alpha-aminopyridine has been researched along with chlorine in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (48.98) | 18.7374 |
| 1990's | 3 (6.12) | 18.2507 |
| 2000's | 4 (8.16) | 29.6817 |
| 2010's | 12 (24.49) | 24.3611 |
| 2020's | 6 (12.24) | 2.80 |
| Authors | Studies |
|---|---|
| Andrès, PF; Hösli, E; Hösli, L | 1 |
| Dun, NJ; Liu, HQ | 1 |
| Zeise, M | 1 |
| Bevan, S; Chiu, SY; Gray, PT; Ritchie, JM | 1 |
| Ascher, P; Berwald-Netter, Y; Nowak, L | 1 |
| Ohba, M | 1 |
| Ichinose, M; Maeno, T; Sawada, M | 1 |
| Demarest, JR; Finn, AL | 1 |
| Akaike, N; Ikemoto, Y; Ono, K | 1 |
| Alkadhi, KA; Hogan, YH | 1 |
| Haberly, LB; Hoffman, WH | 1 |
| Clapham, DE; Logothetis, DE | 1 |
| Gebremedhin, D; Hadházy, P; Magyar, K | 1 |
| Inoue, M; Matsuo, T; Ogata, N | 1 |
| Kita, H; Kita, T; Kitai, ST | 1 |
| Davis, JR; Gilmour, RF; Salata, JJ | 1 |
| Kigoshi, S; Muramatsu, I; Nishio, M | 1 |
| Kenyon, JL; Sutko, JL | 1 |
| Jarowski, CI; Serajuddin, AT | 1 |
| Katalymov, LL | 1 |
| Mulder, AH; Schoffelmeer, AN; Wemer, J | 1 |
| Chiarandini, DJ; Stefani, E | 1 |
| Miledi, R; Parker, I; Zhu, PH | 1 |
| Borowitz, JL; Malavé, A; Yim, GK | 1 |
| Broccoli, AV; Huang, C; Mason, JT | 1 |
| Jakob, R; Krieglstein, J | 1 |
| Roumy, M; Zajac, J | 1 |
| Bilodeau, MT; Manley, PJ | 1 |
| Chung, C; Dubé, D; Friesen, RW; Huang, Z; Kwok, E; Laliberté, F; Liu, S; Tota, MR; Veilleux, A; Young, A; Zhang, L | 1 |
| Demir, E; Kandemirli, F; Yildirim, I | 1 |
| Altman, RA; Buchwald, SL; Fors, BP | 1 |
| Ashlock, M; Burton, B; Decker, CJ; Frizzell, RA; Grootenhuis, PD; Hadida, S; McCartney, J; Miller, M; Negulescu, PA; Olson, ER; Stack, JH; Straley, KS; Van Goor, F; Wine, JJ | 1 |
| Hage, TA; Salkoff, L | 1 |
| Bonnet, S; De Cola, L; Dück, S; Gandubert, A; Klein Gebbink, RJ; Lutz, M; Molenbroek, E; Rashid, Z; Straathof, N; van Lenthe, JH | 1 |
| Finkbeiner, WE; Lukacs, GL; Phuan, PW; Roldan, A; Tan, J; Veit, G; Verkman, AS | 1 |
| Bell, SC; Boyle, MP; Huang, X; Konstan, MW; McColley, SA; Patel, NR; Rietschel, E; Rodman, D; Rowe, SM; Waltz, D | 1 |
| Barnaby, R; Coutermarsh, B; Hogan, D; Stanton, BA | 1 |
| Gupta, N; Li, W; McIntyre, TM | 1 |
| Baumlin, N; Campos, M; Dennis, JS; Ivonnet, P; Krick, S; Salathe, M; Schmid, A | 1 |
| Jeon, DK; Jo, S; Khloya, P; Kumar, S; Lee, HK; Namkung, W; Park, J; Seo, Y; Sharma, PK | 1 |
| Hayashi, M; Inagaki, A; Matsuda, H; Novak, I | 1 |
| Atlante, A; Bobba, A; Casavola, V; Favia, M; Guerra, L; Reshkin, SJ | 1 |
| Beekman, JM; Berkers, G; Bronsveld, I; Clevers, H; de Jonge, HR; de Rijke, YB; de Winter-de Groot, KM; Dekkers, JF; Escher, JC; Heijerman, HG; Houwen, RH; Janssens, HM; Kruisselbrink, E; Majoor, CJ; Nieuwenhuis, EE; van de Graaf, EA; van der Ent, CK; Vleggaar, FP; Vonk, A | 1 |
| Aalbers, BL; Arets, HGM; Bronsveld, I; de Kiviet, AC; de Winter-de Groot, KM; Heijerman, HGM; Hofland, RW; Kruijswijk, MA; Michel, S; Schotman, S; van der Ent, CK; van Oirschot-van de Ven, MMM | 1 |
| Beekman, JM; Graeber, SY; Hirtz, S; Kruisselbrink, E; Mall, MA; van der Ent, CK; van Mourik, P; Vonk, AM | 1 |
| Clancy, JP; Konstan, MW; Mayer-Hamblett, N; Odem-Davis, K; Rowe, SM; Skalland, M; VanDevanter, DR; Zemanick, ET | 1 |
| Chen, J; Conrath, K; Falk Libby, E; Li, Y; Mutyam, V; Peng, N; Rowe, SM; Sharma, J; Singh, AK; Tang, LP | 1 |
| Amato, F; Castaldo, G; Castellani, C; Ferrari, B; Galietta, LJV; Taccetti, G; Terlizzi, V | 1 |
| Astori, A; Gupta, GD; Iazzi, M; Raught, B; St-Germain, J | 1 |
1 trial(s) available for alpha-aminopyridine and chlorine
| Article | Year |
|---|---|
A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial.
Topics: Adolescent; Adult; Aminophenols; Aminopyridines; Base Sequence; Benzodioxoles; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Double-Blind Method; Drug Therapy, Combination; Female; Forced Expiratory Volume; Heterozygote; Homozygote; Humans; Male; Quinolones; Sequence Deletion; Sweat; Young Adult | 2014 |
48 other study(ies) available for alpha-aminopyridine and chlorine
| Article | Year |
|---|---|
Effects of 4-aminopyridine and tetraethylammonium on the depolarization by GABA of cultured satellite glial cells.
Topics: Aminopyridines; Animals; Cell Membrane Permeability; Cells, Cultured; Chlorides; GABA Antagonists; gamma-Aminobutyric Acid; Membrane Potentials; Neuroglia; Neurons; Potassium; Rats; Tetraethylammonium Compounds | 1979 |
Effects of verapamil on synaptic transmission in mammalian sympathetic ganglia.
Topics: Action Potentials; Aminopyridines; Animals; Barium; Barium Compounds; Chlorides; Ganglia, Sympathetic; Guinea Pigs; Male; Neurons; Pyridostigmine Bromide; Rabbits; Soman; Synapses; Synaptic Transmission; Verapamil | 1990 |
Taurine on hippocampal slices: comparison to GABA and glycine, and antagonism by 4-aminopyridine.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Chlorides; gamma-Aminobutyric Acid; Glycine; Guinea Pigs; Hippocampus; In Vitro Techniques; Ion Channels; Membrane Potentials; Neurotransmitter Agents; Taurine | 1985 |
Ion channels in rabbit cultured fibroblasts.
Topics: 4-Aminopyridine; Aminopyridines; Amphibian Proteins; Animals; Calcium; Carrier Proteins; Cells, Cultured; Chlorides; Fibroblasts; Ion Channels; Membrane Potentials; Potassium; Rabbits; Rats; Rats, Inbred Strains; Saxitoxin; Tetraethylammonium Compounds; Tetrodotoxin | 1986 |
Ionic channels in mouse astrocytes in culture.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Astrocytes; Cells, Cultured; Chlorides; Ion Channels; Membrane Potentials; Mice; Potassium; Scorpion Venoms; Sodium; Tetrodotoxin; Veratridine | 1987 |
Effects of tonicity on the pacemaker activity of guinea-pig sino-atrial node.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Animals; Atropine; Calcium; Cesium; Chlorides; Female; Guinea Pigs; Heart Rate; Ion Channels; Magnesium; Male; Membrane Potentials; Phentolamine; Potassium; Propranolol; Sinoatrial Node; Sodium; Sucrose; Tetraethylammonium Compounds; Tetrodotoxin | 1986 |
Ionic mechanism of the outward current induced by intracellular injection of inositol trisphosphate into Aplysia neurons.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Aplysia; Calcium; Chlorides; Egtazic Acid; Electric Conductivity; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Ion Channels; Membrane Potentials; Neurons; Potassium; Sugar Phosphates; Tetraethylammonium; Tetraethylammonium Compounds | 1987 |
Characterization of the basolateral membrane conductance of Necturus urinary bladder.
Topics: 4-Aminopyridine; Amifampridine; Amiloride; Aminopyridines; Animals; Cell Membrane; Chlorides; Decamethonium Compounds; Electric Conductivity; Epithelium; Ion Channels; Male; Membrane Potentials; Necturus; Potassium; Seasons; Tetraethylammonium Compounds; Urinary Bladder; Water-Electrolyte Balance | 1987 |
4-aminopyridine activates a cholinergic chloride conductance in isolated Helix neurons.
Topics: 4-Aminopyridine; Acetylcholine; Aminopyridines; Animals; Chlorides; Drug Interactions; Ganglia; Helix, Snails; In Vitro Techniques; Ion Channels; Receptors, Cholinergic; Snails | 1987 |
Effect of calcium on synaptic facilitation by potassium channel blockers in superior cervical ganglion of rat.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Animals; Calcium; Cesium; Chlorides; Ganglia, Sympathetic; Guanidine; Guanidines; Male; Potassium Channels; Rats; Rats, Inbred Strains; Synapses; Tetraethylammonium Compounds | 1989 |
Bursting induces persistent all-or-none EPSPs by an NMDA-dependent process in piriform cortex.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Aminopyridines; Animals; Aspartic Acid; Cerebral Cortex; Chlorides; In Vitro Techniques; Ketamine; Magnesium; Membrane Potentials; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Time Factors; Valine | 1989 |
Delayed rectifier K+ current in embryonic chick heart ventricle.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Barium; Barium Compounds; Cesium; Chick Embryo; Chlorides; Culture Techniques; Electrophysiology; Heart; Potassium; Reference Values; Tetraethylammonium; Tetraethylammonium Compounds; Ventricular Function | 1988 |
Inhibition by quinine of endothelium-dependent relaxation of rabbit aortic strips.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Aorta, Thoracic; Barium; Barium Compounds; Calcimycin; Chlorides; Endothelium, Vascular; Female; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Quaternary Ammonium Compounds; Quinine; Rabbits; Sodium Nitrite; Tetraethylammonium Compounds | 1987 |
Baclofen activates voltage-dependent and 4-aminopyridine sensitive K+ conductance in guinea-pig hippocampal pyramidal cells maintained in vitro.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Baclofen; Chlorides; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Potassium; Tetraethylammonium Compounds | 1985 |
Effects of 4-aminopyridine (4-AP) on rat neostriatal neurons in an in vitro slice preparation.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Animals; Chlorides; Corpus Striatum; In Vitro Techniques; Male; Membrane Potentials; Neuromuscular Depolarizing Agents; Neurons; Rats; Rats, Inbred Strains; Synapses | 1985 |
Effects of 4-aminopyridine on rate-related depression of cardiac action potentials.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Animals; Caffeine; Cats; Cesium; Chlorides; Dogs; Female; Heart; Heart Atria; Isoproterenol; Male; Papillary Muscles; Purkinje Fibers; Rats; Rats, Inbred Strains | 1986 |
Mechanisms of tetraethylammonium-induced contraction in the canine coronary artery.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Cesium; Chlorides; Coronary Vessels; Dogs; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Phenylephrine; Potassium; Tetraethylammonium Compounds; Vasodilator Agents; Verapamil | 1986 |
Calcium- and voltage-activated plateau currents of cardiac Purkinje fibers.
Topics: Action Potentials; Aminopyridines; Animals; Calcium; Cattle; Cell Membrane; Chlorides; Electric Conductivity; Heart Conduction System; Microelectrodes; Purkinje Fibers; Ryanodine; Sarcoplasmic Reticulum | 1987 |
Effect of diffusion layer pH and solubility on the dissolution rate of pharmaceutical bases and their hydrochloride salts. I: Phenazopyridine.
Topics: Aminopyridines; Buffers; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chlorides; Diffusion; Excipients; Hydrogen-Ion Concentration; Kinetics; Phenazopyridine; Solubility | 1985 |
[Effect of changes in the external concentration of sodium, chlorine, and potassium ions on subsequent depolarization of a single node of Ranvier of isolated nerve fibers].
Topics: Aminopyridines; Animals; Chlorides; In Vitro Techniques; Ion Channels; Potassium; Rana ridibunda; Ranvier's Nodes; Sodium; Tetraethylammonium Compounds | 1980 |
Studies on the role of Na+, K+ and Cl- ion permeabilities in K+-induced release of 3H-noradrenaline from rat brain slices and synaptosomes and in its presynaptic alpha-adrenergic modulation.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Brain; Chlorides; Electrolytes; In Vitro Techniques; Male; Norepinephrine; Potassium; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Sodium; Synaptosomes; Tetrodotoxin | 1981 |
Calcium action potentials in rat fast-twitch and slow-twitch muscle fibres.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; Barium; Calcium; Chlorides; Electric Conductivity; In Vitro Techniques; Ion Channels; Muscles; Nifedipine; Potassium; Rats; Rats, Inbred Strains; Tetraethylammonium Compounds; Time Factors | 1983 |
Extracellular ions and excitation-contraction coupling in frog twitch muscle fibres.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; Arsenazo III; Calcium; Chlorides; In Vitro Techniques; Muscle Contraction; Muscles; Potassium; Sarcoplasmic Reticulum; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1984 |
Block by phencyclidine of acetylcholine and barium induced adrenal catecholamine secretion.
Topics: 4-Aminopyridine; Acetylcholine; Adrenal Glands; Aminopyridines; Animals; Barium; Barium Compounds; Catecholamines; Cattle; Chlorides; In Vitro Techniques; Kinetics; Phencyclidine | 1983 |
A method for the synthesis of isomerically pure saturated mixed-chain phosphatidylcholines.
Topics: 4-Aminopyridine; Aminopyridines; Anhydrides; Catalysis; Chlorides; Imidazoles; Isomerism; Lysophosphatidylcholines; Phosphatidylcholines; Phospholipases A; Pyridines; Pyrrolidines | 1981 |
Influence of flupirtine on a G-protein coupled inwardly rectifying potassium current in hippocampal neurones.
Topics: Aminopyridines; Animals; Barium Compounds; Cell Culture Techniques; Chlorides; Cyclic AMP; Excitatory Amino Acid Agonists; GTP-Binding Proteins; Hippocampus; Membrane Potentials; Muscle Relaxants, Central; N-Methylaspartate; Neurons; Pertussis Toxin; Potassium; Rats; Virulence Factors, Bordetella | 1997 |
Neuropeptide FF selectively attenuates the effects of nociceptin on acutely dissociated neurons of the rat dorsal raphe nucleus.
Topics: Aminopyridines; Analgesics, Opioid; Animals; Barium Compounds; Biological Transport; Calcium; Chlorides; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Narcotic Antagonists; Neurons; Nociceptin; Oligopeptides; Opioid Peptides; Piperazines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Serotonin; Serotonin Antagonists; Vasodilator Agents | 1999 |
A mild method for the formation and in situ reaction of imidoyl chlorides: conversion of pyridine-1-oxides to 2-aminopyridine amides.
Topics: Amides; Aminopyridines; Chemistry, Pharmaceutical; Chlorides; Oxalates; Oxides | 2002 |
Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Aminopyridines; Benzamides; Biotransformation; Blotting, Western; Cell Line; Chlorides; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Activation; Humans; Iodine Radioisotopes; Isoquinolines; Phosphodiesterase Inhibitors; Sulfonamides | 2005 |
Experimental and theoretical studies on the functionalization reactions of 4-benzoyl-1,5-diphenyl-1H-pyrazole-3-carboxylic acid and acid chloride with 2,3-diaminopyridine.
Topics: Acids, Heterocyclic; Aminopyridines; Benzoates; Carboxylic Acids; Chemistry, Pharmaceutical; Chlorides; Kinetics; Models, Molecular; Molecular Conformation; Pyrazoles; Thermodynamics | 2005 |
Pd-catalyzed amination reactions of aryl halides using bulky biarylmonophosphine ligands.
Topics: Amination; Amines; Aminopyridines; Arylsulfonates; Boronic Acids; Bromides; Carbon; Chlorides; Chromatography, Gas; Chromatography, Thin Layer; Lead; Ligands; Nitrogen | 2007 |
Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.
Topics: Aminopyridines; Benzodioxoles; Bronchi; Cell Line; Cells, Cultured; Chemistry, Pharmaceutical; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Design; Drug Evaluation, Preclinical; Epithelial Cells; Homozygote; Humans; In Vitro Techniques; Lung; Models, Genetic; Mutation | 2011 |
Sodium-activated potassium channels are functionally coupled to persistent sodium currents.
Topics: Aminopyridines; Animals; Animals, Newborn; Biophysics; Cells, Cultured; Cesium; Chlorides; Electric Stimulation; Female; Ion Channel Gating; Ions; Male; Membrane Potentials; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Rats; Sodium; Sodium Channel Blockers; Sodium Channels; Tetraethylammonium; Tetrodotoxin; Veratridine | 2012 |
Zinc coordination to the bapbpy ligand in homogeneous solutions and at liposomes: zinc detection via fluorescence enhancement.
Topics: 2,2'-Dipyridyl; Aminopyridines; Chlorides; Fluorescence; Ligands; Liposomes; Models, Molecular; Molecular Structure; Organometallic Compounds; Quantum Theory; Solutions; Zinc Compounds | 2013 |
Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.
Topics: Aminopyridines; Animals; Benzodioxoles; Biological Transport; Bronchi; Cell Line; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dogs; Drug Synergism; Epithelial Cells; Horseradish Peroxidase; Humans; Lung; Madin Darby Canine Kidney Cells; Mutation; Permeability; Protein Folding; Protein Structure, Tertiary; Respiratory Mucosa; Small Molecule Libraries; Structure-Activity Relationship | 2014 |
Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells.
Topics: Aminopyridines; Benzodioxoles; Bronchi; Cell Line; Cell Membrane; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; DNA-Binding Proteins; Epithelial Cells; Humans; Mutation; Nuclear Proteins; Pseudomonas aeruginosa; Pseudomonas Infections; Transcription Factors | 2015 |
Deubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and Thrombosis.
Topics: Aminopyridines; Animals; Benzoates; Blood Platelets; Chlorides; Disease Models, Animal; Enzyme Inhibitors; Ferric Compounds; Furans; Humans; Mice, Inbred C57BL; Microfluidic Analytical Techniques; Microscopy, Interference; Piperidones; Platelet Aggregation; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Proteasome Endopeptidase Complex; Pyrazoles; Receptors, Collagen; Receptors, Thrombin; Signal Transduction; Thiocyanates; Thrombosis; Ubiquitin Thiolesterase; Ubiquitin-Specific Proteases; Ubiquitination | 2015 |
Roflumilast partially reverses smoke-induced mucociliary dysfunction.
Topics: Albuterol; Aminopyridines; Benzamides; Biosensing Techniques; Bronchi; Cells, Cultured; Chlorides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclopropanes; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Fluorescence Resonance Energy Transfer; Formoterol Fumarate; Humans; Mucociliary Clearance; Phosphodiesterase 4 Inhibitors; RNA, Messenger; Second Messenger Systems; Smoke; Smoking; Time Factors; Transfection | 2015 |
Potentiation of ΔF508- and G551D-CFTR-Mediated Cl- Current by Novel Hydroxypyrazolines.
Topics: Aminopyridines; Animals; Bacterial Proteins; Benzodioxoles; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Chlorides; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Gene Deletion; Genistein; Humans; Luminescent Proteins; Mutation; Nose; Patch-Clamp Techniques; Phenylalanine; Pyrazoles; Rats; Structure-Activity Relationship; Sulfonamides | 2016 |
The adenosine A2B receptor is involved in anion secretion in human pancreatic duct Capan-1 epithelial cells.
Topics: Adenosine; Aminopyridines; Animals; Anions; Cell Line; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Female; Guinea Pigs; Humans; Male; Membrane Potentials; Pancreatic Ducts; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A2B; Uridine | 2016 |
Characterization of mitochondrial function in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function.
Topics: Aminopyridines; Benzodioxoles; Cells, Cultured; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Energy Metabolism; Furocoumarins; Humans; Mitochondrial Diseases; Mutation; Respiratory System | 2016 |
Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis.
Topics: Aminophenols; Aminopyridines; Benzodioxoles; Biological Assay; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Genotype; Humans; In Vitro Techniques; Mutation; Organoids; Quinolones | 2016 |
Females with cystic fibrosis have a larger decrease in sweat chloride in response to lumacaftor/ivacaftor compared to males.
Topics: Adolescent; Adult; Aminophenols; Aminopyridines; Benzodioxoles; Body Mass Index; Child; Chlorides; Correlation of Data; Cystic Fibrosis; Drug Combinations; Female; Forced Expiratory Volume; Humans; Male; Quinolones; Retrospective Studies; Sex Factors; Sweat; Young Adult | 2021 |
Comparison of Organoid Swelling and
Topics: Adolescent; Adult; Aminophenols; Aminopyridines; Benzodioxoles; Child; Chlorides; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Combinations; Edema; Female; Forced Expiratory Volume; Homozygote; Humans; In Vitro Techniques; Male; Membrane Potentials; Middle Aged; Nasal Mucosa; Organoids; Precision Medicine; Prospective Studies; Quinolones; Rectum; Sweat; Treatment Outcome; Vital Capacity; Young Adult | 2020 |
Measuring the impact of CFTR modulation on sweat chloride in cystic fibrosis: Rationale and design of the CHEC-SC study.
Topics: Adolescent; Adult; Aged; Aminophenols; Aminopyridines; Benzodioxoles; Child; Chloride Channel Agonists; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Combinations; Female; Humans; Male; Middle Aged; Prospective Studies; Quinolones; Sweat | 2021 |
Novel Correctors and Potentiators Enhance Translational Readthrough in CFTR Nonsense Mutations.
Topics: Aminophenols; Aminopyridines; Animals; Benzoates; Benzodioxoles; Benzopyrans; Cell Line; Chlorides; Codon, Nonsense; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Humans; Ion Transport; Protein Biosynthesis; Pyrans; Pyrazoles; Quinolones; Rats; Recovery of Function; Thyroid Epithelial Cells | 2021 |
Ex vivo model predicted in vivo efficacy of CFTR modulator therapy in a child with rare genotype.
Topics: Aminophenols; Aminopyridines; Benzodioxoles; Cells, Cultured; Child, Preschool; Chloride Channel Agonists; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Female; Genotype; Humans; Mutation, Missense; Nasal Mucosa; Pancreatic Elastase; Quinolones | 2021 |
Proximity Profiling of the CFTR Interaction Landscape in Response to Orkambi.
Topics: Adaptor Proteins, Signal Transducing; Aminophenols; Aminopyridines; Benzodioxoles; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Combinations; HEK293 Cells; Humans; Mass Spectrometry; Mutation; Protein Interaction Maps; Quinolones; Vesicular Transport Proteins | 2022 |