alpha-aminopyridine has been researched along with capsaicin in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Go, K; Namimatsu, A; Okuda, M; Tanimoto, H | 1 |
| Borsini, F; Conte, B; Giuliani, S; Lecci, A; Maggi, CA; Meli, A; Santicioli, P | 1 |
| Frossard, N; Muller, F | 1 |
| Erdélyi, L; Such, G | 1 |
| Bogenstaetter, M; Breitenbucher, JG; Carruthers, NI; Chang, L; Chaplan, SR; Codd, EE; Dax, SL; Dubin, AE; Gonzales, L; Hoey, K; Jetter, M; Lee, DH; Liu, C; Lord, B; Mazur, C; Nasser, N; Rizzolio, M; Shah, C; Swanson, DM; Zhang, SP | 1 |
| Althaus, M; Hanschmann, A; Klein, T; Magerl, W; Treede, RD | 1 |
| Burbach, LR; Cefalu, JS; Cockayne, DA; Ford, AP; Guillon, MA; Ho, MJ; Hu, DQ; Nunn, PA; Zhu, QM | 1 |
| Chancellor, MB; Hinata, N; Honda, M; Inoue, S; Takenaka, A; Yoshimura, N | 1 |
| Hayashi, R; Hirano, N; Momen, S; Nagahara, T; Takahashi, E; Yokokawa, H; Yoshikawa, S | 1 |
| Asaki, T; Brown, K; Engel, J; Hasegawa, T; Iso, Y; Iwamoto, Y; Kanemasa, T; Kato, A; Kurose, N; Kyle, DJ; Ni, C; Patel, A; Shet, M; Shintani, T; Tafesse, L; Tsuno, N; Wu, G; Yamaguchi, Y; Yu, J; Zhou, X | 1 |
| Dang, D; Ono, K; Schmidt, BL; Viet, CT; Ye, Y | 1 |
| Chaplan, SR; Hoffmann, J; Meents, JE; Neeb, L; Reuter, U; Schuh-Hofer, S; Wickenden, A | 1 |
| Branà, MP; Clay, E; Page, C; Patacchini, R; Preti, D; Spina, D; Trevisani, M | 1 |
| Arendt-Nielsen, L; Harris, S; Hummel, M; Kapil, R; Knappenberger, T; Kyle, D; O'Keefe, S; Whiteside, GT | 1 |
| Andresen, MC; Hofmann, ME | 1 |
| Gao, X; Wei, W; Xu, F; Zhao, L; Zhuang, J | 1 |
2 trial(s) available for alpha-aminopyridine and capsaicin
| Article | Year |
|---|---|
Antihyperalgesic and analgesic properties of the N-methyl-D-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia.
Topics: Aminopyridines; Analgesics; Capsaicin; Cross-Over Studies; Cyclopentanes; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; Nervous System Diseases; Pain; Physical Stimulation; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2008 |
A randomized, double-blind, positive-controlled, 3-way cross-over human experimental pain study of a TRPV1 antagonist (V116517) in healthy volunteers and comparison with preclinical profile.
Topics: Adolescent; Adult; Aminopyridines; Animals; Capsaicin; Celecoxib; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Double-Blind Method; Female; Healthy Volunteers; Humans; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Pressure; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Ultraviolet Rays; Young Adult | 2016 |
14 other study(ies) available for alpha-aminopyridine and capsaicin
| Article | Year |
|---|---|
Mechanism of nasal secretion mediated via nerve reflex in guinea pigs and evaluation of antiallergic drugs.
Topics: Allergens; Aminopyridines; Animals; Atropine Derivatives; Bronchodilator Agents; Capsaicin; Ganglionic Blockers; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; Histamine; Hypersensitivity; Lidocaine; Methacholine Chloride; Nasal Mucosa; ortho-Aminobenzoates; Parasympatholytics; Phthalazines; Pyrilamine; Reflex | 1992 |
The effect of 4-aminopyridine on micturition reflex in normal or capsaicin-desensitized rats.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Capsaicin; Male; Rats; Rats, Inbred Strains; Reference Values; Reflex; Urinary Bladder; Urination | 1988 |
Epithelial modulation of tracheal smooth muscle response to antigenic stimulation.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Antigens; Atropine; Capsaicin; Epithelium; Male; Microscopy, Electron, Scanning; Muscle Contraction; Muscle, Smooth; Ovalbumin; Physostigmine; Rats; Rats, Inbred Strains; Trachea | 1986 |
Capsaicin blocks synaptically activated potassium conductance in snail neurone.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Capsaicin; Electric Conductivity; Helix, Snails; Ion Channels; Neurons; Potassium; Quinine; Synapses; Synaptic Transmission | 1984 |
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Topics: Administration, Oral; Aminopyridines; Analgesics; Animals; Biological Availability; Body Temperature; Calcium; Capsaicin; Cell Line; Humans; Hypothermia; Ion Channels; Male; Pain Measurement; Piperazines; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2005 |
Selective pharmacological blockade of the TRPV1 receptor suppresses sensory reflexes of the rodent bladder.
Topics: Aminopyridines; Animals; Capsaicin; Female; Male; Mice; Mice, Inbred C57BL; Piperazines; Rats; Rats, Sprague-Dawley; Reflex; Sulfonamides; Thiourea; TRPV Cation Channels; Urinary Bladder | 2009 |
Inhibitory effect of somatostatin receptor subtype-4 agonist NNC 26-9100 on micturition reflex in rats.
Topics: Afferent Pathways; Aminopyridines; Animals; Capsaicin; Dose-Response Relationship, Drug; Female; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin; Somatostatin; Thiourea; Urination | 2012 |
Discovery of potent transient receptor potential vanilloid 1 antagonists: design and synthesis of phenoxyacetamide derivatives.
Topics: Acetamides; Aminopyridines; Animals; Capsaicin; Cystitis; Drug Design; Drug Evaluation, Preclinical; Humans; Protein Binding; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2013 |
Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517
Topics: Aminopyridines; Analgesics; Animals; Body Temperature; Calcium; Capsaicin; CHO Cells; Cricetulus; Freund's Adjuvant; Ganglia, Spinal; Humans; Hydrogen-Ion Concentration; Male; Pain; Rats, Sprague-Dawley; Sensory Receptor Cells; Stereoisomerism; Structure-Activity Relationship; TRPV Cation Channels | 2014 |
TRPV1 expression level in isolectin B₄-positive neurons contributes to mouse strain difference in cutaneous thermal nociceptive sensitivity.
Topics: Aminopyridines; Animals; Biophysical Phenomena; Capsaicin; Female; Gene Expression Regulation; Glycoproteins; Hyperalgesia; Membrane Potentials; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nociception; Pain Measurement; Pain Threshold; Piperazines; Sensory Receptor Cells; Skin; Species Specificity; Trigeminal Ganglion; TRPV Cation Channels | 2015 |
Two TRPV1 receptor antagonists are effective in two different experimental models of migraine.
Topics: Aminopyridines; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Genes, fos; Male; Migraine Disorders; Piperazines; Rats; Rats, Sprague-Dawley; Treatment Outcome; TRPV Cation Channels; Up-Regulation | 2015 |
Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antitussive Agents; Benzamides; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Citric Acid; Cough; Cyclopropanes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Guinea Pigs; Male; Neutrophil Infiltration; Oxidants, Photochemical; Ozone; Propylene Glycols; Rabbits; Transient Receptor Potential Channels | 2016 |
Dynasore blocks evoked release while augmenting spontaneous synaptic transmission from primary visceral afferents.
Topics: Aminopyridines; Animals; Capsaicin; Excitatory Postsynaptic Potentials; Hydrazones; Male; Patch-Clamp Techniques; Piperazines; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Synaptic Transmission; TRPV Cation Channels; Visceral Afferents | 2017 |
Cross-effect of TRPV1 and EP3 receptor on coughs and bronchopulmonary C-neural activities.
Topics: Aminopyridines; Animals; Bronchi; Capsaicin; Citric Acid; Cough; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Guinea Pigs; Ion Channel Gating; Male; Models, Biological; Nerve Fibers, Unmyelinated; Nodose Ganglion; Piperazines; Protein Kinase Inhibitors; Pulmonary Ventilation; Receptors, Prostaglandin E, EP3 Subtype; Sensory Receptor Cells; TRPV Cation Channels; Vagus Nerve | 2021 |