carbazoles; Carcinoma, Non-Small-Cell Lung; Crizotinib; Drug Resistance, Neoplasm; Humans; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Mutation; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Recombinant Proteins; Sulfones | 2020 |
The combination of radiotherapy and ALK inhibitors is effective in the treatment of intraosseous rhabdomyosarcoma with FUS-TFCP2 fusion transcript.
Topics: Adolescent; Aminopyridines; Anaplastic Lymphoma Kinase; Bone Neoplasms; Carbazoles; Chemoradiotherapy; DNA-Binding Proteins; Female; Humans; Lactams; Lactams, Macrocyclic; Oncogene Proteins, Fusion; Piperidines; Pyrazoles; Rhabdomyosarcoma; RNA-Binding Protein FUS; Transcription Factors | 2020 |
Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Genes, ras; Heterografts; Humans; Indoles; Male; MAP Kinase Signaling System; Mice, Inbred NOD; Mice, SCID; Mitogen-Activated Protein Kinase Kinases; Mutation; Neoplasm Recurrence, Local; Neuroblastoma; Piperidines; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pyridones; Pyrimidines; Pyrimidinones; Pyrroles; Triazoles; Vemurafenib | 2020 |
Chidamide combined with ibrutinib improved the prognosis of primary bone marrow diffuse large B cell lymphoma.
Topics: Adenine; Aged; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Bone Marrow; Bone Marrow Cells; China; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Etoposide; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Piperidines; Prednisone; Prognosis; Rituximab; Transplantation, Autologous; Vincristine | 2020 |
Chidamide, a histone deacetylase inhibitor, inhibits autophagy and exhibits therapeutic implication in chronic lymphocytic leukemia.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Autophagy-Related Proteins; Benzamides; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Phosphatidylinositol 3-Kinase; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Marble Burying in NMRI Male Mice Is Preferentially Sensitive to Pre- Versus Postsynaptic 5-HT1A Receptor Biased Agonists.
Topics: Aminopyridines; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mice, Inbred Strains; Obsessive-Compulsive Disorder; Piperazines; Piperidines; Pyridines; Pyrimidines; Receptor, Serotonin, 5-HT1A; Receptors, Presynaptic; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Synapses | 2021 |
Alectinib and lorlatinib function by modulating EMT-related proteins and MMPs in NSCLC metastasis.
Topics: Aminopyridines; Biomarkers, Tumor; Brain Neoplasms; Carbazoles; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Survival; Down-Regulation; Epithelial-Mesenchymal Transition; Humans; Lactams; Lung Neoplasms; Matrix Metalloproteinases; Piperidines; Pyrazoles; Tumor Cells, Cultured | 2021 |
Targeting N-myristoylation for therapy of B-cell lymphomas.
Topics: Acyltransferases; Adenine; Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dasatinib; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Lymphoma, B-Cell; Mice; Mice, SCID; Models, Biological; Myristic Acid; Piperidines; Pyrazoles; Pyrimidines; Receptors, Antigen, B-Cell; Signal Transduction; src-Family Kinases; Sulfonamides; Xenograft Model Antitumor Assays | 2020 |
Cutaneous sarcoid-like drug reaction caused by an anaplastic lymphoma kinase inhibitor.
Topics: Adenocarcinoma of Lung; Aged; Aminopyridines; Anaplastic Lymphoma Kinase; Biopsy; Carbazoles; Cell Cycle Proteins; Drug-Related Side Effects and Adverse Reactions; Female; Granuloma; Humans; Lactams; Microtubule-Associated Proteins; Neoplasm Staging; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Sarcoidosis; Serine Endopeptidases; Skin; Withholding Treatment | 2021 |
New lung-cancer drugs extend survival times.
Topics: Acrylamides; Afatinib; Aminopyridines; Anaplastic Lymphoma Kinase; Aniline Compounds; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; B7-H1 Antigen; Carbazoles; Carcinoma, Non-Small-Cell Lung; Crizotinib; ErbB Receptors; Gefitinib; Hope; Humans; Lactams; Lung; Lung Neoplasms; Piperidines; Programmed Cell Death 1 Receptor; Pyrazoles; Quinazolinones; Survival Analysis | 2020 |
Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice.
Topics: Aminopyridines; Amphetamines; Animals; Behavior, Animal; Citalopram; Compulsive Behavior; Disease Models, Animal; Female; Fluorobenzenes; Indoles; Mice; Piperidines; Psilocybin; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT2 Receptor Agonists; Serotonin Antagonists | 2021 |
Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer.
Topics: Aminopyridines; Aniline Compounds; Animals; Apoptosis; Benzamides; Carbazoles; Cell Line; Cell Survival; Crizotinib; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Immunoblotting; Indazoles; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Mice; Mice, Inbred BALB C; Molecular Dynamics Simulation; Neoplasm Recurrence, Local; Piperidines; Proto-Oncogene Proteins; Pyrazines; Pyrazoles; Receptor Protein-Tyrosine Kinases | 2021 |
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia.
Topics: Acute Disease; Aminopyridines; Animals; Cell Line, Tumor; Doxycycline; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epigenesis, Genetic; Glycine; HL-60 Cells; Humans; Isocitrate Dehydrogenase; Isoenzymes; Leukemia, Myeloid; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Mitochondria; Mutation; Oxadiazoles; Oxidative Phosphorylation; Piperidines; Pyridines; Triazines; Xenograft Model Antitumor Assays | 2021 |
EML4-ALK positive lung adenocarcinoma with skeletal muscle metastasis in the right calf which was treatable with lorlatinib after resistance to treatment with alectinib.
Topics: Adenocarcinoma of Lung; Aged; Aminopyridines; Carbazoles; Female; Humans; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Muscle, Skeletal; Oncogene Proteins, Fusion; Piperidines; Protein Kinase Inhibitors; Pyrazoles | 2021 |
The selective 5-HT
Topics: Aminopyridines; Animals; Antidepressive Agents; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Locomotion; Male; Mice; Piperidines; Pyrimidines; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Single-Blind Method; Stress, Psychological | 2021 |
Clinical Responses to Crizotinib, Alectinib, and Lorlatinib in a Metastatic Colorectal Carcinoma Patient With ALK Gene Rearrangement: A Case Report.
Topics: Aged; Aminopyridines; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Carbazoles; Colorectal Neoplasms; Crizotinib; Female; Gene Rearrangement; Humans; Lactams; Neoplasm Metastasis; Piperidines; Pyrazoles; Treatment Outcome | 2021 |
Response to lorlatinib on a patient with ALK-rearranged non-small cell lung cancer harboring 1151Tins mutation with uterine metastasis.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Carbazoles; Carcinoma, Non-Small-Cell Lung; Crizotinib; Female; Gene Rearrangement; Humans; Lactams; Lung Neoplasms; Middle Aged; Mutation; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Uterine Neoplasms | 2021 |
BioID-Screening Identifies PEAK1 and SHP2 as Components of the ALK Proximitome in Neuroblastoma Cells.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Animals; Cell Line, Tumor; Chromatography, Liquid; Drug Synergism; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Lactams; Neuroblastoma; PC12 Cells; Phosphorylation; Piperidines; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein-Tyrosine Kinases; Proteomics; Pyrazoles; Pyrimidines; Rats; Tandem Mass Spectrometry | 2021 |
Resistance profiles of anaplastic lymphoma kinase tyrosine kinase inhibitors in advanced non-small-cell lung cancer: a multicenter study using targeted next-generation sequencing.
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Carbazoles; Carcinoma, Non-Small-Cell Lung; Circulating Tumor DNA; Crizotinib; DNA Mutational Analysis; Drug Resistance, Neoplasm; Female; High-Throughput Nucleotide Sequencing; Humans; Lactams; Lung Neoplasms; Male; Middle Aged; Molecular Targeted Therapy; Mutation; Piperidines; Predictive Value of Tests; Prospective Studies; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Risk Factors; Sulfones; Taiwan; Treatment Outcome | 2021 |
Successful treatment with lorlatinib in a patient with meningeal carcinomatosis of ALK-positive non-small cell lung cancer resistant to alectinib and brigatinib: A case report.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Carbazoles; Carcinoma, Non-Small-Cell Lung; Drug Resistance, Neoplasm; Female; Humans; Lactams; Lung Neoplasms; Meningeal Carcinomatosis; Middle Aged; Organophosphorus Compounds; Piperidines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrazoles; Pyrimidines | 2021 |
Discriminative stimulus properties of the 5-HT1A receptor biased agonists NLX-101 and F13714, in rats trained to discriminate 8-OH-DPAT from saline.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Buspirone; Discrimination Learning; Dose-Response Relationship, Drug; Female; Male; Piperazines; Piperidines; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Serotonin 5-HT1 Receptor Agonists | 2021 |
Efficacy of lorlatinib after alectinib-induced interstitial lung disease in a patient with anaplastic lymphoma kinase-positive non-small cell lung cancer: a case report.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Carbazoles; Carcinoma, Non-Small-Cell Lung; Humans; Kidney Diseases; Lactams; Lung Diseases, Interstitial; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles | 2022 |
Cost-effectiveness of ensartinib, crizotinib, ceritinib, alectinib, brigatinib and lorlatinib in patients with anaplastic lymphoma kinase-positive non-small cell lung cancer in China.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Carbazoles; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Cost-Benefit Analysis; Crizotinib; Humans; Lactams; Lung Neoplasms; Network Meta-Analysis; Organophosphorus Compounds; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyridazines; Pyrimidines; Sulfones | 2022 |