alpha-aminopyridine has been researched along with indazoles in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (14.71) | 29.6817 |
| 2010's | 19 (55.88) | 24.3611 |
| 2020's | 10 (29.41) | 2.80 |
| Authors | Studies |
|---|---|
| Boehm, HJ; Boehringer, M; Bur, D; Gmuender, H; Huber, W; Klaus, W; Kostrewa, D; Kuehne, H; Luebbers, T; Meunier-Keller, N; Mueller, F | 1 |
| Aoki, Y; Fukami, TA; Hasegawa, K; Kim, SJ; Miura, T; Na, YJ; Ono, N; Shimma, N; Shindo, H; Shiratori, Y; Suda, A; Tsukuda, T; Yoon, DO | 1 |
| Hatanaka, K; Kimura, Y; Koakutsu, A; Maeno, K; Naitou, Y; Shimada, I; Wanibuchi, F; Yamaguchi, T | 1 |
| Hayashi, A; Kimura, Y; Miyata, K; Sasamata, M; Sonoda, R; Suzuki, M; Takasu, T | 1 |
| Hayashi, A; Miyata, K; Sasamata, M; Suzuki, M | 1 |
| Kimura, Y; Naitou, Y; Wanibuchi, F; Yamaguchi, T | 1 |
| Han, DC; Han, YM; Kim, JA; Kwon, BM; Lee, JS; Lee, YJ; Shin, DS; Shin, KD; Yoon, YJ | 1 |
| Bonar, SL; Brustkern, SJ; Chen, NX; Christine, L; Heier, RF; Hu, Y; Huang, HC; Kishore, NN; Kurumbail, RG; Lennon, PJ; Li, X; Mathialagan, S; Poda, GI; Reding, MT; Selness, SR; Sommers, CD; Venkatraman, N; Wolfson, SG; Xie, J | 1 |
| Bergling, S; Blommers, MJ; Brachmann, SM; Brümmendorf, T; Fritsch, C; Garcia-Echeverria, C; Gaulis, S; Guthy, DA; Hattenberger, M; Henry, C; Hofmann, F; Kauffmann, A; Kazic-Legueux, M; Kleylein-Sohn, J; Laborde, L; Maira, SM; Murakami, M; Romanet, V; Sellers, WR; Stauffer, F; Sterker, D; Vaxelaire, J; Wilson, C | 1 |
| Dan, S; Kong, D; Yamazaki, K; Yamori, T | 1 |
| Galanis, A; Levis, M | 1 |
| Azam, MA; Jubie, S; Thathan, J | 1 |
| Huang, C; Jiang, B; Lu, X; Tong, L; Wang, J; Yang, R; Zhang, W | 1 |
| Bonazzi, VF; Cummings, MC; Geng, X; Ju, RJ; Mahon, CE; Packer, LM; Pollock, PM; Stephenson, SA | 1 |
| Arteaga, CL; Bauer, JA; Bhola, NE; Dugger, TC; Ericsson, PG; Estrada, MV; Formisano, L; Hutchinson, KE; Jansen, VM; Knudsen, ES; Lee, KM; Moore, PD; Pishvaian, MJ; Pohlmann, PR; Riddle, DA; Sánchez, V; Sanders, ME; Wei, W; Witkiewicz, AK | 1 |
| Besse, B; Bria, E; Facchinetti, F; Friboulet, L; Minari, R; Rossi, G; Soria, JC; Tiseo, M | 1 |
| Ai, J; Chen, H; Chen, X; Gao, Y; Geng, M; He, Y; Li, C; Liu, H; Peng, X; Wang, J; Wang, Y; Zheng, M; Zhu, W | 1 |
| Kang, MJ; Lee, JH; Yun, HH | 1 |
| Alessi, DR; Arkin, MR; Bainbridge, TW; Beresini, MH; Blackwood, E; Blake, RA; Brasher, B; Chang, MT; Clark, KR; Cohen, F; Di Lello, P; Drummond, J; Ernst, JA; Forrest, WF; Gnad, F; Hearn, BR; Heideker, J; Jaishankar, P; Kategaya, L; Kleinheinz, T; Klijn, C; Kwok, MCM; Lin, E; Ma, TP; Martin, SE; Maurer, T; McCleland, M; Murray, J; Ndubaku, C; Pastor, R; Peale, F; Prakash, S; Renslo, AR; Ritorto, MS; Rougé, L; Schwerdtfeger, C; Stiffler, Z; Tang, Y; Trost, M; Tsui, V; Upton, JP; Wang, X; Wertz, IE; Yu, K | 1 |
| Benneyworth, M; Lin, YL; Liu, PY; Tsai, HC; Wei, LN | 1 |
| Belaya, Z; Buchfelder, M; Ciato, D; D'Annunzio, S; Hristov, M; Li, R; Monteserin Garcia, JL; Paez-Pereda, M; Papst, L; Rozhinskaya, L; Stalla, GK; Theodoropoulou, M; Tichomirowa, MA | 1 |
| Fujita, N; Gong, B; Hanzawa, H; Hata, AN; Isoyama, T; Iwasaki, S; Kagoshima, Y; Kamai, Y; Katayama, R; Kiga, M; Koike, S; Miyamoto, M; Nakao, N; Nishio, M; Oh-Hara, T; Seto, Y; Shaw, AT; Shimizu, Y; Takeda, Y; Togashi, N; Tominaga, Y; Watanabe, K; Yanagitani, N; Yoda, S | 1 |
| Han, X; Lu, C; Lv, S; Qiao, P; Ren, C; Sun, Y; Wang, D; Wang, L; Yang, T; Yu, Z | 1 |
| Accordi, B; Basso, G; Bresolin, S; Cortese, G; Mariotto, E; Porcù, E; Serafin, V; Veltri, G | 1 |
| Arkenau, HT; Coleman, N; Popat, S; Welsh, L; Yousaf, N | 1 |
| Anyaegbu, G; Bentley, H; Bulusu, VR; Hatcher, H; Horan, G; Watkins, J; Wong, HH | 1 |
| Bang, YJ; Bendell, J; Carlsen, M; Chow, KH; Chung, HC; de Miguel, MJ; Gandhi, L; Italiano, A; Lin, CC; Patnaik, A; Schmidt, S; Su, WC; Szpurka, AM; Vangerow, B; Xu, X; Yap, TA; Yu, D; Zhao, Y | 1 |
| Adachi, J; Araki, M; Friboulet, L; Fujita, N; Katayama, K; Katayama, R; Kukimoto-Niino, M; Kutkowska, J; Ma, B; Maruyama, K; Mizuta, H; Nishio, M; Oh-Hara, T; Okada, K; Okuno, Y; Sagae, Y; Sasakura, Y; Shirouzu, M; Simizu, S; Takagi, S; Takemoto, A; Tamai, K; Watanabe, K; Yanagitani, N | 1 |
| Jung, US; Kim, DH; Kim, HS; Kim, MG; Min, KW | 1 |
| Ren, C; Wang, Y; Xiu, J; Yang, T; Yu, Z | 1 |
| He, X; Ji, X; Jiang, C; Shen, Z; Yin, L; Zhou, H; Zhu, X | 1 |
| Jung, SY; Lee, JH; Yoo, K; Yun, HH | 1 |
| Brodsky, RA; Browett, P; Geffner, M; Huang, M; Kulasekararaj, AG; Lee, JW; Maciejewski, JP; Notaro, R; Risitano, AM | 1 |
| Buzdin, AA; Ivanenko, KA; Khabusheva, ER; Kudryavtseva, AV; Lebedev, TD; Mareeva, SR; Morozov, AV; Prassolov, VS; Rubtsov, PM; Snezhkina, AV; Sorokin, MI; Spirin, PV | 1 |
2 review(s) available for alpha-aminopyridine and indazoles
| Article | Year |
|---|---|
Dual targeting DNA gyrase B (GyrB) and topoisomerse IV (ParE) inhibitors: A review.
Topics: Amino Acid Sequence; Aminopyridines; Anti-Bacterial Agents; Barbiturates; Benzimidazoles; DNA Gyrase; DNA Topoisomerase IV; Fluoroquinolones; Indazoles; Isoxazoles; Morpholines; Organophosphates; Oxazolidinones; Prodrugs; Pyrazoles; Pyrroles; Pyrrolidines; Pyrrolidinones; Quinazolinones; Quinolines; Spiro Compounds; Topoisomerase II Inhibitors; Topoisomerase Inhibitors; Urea | 2015 |
Oncogene addiction in non-small cell lung cancer: Focus on ROS1 inhibition.
Topics: Aminopyridines; Anilides; Antineoplastic Agents; Benzamides; Carcinoma, Non-Small-Cell Lung; Crizotinib; Drug Resistance, Neoplasm; Gene Rearrangement; Humans; Indazoles; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Molecular Diagnostic Techniques; Oncogene Fusion; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrazoles; Pyridines; Pyrimidines; Sulfones | 2017 |
2 trial(s) available for alpha-aminopyridine and indazoles
| Article | Year |
|---|---|
Safety and Clinical Activity of a New Anti-PD-L1 Antibody as Monotherapy or Combined with Targeted Therapy in Advanced Solid Tumors: The PACT Phase Ia/Ib Trial.
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Benzimidazoles; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Indazoles; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Niacinamide; Prognosis; Ramucirumab | 2021 |
Phase 2 study of danicopan in patients with paroxysmal nocturnal hemoglobinuria with an inadequate response to eculizumab.
Topics: Adult; Aged; Aminopyridines; Antibodies, Monoclonal, Humanized; Complement Inactivating Agents; Female; Hemoglobinuria, Paroxysmal; Humans; Indazoles; Male; Middle Aged; Proline; Pyrimidines; Treatment Outcome; Young Adult | 2021 |
30 other study(ies) available for alpha-aminopyridine and indazoles
| Article | Year |
|---|---|
Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening.
Topics: Anti-Infective Agents; Coumarins; Crystallography, X-Ray; DNA Topoisomerases, Type II; Enzyme Inhibitors; Indazoles; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Novobiocin; Protein Binding; Structure-Activity Relationship; Surface Plasmon Resonance; Topoisomerase II Inhibitors; Ultracentrifugation | 2000 |
Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design.
Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Antineoplastic Agents; Benzopyrans; Computer Simulation; Dose-Response Relationship, Drug; Drug Design; Drug Discovery; Escherichia coli; HSP90 Heat-Shock Proteins; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Neoplasms; Reproducibility of Results; Structure-Activity Relationship; Surface Plasmon Resonance; Triazines; Xenograft Model Antitumor Assays | 2011 |
Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist.
Topics: Aminopyridines; Animals; Behavior, Animal; Cell Membrane; CHO Cells; Cloning, Molecular; Cricetinae; Depression, Chemical; Dose-Response Relationship, Drug; Hemodynamics; Indazoles; Indoles; Male; Motor Activity; Penile Erection; Phosphatidylinositols; Pyrimidines; Rats; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists; Synaptic Transmission | 2004 |
Antiobesity effect of YM348, a novel 5-HT2C receptor agonist, in Zucker rats.
Topics: Aminopyridines; Animals; Anti-Obesity Agents; Blood Glucose; Body Temperature; Body Weight; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Eating; Energy Intake; Indazoles; Indoles; Insulin; Lipids; Male; Obesity; Rats; Rats, Zucker; Serotonin 5-HT2 Receptor Agonists; Serotonin Antagonists; Time Factors; Weight Gain | 2004 |
Agonist diversity in 5-HT(2C) receptor-mediated weight control in rats.
Topics: Administration, Oral; Aminopyridines; Animals; Appetite Depressants; Dose-Response Relationship, Drug; Drug Interactions; Energy Metabolism; Ethylamines; Feeding Behavior; Indazoles; Indoles; Male; Piperazines; Rats; Rats, Wistar; Serotonin 5-HT2 Receptor Agonists; Weight Loss | 2005 |
5-HT(2C) receptor activation is a common mechanism on proerectile effects of apomorphine, oxytocin and melanotan-II in rats.
Topics: alpha-MSH; Aminopyridines; Animals; Apomorphine; Dopamine Agonists; Dose-Response Relationship, Drug; Indazoles; Indoles; Lumbosacral Region; Male; Medulla Oblongata; Neural Pathways; Oxytocin; Penile Erection; Penis; Peptides, Cyclic; Piperazines; Pressure; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Urea | 2008 |
KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Diamines; DNA-Binding Proteins; Drug Delivery Systems; Heat Shock Transcription Factors; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Indazoles; Mice; Mice, Nude; Molecular Chaperones; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms; Poly(ADP-ribose) Polymerases; Positive Transcriptional Elongation Factor B; Promoter Regions, Genetic; Transcription Factors | 2011 |
Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure-activity relationship.
Topics: Administration, Inhalation; Aminopyridines; Asthma; Binding, Competitive; Drug Design; HEK293 Cells; Humans; I-kappa B Kinase; Indazoles; Isonicotinic Acids; Microsomes, Liver; Models, Molecular; Molecular Structure; Molecular Targeted Therapy; Niacinamide; Phenethylamines; Potassium Channel Blockers; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Structure-Activity Relationship; Sulfonamides | 2011 |
Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations.
Topics: Aminopyridines; Animals; Cell Cycle Checkpoints; Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Mice; Mitosis; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Multimerization; Rats; Sulfonamides; Tubulin | 2012 |
In vitro multifaceted activities of a specific group of novel phosphatidylinositol 3-kinase inhibitors on hotspot mutant PIK3CA.
Topics: Aminopyridines; Antineoplastic Agents; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Humans; Imidazoles; Indazoles; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinolines; Sulfonamides; Triazines | 2014 |
Inhibition of c-Kit by tyrosine kinase inhibitors.
Topics: Aminopyridines; Antineoplastic Agents; Benzothiazoles; Biomarkers; Bone Marrow; Cell Line, Tumor; Clinical Trials as Topic; Dasatinib; fms-Like Tyrosine Kinase 3; Gene Expression; Hair; Hematopoietic Stem Cells; Humans; Indazoles; Leukemia, Myeloid, Acute; Niacinamide; Phenylurea Compounds; Pigmentation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Sorafenib; Sulfonamides; Thiazoles | 2015 |
Requirement for endogenous heat shock factor 1 in inducible nitric oxide synthase induction in murine microglia.
Topics: Aminopyridines; Animals; Animals, Newborn; Cell Survival; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Heat Shock Transcription Factors; Indazoles; Interferon-gamma; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; NF-kappa B; Nitric Oxide Synthase Type II; Protein Binding; RNA, Messenger; RNA, Small Interfering; Signal Transduction; STAT1 Transcription Factor; Transcription Factors | 2015 |
PI3K Inhibitors Synergize with FGFR Inhibitors to Enhance Antitumor Responses in FGFR2
Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Endometrial Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Mice; Morpholines; Mutation; Phenylurea Compounds; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Receptor, Fibroblast Growth Factor, Type 2; Sulfonamides; Thiazoles; Xenograft Model Antitumor Assays | 2017 |
Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer.
Topics: Aminopyridines; Animals; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Proliferation; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Indazoles; MCF-7 Cells; Mice; Phosphatidylinositol 3-Kinases; Piperazines; Protein Serine-Threonine Kinases; Purines; Pyridines; Pyrimidines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Receptors, Estrogen; Xenograft Model Antitumor Assays | 2017 |
Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Databases, Chemical; Drug Design; Drug Screening Assays, Antitumor; Female; Heterografts; Humans; Indazoles; Lung Neoplasms; Mice; Mice, Nude; Molecular Docking Simulation; Neoplasm Transplantation; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Rats, Sprague-Dawley; Signal Transduction; Stereoisomerism; Structure-Activity Relationship | 2017 |
KRIBB11 accelerates Mcl-1 degradation through an HSF1-independent, Mule-dependent pathway in A549 non-small cell lung cancer cells.
Topics: Aminopyridines; Apoptosis; Carcinoma, Non-Small-Cell Lung; DNA-Binding Proteins; Heat Shock Transcription Factors; HSP70 Heat-Shock Proteins; Humans; Indazoles; Lung Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Proteasome Endopeptidase Complex; Proteolysis; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2017 |
USP7 small-molecule inhibitors interfere with ubiquitin binding.
Topics: Aminopyridines; Animals; Binding, Competitive; Cell Line, Tumor; Drug Synergism; Female; Humans; Indazoles; Mice; Mice, SCID; Models, Molecular; Neoplasms; Phenols; Protein Binding; Proto-Oncogene Proteins c-mdm2; Proto-Oncogene Proteins c-pim-1; Pyridines; Substrate Specificity; Tumor Suppressor Protein p53; Ubiquitin; Ubiquitin-Specific Peptidase 7 | 2017 |
Receptor-interacting protein 140 as a co-repressor of Heat Shock Factor 1 regulates neuronal stress response.
Topics: Adaptor Proteins, Signal Transducing; Aminopyridines; Animals; Arsenites; Cell Line; Embryo, Mammalian; Gene Expression Regulation; Genetic Vectors; Heat Shock Transcription Factors; Heat-Shock Response; Hippocampus; Hot Temperature; Indazoles; Lentivirus; Maze Learning; Mice; Mice, Inbred C57BL; Neurons; Nuclear Proteins; Nuclear Receptor Interacting Protein 1; Primary Cell Culture; RNA, Small Interfering; Rotarod Performance Test; Signal Transduction; Sodium Compounds; Spatial Behavior; Syk Kinase | 2017 |
Inhibition of Heat Shock Factor 1 Enhances Repressive Molecular Mechanisms on the POMC Promoter.
Topics: Adrenocorticotropic Hormone; Adult; Aminopyridines; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Female; Gene Silencing; Heat Shock Transcription Factors; Humans; Immunohistochemistry; Indazoles; Male; Pituitary ACTH Hypersecretion; Pro-Opiomelanocortin; RNA Interference; Transcription Factor AP-1; Transcriptional Activation; Young Adult | 2019 |
The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models.
Topics: Aminopyridines; Benzamides; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Crizotinib; Drug Development; Drug Resistance, Neoplasm; Humans; Indazoles; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Membrane Glycoproteins; Mutation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrazoles; Receptor, trkB | 2019 |
Phosphorylation of HSF1 by PIM2 Induces PD-L1 Expression and Promotes Tumor Growth in Breast Cancer.
Topics: Aminopyridines; Animals; Autophagy; B7-H1 Antigen; Benzylidene Compounds; Breast Neoplasms; Carboplatin; F-Box-WD Repeat-Containing Protein 7; Female; Gene Expression Regulation, Neoplastic; Heat Shock Transcription Factors; Humans; Indazoles; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; Neoplasm Proteins; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Stability; Proto-Oncogene Proteins; RNA Interference; RNA, Small Interfering; Substrate Specificity; Thiazolidinediones; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2019 |
SYK Targeting Represents a Potential Therapeutic Option for Relapsed Resistant Pediatric
Topics: Aminopyridines; Cell Proliferation; Child; Core Binding Factor Alpha 2 Subunit; Cyclohexylamines; Drug Resistance, Neoplasm; Humans; Indazoles; Morpholines; Neoplasm Recurrence, Local; Oncogene Proteins, Fusion; Oxazines; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrazines; Pyridines; Pyrimidines; Syk Kinase; Tumor Cells, Cultured | 2019 |
Lorlatinib Salvages Central Nervous System-Only Relapse on Entrectinib in ROS1-Positive NSCLC.
Topics: Aminopyridines; Benzamides; Central Nervous System; Humans; Indazoles; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Neoplasm Recurrence, Local; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrazoles | 2020 |
Lorlatinib for the treatment of inflammatory myofibroblastic tumour with TPM4-ALK fusion following failure of entrectinib.
Topics: Adult; Aminopyridines; Anaplastic Lymphoma Kinase; Benzamides; Gene Fusion; Granuloma, Plasma Cell; Humans; Indazoles; Inflammation; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Male; Protein Kinase Inhibitors; Pyrazoles; Treatment Failure; Tropomyosin | 2020 |
Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer.
Topics: Aminopyridines; Aniline Compounds; Animals; Apoptosis; Benzamides; Carbazoles; Cell Line; Cell Survival; Crizotinib; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Immunoblotting; Indazoles; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Mice; Mice, Inbred BALB C; Molecular Dynamics Simulation; Neoplasm Recurrence, Local; Piperidines; Proto-Oncogene Proteins; Pyrazines; Pyrazoles; Receptor Protein-Tyrosine Kinases | 2021 |
High MMP-11 expression associated with low CD8+ T cells decreases the survival rate in patients with breast cancer.
Topics: Aminopyridines; Breast Neoplasms; CD8-Positive T-Lymphocytes; Female; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Lymphocytes, Tumor-Infiltrating; Matrix Metalloproteinase 11; MCF-7 Cells; Middle Aged; Pyrazoles; Receptor, ErbB-2; Sulfonamides; Survival Analysis; Survival Rate; Tumor Microenvironment | 2021 |
HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression.
Topics: Aminopyridines; Animals; Blotting, Western; Cell Count; Cell Line; Cell Movement; Cell Proliferation; Disease Models, Animal; Endometriosis; Female; Gene Knockdown Techniques; Glucose; Glycolysis; Heat Shock Transcription Factors; Humans; Indazoles; Lactic Acid; Mice; Phosphofructokinase-2; Real-Time Polymerase Chain Reaction; Up-Regulation | 2021 |
Combined inhibition of AURKA and HSF1 suppresses proliferation and promotes apoptosis in hepatocellular carcinoma by activating endoplasmic reticulum stress.
Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Aurora Kinase A; Benzamides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum Stress; Female; Gene Expression Regulation, Neoplastic; Heat Shock Transcription Factors; Hep G2 Cells; Humans; Indazoles; Kaplan-Meier Estimate; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; Pyrazoles; RNA Interference; Xenograft Model Antitumor Assays | 2021 |
KRIBB11 Induces Apoptosis in A172 Glioblastoma Cells via MULE-Dependent Degradation of MCL-1.
Topics: Aminopyridines; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Glioblastoma; Glioma; Humans; Indazoles; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Proteins; Ubiquitin; Ubiquitin-Protein Ligases | 2021 |
Identification of cell type-specific correlations between ERK activity and cell viability upon treatment with ERK1/2 inhibitors.
Topics: Aminopyridines; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Cell Survival; Diphenylamine; Humans; Indazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Neuroblastoma; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Pyrazoles; Pyridones; Pyrimidines; Pyrroles | 2022 |