alpha-aminopyridine has been researched along with nutlin-3a in 5 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Esfandiari, A; Hawthorne, TA; Lunec, J; Nakjang, S | 1 |
| Benada, J; Burdova, K; Jenikova, G; Kleiblova, P; Macurek, L; Pechackova, S | 1 |
| Dobbelstein, M; Li, Y; Najafova, Z; Radovanovic, M; Sriraman, A; Wienken, M | 1 |
| Kimura, S; Kojima, K; Maeda, A; Nishida, Y; Yoshimura, M | 1 |
| Aptullahoglu, E; Esfandiari, A; Ho, YH; Lovat, P; Lunec, J; Mahdi, AK; Wang, N; Wu, CE | 1 |
5 other study(ies) available for alpha-aminopyridine and nutlin-3a
| Article | Year |
|---|---|
Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner.
Topics: Aminopyridines; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Catalysis; Cell Line, Tumor; Cell Survival; Dipeptides; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Humans; Imidazoles; Mutation; Neoplasms; para-Aminobenzoates; Piperazines; Protein Phosphatase 2C; Proteolysis; Proto-Oncogene Proteins c-mdm2; Pyrrolidines; Transcription, Genetic; Tumor Suppressor Protein p53; Ubiquitin | 2016 |
Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3.
Topics: Aminopyridines; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Proliferation; Dipeptides; DNA Damage; Drug Resistance, Neoplasm; Female; Humans; Imidazoles; Piperazines; Protein Phosphatase 2C; Proto-Oncogene Proteins c-mdm2; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2016 |
Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity.
Topics: Acetylation; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Cellular Senescence; Dipeptides; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Imidazoles; MCF-7 Cells; Neoplasms; Phosphorylation; Piperazines; Protein Phosphatase 2C; Proto-Oncogene Proteins c-mdm2; RNA Interference; Signal Transduction; Time Factors; Transcriptome; Transfection; Tumor Suppressor Protein p53; Up-Regulation | 2016 |
The pathophysiological significance of PPM1D and therapeutic targeting of PPM1D-mediated signaling by GSK2830371 in mantle cell lymphoma.
Topics: Aminopyridines; Apoptosis; Bortezomib; Cell Line, Tumor; Dipeptides; Doxorubicin; Genes, p53; Humans; Imidazoles; Lymphoma, Mantle-Cell; Phosphorylation; Piperazines; Prognosis; Protein Phosphatase 2C; Signal Transduction | 2016 |
Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma.
Topics: Aminopyridines; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dipeptides; Drug Synergism; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Melanoma; Melanoma, Cutaneous Malignant; Mutagenesis, Site-Directed; para-Aminobenzoates; Phosphorylation; Piperazines; Protein Binding; Protein Phosphatase 2C; Protein Stability; Proto-Oncogene Proteins c-mdm2; Pyrrolidines; Skin Neoplasms; Tumor Suppressor Protein p53 | 2018 |