Compounds > alpha-aminopyridine
Page last updated: 2024-08-21

alpha-aminopyridine and bms 777607

alpha-aminopyridine has been researched along with bms 777607 in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (3.85)29.6817
2010's23 (88.46)24.3611
2020's2 (7.69)2.80

Authors

AuthorsStudies
An, Y; Borzilleri, RM; Cai, ZW; Chen, XT; Clark, C; Cornelius, LA; Dai, J; Fargnoli, J; Gullo-Brown, J; Gupta, A; Henley, B; Hunt, JT; Jeyaseelan, R; Kamath, A; Kim, K; Lippy, J; Lombardo, LJ; Manne, V; Oppenheimer, S; Sack, JS; Schmidt, RJ; Schroeder, GM; Shen, G; Stefanski, K; Tokarski, JS; Trainor, GL; Wautlet, BS; Wei, D; Williams, DK; Zhang, Y1
Dai, Y; Siemann, DW2
Bae, K; Dai, Y; Pampo, C; Siemann, DW1
Chang, RP; Giaccone, G; Harada, T; Killian, JK; Lucchi, M; Meltzer, PS; Smith, WI; Suuriniemi, M; Voortman, J; Wang, Y1
Hu, X; Sharma, S; Wang, MH; Yao, HP; Zeng, JY; Zhang, R; Zhou, YQ; Zhuang, CM1
Hu, X; Sharma, S; Wang, MH; Yao, HP; Zeng, JY; Zhang, R; Zhou, YQ1
Bernard-Pierrot, I; Cavagnino, A; Legraverend, M; Piguel, S; Radvanyi, F; Saettel, N; Stoven, V; Traoré, T1
Sharma, S; Wang, MH; Yao, HP; Zhang, R; Zhou, J; Zhou, YQ1
Ai, J; Geng, M; Ji, Y; Li, Y; Liu, J; Peng, X; Shi, D; Zhang, W2
Axel, U; Baska, F; Greff, Z; Gyulavári, P; Ibolya, K; Kéri, G; Orfi, L; Peták, I; Szántai, KC; Szokol, B; Vantus, T; Zoltán, O1
Nurhayati, RW; Ojima, Y; Taya, M1
Blank, C; Cornelissen-Steijger, PD; Geukes Foppen, MH; Goding, CR; Graeber, TG; Haanen, J; Hugo, W; Kemper, K; Kong, X; Krijgsman, O; Lo, RS; McDermott, U; Müller, J; Peeper, DS; Possik, PA; Ribas, A; Robert, L; Song, C; Tsoi, J1
Bai, X; Heppner, F; Korsing, S; Krementeskaia, I; Nieminen, M; Onken, J; Radke, J; Torka, R; Ullrich, A; Vajkoczy, P1
Gao, H; Hu, Y; Liu, WF; Liu, XP; Liu, XX; Luo, ML; Zhao, Y; Zheng, YF; Zou, L1
Anderson, N; Andrade, K; Fornetti, J; McHale, M; Miller, SC; Randall, RL; Waltz, SE; Welm, AL; Zhao, L1
Behrmann, CA; Ennis, KN; Feng, X; Jiang, TT; Kofuji, S; Liu, H; Niu, L; Plas, DR; Sarma, P; Sasaki, AT; Stratton, Y; Thomas, HE; Yoon, SO1
Adjei, EA; Afangbedji, N; Almeida, LEF; Ivanov, A; Jerebtsova, M; Khaibullina, A; Kumari, N; Nekhai, S; Quezado, ZMN1
Chen, MH; Chen, YY; Cheng, CT; Chiang, KC; Tsai, CY; Wu, RC; Yeh, CN; Yeh, TS1
Chang, CL; Hsu, YT; Weng, CS; Wu, CC1
Birge, RB; Calianese, D; Davra, V; De Lorenzo, MS; Geng, K; Kasikara, C; Kotenko, SV; Quigley, M; Spires, TE; Sriram, G; Suarez-Lopez, L; Wichroski, M; Yaffe, MB1
Jiang, Q; Li, J; Li, Y; Shi, D; Wang, R; Wu, R; Xu, X; Yao, C1
Lauter, M; Torka, R; Weber, A1
Dayang, EZ; Kuiper, T; Luxen, M; Molema, G; Moser, J; Rangarajan, S; van Meurs, M; Yan, R1
He, WB; Huang, KQ; Liu, JN; Ma, ZL; Su, RJ1

Other Studies

26 other study(ies) available for alpha-aminopyridine and bms 777607

ArticleYear
Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.
    Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5

    Topics: Administration, Oral; Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Dihydropyridines; Dogs; Humans; Mice; Mice, Nude; Models, Molecular; Proto-Oncogene Proteins c-met; Pyridones; Rats; Solubility; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2009
BMS-777607, a small-molecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro.
    Molecular cancer therapeutics, 2010, Volume: 9, Issue:6

    Topics: Aminopyridines; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Extracellular Signal-Regulated MAP Kinases; Hepatocyte Growth Factor; Humans; Male; Neoplasm Invasiveness; Neoplasm Metastasis; Phenotype; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridones; Signal Transduction; Small Molecule Libraries

2010
Impact of the small molecule Met inhibitor BMS-777607 on the metastatic process in a rodent tumor model with constitutive c-Met activation.
    Clinical & experimental metastasis, 2012, Volume: 29, Issue:3

    Topics: Aminopyridines; Animals; Cell Line, Tumor; Cell Movement; Female; Humans; Mice; Mice, Inbred C3H; Neoplasm Invasiveness; Neoplasm Metastasis; Proto-Oncogene Proteins c-met; Pyridones; Sarcoma, Experimental; Signal Transduction

2012
Constitutively active c-Met kinase in PC-3 cells is autocrine-independent and can be blocked by the Met kinase inhibitor BMS-777607.
    BMC cancer, 2012, May-28, Volume: 12

    Topics: Aminopyridines; Antibodies, Neutralizing; Autocrine Communication; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Male; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridones; RNA, Messenger; Signal Transduction

2012
Detection and therapeutic implications of c-Met mutations in small cell lung cancer and neuroendocrine tumors.
    Current pharmaceutical design, 2013, Volume: 19, Issue:5

    Topics: Aminopyridines; Animals; Cell Line, Tumor; Humans; Indoles; Lung Neoplasms; Mutation; Neuroendocrine Tumors; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-met; Pyridones; Small Cell Lung Carcinoma; Sulfonamides

2013
Small-molecule inhibitor BMS-777607 induces breast cancer cell polyploidy with increased resistance to cytotoxic chemotherapy agents.
    Molecular cancer therapeutics, 2013, Volume: 12, Issue:5

    Topics: Aminopyridines; Aurora Kinase B; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromosome Aberrations; Drug Resistance, Neoplasm; Female; Histones; Humans; Phosphorylation; Polyploidy; Protein Kinase Inhibitors; Pyridones; Receptor Protein-Tyrosine Kinases; Spindle Apparatus

2013
Synergistic activities of MET/RON inhibitor BMS-777607 and mTOR inhibitor AZD8055 to polyploid cells derived from pancreatic cancer and cancer stem cells.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:1

    Topics: Aminopyridines; Apoptosis; Cell Line, Tumor; Drug Synergism; Humans; Morpholines; Neoplastic Stem Cells; Pancreatic Neoplasms; Polyploidy; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridones; Signal Transduction

2014
New aminopyrimidine derivatives as inhibitors of the TAM family.
    European journal of medicinal chemistry, 2013, Volume: 70

    Topics: Aminopyridines; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridones; Receptor Protein-Tyrosine Kinases; Structure-Activity Relationship

2013
Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics.
    Molecular oncology, 2014, Volume: 8, Issue:3

    Topics: Aging; Aminopyridines; Breast; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Morpholines; Polyploidy; Protein Kinase Inhibitors; Pyridones; Signal Transduction; TOR Serine-Threonine Kinases

2014
Discovery of novel c-Met inhibitors bearing a 3-carboxyl piperidin-2-one scaffold.
    Molecules (Basel, Switzerland), 2014, Feb-24, Volume: 19, Issue:2

    Topics: Aminopyridines; Cell Line, Tumor; Cell Proliferation; Drug Design; Humans; Molecular Structure; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridones; Structure-Activity Relationship

2014
[Development and biochemical characterization of EGFR/c-Met dual inhibitors].
    Acta pharmaceutica Hungarica, 2013, Volume: 83, Issue:4

    Topics: Afatinib; Aminopyridines; Anilides; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Computer Simulation; Crizotinib; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Imidazoles; Lapatinib; Lung Neoplasms; Molecular Structure; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-met; Pyrazines; Pyrazoles; Pyridines; Pyridones; Quinazolines; Quinolines

2013
Discovery of novel type II c-Met inhibitors based on BMS-777607.
    European journal of medicinal chemistry, 2014, Jun-10, Volume: 80

    Topics: Aminopyridines; Cell Line, Tumor; Drug Discovery; Humans; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridones; Structure-Activity Relationship

2014
BMS-777607 promotes megakaryocytic differentiation and induces polyploidization in the CHRF-288-11 cells.
    Human cell, 2015, Volume: 28, Issue:2

    Topics: Aminopyridines; Cell Differentiation; Cells, Cultured; Humans; K562 Cells; Platelet Membrane Glycoprotein IIb; Polyploidy; Protein Kinase Inhibitors; Pyridones; Stimulation, Chemical

2015
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.
    Nature communications, 2014, Dec-15, Volume: 5

    Topics: Aminopyridines; Animals; Antineoplastic Agents; Axl Receptor Tyrosine Kinase; Benzamides; Cell Line, Tumor; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Imatinib Mesylate; Imidazoles; Indoles; Melanoma; Mice; Microphthalmia-Associated Transcription Factor; Oximes; Piperazines; Prognosis; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidines; Pyrimidinones; Receptor Protein-Tyrosine Kinases; Signal Transduction; Skin Neoplasms; Sulfonamides; Vemurafenib; Xenograft Model Antitumor Assays

2014
Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo.
    Oncotarget, 2016, Mar-01, Volume: 7, Issue:9

    Topics: Aminopyridines; Angiogenesis Inhibitors; Animals; Apoptosis; Axl Receptor Tyrosine Kinase; Blotting, Western; Brain Neoplasms; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Glioblastoma; Humans; Immunohistochemistry; Mice, Nude; Microscopy, Fluorescence; Neoplasm Invasiveness; Phosphorylation; Proto-Oncogene Proteins; Pyridones; Receptor Protein-Tyrosine Kinases; Tumor Burden; Xenograft Model Antitumor Assays

2016
Role of axl in preeclamptic EPCs functions.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2016, Volume: 36, Issue:3

    Topics: Adult; Aminopyridines; Axl Receptor Tyrosine Kinase; Blood Pressure; Case-Control Studies; Cell Adhesion; Cell Differentiation; Cell Movement; Cell Proliferation; Female; Fetal Blood; Gene Expression Regulation; Gestational Age; Human Umbilical Vein Endothelial Cells; Humans; Placenta; Pre-Eclampsia; Pregnancy; Primary Cell Culture; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyridones; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Stem Cells

2016
RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis.
    Science translational medicine, 2017, 01-25, Volume: 9, Issue:374

    Topics: Aminopyridines; Animals; Bone and Bones; Estrogens; Female; Humans; Mice; Mice, Transgenic; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms; Osteoblasts; Osteoclasts; Osteoporosis; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Mas; Pyridones; Receptor Protein-Tyrosine Kinases; Signal Transduction; Treatment Outcome

2017
Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.
    Cell reports, 2017, 02-28, Volume: 18, Issue:9

    Topics: Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Gene Knockdown Techniques; Glioblastoma; Heterocyclic Compounds, 4 or More Rings; Humans; Leukemia, T-Cell; Mice; Neoplasms; Phosphorylation; PTEN Phosphohydrolase; Pyridones; Receptor Protein-Tyrosine Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases

2017
RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice.
    Haematologica, 2018, Volume: 103, Issue:5

    Topics: Aminopyridines; Anemia, Sickle Cell; Animals; Cells, Cultured; Endothelium, Vascular; Humans; Kidney; Macrophages; Mice; Pyridones; Receptor Protein-Tyrosine Kinases

2018
MET‑RON dual inhibitor, BMS‑777607, suppresses cholangiocarcinoma cell growth, and MET‑RON upregulation indicates worse prognosis for intra‑hepatic cholangiocarcinoma patients.
    Oncology reports, 2018, Volume: 40, Issue:3

    Topics: Aminopyridines; Animals; Apoptosis; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biomarkers, Tumor; Cell Proliferation; Cholangiocarcinoma; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Prognosis; Proto-Oncogene Proteins c-met; Pyridones; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Tumor Cells, Cultured

2018
Antitumor effects of BMS-777607 on ovarian cancer cells with constitutively activated c-MET.
    Taiwanese journal of obstetrics & gynecology, 2019, Volume: 58, Issue:1

    Topics: Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Aurora Kinase B; Blotting, Western; Cell Proliferation; Disease Models, Animal; Female; Humans; Mice; Molecular Targeted Therapy; Ovarian Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-met; Pyridones; Signal Transduction

2019
Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer.
    Cancer research, 2019, 05-15, Volume: 79, Issue:10

    Topics: Aminopyridines; Animals; Antibodies, Monoclonal; Cell Line, Tumor; Disease Models, Animal; Female; Lymphocytes, Tumor-Infiltrating; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Protein-Tyrosine Kinases; Pyridones; Triple Negative Breast Neoplasms; Tumor Microenvironment; Xenograft Model Antitumor Assays

2019
A C-Met chemical inhibitor promotes fracture healing through interacting with osteogenic differentiation via the mTORC1 pathway.
    Experimental cell research, 2019, 08-01, Volume: 381, Issue:1

    Topics: Aminopyridines; Animals; Bony Callus; Cell Proliferation; Cells, Cultured; Collagen Type I; Core Binding Factor Alpha 1 Subunit; Female; Fracture Healing; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Osteoblasts; Osteogenesis; Proto-Oncogene Proteins c-met; Pyridones; Signal Transduction

2019
Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation.
    Cell communication and signaling : CCS, 2019, 06-06, Volume: 17, Issue:1

    Topics: Aminopyridines; Axl Receptor Tyrosine Kinase; Cell Line, Tumor; Cell Membrane; Humans; Mutation; Protein Kinase Inhibitors; Protein Transport; Proteolysis; Proto-Oncogene Proteins; Pyridones; Receptor Protein-Tyrosine Kinases; Spheroids, Cellular; Ubiquitin

2019
Pharmacological inhibition of focal adhesion kinase 1 (FAK1) and anaplastic lymphoma kinase (ALK) identified via kinome profile analysis attenuates lipopolysaccharide-induced endothelial inflammatory activation.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 133

    Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Anti-Inflammatory Agents; Axl Receptor Tyrosine Kinase; Focal Adhesion Kinase 1; Gene Expression Profiling; HL-60 Cells; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipopolysaccharides; Protein Array Analysis; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyridones; Pyrimidines; Receptor Protein-Tyrosine Kinases; Signal Transduction; Sulfones; Time Factors; Transcriptome

2021
[Effect of Met kinase inhibitor BMS-777607 on proliferation and apoptosis of tongue cell line CAL 27 squamous cell carcinoma].
    Shanghai kou qiang yi xue = Shanghai journal of stomatology, 2021, Volume: 30, Issue:6

    Topics: Aminopyridines; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; Cell Proliferation; Humans; Poly(ADP-ribose) Polymerase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridones; Tongue; Tongue Neoplasms

2021