alpha-aminopyridine has been researched along with flupirtine in 253 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (18.18) | 18.7374 |
| 1990's | 45 (17.79) | 18.2507 |
| 2000's | 56 (22.13) | 29.6817 |
| 2010's | 96 (37.94) | 24.3611 |
| 2020's | 10 (3.95) | 2.80 |
| Authors | Studies |
|---|---|
| Desi, I; Nagymajtenyi, L; Nickel, B; Szelenyi, I | 1 |
| Magnussen, H; Scheidt-Mackes, M | 1 |
| Borbe, HO; Hummel, T; Kobal, G; Niebch, G | 1 |
| Nickel, B; Szelenyi, I | 2 |
| McMahon, FG; Vargas, R | 1 |
| Borbe, HO; Friedmann, T; Hummel, T; Kobal, G; Niebch, G; Pauli, E | 1 |
| Borbe, HO; Nickel, B; Szelenyi, I | 1 |
| Wörz, R | 2 |
| Bigelow, GE; Funderburk, FR; Liebson, IA; Preston, KL | 1 |
| Jakovlev, V; Nickel, B; Szelenyi, I | 1 |
| Bromm, B; Ganzel, R; Herrmann, WM; Meier, W; Scharein, E | 2 |
| Scheef, W | 1 |
| Heusinger, JH | 1 |
| Aigner, M; Herrmann, WM; Kern, U | 1 |
| Dimpfel, W; Nickel, B; Spüler, M | 2 |
| Borbe, HO; Brune, K; Nickel, B; Szelenyi, I | 1 |
| Porter, RJ | 1 |
| Powell-Jackson, P; Williams, R | 1 |
| Becketts, K; Nickel, B; Vaupel, DB | 1 |
| Nickel, B | 1 |
| Aledter, A; Nickel, B | 1 |
| Bleyer, H; Carlsson, KH; Erkel, HJ; Jurna, I | 1 |
| Goldberg, SR; Nickel, B; Shannon, HE; Swedberg, MD | 1 |
| Achterrath-Tuckermann, U; Jakovlev, V; Sofia, RD; Thiemer, K; von Schlichtegroll, A | 1 |
| Herz, A; Jakovlev, V; Nickel, B; Tibes, U | 1 |
| Abrams, SM; Ankier, SI; Baker, LR; Crome, P; Johnston, A; Niebch, G; Turner, P; Warrington, SJ; White, AS | 1 |
| Ceccarelli, G; Ciampini, M; Frontespezi, S | 1 |
| Riethmüller-Winzen, H | 1 |
| Arndt, WF; McMahon, FG; Montgomery, PA; Newton, JJ; Perhach, JL | 1 |
| Engel, J; Nickel, B; Szelenyi, I | 1 |
| Hummel, T; Kobal, G | 1 |
| Hedges, A; Niebch, G; Turner, P; Warrington, SJ | 1 |
| Engel, J | 1 |
| Diamantis, W; Gordon, R; Sofia, RD | 3 |
| Nickel, B; Zerrahn, H | 1 |
| Johnston, A; Riethmuller-Winzen, H; Turner, P; Warrington, SJ | 1 |
| Carlsson, KH; Jurna, I | 1 |
| Darius, H; Schrör, K | 1 |
| Scheef, W; Wolf-Gruber, D | 1 |
| Courtenay, PM; Galasko, CS; Jane, M; Stamp, TC | 1 |
| Bickel, E; Saus, A; von Bebenburg, W | 1 |
| Achterrath-Tuckermann, U; Jakovlev, V; Stroman, F; Thiemer, K; von Schlichtegroll, A | 1 |
| Niebch, G; Obermeier, K; Thiemer, K | 1 |
| Hlavica, P; Niebch, G | 1 |
| Biehl, B | 1 |
| Müller-Limmroth, W | 1 |
| Bullingham, RE; Evans, PJ; Lloyd, JW; McQuay, HJ; Moore, RA; O'Sullivan, G; Simpson, S | 1 |
| Finlay, BR; Million, R; Whittington, JR | 1 |
| Chatterji, DC; Gallelli, JF; Narang, PK; Tourville, JF | 1 |
| Koch, HR; Kremer, F; Marzinkowski, A; Trier, HG | 1 |
| Block, F; Pergande, G; Schmitt, T; Schwarz, M | 1 |
| Diener, HC; Plummer, C; Schwarz, M; Timmann, D | 1 |
| Fitton, A; Friedel, HA | 1 |
| Block, F; Pergande, G; Schwarz, M | 3 |
| Block, F; Osborne, NN; Pergande, G; Schwarz, M | 1 |
| Iskric, S; Müller, WE; Pergande, G; Perovic, S; Rytik, P; Schleger, C; Ushijima, H | 1 |
| Harder, S; Hermann, R; Mayer, M; Thürmann, P; Weller, S | 1 |
| Lobisch, M; Lüben, V; Müller, H; Wörz, R | 1 |
| Coats, EA; Cordes, HP; Emig, P; Engel, J; Kutscher, B; Polymeropoulos, EE; Schaper, KJ; Seydel, JK | 1 |
| Aigner, M; Herrmann, WM; Hiersemenzel, R; Lobisch, M; Michel, I; Riethmüller-Winzen, H | 1 |
| Gessler, M; Grotemeyer, KH; Langohr, HD; Lobisch, M; Lüben, V; May, A; Nehrdich, D; Schabet, M; Schwittmann, B; Wörz, R | 1 |
| Osborne, NN; Pergande, G; Schwarz, M | 1 |
| Cao, W; Krieglstein, J; Rupalla, K | 1 |
| Block, F; Nolden-Koch, M; Pergande, G; Purr, J; Schwarz, M | 1 |
| Kelve, M; Müller, WE; Pergande, G; Perovic, S; Schleger, C; Ushijima, H | 1 |
| Forrest, J; Kelve, M; Müller, WE; Pergande, G; Perovic, S; Ushijima, H | 1 |
| Lobisch, M; Nickel, B; Schaffler, K; Wauschkuhn, H | 1 |
| Müller, WE; Pergande, G; Perovic, S; Pialoglou, P; Schröder, HC | 1 |
| Bolten, W; Heller, B; Krainick, JU; Pergande, G; Wörz, R | 1 |
| Müller, WE; Pergande, G; Perovic, S; Pialoglou, P; Romero, FJ | 1 |
| Pergande, G; Schmidt, WJ; Schuster, G; Wacker, E | 1 |
| Cazevieille, C; Osborne, NN; Pergande, G; Wood, JP | 1 |
| Müller, WE; Pergande, G; Perovic, S; Schröder, HC; Ushijima, H | 1 |
| Jakob, R; Krieglstein, J | 1 |
| Block, F; Cazevieille, C; Kosinski, C; Nash, MS; Osborne, NN; Pergande, G; Schwarz, M; Wood, JP | 1 |
| Balakirev, M; Hofmann, M; Pergande, G; Woodcock, BG; Zimmer, G; Zwicker, K | 1 |
| Böhm, M; Meesters, E; Meinhardt, A; Müller, WE; Pergande, G; Perovic, S | 1 |
| Nash, MS; Osborne, NN; Wood, JP | 1 |
| Gassen, M; Pergande, G; Youdim, MB | 1 |
| Emig, P; Kutscher, B; Landgraf, KF; Olbrich, A; Pauluhn, S; Stange, H | 1 |
| Bohnensack, R; Lorenz, B; Müller, WE; Pergande, G; Schlüter, T | 1 |
| Bleich, S; Degner, D; Kornhuber, J; Maler, M; Rüther, E; Wiltfang, J | 1 |
| Bleich, S; Kornhuber, J; Maler, M; Parsons, CG; Wiltfang, J | 1 |
| Melena, J; Nash, MS; Osborne, NN; Wood, JP | 1 |
| Locher, H | 1 |
| Dierkes-Globisch, A; Mohr, HH; Schäfer, R | 1 |
| Schlüter, T; Schönfeld, P; Struy, H | 1 |
| Evert, BO; Klockgether, T; Kovar, KA; Rundfeldt, C; Schulz, JB; Seyfried, J; Wüllner, U | 1 |
| Lawson, K | 2 |
| Brück, W; Burgmaier, G; Kuhlmann, T; Richter-Landsberg, C; Schönrock, LM | 1 |
| Hezky, P; Krejcí, I; Proska, J; Rádl, S | 1 |
| Blume, H; Chen, X; Schug, B; Xu, H; Zhong, D | 1 |
| Amalfitano, A; Bitting, RL; Boustany, RM; Dhar, S; Jansen, PJ; Koeberl, DD; Lockhart, E; Rylova, SN | 1 |
| Rösche, J | 1 |
| Diener, HC; Drepper, J; Maschke, M; Putzki, N; Timmann, D | 1 |
| Müller, WE; Schröder, HC | 1 |
| Armony, T; Finberg, JP; Gassen, M; Lamensdorf, I; Youdim, MB | 1 |
| Miethe, D; Pittrow, D; Ringe, JD; Wegscheider, K | 1 |
| Annunziato, L; Castaldo, P; D'Amico, M; Martire, M; Preziosi, P; Taglialatela, M | 1 |
| Boekhoff, I; Cepek, L; Doehlinger, S; Ellers-Lenz, B; Irle, E; Kretzschmar, HA; Otto, M; Pergande, G; Poser, S; Prange, H; Ratzka, P; Wiltfang, J; Windl, O | 1 |
| Mueller-Schwefe, G | 2 |
| Müller-Schwefe, G | 1 |
| Azad, SC; Dodt, HU; Eder, M; Hapfelmeier, G; Rammes, G; Simon, W; Zieglgänsberger, W | 1 |
| Egert, M; Gommert, LR; Hoffmann, O | 1 |
| Dworetzky, SI; Wua, YJ | 1 |
| Bechmann, I; Deisz, R; Dörr, J; Lehmann, TN; Meier, S; Nitsch, R; Roth, K; Zipp, F; Zurbuchen, U | 1 |
| Annunziato, L; Boscia, F; Taglialatela, M | 1 |
| Fomin, GI; Pavlenko, SS; Sorogina, LD; Taneeva, EV; Veretel'nikov, IA | 1 |
| Kunze, DL; Wladyka, CL | 1 |
| De Ridder, D; Salembier, L; Van de Heyning, PH | 1 |
| Filatova, EG; Naprienko, MV | 1 |
| Adrian, R; Koob, GF; Solbrig, MV; Wechsler, SL | 1 |
| Boĭko, AN; Btysheva, TT; Ganzhula, PA; Gaponova, OV; Ismailov, AM; Kamchatnov, PR; Kostenko, EV; Zhuravleva, EIu | 1 |
| Althaus, M; Hanschmann, A; Klein, T; Magerl, W; Treede, RD | 1 |
| Greenwood, IA; Moffatt, JD; Ohya, S; Pucovský, V; Saldanha, L; Schwake, M; Yeung, SY | 1 |
| Fawcett, RJ; Osborne, NN | 1 |
| Schmerz, F | 1 |
| Müller-Schwefe, GH; Uberall, MA | 2 |
| Martire, M; Miceli, F; Soldovieri, MV; Taglialatela, M | 1 |
| Brueggemann, LI; Byron, KL; Cribbs, LL; Henderson, KK; Mackie, AR; Scrogin, KE; Shiels, AJ | 1 |
| Keogh, GF; Knight, RS; Rydzewska, LH; Stewart, LA | 1 |
| Greenwood, Ia; Pucovský, V; Schwake, M; Yeung, S | 1 |
| Bähr, M; Diem, R; Neusch, C; Otto, M; Pehlke, JR; Sättler, MB; Williams, SK | 1 |
| Cooke, I; Goodchild, CS; Kolosov, A; Tucker, AP | 1 |
| Ashby, M; Cooke, I; Goodchild, CS; Jackson, K; Nelson, J | 1 |
| Gasparic, M; Li, C; Li, M; Ni, J; Terhaag, B; Uberall, MA; Wang, Z | 1 |
| Bednarski, PJ; Lalk, M; Methling, K; Reszka, P; Scheuch, E; Siegmund, W; Terhaag, B; Vrana, O | 1 |
| Voropaev, AA | 1 |
| Hufschmidt, A; Krisch, A; Peschen, I | 1 |
| Geschwind, MD | 1 |
| Brooks-Kayal, AR; Cooper, EC; Keating, JG; Lapides, DA; Raol, YH | 1 |
| Klawe, C; Maschke, M | 1 |
| Gurney, AM; MacLean, MR; Morecroft, I; Murray, A; Nilsen, M | 1 |
| Sakaguchi, S | 1 |
| Cooke, I; Goodchild, CS; Kolosov, A | 1 |
| England, SK; Greenwood, IA; McCallum, LA; Pierce, SL; Tribe, RM | 1 |
| Bleich, S; Heberlein, A; Hillemacher, T; Kornhuber, J; Stoessel, C | 1 |
| Carr, RW; Grafe, P; Schwarz, JR; Sittl, R | 1 |
| Ekici, B; Ozmen, M; Tatli, B | 1 |
| Strohmeier, M | 1 |
| Devulder, J | 1 |
| Porter, JT; Santini, E | 1 |
| Liu, Y; Maier, A; Scholze, A; Tepel, M; Westhoff, TH | 1 |
| Capuano, A; De Corato, A; Navarra, P; Treglia, M; Tringali, G | 1 |
| Pergolizzi, JV; Raffa, RB | 1 |
| Filatova, EG; Latysheva, NV; Naprienko, MV | 1 |
| Häckel, A | 1 |
| Dalle, C; Gamper, N; Ooi, L; Robertson, B; Rose, K; Wood, IC | 1 |
| Pohle, K; Simon, JC; Treudler, R | 1 |
| Danilov, AB; Podymova, IG | 1 |
| Adams, H; Augustine, EF; Cialone, J; de Blieck, EA; Kwon, J; Marshall, FJ; Mink, JW; Newhouse, N; Rothberg, PG; Vierhile, A | 1 |
| Agne, C; Borlak, J; Klein, F; Koch, M; Kreipe, HH; Manns, MP; Puls, F; Rifai, K | 1 |
| Glanemann, M; Klein, F; Neuhaus, P; Rudolph, B; Seehofer, D | 1 |
| He, X; Liu, W; Liu, Y; Peng, B; Wang, H; Wang, Y; Yin, J; Yu, F | 1 |
| Alekseev, VV | 1 |
| Brueggemann, LI; Byron, KL; Cribbs, LL; Dowell, ML; Kakad, PP; Love, RB; Solway, J | 1 |
| Mueller-Schwefe, GH; Terhaag, B; Ueberall, MA | 1 |
| Anderson, N; Borlak, J | 1 |
| Blot, K; Falconer, C; Marschall-Kehrel, D; Michel, MC; Radziszewski, P | 1 |
| Hamann, M; Lange, N; Lemm, C; Richter, A; Sander, SE | 1 |
| Capuano, A; Currò, D; Greco, MC; Guerriero, G; Navarra, P; Tringali, G | 1 |
| Gamper, N; Huang, D; Linley, JE; Pettinger, L | 1 |
| Boehm, S; Chandaka, GK; Dorostkar, MM; Geier, P; Klinger, F; Kubista, H; Salzer, I; Yousuf, A | 1 |
| Govindarajan, AK; Gowdra, VS; Kandasamy, K; Nammalvar, H | 1 |
| Bhatnagar, S; Choudhary, P; Joshi, S; Mishra, S | 1 |
| Kapur, J; Sun, J | 1 |
| Diener, M; Steidle, J; Würner, L | 1 |
| Mueller-Schwefe, GH; Terhaag, B; Uberall, MA | 1 |
| Biswas, A; Das, AK; Kamal, F; Naser, SM; Prakash, R; Rahaman, QM; Sarkar, N | 1 |
| Cooke, I; Goodchild, CS; Kolosov, A; Williams, ED | 1 |
| Szelenyi, I | 1 |
| Radbruch, L; Schaible, HG | 1 |
| Averbeck, B; Carr, RW; Fleckenstein, J; Irnich, D; Lang, PM; Sittl, R | 1 |
| King, AE; Visockis, V | 1 |
| Behera, SS; Choupoo, S; Das, SK; Khuba, S; Mishra, LD; Singh, DK; Yadav, G | 1 |
| Freudenmann, RW; Gahr, M; Kölle, MA; Schönfeldt-Lecuona, C | 1 |
| Connemann, BJ; Freudenmann, RW; Gahr, M; Hiemke, C; Schönfeldt-Lecuona, C | 1 |
| Clepce, M; Kornhuber, J; Reich, K; Thuerauf, N; Wielopolski, J | 1 |
| Adduci, A; Arena, V; Coco, C; Currò, D; Martire, M; Rizzo, G; Taglialatela, M | 1 |
| Song, X; Su, J; Zhang, D | 1 |
| Andersohn, F; Bronder, E; Douros, A; Garbe, E; Klimpel, A; Kreutz, R; Orzechowski, HD; Thomae, M | 1 |
| Lee, BH; Lee, SY; Ryu, PD | 1 |
| Hennings, JM; Ising, M; Klengel, T; Knop, M; Rosenhagen, MC | 1 |
| Essner, U; Müller-Schwefe, GH; Uberall, MA | 1 |
| De Vito, V; Giorgi, M; Kowalski, CJ; Lebkowska-Wieruszewska, B; Owen, H | 1 |
| Guo, L; Huang, P; Li, C; Lu, Q; Xu, X; Zhou, M | 1 |
| Bednarski, PJ; Borlak, J; Keiser, M; Methling, K; Modess, C; Nassif, A; Rosskopf, D; Scheuch, E; Siegmund, W; Terhaag, B | 1 |
| Uberall, MA | 1 |
| Brennan, S; Ghaly, Y; Gurney, AM; Herget, J; Joshi, S; Mizera, R; Novotna, J; Sedivy, V; Zaloudikova, M | 1 |
| Bednarski, PJ; Bodtke, A; Lemmerhirt, CJ; Link, A; Rombach, M | 1 |
| Bednarski, PJ; Methling, K; Oswald, S; Scheuch, E; Siegmund, W | 1 |
| De Vito, V; Giorgi, M; Kowaski, CJ; Lisowski, A; Shaban, A; Łebkowska-Wieruszewska, B | 1 |
| Hsu, HT; Lo, YC; Tseng, YT; Wu, SN | 1 |
| de Mey, C; Deliyska, B; Gatchev, E; Terhaag, B | 1 |
| Fu, T; Guo, L; Huang, P; Li, C; Lu, Q; Xu, X; Yi, Z; Zhao, D | 1 |
| De Vito, V; Giorgi, M; Lee, H; Yun, H | 1 |
| Bähr, M; Doeppner, TR; Hermann, DM; Jaeger, HM; Kaltwasser, B; Kilic, E; Pehlke, JR | 1 |
| Bajric, M; Boehm, S; Dorostkar, MM; Khan, D; Klinger, F; Koenig, X; Kubista, H; Pollak, DD; Salzer, I | 1 |
| Burkhardt, H; Wehling, M | 1 |
| Kreutzkamp, B | 1 |
| Raol, YH; Sampath, D; Shmueli, D; White, AM | 1 |
| De Vito, V; Giorgi, M; Owen, H; Poapolathep, A; Rychshanova, R; Sgorbini, M | 1 |
| Ambrosino, P; Barrese, V; Breschi, MC; Calderone, V; Canduela, MJ; Curtis, MJ; Grandes, P; Greenwood, IA; Martelli, A; Miceli, F; Scorziello, A; Sisalli, MJ; Soldovieri, MV; Taglialatela, M; Testai, L; Vinciguerra, I | 1 |
| Berwick, ZC; Casalini, ED; Dick, GM; Fu, L; Goodwill, AG; Kassab, GS; Noblet, JN; Sassoon, D; Tune, JD | 1 |
| Bøtker, HE; Hedegaard, ER; Jespersen, NR; Johnsen, J; Kristiansen, SB; Laursen, MR; Povlsen, JA; Shanmuganathan, JA; Simonsen, U | 1 |
| Aithal, GP; Bjornsson, ES; Cascorbi, I; Coulthard, SA; Daly, AK; Floratos, A; Gundert-Remy, U; Nelson, MR; Nicoletti, P; Sawle, A; Shen, Y; Stammschulte, T; Urban, TJ; Werk, AN | 1 |
| Augustine, EF; Mink, JW | 1 |
| Berg, T; Engelmann, C; Schmelzle, M; Splith, K | 1 |
| Doh-Ura, K; Teruya, K | 1 |
| Mooney, J; Rawls, SM | 1 |
| Lopez-Garcia, JA; Rivera-Arconada, I; Vicente-Baz, J | 1 |
| Raol, YH; Sampath, D; Valdez, R; White, AM | 1 |
| Maruyama, M; Miyake, K; Miyake, N; Okada, T; Saitow, F; Sakai, A; Shimada, T; Suzuki, H | 1 |
| Berg, T; Borlak, J; van Bömmel, F | 1 |
| Nair, AS | 1 |
| Amaro, P; Ferreira, M; Perdigoto, DN; Tomé, L | 1 |
| Puljak, L | 2 |
| Ehlken, B; Hamann, X; Kaplan, S | 2 |
| Fukami, T; Konishi, K; Nakajima, M; Ogiso, T | 1 |
| Fan, X; Li, H; Liu, Y; Shao, D; Zhang, D; Zhang, F | 1 |
| Behnisch, S; Bock, C; Fassauer, GM; Grathwol, CW; Hasan, M; Hofstetter, RK; Link, A; Oergel, T; Potlitz, F; Siegmund, W; Surur, AS | 1 |
| Burris, KD; Eastwood, BJ; Priest, BT; Sher, E; Wilenkin, B; Williams, AC | 1 |
| Busquet, N; Diaz, MJ; Gonzalez, MI; Lam, PM; Laoprasert, M; Raol, YH; Sampath, D; White, AM | 1 |
| Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X | 1 |
| Rivera-Arconada, I; Vicente-Baz, J | 1 |
| Ardelt, M; Croner, RS; Dondorf, F; Felgendreff, P; Rauchfuss, F; Settmacher, U; Tautenhahn, HM | 1 |
| Fujino, Y; Furue, H; Matsumoto, Y | 1 |
| Bian, WJ; Chen, C; Damonte, VM; de Lecea, L; Kauer, JA; Kebschull, JM; Li, SB; Mourrain, P; Pattni, R; Purmann, C; Scherrer, G; Urban, AE; Wang, GX; Yamaguchi, H | 1 |
| Bartz, FM; Bednarski, PJ; Bodtke, A; Link, A; Schulig, L; Wurm, KW | 1 |
| Carvalho, DM; Filho, SPL; Júnior, JAC; Júnior, RMA; Lima, PTMBQ; Magalhães, JGM; Melo, HMA; Miranda, LHL; Oliveira, AFPH; Souza, GMF | 1 |
| Bao, Y; Chen, Y; Huang, C; Qin, H; Xiao, X; Zhang, G; Zhou, H; Zhu, J; Zhuang, T | 1 |
| Bednarski, PJ; Beirow, K; Hofstetter, RK; Jedamzik, J; Lemmerhirt, CJ; Link, A; Schulig, L; Wurm, KW | 1 |
22 review(s) available for alpha-aminopyridine and flupirtine
| Article | Year |
|---|---|
Flupirtine in the treatment of post-operative pain.
Topics: Adult; Aminopyridines; Analgesics; Child; Clinical Trials as Topic; Double-Blind Method; Humans; Pain, Postoperative; Random Allocation | 1987 |
Flupirtine. A review of its pharmacological properties, and therapeutic efficacy in pain states.
Topics: Aminopyridines; Analgesics; Animals; Humans; Pain | 1993 |
Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist.
Topics: Aminopyridines; Analgesics; Animals; Excitatory Amino Acid Antagonists; Receptors, N-Methyl-D-Aspartate; Retina | 1998 |
[Neuronal potassium channel opening with flupirtine].
Topics: Aminopyridines; Animals; Humans; Neurons; Neuroprotective Agents; Potassium Channels | 1999 |
[Asymptomatic diclofenac-induced acute hepatitis].
Topics: Acute Disease; Aminopyridines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Diclofenac; Drug Therapy, Combination; Humans; Liver; Male; Middle Aged; Pain, Postoperative; Recurrence | 2000 |
Is there a role for potassium channel openers in neuronal ion channel disorders?
Topics: Aminopyridines; Animals; Anticonvulsants; Antihypertensive Agents; Ataxia; Carbamates; Diazoxide; Epilepsy; Humans; Ion Channels; Isaacs Syndrome; Membrane Potentials; Mice; Mice, Neurologic Mutants; Mutation; Nervous System Diseases; Neuroprotective Agents; Parkinson Disease; Phenylenediamines; Potassium Channels | 2000 |
Neuroprotective effect of flupirtine in prion disease.
Topics: Aminopyridines; Animals; Calcium; Genes, bcl-2; Glutathione; Humans; Neuroprotective Agents; Prion Diseases | 2002 |
Recent developments on KCNQ potassium channel openers.
Topics: Acrylamides; Aminopyridines; Benzamides; Carbamates; Epilepsy; Humans; Indoles; Ion Channel Gating; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Migraine Disorders; Oxindoles; Pain; Phenylenediamines; Potassium Channels, Voltage-Gated | 2005 |
Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs.
Topics: Aminopyridines; Animals; Binding Sites; Carbamates; Epilepsy, Benign Neonatal; Hearing Loss; Humans; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Phenylenediamines | 2008 |
Systematic review of therapeutic interventions in human prion disease.
Topics: Aminopyridines; Analgesics; Clinical Trials as Topic; Creutzfeldt-Jakob Syndrome; Disease Progression; Drug Evaluation, Preclinical; Humans; Neuropharmacology; Prion Diseases; Survival Rate; Treatment Failure | 2008 |
Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compound.
Topics: Alzheimer Disease; Aminopyridines; Analgesics; Animals; Humans; Neuroprotective Agents | 2009 |
[Systematic review of the therapeutics for prion diseases].
Topics: Aminopyridines; Animals; Antibodies, Monoclonal; Blood-Brain Barrier; Brain; Cattle; Clinical Trials as Topic; Drug Discovery; Gene Silencing; Humans; Pentosan Sulfuric Polyester; Polyelectrolytes; Polymers; Prion Diseases; Protein Isoforms; PrPC Proteins; PrPSc Proteins; Quinacrine; Species Specificity | 2009 |
[IGOST guideline for pharmacotherapy of low back pain].
Topics: Amines; Aminopyridines; Analgesics; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents; Cyclohexanecarboxylic Acids; Diagnosis, Differential; Gabapentin; gamma-Aminobutyric Acid; Humans; Low Back Pain; Methocarbamol; Muscle Relaxants, Central; Neuromuscular Agents; Osteoporosis; Practice Guidelines as Topic; Tolperisone | 2010 |
Flupirtine in pain management: pharmacological properties and clinical use.
Topics: Aminopyridines; Analgesics; Humans; Pain | 2010 |
The evolving understanding of the analgesic mechanism of action of flupirtine.
Topics: Acute Pain; Aminopyridines; Analgesics; Animals; Chronic Pain; Dose-Response Relationship, Drug; Humans; Musculoskeletal Pain | 2012 |
[Flupirtin (katadolon): a nonstandard action on pain transmission].
Topics: Aminopyridines; Analgesics, Non-Narcotic; Humans; Pain | 2011 |
Flupirtine, a re-discovered drug, revisited.
Topics: Aminopyridines; Analgesics; Epilepsy; Humans; KCNQ Potassium Channels; Neuralgia; Neuromuscular Agents; Urinary Bladder, Overactive | 2013 |
[Long-term-treatment of chronic pain patients with flupirtine--on hepatotoxicity and persistent effectiveness from 7 months to 22 years].
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Chemical and Drug Induced Liver Injury; Chronic Pain; Female; Follow-Up Studies; Humans; Long-Term Care; Male; Middle Aged; Treatment Outcome | 2014 |
[Non-opioid pain medication in the elderly].
Topics: Acetaminophen; Age Factors; Aged; Aminopyridines; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Humans; Pain Management; Pain Measurement | 2015 |
Juvenile NCL (CLN3 Disease): Emerging Disease-Modifying Therapeutic Strategies.
Topics: Aminopyridines; Anti-Inflammatory Agents; Genetic Therapy; Humans; Immunosuppressive Agents; Membrane Glycoproteins; Molecular Chaperones; Mycophenolic Acid; Neuronal Ceroid-Lipofuscinoses; Prednisone | 2016 |
Insights from Therapeutic Studies for PrP Prion Disease.
Topics: Aminopyridines; Animals; Creutzfeldt-Jakob Syndrome; Disease Models, Animal; Doxycycline; Drug Discovery; History, 20th Century; History, 21st Century; Humans; Pentosan Sulfuric Polyester; Quinacrine; Randomized Controlled Trials as Topic; Translational Research, Biomedical | 2017 |
Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far?
Topics: Aminopyridines; Creutzfeldt-Jakob Syndrome; Doxycycline; Humans; Pentosan Sulfuric Polyester; Prion Diseases; Quinacrine | 2022 |
47 trial(s) available for alpha-aminopyridine and flupirtine
| Article | Year |
|---|---|
[The effect of flupirtine on respiratory drive in healthy probands and patients with various lung diseases].
Topics: Airway Resistance; Aminopyridines; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Lung Diseases, Obstructive; Pulmonary Ventilation; Respiratory Center | 1992 |
Dose-proportional plasma levels of the analgesic flupirtine maleate in man. Application of a new HPLC assay.
Topics: Aminopyridines; Analgesics; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Double-Blind Method; Humans | 1992 |
A new clinical bioassay for antipyresis.
Topics: Adult; Alkynes; Aminopyridines; Biological Assay; Double-Blind Method; Endotoxins; Evaluation Studies as Topic; Fever; Humans; Male; Middle Aged; Phenols; Reference Standards | 1991 |
Dose-related analgesic effects of flupirtine.
Topics: Administration, Oral; Adult; Aminopyridines; Analgesia; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Evoked Potentials, Somatosensory; Female; Humans; Male; Psychomotor Performance | 1991 |
Evaluation of the abuse potential of the novel analgesic flupirtine maleate.
Topics: Adult; Affect; Aminopyridines; Analgesics; Arousal; Attention; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Lorazepam; Male; Neuropsychological Tests; Psychomotor Performance; Substance-Related Disorders | 1991 |
The analgesic efficacy of flupirtine in comparison to pentazocine and placebo assessed by EEG and subjective pain ratings.
Topics: Aminopyridines; Analgesics; Clinical Trials as Topic; Double-Blind Method; Electroencephalography; Evoked Potentials, Auditory; Evoked Potentials, Somatosensory; Humans; Male; Pain; Pain Measurement; Palliative Care; Pentazocine | 1987 |
Analgesic efficacy and safety of oral flupirtine in the treatment of cancer pain.
Topics: Administration, Oral; Aminopyridines; Analgesics; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Neoplasms; Pain; Palliative Care; Pentazocine; Random Allocation | 1987 |
Efficacy and tolerance of flupirtine and pentazocine in two multicentre trials.
Topics: Administration, Oral; Administration, Rectal; Aminopyridines; Analgesics; Clinical Trials as Topic; Drug Tolerance; Fatigue; Humans; Palliative Care; Pentazocine | 1987 |
On the adverse reactions and efficacy of long-term treatment with flupirtine: preliminary results of an ongoing twelve-month study with 200 patients suffering from chronic pain states in arthrosis or arthritis.
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Analgesics; Arthritis, Rheumatoid; Chronic Disease; Clinical Trials as Topic; Drug Tolerance; Female; Humans; Long-Term Care; Male; Middle Aged; Palliative Care; Substance Withdrawal Syndrome; Substance-Related Disorders | 1987 |
Flupirtine: the first Italian experience.
Topics: Acetaminophen; Aminopyridines; Analgesics; Athletic Injuries; Clinical Trials as Topic; Episiotomy; Female; Humans; Italy; Pain Measurement; Pain, Postoperative; Suprofen | 1987 |
Flupirtine in the treatment of post-operative pain.
Topics: Adult; Aminopyridines; Analgesics; Child; Clinical Trials as Topic; Double-Blind Method; Humans; Pain, Postoperative; Random Allocation | 1987 |
Clinical experience with flupirtine in the U.S.
Topics: Acetaminophen; Aminopyridines; Analgesics; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Episiotomy; Female; Humans; Pain, Postoperative; Random Allocation; Sleep Stages; United States | 1987 |
Comparison of flupirtine and indomethacin on frusemide-induced diuresis.
Topics: Adult; Aminopyridines; Analgesics; Diuresis; Double-Blind Method; Female; Furosemide; Humans; Indomethacin; Male; Random Allocation | 1987 |
[Flupirtine in patients with cancer pain].
Topics: Aged; Aminopyridines; Analgesics; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Neoplasms; Pain; Pentazocine; Random Allocation | 1985 |
Trial of oral flupirtine maleate in the treatment of pain after orthopaedic surgery.
Topics: Administration, Oral; Adult; Aged; Aminopyridines; Analgesics; Clinical Trials as Topic; Female; Hip Prosthesis; Humans; Male; Middle Aged; Pain, Postoperative; Pentazocine; Random Allocation | 1985 |
[The effect of the analgesic flupirtine on automobile driving].
Topics: Adult; Aminopyridines; Analgesics; Attention; Automobile Driving; Female; Humans; Male; Pentazocine; Psychomotor Performance | 1985 |
[The effect of a new analgesic, flupirtine, on psychomotor performance in humans].
Topics: Aminopyridines; Analgesics; Chlorpheniramine; Diazepam; Humans; Hypnotics and Sedatives; Male; Mental Processes; Psychomotor Performance; Reaction Time | 1985 |
Comparison of flupirtine maleate and dihydrocodeine in patients following surgery.
Topics: Adult; Aminopyridines; Analgesics; Clinical Trials as Topic; Codeine; Double-Blind Method; Female; Humans; Hysterectomy; Pain, Postoperative | 1983 |
Clinical trial of flupirtine maleate in patients with migraine.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Aminopyridines; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Migraine Disorders; Pain; Random Allocation; Sex Factors | 1984 |
[An ocular toxicity study with flupirtine as an example of evaluation of possible ocular drug side effects in human volunteers (author's transl)].
Topics: Adult; Aminopyridines; Analgesics; Clinical Trials as Topic; Double-Blind Method; Eye; Female; Humans; Intraocular Pressure; Male | 1982 |
[Treatment of tumor pain with flupirtine. Results of a double-blind study versus tramadol].
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Analgesics; Female; Humans; Male; Middle Aged; Neoplasms; Pain; Pain Measurement; Prospective Studies; Tramadol | 1994 |
[Long-term tolerance of flupirtine. Open multicenter study over one year].
Topics: Adult; Aged; Aminopyridines; Analgesics; Chronic Disease; Female; Humans; Long-Term Care; Male; Middle Aged; Musculoskeletal Diseases; Pain; Pain Measurement | 1993 |
[Effectiveness of flupirtine in chronic tension headache. Results of a double-blind study versus placebo].
Topics: Adult; Aminopyridines; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Headache; Humans; Male; Middle Aged | 1995 |
[Clinical pilot study of the myogenic effects of flupirtine in comparison to tetrazepam and placebo].
Topics: Adult; Aminopyridines; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Electromyography; H-Reflex; Humans; Isometric Contraction; Male; Middle Aged; Muscle Contraction; Muscle Relaxants, Central; Muscle, Skeletal; Neuroprotective Agents; Pilot Projects | 1996 |
[Flupirtine in comparison with chlormezanone in chronic musculoskeletal back pain. Results of a multicenter randomized double-blind study].
Topics: Adult; Aminopyridines; Analgesics; Chlormezanone; Double-Blind Method; Female; Humans; Low Back Pain; Male; Middle Aged; Muscle Relaxants, Central; Myofascial Pain Syndromes | 1996 |
Effect of functional NMDA-antagonist flupirtine on automatic postural responses in Parkinson's disease.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aminopyridines; Autonomic Nervous System; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Motor Skills Disorders; Neuroprotective Agents; Parkinson Disease; Posture | 2002 |
Analgesic efficacy of flupirtine in primary care of patients with osteoporosis related pain. A multivariate analysis.
Topics: Aged; Aminopyridines; Analgesics; Female; Humans; Male; Middle Aged; Multivariate Analysis; Osteoporosis; Pain; Pain Measurement; Prospective Studies | 2003 |
Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study.
Topics: Adult; Aged; Aminopyridines; Cognition; Creutzfeldt-Jakob Syndrome; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuropsychological Tests | 2004 |
[Flupirtine in acute and chronic pain associated with muscle tenseness. Results of a postmarket surveillance study].
Topics: Acute Disease; Adult; Aged; Aminopyridines; Analgesics; Back Pain; Chronic Disease; Facial Pain; Female; Follow-Up Studies; Humans; Male; Middle Aged; Musculoskeletal Diseases; Neck Pain; Pain Measurement; Quality of Life; Spasm; Sprains and Strains; Tension-Type Headache | 2003 |
[Parental administration of flupirtine in musculoskeletal pain. Results of a postmarket surveillance study].
Topics: Acute Disease; Aminopyridines; Analgesics; Humans; Injections, Intramuscular; Membrane Potentials; Neurons; Pain; Pain Measurement; Potassium Channels; Receptors, N-Methyl-D-Aspartate | 2004 |
The use of flupirtine in treatment of tinnitus.
Topics: Adult; Aminopyridines; Amnesia; Analgesics; Attention; Cost of Illness; Female; Humans; Male; Prospective Studies; Receptors, N-Methyl-D-Aspartate; Surveys and Questionnaires; Tinnitus; Treatment Outcome | 2006 |
Antihyperalgesic and analgesic properties of the N-methyl-D-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia.
Topics: Aminopyridines; Analgesics; Capsaicin; Cross-Over Studies; Cyclopentanes; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; Nervous System Diseases; Pain; Physical Stimulation; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2008 |
[Analgesic and muscle tonus normalizing effect of flupirtine retard in chronic back pain].
Topics: Aminopyridines; Analgesics; Delayed-Action Preparations; Humans; Low Back Pain; Muscle Tonus; Pain Measurement; Prospective Studies | 2007 |
[Analgesic and muscle tonus normalizing effect of flupirtine retard in chronic back pain. Results of a standardized therapeutic evaluation applying objective methods for measuring pain pressure threshold, pain pressure tolerance and muscle tension].
Topics: Adolescent; Adult; Aged; Aminopyridines; Analgesics; Back Pain; Delayed-Action Preparations; Drug Therapy, Combination; Female; Germany; Humans; Male; Middle Aged; Muscle Tonus; Pain Clinics; Pain Threshold; Prospective Studies; Treatment Outcome | 2008 |
Combination therapy with flupirtine and opioid: open-label case series in the treatment of neuropathic pain associated with cancer.
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Analgesics; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Male; Middle Aged; Morphine; Neuralgia; Pain Measurement; Palliative Care; Treatment Outcome | 2008 |
Analgesic efficacy and tolerability of flupirtine vs. tramadol in patients with subacute low back pain: a double-blind multicentre trial*.
Topics: Adolescent; Adult; Aged; Aminopyridines; Analgesics, Opioid; Double-Blind Method; Female; Humans; Low Back Pain; Male; Middle Aged; Time Factors; Tramadol | 2008 |
Efficacy and tolerability of flupirtine in subacute/ chronic musculoskeletal pain - results of a patient level, pooled re-analysis of randomized, double-blind, controlled trials.
Topics: Aminopyridines; Analgesics; Chronic Pain; Double-Blind Method; Female; Humans; Male; Middle Aged; Musculoskeletal Pain | 2011 |
Unexpected frequent hepatotoxicity of a prescription drug, flupirtine, marketed for about 30 years.
Topics: Aged; Aminopyridines; Analgesics; Benzhydryl Compounds; Chemical and Drug Induced Liver Injury; Cresols; Double-Blind Method; Female; Humans; Liver; Male; Middle Aged; Muscarinic Antagonists; Phenylpropanolamine; Syndrome; Tolterodine Tartrate; Urinary Bladder, Overactive | 2012 |
Efficacy and safety of flupirtine modified release for the management of moderate to severe chronic low back pain: results of SUPREME, a prospective randomized, double-blind, placebo- and active-controlled parallel-group phase IV study.
Topics: Adolescent; Adult; Aged; Aminopyridines; Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Low Back Pain; Male; Middle Aged; Prospective Studies; Time Factors; Tramadol | 2012 |
Efficacy and safety of flupirtine maleate and tramadol hydrochloride in postoperative pain management--a prospective randomised double blinded study.
Topics: Administration, Oral; Adult; Aminopyridines; Analgesics; Drug Monitoring; Female; Humans; Male; Pain Management; Pain Measurement; Pain, Postoperative; Pharmacovigilance; Tramadol; Treatment Outcome | 2012 |
Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial.
Topics: Administration, Oral; Aged; Aged, 80 and over; Aminopyridines; Axons; Double-Blind Method; Electromyography; Female; Humans; Ischemia; KCNQ1 Potassium Channel; Male; Middle Aged; Muscle Relaxants, Central; Myelin Sheath; Peripheral Nerves; Peripheral Nervous System Diseases; Sural Nerve | 2013 |
Evaluating the role of flupirtine for postcraniotomy pain and compare it with diclofenac sodium: a prospective, randomized, double blind, placebo-controlled study.
Topics: Adult; Aged; Aminopyridines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Craniotomy; Diclofenac; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Prospective Studies; Sample Size; Treatment Outcome | 2014 |
Pharmacokinetic profiles of the analgesic drug flupirtine in cats.
Topics: Administration, Oral; Aminopyridines; Analgesics; Animals; Area Under Curve; Biological Availability; Cats; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Injections, Intravenous; Male | 2014 |
Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1.
Topics: Acetylcysteine; Activation, Metabolic; Administration, Oral; Adult; Aminopyridines; Analgesics; Animals; Arylamine N-Acetyltransferase; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glucuronosyltransferase; Glutathione S-Transferase pi; Healthy Volunteers; Humans; Injections, Intravenous; Madin Darby Canine Kidney Cells; Male; Multidrug Resistance-Associated Protein 2; Pain Threshold; Polymorphism, Genetic; Young Adult | 2015 |
Pharmacokinetic profiles of the analgesic flupirtine in dogs after the administration of four pharmaceutical formulations.
Topics: Administration, Oral; Administration, Rectal; Aminopyridines; Analgesics, Non-Narcotic; Animals; Delayed-Action Preparations; Dogs; Female; Injections, Intravenous; Male | 2015 |
Effects of advanced age and renal dysfunction on the single- and repeated-dose pharmacokinetics of modified-release flupirtine.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aging; Aminopyridines; Analgesics; Area Under Curve; Biomarkers; Creatinine; Delayed-Action Preparations; Drug Administration Schedule; Drug Monitoring; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged; Prospective Studies; Severity of Illness Index; Young Adult | 2015 |
Simultaneous quantification of acidic and basic flupirtine metabolites by supercritical fluid chromatography according to European Medicines Agency validation.
Topics: Acids; Adult; Aminopyridines; Analgesics; Calibration; Chromatography, Supercritical Fluid; Europe; Female; Humans; Limit of Detection; Male; Metabolome; Reproducibility of Results; Solvents; Temperature; Young Adult | 2019 |
185 other study(ies) available for alpha-aminopyridine and flupirtine
| Article | Year |
|---|---|
Influence of flupirtine, a novel nonopioid analgesic agent on somatosensory evoked potentials in rats.
Topics: Aminopyridines; Analgesics; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials, Somatosensory; Male; Rats; Rats, Wistar; Reference Values; Skin; Time Factors; Vibrissae | 1992 |
Pharmacological profile of flupirtine, a novel centrally acting, non-opioid analgesic drug.
Topics: Adrenergic alpha-Antagonists; Aminopyridines; Analgesics; Animals; Dioxanes; Drug Interactions; Electric Stimulation; Idazoxan; Mice; Muscle Relaxation; Muscle Tonus; Pain Measurement; Prazosin; Rats; Rats, Inbred Strains; Reaction Time; Reserpine | 1991 |
Investigations with the novel non-opioid analgesic flupirtine in regard to possible benzodiazepine-like abuse inducing potential.
Topics: Aminopyridines; Analgesics; Animals; Anti-Anxiety Agents; Binding, Competitive; Body Weight; Brain Chemistry; Conditioning, Operant; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Female; Lorazepam; Male; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, GABA-A; Reinforcement Schedule; Substance-Related Disorders | 1990 |
[Flupirtine in chronic myofacial pain conditions].
Topics: Adult; Aged; Aminopyridines; Analgesics; Chronic Disease; Female; Humans; Male; Middle Aged; Myofascial Pain Syndromes; Prospective Studies | 1991 |
[The effect of flupirtine, various analgesics and muscle relaxants on skeletal muscle tone in the conscious rat].
Topics: Aminopyridines; Analgesics; Animals; Anti-Anxiety Agents; Baclofen; Benzodiazepines; Benzodiazepinones; Codeine; Dantrolene; Diazepam; Female; Mephenesin; Morphine; Motor Activity; Muscle Relaxants, Central; Muscle Tonus; Rats; Rats, Inbred Strains; Tramadol | 1990 |
Dose- and time-dependent action of morphine, tramadol and flupirtine as studied by radioelectroencephalography in the freely behaving rat.
Topics: Aminopyridines; Analgesics; Animals; Brain; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Frontal Lobe; Male; Morphine; Rats; Rats, Inbred F344; Receptors, Adrenergic; Reticular Formation; Signal Processing, Computer-Assisted; Thalamus; Tramadol | 1989 |
Mode of antinociceptive action of flupirtine in the rat.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Aminopyridines; Analgesics; Animals; Brain Chemistry; Clonidine; Imipramine; Male; Methyltyrosines; Neurotoxins; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Neurotransmitter; Reserpine; Serotonin Antagonists | 1989 |
Mechanisms of action of new antiepileptic drugs.
Topics: Acetamides; Acetates; Amines; Aminocaproates; Aminopyridines; Anti-Anxiety Agents; Anticonvulsants; Aspartic Acid; Benzodiazepines; Benzodiazepinones; Clobazam; Cyclohexanecarboxylic Acids; Dibenzocycloheptenes; Dizocilpine Maleate; Epilepsy; Felbamate; Flumazenil; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Imidazoles; Lamotrigine; Phenylcarbamates; Propylene Glycols; Receptors, GABA-A; Triazines; Vigabatrin | 1989 |
Use of flupirtine maleate as an analgesic in patients with liver disease.
Topics: Adult; Aged; Aminopyridines; Analgesics; Female; Humans; Liver Diseases; Male; Middle Aged; Palliative Care | 1985 |
Flupirtine antinociception in the dog is primarily mediated by nonopioid supraspinal mechanisms.
Topics: Aminopyridines; Analgesics; Animals; Decerebrate State; Dogs; Female; Naltrexone; Pentazocine; Reflex; Temperature; Time Factors | 1989 |
The antinociceptive activity of flupirtine: a structurally new analgesic.
Topics: Aminopyridines; Analgesics; Animals; Brain; Dogs; Drug Evaluation, Preclinical; Electroencephalography; Female; Male; Mice; Nociceptors; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Comparative physical dependence studies in rats with flupirtine and opiate receptor stimulating analgesics.
Topics: Aminopyridines; Analgesics; Animals; Body Weight; Buprenorphine; Codeine; Female; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance-Related Disorders; Tramadol | 1987 |
Flupirtine depresses nociceptive activity evoked in rat thalamus.
Topics: Afferent Pathways; Aminopyridines; Analgesics; Animals; Female; Male; Naloxone; Nociceptors; Rats; Rats, Inbred Strains; Synaptic Transmission; Thalamus | 1988 |
Pharmacological mechanisms of action of flupirtine: a novel, centrally acting, nonopioid analgesic evaluated by its discriminative effects in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aminopyridines; Analgesics; Animals; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Male; Naltrexone; Narcotics; Rats; Rats, Inbred F344 | 1988 |
[The pharmacologic effect of flupirtine, a structurally new analgesic].
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antitussive Agents; Drug Tolerance; Guinea Pigs; In Vitro Techniques; Kinetics; Lethal Dose 50; Levallorphan; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Rats; Reaction Time; Receptors, Opioid; Species Specificity | 1985 |
[Mechanism of action of the analgesic flupirtine].
Topics: Aminopyridines; Analgesics; Animals; Brain; Cyproheptadine; Fenclonine; Injections, Intraventricular; Injections, Spinal; Mice; Naloxone; Rats; Receptors, Opioid; Substance-Related Disorders | 1985 |
Pharmacokinetics of flupirtine in elderly volunteers and in patients with moderate renal impairment.
Topics: Age Factors; Aged; Aged, 80 and over; Aminopyridines; Female; Half-Life; Humans; Kidney; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged | 1988 |
Possible involvement of noradrenergic descending pain-modulating pathways in the mode of antinociceptive action of flupirtine, a novel non-opioid analgesic.
Topics: Aminopyridines; Analgesics; Animals; Efferent Pathways; Male; Norepinephrine; Pain; Rats; Rats, Inbred Strains | 1988 |
Effects of flupirtine on the pain-related evoked potential and the spontaneous EEG.
Topics: Adult; Aminopyridines; Analgesics; Electroencephalography; Evoked Potentials; Female; Humans; Male; Pain | 1988 |
Flupirtine maleate and antipyrine half-life.
Topics: Adult; Aminopyridines; Analgesics; Antipyrine; Chromatography, Gas; Half-Life; Humans; Male | 1987 |
Flupirtine--a centrally acting analgesic. Clinical and experimental aspects. Monte Carlo, 21 March 1986. Proceedings.
Topics: Aminopyridines; Analgesics; Animals; Humans | 1987 |
Flupirtine--a new centrally acting analgesic with unique chemical structure.
Topics: Aminopyridines; Analgesics; Chemical Phenomena; Chemistry; Computer Graphics; Models, Molecular; Morphine | 1987 |
Analgesic activity following combined oral administration of flupirtine maleate and peripherally acting analgesics in mice and rats.
Topics: Acetaminophen; Administration, Oral; Aminopyridines; Analgesics; Animals; Aspirin; Drug Evaluation, Preclinical; Drug Synergism; Ibuprofen; Indomethacin; Male; Mice; Mice, Inbred Strains; Pain Measurement; Peripheral Nerves; Rats; Rats, Inbred Strains | 1987 |
Abuse potential and physical dependence liability studies with flupirtine maleate in laboratory animals.
Topics: Aminopyridines; Analgesics; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Macaca mulatta; Mice; Mice, Inbred Strains; Rats; Substance-Related Disorders | 1987 |
Pharmaco-electroencephalography in the rat as a method for characterization of different types of analgesics.
Topics: Acetaminophen; Aminopyridines; Analgesics; Animals; Aspirin; Brain; Electroencephalography; Evoked Potentials, Somatosensory; Female; Pain Measurement; Pentazocine; Rats; Rats, Inbred Strains | 1987 |
Effect of flupirtine maleate on the nociceptive pathway, EEG, evoked potentials and polysynaptic reflexes in laboratory animals.
Topics: Aminopyridines; Analgesics; Animals; Cats; Central Nervous System; Electroencephalography; Evoked Potentials, Somatosensory; Male; Neural Pathways; Nociceptors; Pain Measurement; Rabbits; Reflex | 1987 |
Putative site(s) and mechanism(s) of action of flupirtine, a novel analgesic compound.
Topics: Aminopyridines; Analgesics; Animals; Clonidine; Drug Evaluation, Preclinical; Efferent Pathways; Electroencephalography; Male; Mice; Mice, Inbred Strains; Nociceptors; Pain Measurement; Rats; Rats, Inbred Strains; Reserpine; Yohimbine | 1987 |
Pentazocine and flupirtine effects on spontaneous and evoked EEG activity.
Topics: Aminopyridines; Brain; Double-Blind Method; Electric Stimulation; Electroencephalography; Evoked Potentials, Auditory; Evoked Potentials, Somatosensory; Humans; Male; Pain; Pentazocine | 1986 |
Radioelectroencephalography (Tele-Stereo-EEG) in the rat as a pharmacological model to differentiate the central action of flupirtine from that of opiates, diazepam and phenobarbital.
Topics: Aminopyridines; Animals; Brain; Buprenorphine; Diazepam; Electroencephalography; Male; Morphine; Phenobarbital; Rats; Rats, Inbred Strains; Tramadol | 1986 |
Depression by flupirtine, a novel analgesic agent, of motor and sensory responses of the nociceptive system in the rat spinal cord.
Topics: Aminopyridines; Analgesics; Animals; Axons; Dose-Response Relationship, Drug; Female; Male; Microinjections; Motor Neurons; Naloxone; Neurons, Afferent; Nociceptors; Periaqueductal Gray; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord | 1987 |
The action of flupirtine on prostaglandin formation and platelet aggregation in vitro.
Topics: Adenosine Diphosphate; Aminopyridines; Analgesics; Anesthetics, Local; Animals; Aorta, Thoracic; Epoprostenol; Female; Guinea Pigs; Humans; In Vitro Techniques; Indomethacin; Muscle, Smooth, Vascular; Myocardial Contraction; Platelet Aggregation; Prostaglandins; Rabbits; Rats; Rats, Inbred Strains; Thromboxanes | 1985 |
[Synthesis of C14-flupirtine maleate].
Topics: Aminopyridines; Carbon Radioisotopes; Chemical Phenomena; Chemistry; Isotope Labeling | 1985 |
[General pharmacologic studies on the analgesic flupirtine].
Topics: Aminopyridines; Amphetamine; Analgesics; Animals; Anticonvulsants; Catalepsy; Central Nervous System; Diuresis; Dogs; Drug Interactions; Female; Hemodynamics; Hexobarbital; Humans; Hypnotics and Sedatives; In Vitro Techniques; Male; Mice; Morphine; Motor Activity; Muscle Tonus; Oxotremorine; Parasympatholytics; Rats; Respiration | 1985 |
[Pharmacokinetics and biotransformation of the analgesic flupirtine in the rat and dog].
Topics: Aminopyridines; Analgesics; Animals; Bile; Biotransformation; Dogs; Feces; Kidney; Kinetics; Male; Photometry; Protein Binding; Rats; Rats, Inbred Strains; Species Specificity | 1985 |
[Pharmacokinetics and biotransformation of the analgesic flupirtine in humans].
Topics: Adult; Aminopyridines; Analgesics; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Female; Humans; Kinetics; Male; Mass Spectrometry; Photometry | 1985 |
Quantitation of flupirtine and its active acetylated metabolite by reversed-phase high-performance liquid chromatography using fluorometric detection.
Topics: Acetylation; Aminopyridines; Biotransformation; Chromatography, High Pressure Liquid; Humans; Spectrometry, Fluorescence | 1984 |
N-methyl-D-aspartate and alpha 2-adrenergic mechanisms are involved in the depressant action of flupirtine on spinal reflexes in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Aminopyridines; Analgesics; Animals; GABA Agonists; Injections, Intraperitoneal; Injections, Spinal; Male; Muscle Contraction; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex | 1995 |
Influence of flupirtine on human lower limb reflexes.
Topics: Adult; Aminopyridines; Analgesics; Analysis of Variance; Electromyography; Humans; Leg; Middle Aged; Reaction Time; Reflex | 1995 |
Flupirtine protects against ischaemic retinal dysfunction in rats.
Topics: Aminopyridines; Animals; Electroretinography; Ischemia; Male; Rats; Rats, Wistar; Reaction Time; Reperfusion; Retinal Vessels | 1994 |
Immunohistochemical evidence for flupirtine acting as an antagonist on the N-methyl-D-aspartate and homocysteic acid-induced release of GABA in the rabbit retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminopyridines; Animals; Dizocilpine Maleate; gamma-Aminobutyric Acid; Homocysteine; Immunohistochemistry; Kainic Acid; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina | 1994 |
The triaminopyridine flupirtine prevents cell death in rat cortical cells induced by N-methyl-D-aspartate and gp120 of HIV-1.
Topics: AIDS Dementia Complex; Aminopyridines; Analgesics; Animals; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; HIV Envelope Protein gp120; HIV-1; Molecular Weight; N-Methylaspartate; Neurons; Rats; Rats, Wistar | 1994 |
N-methyl-D-aspartate (NMDA)-mediated muscle relaxant action of flupirtine in rats.
Topics: Aminopyridines; Analgesics; Animals; Dose-Response Relationship, Drug; H-Reflex; Injections, Intraperitoneal; Injections, Spinal; Male; Muscle Relaxants, Central; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex | 1994 |
Effects of flupirtine coadministration on phenprocoumon plasma concentrations and prothrombin time.
Topics: Administration, Oral; Adult; Aminopyridines; Analgesics; Humans; Isomerism; Male; Phenprocoumon; Protein Binding; Prothrombin Time; Reference Values | 1994 |
Synthesis and quantitative structure-activity relationships of anticonvulsant 2,3,6-triaminopyridines.
Topics: Aminopyridines; Analgesics; Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Conformation; Molecular Structure; Structure-Activity Relationship | 1994 |
Protection of rabbit retina from ischemic injury by flupirtine.
Topics: Adenosine Triphosphate; Aminopyridines; Analgesics; Animals; Electroretinography; gamma-Aminobutyric Acid; Immunohistochemistry; Ischemia; Neuroprotective Agents; Rabbits; Rats; Reperfusion; Reperfusion Injury; Retina; Retinal Diseases; Retinal Vessels; Serotonin | 1996 |
Flupirtine protects neurons against excitotoxic or ischemic damage and inhibits the increase in cytosolic Ca2+ concentration.
Topics: Aminopyridines; Animals; Brain Ischemia; Calcium; Cells, Cultured; Glutamic Acid; Hippocampus; Neurons; Neuroprotective Agents; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate | 1995 |
Antiparkinsonian effect of flupirtine in monoamine-depleted rats.
Topics: Aminopyridines; Analgesics; Animals; Antiparkinson Agents; Biogenic Monoamines; Drug Synergism; Electromyography; Levodopa; Male; Neuroprotective Agents; Parkinson Disease, Secondary; Rats; Rats, Wistar | 1996 |
Neurotoxicity in rat cortical cells caused by N-methyl-D-aspartate (NMDA) and gp120 of HIV-1: induction and pharmacological intervention.
Topics: Aminopyridines; Animals; Apoptosis; Arachidonic Acid; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; HIV Envelope Protein gp120; HIV-1; Memantine; Models, Biological; N-Methylaspartate; Neurons; Neuroprotective Agents; Phospholipases A; Phospholipases A2; Rats | 1996 |
Flupirtine partially prevents neuronal injury induced by prion protein fragment and lead acetate.
Topics: Amino Acid Sequence; Aminopyridines; Analgesics; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Lead; Molecular Sequence Data; Neurons; Neuroprotective Agents; Organometallic Compounds; Peptide Fragments; Prions; Rats; Rats, Wistar | 1995 |
Flupirtine increases the levels of glutathione and Bc1-2 in hNT (human Ntera/D1) neurons: mode of action of the drug-mediated anti-apoptotic effect.
Topics: Aminopyridines; Analgesics, Non-Narcotic; Apoptosis; Cell Line; DNA Fragmentation; Excitatory Amino Acid Agonists; Glutamic Acid; Glutathione; Humans; Immunohistochemistry; N-Methylaspartate; Neurons; Proto-Oncogene Proteins c-bcl-2 | 1996 |
Flupirtine reduces functional deficits and neuronal damage after global ischemia in rats.
Topics: Aminopyridines; Animals; Corpus Striatum; Escape Reaction; Hippocampus; Ischemic Attack, Transient; Male; Maze Learning; Memory; Neurons; Neuroprotective Agents; Pyramidal Cells; Rats; Rats, Wistar | 1997 |
Protection of flupirtine on beta-amyloid-induced apoptosis in neuronal cells in vitro: prevention of amyloid-induced glutathione depletion.
Topics: Aminopyridines; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Cell Survival; Cerebral Cortex; Glutathione; Neurons; Neuroprotective Agents; Oxidative Stress; Peptide Fragments; Rats; Rats, Wistar | 1997 |
Antiparkinsonian and other motor effects of flupirtine alone and in combination with dopaminergic drugs.
Topics: Aminopyridines; Animals; Antiparkinson Agents; Behavior, Animal; Catalepsy; Dextroamphetamine; Dose-Response Relationship, Drug; Grooming; Levodopa; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Induction of apoptosis in cultured human retinal pigment epithelial cells is counteracted by flupirtine.
Topics: Aged; Aminopyridines; Analgesics; Animals; Apoptosis; Blotting, Western; Cell Hypoxia; Cell Survival; Cells, Cultured; Chickens; DNA Fragmentation; Electrophoresis, Agar Gel; Humans; Middle Aged; Oncogene Proteins; Oxidative Stress; Pigment Epithelium of Eye; Reactive Oxygen Species; Up-Regulation | 1997 |
Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP106-126).
Topics: Amino Acid Sequence; Aminopyridines; Analgesics, Non-Narcotic; Animals; Apoptosis; Cells, Cultured; Gene Expression Regulation; Genes, bcl-2; Glutathione; Molecular Sequence Data; Neurons; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Prions; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar | 1997 |
Influence of flupirtine on a G-protein coupled inwardly rectifying potassium current in hippocampal neurones.
Topics: Aminopyridines; Animals; Barium Compounds; Cell Culture Techniques; Chlorides; Cyclic AMP; Excitatory Amino Acid Agonists; GTP-Binding Proteins; Hippocampus; Membrane Potentials; Muscle Relaxants, Central; N-Methylaspartate; Neurons; Pertussis Toxin; Potassium; Rats; Virulence Factors, Bordetella | 1997 |
Effect of the triaminopyridine flupirtine on calcium uptake, membrane potential and ATP synthesis in rat heart mitochondria.
Topics: Adenosine Triphosphate; Aminopyridines; Analgesics; Animals; Calcium; Male; Membrane Potentials; Mitochondria, Heart; Rats; Rats, Wistar | 1998 |
Pharmacological intervention in age-associated brain disorders by Flupirtine: Alzheimer's and prion diseases.
Topics: Aging; Alzheimer Disease; Amino Acid Sequence; Aminopyridines; Amyloid beta-Peptides; Animals; Apoptosis; Calcium; Cell Survival; Cells, Cultured; Glutamates; Molecular Sequence Data; Neurons; Neuroprotective Agents; Peptide Fragments; Prion Diseases; Prions; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Time Factors | 1998 |
Melatonin counteracts ischemia-induced apoptosis in human retinal pigment epithelial cells.
Topics: Aged; Aminopyridines; Animals; Antioxidants; Apoptosis; Ascorbic Acid; Blotting, Western; Cell Hypoxia; Cell Survival; Cells, Cultured; Chickens; DNA; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Humans; In Situ Nick-End Labeling; Iron Compounds; Melatonin; Middle Aged; Pigment Epithelium of Eye; Proto-Oncogene Mas; Proto-Oncogene Proteins; Reactive Oxygen Species; Retina; RNA, Messenger | 1998 |
Antioxidant properties of the triaminopyridine, flupirtine.
Topics: Aminopyridines; Analgesics; Animals; Antioxidants; Hydrogen Peroxide; Male; Neuroprotective Agents; PC12 Cells; Rats; Rats, Sprague-Dawley | 1998 |
Polymorphism and desolvation of flupirtine maleate.
Topics: Aminopyridines; Analgesics; Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Crystallization; Microscopy, Polarization; Solubility; Temperature; Thermogravimetry; X-Ray Diffraction | 1998 |
Effect of flupirtine on cell death of human umbilical vein endothelial cells induced by reactive oxygen species.
Topics: Aminopyridines; Calcium; Cell Death; Cells, Cultured; DNA Fragmentation; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Necrosis; Reactive Oxygen Species; Umbilical Veins; Xanthine; Xanthine Oxidase | 1998 |
Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels. Rapid communication.
Topics: Aminopyridines; Animals; Cells, Cultured; Embryo, Mammalian; Magnesium; Membrane Potentials; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Potassium Channels; Rats; Receptors, N-Methyl-D-Aspartate; Superior Colliculi | 1999 |
Flupirtine ameliorates ischaemic-like death of rat retinal ganglion cells by preventing calcium influx.
Topics: Aminopyridines; Animals; Biological Transport; Calcium; Cell Death; Cerebral Cortex; Fetus; Ischemia; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Retinal Ganglion Cells; Retinal Vessels; RNA, Messenger; Thy-1 Antigens; Transcription, Genetic | 2000 |
[Drugs for back pain: caution, liver damage!].
Topics: Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Humans; Low Back Pain | 2000 |
Protection of mitochondrial integrity from oxidative stress by the triaminopyridine derivative flupirtine.
Topics: Aminopyridines; Animals; Antiporters; Apoptosis; Ascorbic Acid; Calcium; Cell Respiration; Electron Spin Resonance Spectroscopy; Female; Hydroxyl Radical; Ion Channels; Iron; Lipid Peroxidation; Membrane Lipids; Membrane Proteins; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidants; Oxidation-Reduction; Oxidative Phosphorylation; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Spin Labels; Thiobarbituric Acid Reactive Substances | 2000 |
Flupirtine and retigabine prevent L-glutamate toxicity in rat pheochromocytoma PC 12 cells.
Topics: Aminopyridines; Analgesics; Animals; Antidepressive Agents; Carbamates; Cell Death; Clorgyline; Culture Media; Cystine; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; PC12 Cells; Phenylenediamines; Rats; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate | 2000 |
Association of increased bcl-2 expression with rescue from tumor necrosis factor-alpha-induced cell death in the oligodendrocyte cell line OLN-93.
Topics: Aminopyridines; Animals; Apoptosis; Cell Death; Cell Line; Dose-Response Relationship, Drug; Immunohistochemistry; In Situ Nick-End Labeling; Neuroprotective Agents; Oligodendroglia; Polymerase Chain Reaction; Proto-Oncogene Proteins c-bcl-2; Rats; RNA, Messenger; Tumor Necrosis Factor-alpha | 2000 |
Synthesis and analgesic activity of some quinazoline analogs of anpirtoline.
Topics: Aminopyridines; Analgesics; Animals; Hot Temperature; Male; Mice; Mice, Inbred Strains; Molecular Structure; Pain; Piperidines; Pyridines; Quinazolines; Reaction Time; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Structure-Activity Relationship; Tramadol | 2000 |
Simultaneous determination of flupirtine and its major active metabolite in human plasma by liquid chromatography-tandem mass spectrometry.
Topics: Aminopyridines; Analgesics; Calibration; Chromatography, Liquid; Diphenhydramine; Humans; Mass Spectrometry; Reproducibility of Results | 2001 |
Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons.
Topics: Aminopeptidases; Aminopyridines; Apoptosis; Cell Division; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Gene Expression; Humans; In Situ Nick-End Labeling; In Vitro Techniques; Lymphocytes; Membrane Glycoproteins; Membrane Proteins; Mitosis; Molecular Chaperones; Neuronal Ceroid-Lipofuscinoses; Neurons; Neuroprotective Agents; Peptide Hydrolases; Proteins; RNA, Messenger; Serine Proteases; Teratocarcinoma; Thiolester Hydrolases; Transfection; Tripeptidyl-Peptidase 1; Tumor Cells, Cultured | 2002 |
Treatment of spasticity.
Topics: Acetates; Amines; Aminopyridines; Baclofen; Benzodiazepines; Botulinum Toxins, Type A; Clonidine; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Memantine; Muscle Spasticity; Paralysis; Rhizotomy | 2002 |
[Centrally acting analgesic against fibromyalgia. The body's own pain control is activated].
Topics: Aminopyridines; Analgesics; Calcium; Central Nervous System; Fibromyalgia; Humans; Membrane Potentials; Neural Inhibition; Neurons; Potassium Channels | 2002 |
Attenuation of methamphetamine induced dopaminergic neurotoxicity by flupirtine: microdialysis study on dopamine release and free radical generation.
Topics: Aminopyridines; Animals; Dopamine; Drug Interactions; Extracellular Space; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Microdialysis; Neostriatum; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Presynaptic Terminals; Rats; Rats, Sprague-Dawley | 2003 |
M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals.
Topics: Aminopyridines; Animals; Anthracenes; Anticonvulsants; Aspartic Acid; Carbamates; CHO Cells; Cricetinae; gamma-Aminobutyric Acid; Hippocampus; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Norepinephrine; Patch-Clamp Techniques; Phenylenediamines; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Presynaptic Terminals; Protein Subunits; Rats; Synaptosomes | 2004 |
[Flupirtine in acute and chronic pain associated with muscle tenseness. Results of a postmarket surveillance study].
Topics: Aminopyridines; Analgesics; Humans; Musculoskeletal Diseases; Neuroprotective Agents; Pain; Pain Measurement; Treatment Outcome | 2003 |
The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice.
Topics: Aminopyridines; Animals; Animals, Newborn; Dose-Response Relationship, Radiation; Electric Stimulation; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Membrane Potentials; Mice; Neurons; Synapses; Synaptic Transmission | 2004 |
Paradoxical cerebral cortical hyperexcitability following flupirtine overdose.
Topics: Adult; Aminopyridines; Analgesics; Anticonvulsants; Benzodiazepines; Cerebral Cortex; Electroencephalography; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Humans; Phenytoin; Potassium Channels, Inwardly Rectifying; Seizures | 2004 |
Tumor-necrosis-factor-related apoptosis-inducing-ligand (TRAIL)-mediated death of neurons in living human brain tissue is inhibited by flupirtine-maleate.
Topics: Aminopyridines; Apoptosis Regulatory Proteins; Cell Count; Cell Death; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Humans; In Vitro Techniques; Membrane Glycoproteins; N-Methylaspartate; Neocortex; Neurons; Neuroprotective Agents; Propidium; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2005 |
Retigabine and flupirtine exert neuroprotective actions in organotypic hippocampal cultures.
Topics: Aminopyridines; Animals; Carbamates; Culture Media, Serum-Free; Glucose; Hippocampus; KCNQ Potassium Channels; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Oxygen; Phenylenediamines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Tissue Culture Techniques | 2006 |
[The use of katadolon (flupirtine) in the treatment of lower back pain].
Topics: Aminopyridines; Analgesics, Non-Narcotic; Female; Humans; Low Back Pain; Male; Middle Aged; Pain Measurement; Receptors, N-Methyl-D-Aspartate | 2006 |
KCNQ/M-currents contribute to the resting membrane potential in rat visceral sensory neurons.
Topics: Aminopyridines; Animals; Anthracenes; Cells, Cultured; Dose-Response Relationship, Drug; Indoles; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Potentials; Neurons, Afferent; Nodose Ganglion; Potassium; Potassium Channel Blockers; Pyridines; Rats; Rats, Sprague-Dawley; Visceral Afferents | 2006 |
[Backache is often caused by strained muscles].
Topics: Aminopyridines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Diagnosis, Differential; Humans; Sprains and Strains; Treatment Outcome | 2006 |
[Use of katadolon in the treatment of abuse headache].
Topics: Adult; Aminopyridines; Analgesics; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Headache; Humans; Male; Pain Measurement; Treatment Outcome | 2006 |
Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis.
Topics: Aminopyridines; Analgesics; Animals; Anticonvulsants; Borna Disease; Encephalitis, Viral; Herpes Simplex; Herpesvirus 1, Human; Male; Naloxone; Naltrexone; Narcotic Antagonists; Potassium; Rats; Rats, Inbred Lew; Receptors, Opioid, delta; Seizures; Substance Withdrawal Syndrome | 2007 |
[The use of katadolon in patients with spondylogenic dorsalgia].
Topics: Adult; Aged; Aminopyridines; Analgesics; Back Pain; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pain Measurement; Severity of Illness Index; Spinal Osteophytosis; Treatment Outcome | 2006 |
Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity.
Topics: Aminopyridines; Animals; Anthracenes; Carbamates; Dose-Response Relationship, Drug; Gene Expression Profiling; Immunohistochemistry; Indoles; Isometric Contraction; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Meclofenamic Acid; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2007 |
Flupirtine attenuates sodium nitroprusside-induced damage to retinal photoreceptors, in situ.
Topics: Aminopyridines; Analgesics; Animals; Antihypertensive Agents; Antioxidants; Caspase 3; Chromans; Ciliary Neurotrophic Factor; Dose-Response Relationship, Drug; Electroretinography; Fibroblast Growth Factor 2; Glial Fibrillary Acidic Protein; Humans; In Situ Nick-End Labeling; Lipid Peroxidation; Metipranolol; Neuroprotective Agents; Nitric Oxide Donors; Nitroprusside; Photoreceptor Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Rhodopsin; Thiobarbituric Acid Reactive Substances | 2007 |
[Many faces--one disease: fibromyalgia].
Topics: Acetaminophen; Aminopyridines; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anticonvulsants; Diagnosis, Differential; Drug Therapy, Combination; Exercise; Fibromyalgia; Humans | 2007 |
Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance.
Topics: Aminopyridines; Animals; Blood Pressure; Calcium Channels, L-Type; Heart Rate; Indoles; KCNQ Potassium Channels; Male; Mesenteric Arteries; Muscle Cells; Potassium Channel Blockers; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Vascular Resistance; Vasoconstrictor Agents; Vasopressins | 2008 |
Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents.
Topics: Aminopyridines; Animals; Anthracenes; Carbamates; Dose-Response Relationship, Drug; In Vitro Techniques; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Membrane Potentials; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylenediamines; Portal Vein; Potassium; Potassium Channel Blockers; Recombinant Proteins; RNA, Messenger; Time Factors; Vasoconstriction; Vasodilator Agents; Xenopus laevis | 2008 |
Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis.
Topics: Aminopyridines; Animals; Autoimmune Diseases; Cell Survival; Cells, Cultured; Cytoprotection; Disease Progression; Drug Therapy, Combination; Evoked Potentials, Visual; Female; Inflammation; Interferon-beta; Ion Channel Gating; Neuroprotective Agents; Optic Nerve; Optic Neuritis; Potassium Channels, Inwardly Rectifying; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred BN; Rats, Wistar; Retinal Ganglion Cells | 2008 |
Combination therapy with flupirtine and opioid: studies in rat pain models.
Topics: Aminopyridines; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Male; Morphine; Neuralgia; Pain Measurement; Rats; Rats, Wistar; Treatment Outcome | 2008 |
Investigation of the in vitro metabolism of the analgesic flupirtine.
Topics: Aminopyridines; Analgesics; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Electrochemistry; Esterases; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Microsomes, Liver; NADP; Peroxidases; Rats; Swine; Tandem Mass Spectrometry | 2009 |
[Efficacy of katadolon and cranial-spine electromagnetic neuromodulation in patients with discogenic radiculopathy].
Topics: Aminopyridines; Analgesics; Electric Stimulation Therapy; Electromagnetic Fields; Follow-Up Studies; Humans; Intervertebral Disc Displacement; Magnetic Field Therapy; Male; Middle Aged; Pain Measurement; Radiculopathy; Treatment Outcome | 2008 |
A girl with headache, confusion and green urine.
Topics: Adolescent; Aminopyridines; Analgesics; Ataxia; Confusion; Dysarthria; Electroencephalography; Female; Gait Disorders, Neurologic; Gas Chromatography-Mass Spectrometry; Headache; Humans; Magnetic Resonance Imaging; Potassium Channels; Syncope; Urinalysis; Urine; Vision, Low | 2009 |
Clinical trials for prion disease: difficult challenges, but hope for the future.
Topics: Aminopyridines; Clinical Trials as Topic; Humans; Prion Diseases; Quinacrine; Randomized Controlled Trials as Topic | 2009 |
A KCNQ channel opener for experimental neonatal seizures and status epilepticus.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Female; Flurothyl; Kainic Acid; KCNQ Potassium Channels; Male; Phenobarbital; Pregnancy; Rats; Seizures; Spectrum Analysis; Status Epilepticus; Time Factors | 2009 |
Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension.
Topics: Aminopyridines; Animals; Disease Models, Animal; Female; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Mice; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels, Voltage-Gated; Pulmonary Artery; Serotonin Plasma Membrane Transport Proteins | 2009 |
CNSB004 (Leconotide) causes antihyperalgesia without side effects when given intravenously: a comparison with ziconotide in a rat model of diabetic neuropathic pain.
Topics: Aminopyridines; Analgesics, Non-Narcotic; Animals; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Drug Interactions; Hemodynamics; Hot Temperature; Hyperalgesia; Injections, Intravenous; Male; Motor Activity; omega-Conotoxins; Pain Measurement; Rats; Rats, Wistar | 2010 |
[Efficient treatment of chronic backache].
Topics: Aminopyridines; Analgesics; Back Pain; Chronic Disease; Fatigue; Humans; Pilot Projects; Polysomnography; Quality of Life; Sleep Wake Disorders; Surveys and Questionnaires; Time Factors | 2009 |
The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.
Topics: Aminopyridines; Animals; Anthracenes; Anticonvulsants; Carbamates; Female; Gene Expression; Gestational Age; Humans; KCNQ Potassium Channels; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Myometrium; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pregnancy; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Uterine Contraction | 2011 |
Positive reinforcing effects of flupirtine--two case reports.
Topics: Adult; Aminopyridines; Analgesics; Humans; Low Back Pain; Male; Middle Aged; Pleasure; Substance Withdrawal Syndrome | 2010 |
The Kv7 potassium channel activator flupirtine affects clinical excitability parameters of myelinated axons in isolated rat sural nerve.
Topics: Action Potentials; Aminopyridines; Analgesics; Animals; Anthracenes; Axons; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; KCNQ Potassium Channels; Male; Membrane Potentials; Microelectrodes; Nerve Fibers, Myelinated; Potassium Channel Blockers; Rats; Rats, Wistar; Sural Nerve; Time Factors | 2010 |
Flupirtine may stop the progressive course of subacute sclerosing panencephalitis.
Topics: Aminopyridines; Apoptosis; Humans; Subacute Sclerosing Panencephalitis | 2010 |
M-type potassium channels modulate the intrinsic excitability of infralimbic neurons and regulate fear expression and extinction.
Topics: Acoustic Stimulation; Action Potentials; Aminopyridines; Analgesics; Animals; Anthracenes; Conditioning, Psychological; Extinction, Psychological; Fear; KCNQ Potassium Channels; Male; Memory; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Potassium Channel Blockers; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 2010 |
Green urine following exposure to flupirtine.
Topics: Adult; Aminopyridines; Analgesics; Color; Diagnosis, Differential; Humans; Male; Substance-Related Disorders; Urinalysis | 2010 |
Flupirtine antinociception in the rat orofacial formalin test: an analysis of combination therapies with morphine and tramadol.
Topics: Aminopyridines; Analgesics; Animals; Male; Morphine; Pain Measurement; Rats; Rats, Wistar; Tramadol | 2011 |
[New approaches to the treatment of chronic daily headache].
Topics: Adult; Aminopyridines; Analgesics; Attention Deficit Disorder with Hyperactivity; Constipation; Cyclohexanols; Diarrhea; Female; Headache Disorders; Humans; Male; Nausea; Pain Threshold; Treatment Outcome; Venlafaxine Hydrochloride | 2010 |
[Musculoskeletal pain. Pain relief with muscle relaxant].
Topics: Aminopyridines; Analgesics; Back Pain; Controlled Clinical Trials as Topic; Delayed-Action Preparations; Evidence-Based Medicine; Germany; Humans; Long-Term Care; Randomized Controlled Trials as Topic; Tramadol | 2010 |
[2010 German Pain Congress. Backache - new data, specific muscle etiology and targeted therapy].
Topics: Aminopyridines; Analgesics; Back Pain; Delayed-Action Preparations; Germany; Humans; Randomized Controlled Trials as Topic | 2010 |
Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury.
Topics: Aminopyridines; Analgesics; Analysis of Variance; Anesthetics, Local; Animals; Chronic Disease; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glycoproteins; Hyperalgesia; Indoles; KCNQ2 Potassium Channel; Lectins; Lidocaine; Male; Membrane Potentials; Neurofilament Proteins; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Repressor Proteins; RNA, Messenger; Sciatic Neuropathy; TRPV Cation Channels; Versicans | 2011 |
Flupirtine is a safe alternative drug in patients with hypersensitivity to NSAIDs.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Aminopyridines; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Female; Humans; Male; Medical Records; Middle Aged; Retrospective Studies; Skin Tests; Surveys and Questionnaires; Young Adult | 2011 |
[Effect of maladaptive sets on the clinical picture and prediction of chronic headache of tension].
Topics: Adaptation, Psychological; Adult; Aminopyridines; Analgesics; Chronic Disease; Female; Humans; Middle Aged; Prognosis; Set, Psychology; Tension-Type Headache; Young Adult | 2011 |
Parent-reported benefits of flupirtine in juvenile neuronal ceroid lipofuscinosis (Batten disease; CLN3) are not supported by quantitative data.
Topics: Adolescent; Adult; Algorithms; Aminopyridines; Analgesics; Child; Child, Preschool; Female; Follow-Up Studies; Health Surveys; Humans; Infant; Male; Neuronal Ceroid-Lipofuscinoses; Parents; Reproducibility of Results; Research Design; Research Report; Treatment Outcome; Young Adult | 2011 |
Pathology of flupirtine-induced liver injury: a histological and clinical study of six cases.
Topics: Aged; Alanine Transaminase; Aminopyridines; Analgesics; Aspartate Aminotransferases; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Lymphocytes; Macrophages; Male; Middle Aged | 2011 |
Flupirtine-induced hepatic failure requiring orthotopic liver transplant.
Topics: Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Graft Rejection; Humans; Immunosuppressive Agents; Liver Failure; Liver Transplantation; Male; Middle Aged; Pulse Therapy, Drug; Steroids; Treatment Outcome | 2011 |
Protective effect of the KCNQ activator flupirtine on a model of repetitive febrile seizures.
Topics: Aminopyridines; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Female; Fever; KCNQ Potassium Channels; Male; Maze Learning; Memory; Nerve Degeneration; Neuroprotective Agents; Phenobarbital; Rats; Rats, Sprague-Dawley; Risk Factors; Secondary Prevention; Seizures, Febrile | 2011 |
Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy.
Topics: Aminopyridines; Animals; Anthracenes; Bronchoconstriction; Bronchodilator Agents; Calcium Channel Blockers; Carbamates; Celecoxib; Guinea Pigs; Histamine; Humans; KCNQ Potassium Channels; Male; Methacholine Chloride; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Phenylenediamines; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sulfonamides; Verapamil | 2012 |
Correlation versus causation? Pharmacovigilance of the analgesic flupirtine exemplifies the need for refined spontaneous ADR reporting.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aminopyridines; Analgesics; Bile Duct Diseases; Causality; Chemical and Drug Induced Liver Injury; Female; Germany; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Middle Aged; Pharmacovigilance; Virus Diseases; World Health Organization | 2011 |
Retigabine, a K(V)7 (KCNQ) potassium channel opener, attenuates L-DOPA-induced dyskinesias in 6-OHDA-lesioned rats.
Topics: Amantadine; Aminopyridines; Animals; Anticonvulsants; Antiparkinson Agents; Behavior, Animal; Carbamates; Dyskinesia, Drug-Induced; Female; Motor Activity; Oxidopamine; Phenylenediamines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 2012 |
Flupirtine inhibits calcitonin-gene related peptide release from rat brainstem in vitro.
Topics: Aminopyridines; Analgesics; Animals; Brain Stem; Calcitonin Gene-Related Peptide; In Vitro Techniques; Radioimmunoassay; Rats | 2012 |
M channel enhancers and physiological M channel block.
Topics: Aminopyridines; Animals; Bradykinin; Calcium; Carbamates; CHO Cells; Cricetinae; Cricetulus; Ganglia, Spinal; Hydrogen Peroxide; Inflammation; KCNQ Potassium Channels; Organometallic Compounds; Pain; Phenylenediamines; Phosphatidylinositol 4,5-Diphosphate; Pyridines; Rats; Rats, Wistar; Sensory Receptor Cells; Type C Phospholipases | 2012 |
Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine.
Topics: Aminopyridines; Analgesics, Non-Narcotic; Animals; Cell Line; Cells, Cultured; Ganglia, Spinal; Hippocampus; Humans; KCNQ Potassium Channels; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Superior Cervical Ganglion | 2012 |
Bioanalytical method development, validation and quantification of flupirtine maleate in rat plasma by liquid chromatography-tandem mass spectrometry.
Topics: Aminopyridines; Analgesics, Non-Narcotic; Animals; Calibration; Chromatography, High Pressure Liquid; Indicators and Reagents; Male; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry | 2011 |
[Chronic backache. Rational therapy of muscle-induced pain].
Topics: Aminopyridines; Analgesics; Back Pain; Evidence-Based Medicine; Humans; Pain Measurement; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Tension-Type Headache | 2012 |
Successful use of flupirtine in refractory neuropathic pain due to small fiber neuropathy.
Topics: Adult; Aminopyridines; Analgesics; Erythromelalgia; Humans; Male; Oligodendroglioma | 2013 |
M-type potassium channels modulate Schaffer collateral-CA1 glutamatergic synaptic transmission.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Action Potentials; Aminopyridines; Animals; Anthracenes; Calcium; Calcium Channels, L-Type; Glutamic Acid; Indoles; Male; Neurons; Potassium Channel Blockers; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Synaptic Transmission | 2012 |
Altered response to hydrogen sulphide during experimental colitis in rats.
Topics: Aminopyridines; Analgesics; Animals; Colitis; Diet; Female; Hydrogen Sulfide; Inflammation; Intestines; Male; Rats; Rats, Wistar; Sulfur; Trinitrobenzenesulfonic Acid | 2013 |
Flupirtine enhances the anti-hyperalgesic effects of morphine in a rat model of prostate bone metastasis.
Topics: Aminopyridines; Analgesics; Animals; Bone Neoplasms; Disease Models, Animal; Hyperalgesia; Male; Morphine; Pain; Prostatic Neoplasms; Rats; Rats, Wistar | 2012 |
[On the right to have a personal opinion].
Topics: Aminopyridines; Analgesics; Attitude of Health Personnel; Back Pain; Drug Industry; Evidence-Based Medicine; Germany; Guideline Adherence; Humans; National Health Programs; Practice Guidelines as Topic | 2013 |
M-channels modulate network excitatory activity induced by 4-aminopyridine in immature rat substantia gelatinosa in vitro.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Analgesics; Animals; Animals, Newborn; Anthracenes; Biological Clocks; Biophysical Phenomena; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Female; In Vitro Techniques; Indoles; Male; Membrane Transport Modulators; Nerve Net; Neurons; Phenylenediamines; Potassium Channel Blockers; Pyridines; Rats; Rats, Wistar; Substantia Gelatinosa | 2013 |
Dependence on flupirtine.
Topics: Aminopyridines; Analgesics; Behavior, Addictive; Female; Humans; Middle Aged; Substance Abuse Detection | 2013 |
Abuse liability of flupirtine revisited: implications of spontaneous reports of adverse drug reactions.
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Analgesics; Female; Germany; Humans; Male; Middle Aged; Substance-Related Disorders; Young Adult | 2013 |
Long-term use of flupirtine leads to withdrawal symptoms and is associated with dependency.
Topics: Adult; Aminopyridines; Analgesics; Butyrophenones; Female; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 2013 |
Expression and motor functional roles of voltage-dependent type 7 K(+) channels in the human taenia coli.
Topics: Aged; Aged, 80 and over; Aminopyridines; Anthracenes; Carbamates; Colon; Gastrointestinal Motility; Gene Expression Regulation; Humans; In Vitro Techniques; KCNQ Potassium Channels; Middle Aged; Phenylenediamines; RNA, Messenger | 2013 |
Isolation, identification and characterization of novel process-related impurities in flupirtine maleate.
Topics: Aminopyridines; Analgesics; Chromatography, High Pressure Liquid; Drug Contamination; Magnetic Resonance Spectroscopy; Mass Spectrometry; Spectrophotometry, Infrared | 2014 |
Flupirtine-induced liver injury--seven cases from the Berlin Case-control Surveillance Study and review of the German spontaneous adverse drug reaction reporting database.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Aminopyridines; Analgesics; Berlin; Case-Control Studies; Chemical and Drug Induced Liver Injury; Female; Germany; Humans; Male; Middle Aged | 2014 |
Serum starvation-induced voltage-gated potassium channel Kv7.5 expression and its regulation by Sp1 in canine osteosarcoma cells.
Topics: Aminopyridines; Animals; Cell Line, Tumor; Cell Proliferation; Culture Media, Serum-Free; Dogs; KCNQ Potassium Channels; Osteosarcoma; Plicamycin; Sp1 Transcription Factor; Transcription, Genetic | 2014 |
Hypothalamic-pituitary-adrenocortical axis activity as a potential predictor for withdrawal symptoms in addiction to flupirtine, a nonopiate analgesic.
Topics: Aminopyridines; Analgesics; Humans; Hypothalamo-Hypophyseal System; Male; Middle Aged; Pituitary-Adrenal System; Predictive Value of Tests; Substance Withdrawal Syndrome | 2014 |
[Flupirtine. Therapy of episodic tension headache].
Topics: Adult; Aminopyridines; Analgesics; Controlled Clinical Trials as Topic; Female; Humans; Male; Muscle Tonus; Neck Muscles; Pain Measurement; Tension-Type Headache | 2014 |
[2-week efficacy and tolerability of flupirtine MR and diclofenac in patients with acute low/back pain--results of a post-hoc subgroup analysis of patient-level data from four non-interventional studies].
Topics: Acute Disease; Adult; Aged; Aminopyridines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Delayed-Action Preparations; Diclofenac; Evidence-Based Medicine; Female; Germany; Humans; Male; Middle Aged; Pain Measurement; Retrospective Studies | 2013 |
KCNQ/Kv7 channel activator flupirtine protects against acute stress-induced impairments of spatial memory retrieval and hippocampal LTP in rats.
Topics: Aminopyridines; Animals; Anthracenes; Carbamates; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Nootropic Agents; Phenylenediamines; Phosphorylation; Potassium Channel Blockers; Rats, Sprague-Dawley; Spatial Memory; Stress, Psychological | 2014 |
[Tension headache. Cramped neck muscles are often the cause].
Topics: Aminopyridines; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Muscle Cramp; Neck Muscles; Tension-Type Headache | 2014 |
[Interview with PD Dr. Michael A Uberall, Nürnberg. Flupirtine once daily in tension headache (interview by Abdol A. Ameri)].
Topics: Aminopyridines; Clinical Trials as Topic; Drug Administration Schedule; Humans; Muscle Tonus; Tension-Type Headache | 2014 |
Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.
Topics: Aminopyridines; Analgesics; Animals; Gene Expression Regulation; Hypertension, Pulmonary; Hypoxia; Indoles; KCNQ Potassium Channels; Lung; Male; Membrane Potentials; Muscle, Smooth; Potassium Channel Blockers; Pulmonary Artery; Pulmonary Circulation; Pyridines; Rats; Rats, Wistar; Vascular Resistance | 2015 |
Oxidation potentials of N-modified derivatives of the analgesic flupirtine linked to potassium KV 7 channel opening activity but not hepatocyte toxicity.
Topics: Aminopyridines; Analgesics; Animals; Cell Line; Cell Survival; Electrochemical Techniques; HEK293 Cells; Hepatocytes; Humans; KCNQ Potassium Channels; Mice; Mice, Transgenic; Nitrogen; Oxidation-Reduction; Structure-Activity Relationship; Transforming Growth Factor alpha | 2015 |
Quantitative LC-MS/MS determination of flupirtine, its N-acetylated and two mercapturic acid derivatives in man.
Topics: Acetylation; Acetylcysteine; Aminopyridines; Chromatography, Liquid; Humans; Male; Mass Spectrometry; Tandem Mass Spectrometry | 2015 |
Ability of naringenin, a bioflavonoid, to activate M-type potassium current in motor neuron-like cells and to increase BKCa-channel activity in HEK293T cells transfected with α-hSlo subunit.
Topics: Aminopyridines; Animals; Dose-Response Relationship, Drug; Flavanones; HEK293 Cells; Humans; Indoles; KCNQ Potassium Channels; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Membrane Potentials; Mice; Motor Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Pyridines; Transfection | 2014 |
Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice.
Topics: Aminopyridines; Animals; Apoptosis; Chronic Disease; Cognition Disorders; Dendritic Spines; Disease Models, Animal; Hippocampus; Male; Maze Learning; Mice; Neurons; Neuroprotective Agents; Nootropic Agents; Random Allocation; Restraint, Physical; Spatial Memory; Stress, Psychological | 2015 |
Synergistic interaction between tapentadol and flupirtine in the rat orafacial formalin test.
Topics: Aminopyridines; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Facial Pain; Formaldehyde; Male; Nociception; Phenols; Rats; Rats, Wistar; Tapentadol | 2015 |
The indirect NMDAR inhibitor flupirtine induces sustained post-ischemic recovery, neuroprotection and angioneurogenesis.
Topics: Aminopyridines; Analgesics; Angiogenesis Inducing Agents; Animals; Dyskinesias; Ischemic Attack, Transient; Male; Mice; Mice, Inbred C57BL; Neurogenesis; Neuroprotection; Random Allocation; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2015 |
δ Subunit-containing GABAA receptors are preferred targets for the centrally acting analgesic flupirtine.
Topics: Aminopyridines; Analgesics; Animals; Cell Line; Cells, Cultured; Ganglia, Spinal; Hippocampus; Humans; Inhibitory Postsynaptic Potentials; KCNQ Potassium Channels; Neurons; Rats; Receptors, GABA-A; Spinal Cord Dorsal Horn | 2015 |
[Flupirtine helps - but pay attention to the liver!].
Topics: Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Humans; Myalgia | 2015 |
Flupirtine effectively prevents development of acute neonatal seizures in an animal model of global hypoxia.
Topics: Acute Disease; Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Female; Hypoxia; KCNQ Potassium Channels; Male; Rats, Sprague-Dawley; Seizures | 2015 |
Pharmacokinetics and disposition of flupirtine in the horse.
Topics: Aminopyridines; Analgesics; Analgesics, Non-Narcotic; Animals; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Horses; Injections, Intravenous; Intubation, Gastrointestinal; Random Allocation | 2016 |
Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection.
Topics: Aminopyridines; Animals; Carbamates; KCNQ Potassium Channels; Male; Membrane Potentials; Mitochondria, Heart; Myocytes, Cardiac; Phenylenediamines; Potassium Channel Blockers; Rats | 2016 |
KV7 channels contribute to paracrine, but not metabolic or ischemic, regulation of coronary vascular reactivity in swine.
Topics: Adventitia; Aminopyridines; Animals; Blotting, Western; Bradykinin; Coronary Circulation; Coronary Vessels; Endothelium, Vascular; Indoles; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Paracrine Communication; Potassium Channel Blockers; Pyridines; Real-Time Polymerase Chain Reaction; Swine; Vasoconstriction; Vasodilation; Vasodilator Agents | 2016 |
Inhibition of KV7 Channels Protects the Rat Heart against Myocardial Ischemia and Reperfusion Injury.
Topics: Aminopyridines; Animals; Anthracenes; Coronary Circulation; Coronary Vessels; Indoles; Ischemic Preconditioning, Myocardial; KCNQ Potassium Channels; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Potassium Channel Blockers; Pyridines; Rats; Rats, Wistar; Vasodilation | 2016 |
HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury.
Topics: Adult; Aged; Aminopyridines; Chemical and Drug Induced Liver Injury; Female; Genome-Wide Association Study; HLA-DQ beta-Chains; HLA-DRB1 Chains; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide | 2016 |
Effects of granulocyte-colony stimulating factor (G-CSF) on stem cell mobilization in patients with liver failure.
Topics: Acute-On-Chronic Liver Failure; Aminopyridines; Analgesics; Bacterial Infections; Bilirubin; Cell Count; Chemical and Drug Induced Liver Injury; Filgrastim; Granulocyte Colony-Stimulating Factor; Hematologic Agents; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Hepatitis E; Hepatitis, Alcoholic; Humans; Prothrombin Time | 2016 |
KCNQ2/3 channel agonist flupirtine reduces cocaine place preference in rats.
Topics: Aminopyridines; Animals; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Dopamine Agents; Dose-Response Relationship, Drug; KCNQ3 Potassium Channel; Locomotion; Male; Motor Activity; Rats; Receptors, Dopamine; Reward | 2017 |
Targeting Kv7 channels in pain pathways.
Topics: Aminopyridines; Animals; Carbamates; Deafness; Epilepsy; Humans; Inflammation; KCNQ Potassium Channels; Long QT Syndrome; Mutation; Neurons; Pain; Pain Management; Phenylenediamines; Protein Conformation | 2017 |
Anticonvulsant effect of flupirtine in an animal model of neonatal hypoxic-ischemic encephalopathy.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Disease Progression; Electrocorticography; Hypoxia-Ischemia, Brain; Injections, Intraperitoneal; Male; Phenobarbital; Random Allocation; Rats, Sprague-Dawley; Seizures; Time Factors | 2017 |
MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain.
Topics: Aminopyridines; Animals; Chronic Pain; Down-Regulation; Ganglia, Spinal; Hyperalgesia; Male; MicroRNAs; Neuralgia; Neurons; Phenylurea Compounds; Potassium Channels, Voltage-Gated; Rats, Sprague-Dawley; Tetrazoles | 2017 |
N-acetylcysteine and prednisolone treatment improved serum biochemistries in suspected flupirtine cases of severe idiosyncratic liver injury.
Topics: Acetylcysteine; Administration, Oral; Adult; Aged; Aged, 80 and over; Aminopyridines; Analgesics; Antidotes; Biomarkers; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Progression; Drug Therapy, Combination; Female; Glucocorticoids; Glutathione; Hepatocytes; Humans; Infusions, Intravenous; Liver; Liver Transplantation; Male; Middle Aged; Prednisolone; Recovery of Function; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2018 |
Flupirtine: A Less-Explored, Neglected Nonopioid Analgesic.
Topics: Aminopyridines; Analgesics, Non-Narcotic; Analgesics, Opioid; Humans; Pain | 2018 |
Flupirtine drug-induced liver injury in a patient developing acute liver failure.
Topics: Adult; Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Interactions; Fatal Outcome; Female; Hepatic Encephalopathy; Humans; Hypericum; Liver Failure, Acute; Shock, Septic | 2018 |
Flupirtine, an Effective Analgesic, but Hepatotoxicity Should Limit Its Use.
Topics: Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Humans; Pain | 2018 |
Flupirtine Is an Effective Analgesic: Is the Associated Rare Liver Injury a Limiting Factor to Its Use?
Topics: Aminopyridines; Analgesics; Humans; Liver; Pain | 2018 |
The impact of risk minimization measures on compliance and prescribing practices of flupirtine in Germany.
Topics: Adolescent; Adult; Aged; Aminopyridines; Analgesics; Cohort Studies; Female; Germany; Humans; Liver Function Tests; Male; Middle Aged; Patient Compliance; Physicians; Retrospective Studies; Young Adult | 2019 |
In vitro approach to elucidate the relevance of carboxylesterase 2 and N-acetyltransferase 2 to flupirtine-induced liver injury.
Topics: Adolescent; Adult; Aged; Aminopyridines; Analgesics; Arylamine N-Acetyltransferase; Carboxylesterase; Dose-Response Relationship, Drug; HEK293 Cells; Hep G2 Cells; Humans; Liver; Microsomes, Liver; Middle Aged | 2018 |
Prescribers' compliance is part of benefit-risk assessment of medicines and it can lead to failure of risk minimization measures and withdrawals of medicines.
Topics: Aminopyridines; Drug Prescriptions; Germany; Humans; Risk Assessment | 2019 |
Suppression of KCNQ/M Potassium Channel in Dorsal Root Ganglia Neurons Contributes to the Development of Osteoarthritic Pain.
Topics: Aminopyridines; Analgesics; Animals; Anthracenes; Arthritis, Experimental; Behavior, Animal; Ganglia, Spinal; Hyperalgesia; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Osteoarthritis; Pain; Rats; Rats, Sprague-Dawley | 2019 |
Drug utilization patterns of flupirtine following implementation of risk minimization measures in Germany.
Topics: Aminopyridines; Analgesics; Drug Utilization; Germany; Humans; Practice Patterns, Physicians'; Retrospective Studies | 2019 |
Development of an Electrophysiological Assay for Kv7 Modulators on IonWorks Barracuda.
Topics: Aminopyridines; Carbamates; Cells, Cultured; Drug Development; Electrophysiological Phenomena; HEK293 Cells; High-Throughput Screening Assays; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Patch-Clamp Techniques; Phenylenediamines | 2019 |
Effects of a potassium channel opener on brain injury and neurologic outcomes in an animal model of neonatal hypoxic-ischemic injury.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Brain; Brain Injuries; Carotid Arteries; Cognition; Disease Models, Animal; Hand Strength; Hypoxia; Hypoxia-Ischemia, Brain; Male; Maze Learning; Motor Skills; Nervous System Diseases; Neuroprotection; Neuroprotective Agents; Potassium Channels; Quality of Life; Rats; Seizures | 2020 |
Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain.
Topics: Aminopyridines; Analgesics; Animals; Arthritis, Experimental; Arthritis, Gouty; Behavior, Animal; Carbamates; Disease Models, Animal; Hyperalgesia; KCNQ Potassium Channels; Male; Pain; Phenylenediamines; Rats; Rats, Sprague-Dawley; Uric Acid | 2020 |
Spinal Actions of the NSAID Diclofenac on Nociceptive Transmission in Comparison to the K
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; KCNQ Potassium Channels; Mice; Nociception | 2020 |
Liver Transplant Due to Flupirtine-Induced Acute Liver Failure.
Topics: Adult; Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Female; Germany; Humans; Liver Failure, Acute; Liver Transplantation; Risk Factors; Time Factors; Treatment Outcome | 2020 |
Anti-nociceptive and anxiolytic effects of systemic flupirtine and its direct inhibitory actions on in vivo neuronal mechanical sensory responses in the adult rat anterior cingulate cortex.
Topics: Administration, Intravenous; Aminopyridines; Analgesics; Animals; Anti-Anxiety Agents; Behavior, Animal; Elevated Plus Maze Test; Gyrus Cinguli; Inhibitory Postsynaptic Potentials; Male; Microinjections; Neurons; Patch-Clamp Techniques; Rats, Sprague-Dawley | 2020 |
Hyperexcitable arousal circuits drive sleep instability during aging.
Topics: Aging; Aminopyridines; Animals; CRISPR-Cas Systems; Electroencephalography; Electromyography; Female; Hypothalamic Area, Lateral; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Mice; Narcolepsy; Nerve Tissue Proteins; Neural Pathways; Neurons; Optogenetics; Orexins; Patch-Clamp Techniques; RNA-Seq; Sleep; Sleep Deprivation; Sleep Quality; Wakefulness | 2022 |
Carba Analogues of Flupirtine and Retigabine with Improved Oxidation Resistance and Reduced Risk of Quinoid Metabolite Formation.
Topics: Aminopyridines; Carbamates; KCNQ Potassium Channels; Phenylenediamines | 2022 |
Flupirtine and antihistamines exert synergistic anti-nociceptive effects in mice.
Topics: Aminopyridines; Analgesics; Animals; Carrageenan; Histamine Antagonists; Mice; Neuralgia; Promethazine | 2023 |
Structure-Activity Relationships of Flupirtine Analogues for Liver Esterase-Mediated Cleavage of the 4-Fluorobenzylamine Moiety and Its Possible Relevance to Liver Toxicity.
Topics: Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Esterases; Humans; Structure-Activity Relationship | 2023 |