alpha-aminopyridine has been researched along with ddd 85646 in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (90.91) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Cross, GA | 1 |
| Brand, S; Brannigan, JA; Brenk, R; Cleghorn, LA; Fairlamb, AH; Ferguson, MA; Frearson, JA; Gilbert, IH; Guther, ML; Hallyburton, I; Hodgkinson, M; Hui, R; McElroy, SP; Mpamhanga, CP; Price, HP; Qiu, W; Raimi, OG; Read, KD; Robinson, DA; Smid, O; Smith, DF; Stojanovski, L; Torrie, LS; van Aalten, DM; Wilkinson, AJ; Wyatt, PG | 1 |
| Bayliss, T; Brand, S; Brenk, R; Cleghorn, LA; Fairlamb, AH; Ferguson, MA; Frearson, JA; Gilbert, IH; Hallyburton, I; Harrison, JR; McElroy, SP; Norcross, NR; Norval, S; Read, KD; Robinson, DA; Smith, VC; Spinks, D; Stojanovski, L; Torrie, LS; Wyatt, PG | 1 |
| Fairlamb, AH; Roberts, AJ; Torrie, LS; Wyllie, S | 1 |
| Begolo, D; Clayton, C; Erben, E | 1 |
| Brand, S; Brenk, R; Fairlamb, AH; Ferguson, MA; Frearson, JA; Gilbert, IH; Hallyburton, I; Harrison, JR; McElroy, SP; Norcross, NR; Norval, S; Read, KD; Robinson, DA; Scullion, P; Simeons, FR; Smith, VC; Stojanovski, L; Thompson, S; Torrie, LS; van Aalten, D; Wyatt, PG | 1 |
| Blair, DE; Fang, W; Gilbert, IH; Harrison, JR; Lockhart, DE; Raimi, OG; Robinson, DA; Ruda, GF; Torrie, LS; van Aalten, DM; Wyatt, PG | 1 |
| Robinson, DA; Wyatt, PG | 1 |
| Bayliss, T; Brand, S; Brenk, R; Frearson, JA; Gilbert, IH; McElroy, SP; Mpamhanga, C; Norval, S; Read, KD; Robinson, DA; Smith, VC; Stojanovski, L; Torrie, LS; Wyatt, PG | 1 |
| Blaas, D; Corbic Ramljak, I; Dreier, D; Fischl, W; Klingel, K; Kowalski, H; Mihovilovic, MD; Real-Hohn, A; Redlberger-Fritz, M; Stanger, J; Wimmer, L | 1 |
| Beauchamp, E; Berthiaume, LG; Dong, WF; Gamma, JM; Gray, DW; Iyer, A; Lakshmanan, M; Lim, ST; Mackey, JR; Perinpanayagam, MA; Postovit, LM; Raju, A; Read, KD; Tan, SY; Tergaonkar, V; Vincent, KM; Wyatt, PG; Yap, MC | 1 |
11 other study(ies) available for alpha-aminopyridine and ddd 85646
| Article | Year |
|---|---|
Drug discovery: Fat-free proteins kill parasites.
Topics: Acyltransferases; Aminopyridines; Animals; Antiparasitic Agents; Enzyme Inhibitors; Humans; Mice; Sulfonamides; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
Topics: Acyltransferases; Aminopyridines; Animals; Antiparasitic Agents; Enzyme Assays; Enzyme Inhibitors; Female; Humans; Mice; Molecular Structure; Pyrazoles; Rats; Sulfonamides; Time Factors; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
Topics: Acyltransferases; Administration, Oral; Aminopyridines; Animals; Cell Line; Cell Survival; Crystallography, X-Ray; Databases, Factual; Humans; Models, Molecular; Molecular Conformation; Parasitic Sensitivity Tests; Structure-Activity Relationship; Sulfonamides; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2012 |
Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase.
Topics: Acyltransferases; Aminopyridines; Animals; Chlorocebus aethiops; Cloning, Molecular; Gene Deletion; Gene Expression Regulation, Enzymologic; Kinetics; Organisms, Genetically Modified; Recombinant Proteins; Sulfonamides; Trypanosoma cruzi; Vero Cells | 2014 |
Drug target identification using a trypanosome overexpression library.
Topics: Acyltransferases; Aminopyridines; Eflornithine; Ornithine Decarboxylase; Sulfonamides; Trypanocidal Agents; Trypanosoma brucei brucei | 2014 |
Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis.
Topics: Acyltransferases; Aminopyridines; Animals; Blood-Brain Barrier; Central Nervous System; Female; Humans; Inhibitory Concentration 50; Mice; Pyrazoles; Structure-Activity Relationship; Sulfonamides; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2014 |
N-myristoyltransferase is a cell wall target in Aspergillus fumigatus.
Topics: Acyltransferases; Aminopyridines; Antifungal Agents; Aspergillus fumigatus; Catalytic Domain; Cell Wall; Crystallography, X-Ray; Fungal Proteins; Kinetics; Microbial Sensitivity Tests; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Secondary; Pyrazoles; Structure-Activity Relationship; Sulfonamides | 2015 |
Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase.
Topics: Acyltransferases; Aminopyridines; Humans; Kinetoplastida; Protein Binding; Protein Structure, Secondary; Structure-Activity Relationship; Sulfonamides; Trypanosoma brucei brucei | 2015 |
Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.
Topics: Acyltransferases; Aminopyridines; Animals; Brain; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Mice; Sulfonamides; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2017 |
Cellular N-myristoyltransferases play a crucial picornavirus genus-specific role in viral assembly, virion maturation, and infectivity.
Topics: Acyltransferases; Aminopyridines; Capsid Proteins; Coxsackievirus Infections; Enterovirus; HeLa Cells; Humans; Sulfonamides; Virion; Virus Assembly | 2018 |
Targeting N-myristoylation for therapy of B-cell lymphomas.
Topics: Acyltransferases; Adenine; Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dasatinib; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Lymphoma, B-Cell; Mice; Mice, SCID; Models, Biological; Myristic Acid; Piperidines; Pyrazoles; Pyrimidines; Receptors, Antigen, B-Cell; Signal Transduction; src-Family Kinases; Sulfonamides; Xenograft Model Antitumor Assays | 2020 |