alpha-aminopyridine has been researched along with morphine in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (56.52) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jakovlev, V; Nickel, B; Szelenyi, I | 1 |
| Dimpfel, W; Nickel, B; Spüler, M | 2 |
| Engel, J | 1 |
| Achterrath-Tuckermann, U; Jakovlev, V; Stroman, F; Thiemer, K; von Schlichtegroll, A | 1 |
| Houston, T; Pleuvry, BJ | 1 |
| Herz, A; Illes, P; Zieglgänsberger, W | 1 |
| Williams, J; Zieglgänsberger, W | 1 |
| Mulder, AH; Schoffelmeer, AN | 2 |
| Casamenti, F; Corradetti, R; Löffelholz, K; Mantovani, P; Pepeu, G | 1 |
| Crain, B; Crain, SM; Peterson, ER | 1 |
| Stone, TW | 1 |
| Sia, RL; Zandstra, DF | 1 |
| Ferreira, M; Gillis, RA; Sahibzada, N; Taveira-DaSilva, AM; Wasserman, AM | 1 |
| Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Adriaensen, H; Colpaert, FC; Deseure, K; Koek, W | 1 |
| Adriaensen, HF; Colpaert, FC; Deseure, KR | 1 |
| Cooke, I; Goodchild, CS; Kolosov, A; Tucker, AP | 1 |
| Ashby, M; Cooke, I; Goodchild, CS; Jackson, K; Nelson, J | 1 |
| Capuano, A; De Corato, A; Navarra, P; Treglia, M; Tringali, G | 1 |
| Cooke, I; Goodchild, CS; Kolosov, A; Williams, ED | 1 |
| Dong, L; Jiang, Q; Liu, H; Pang, G; Stackman, RW; Tao, X; Wu, X; Zhang, G; Zhang, YM | 1 |
1 trial(s) available for alpha-aminopyridine and morphine
| Article | Year |
|---|---|
Combination therapy with flupirtine and opioid: open-label case series in the treatment of neuropathic pain associated with cancer.
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Analgesics; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Male; Middle Aged; Morphine; Neuralgia; Pain Measurement; Palliative Care; Treatment Outcome | 2008 |
22 other study(ies) available for alpha-aminopyridine and morphine
| Article | Year |
|---|---|
[The effect of flupirtine, various analgesics and muscle relaxants on skeletal muscle tone in the conscious rat].
Topics: Aminopyridines; Analgesics; Animals; Anti-Anxiety Agents; Baclofen; Benzodiazepines; Benzodiazepinones; Codeine; Dantrolene; Diazepam; Female; Mephenesin; Morphine; Motor Activity; Muscle Relaxants, Central; Muscle Tonus; Rats; Rats, Inbred Strains; Tramadol | 1990 |
Dose- and time-dependent action of morphine, tramadol and flupirtine as studied by radioelectroencephalography in the freely behaving rat.
Topics: Aminopyridines; Analgesics; Animals; Brain; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Frontal Lobe; Male; Morphine; Rats; Rats, Inbred F344; Receptors, Adrenergic; Reticular Formation; Signal Processing, Computer-Assisted; Thalamus; Tramadol | 1989 |
Flupirtine--a new centrally acting analgesic with unique chemical structure.
Topics: Aminopyridines; Analgesics; Chemical Phenomena; Chemistry; Computer Graphics; Models, Molecular; Morphine | 1987 |
Radioelectroencephalography (Tele-Stereo-EEG) in the rat as a pharmacological model to differentiate the central action of flupirtine from that of opiates, diazepam and phenobarbital.
Topics: Aminopyridines; Animals; Brain; Buprenorphine; Diazepam; Electroencephalography; Male; Morphine; Phenobarbital; Rats; Rats, Inbred Strains; Tramadol | 1986 |
[General pharmacologic studies on the analgesic flupirtine].
Topics: Aminopyridines; Amphetamine; Analgesics; Animals; Anticonvulsants; Catalepsy; Central Nervous System; Diuresis; Dogs; Drug Interactions; Female; Hemodynamics; Hexobarbital; Humans; Hypnotics and Sedatives; In Vitro Techniques; Male; Mice; Morphine; Motor Activity; Muscle Tonus; Oxotremorine; Parasympatholytics; Rats; Respiration | 1985 |
Comparison of some pharmacological properties of 4-aminopyridine and 3,4-diaminopyridine in vivo.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Central Nervous System Stimulants; Depression, Chemical; Drug Interactions; Mice; Morphine; Respiration | 1984 |
Calcium reverses the inhibitory action of morphine on neuroeffector transmission in the mouse vas deferens.
Topics: Aminopyridines; Animals; Calcium; Dose-Response Relationship, Drug; Electric Stimulation; Magnesium; Male; Membrane Potentials; Mice; Morphine; Naloxone; Neuroeffector Junction; Synaptic Transmission; Vas Deferens | 1980 |
Mature spinal ganglion cells are not sensitive to opiate receptor mediated actions.
Topics: Action Potentials; Aminopyridines; Animals; Barium; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Ganglia, Spinal; Iontophoresis; Morphine; Morphine Derivatives; Naloxone; Narcotics; Rats; Receptors, Opioid | 1981 |
Presynaptic alpha-adrenoceptors and opiate receptors: inhibition of [3H]noradrenaline release from rat cerebral cortex slices by different mechanisms.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Cerebral Cortex; Electric Stimulation; In Vitro Techniques; Male; Morphine; Norepinephrine; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Opioid | 1982 |
Differential control of Ca2+-dependent [3H]noradrenaline release from rat brain slices through presynaptic opiate receptors and alpha-adrenoceptors.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Brain; Cadmium; Calcium; Cell Membrane Permeability; Electric Stimulation; Electrolytes; In Vitro Techniques; Male; Morphine; Norepinephrine; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Opioid; Tritium | 1983 |
Effects of 4-aminopyridine on acetylcholine output from the cerebral cortex of the rat in vivo.
Topics: 4-Aminopyridine; Acetylcholine; Aminopyridines; Anesthesia; Animals; Blood Pressure; Cerebral Cortex; Male; Morphine; Neuromuscular Depolarizing Agents; Rats; Rats, Inbred Strains | 1982 |
Development of cross-tolerance to 5-hydroxytryptamine in organotypic cultures of mouse spinal cord-ganglia during chronic exposure to morphine.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Drug Tolerance; Ganglia, Spinal; Mice; Morphine; Naloxone; Organ Culture Techniques; Serotonin; Spinal Cord | 1982 |
The effects of 4-aminopyridine on the isolated vas deferens and its effects on the inhibitory properties of adenosine, morphine, noradrenaline and gamma-aminobutyric acid.
Topics: 4-Aminopyridine; Adenosine; Aminopyridines; Animals; Calcium; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Morphine; Muscle Contraction; Neuromuscular Depolarizing Agents; Norepinephrine; Potassium Chloride; Quinidine; Tetraethylammonium Compounds; Vas Deferens | 1981 |
Use of 4-aminopyridine to reverse morphine-induced respiratory depression in man.
Topics: 4-Aminopyridine; Adolescent; Adult; Aminopyridines; Anesthesia, Intravenous; Depression, Chemical; Female; Humans; Male; Middle Aged; Morphine; Respiration; Respiratory Insufficiency; Tidal Volume | 1981 |
Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Apnea; Buspirone; Diaphragm; Drug Interactions; Electromyography; Male; Morphine; Muscle Contraction; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2000 |
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cells, Cultured; CHO Cells; Cricetinae; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Synergism; Female; Fentanyl; Gabapentin; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Imipramine; Ketamine; Male; Morphine; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Time Factors; Transfection | 2002 |
The 5-HT(1A) receptor agonist F 13640 attenuates mechanical allodynia in a rat model of trigeminal neuropathic pain.
Topics: Aminopyridines; Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Morphine; Muscle Relaxants, Central; Narcotics; Pain; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Stress, Mechanical; Trigeminal Neuralgia | 2002 |
Effects of the combined continuous administration of morphine and the high-efficacy 5-HT1A agonist, F 13640 in a rat model of trigeminal neuropathic pain.
Topics: Aminopyridines; Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug Tolerance; Infusion Pumps, Implantable; Male; Morphine; Pain Measurement; Physical Stimulation; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin Receptor Agonists; Trigeminal Neuralgia | 2004 |
Combination therapy with flupirtine and opioid: studies in rat pain models.
Topics: Aminopyridines; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Male; Morphine; Neuralgia; Pain Measurement; Rats; Rats, Wistar; Treatment Outcome | 2008 |
Flupirtine antinociception in the rat orofacial formalin test: an analysis of combination therapies with morphine and tramadol.
Topics: Aminopyridines; Analgesics; Animals; Male; Morphine; Pain Measurement; Rats; Rats, Wistar; Tramadol | 2011 |
Flupirtine enhances the anti-hyperalgesic effects of morphine in a rat model of prostate bone metastasis.
Topics: Aminopyridines; Analgesics; Animals; Bone Neoplasms; Disease Models, Animal; Hyperalgesia; Male; Morphine; Pain; Prostatic Neoplasms; Rats; Rats, Wistar | 2012 |
Activation of serotonin 5-HT(2C) receptor suppresses behavioral sensitization and naloxone-precipitated withdrawal symptoms in morphine-dependent mice.
Topics: Aminopyridines; Analgesics, Opioid; Animals; Benzazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Indoles; Locomotion; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Reaction Time; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Substance Withdrawal Syndrome; Time Factors | 2016 |