Compounds > alpha-aminopyridine
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alpha-aminopyridine and 4-(2'-methoxyphenyl)-1-(2'-(n-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine

alpha-aminopyridine has been researched along with 4-(2'-methoxyphenyl)-1-(2'-(n-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine in 53 studies

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's24 (45.28)18.2507
2000's23 (43.40)29.6817
2010's6 (11.32)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Burris, KD; Butkerait, P; Graham, TE; Hallak, H; Manning, DR; Miller, HA; Molinoff, PB; Zheng, Y1
Chumpradit, S; Kung, HF; Kung, MP; Mu, M; Zhuang, ZP1
Frederick, D; Kung, HF; Kung, MP; Mu, M; Zhuang, ZP1
Frazer, A; Thielen, RJ1
Frederick, D; Kung, HF; Kung, MP; Zhuang, ZP1
Clarke, W; Kung, HF; Kung, MP; Maayani, S; Zhuang, ZP1
Kung, HF; Kung, MP; Zhuang, ZP1
Fangon, NB; Frazer, A; Thielen, RJ1
Frederick, D; Kim, HJ; Kung, HF; Kung, MP; Kushner, SA; McElgin, W; Mozley, PD; Mu, M; Stevenson, DA; Vessotskie, JM; Zhuang, ZP1
Cao, BJ; Rodgers, RJ1
De Lanerolle, NC; Shaikh, MB; Siegel, A1
Leander, JD; Wolff, MC1
Barr, AJ; Manning, DR1
Ahlemeyer, B; Krieglstein, J1
Kung, HF; Kung, MP; Mu, M; Zhuang, ZP1
Hull, EM; Lorrain, DS; Matuszewich, L1
Cook, DF; Wirtshafter, D1
Colpaert, FC; Dupuis, DS; Pauwels, PJ1
Bjorvatn, B; Fornal, CA; Jacobs, BL; Martín, FJ; Metzler, CW2
Koob, GF; Parsons, LH; Weiss, F1
Sugimoto, Y; Yamada, J; Yoshikawa, T1
Dominguez, J; Hull, EM; Lorrain, DS; Matuszewich, L; Putnam, SK; Trujillo, R1
Roumy, M; Zajac, J1
Heils, A; Lesch, KP; Li, Q; Murphy, DL; Van De Kar, LD; Wichems, C1
Ferreira, M; Gillis, RA; Sahibzada, N; Taveira-DaSilva, AM; Wasserman, AM1
Chen, CA; Manning, DR1
Griebel, G; Perrault, G; Rodgers, RJ; Sanger, DJ1
Bjorvatn, B; Sørensen, E; Ursin, R1
Moerschbaecher, JM; Winsauer, PJ1
Harrison, AA; Markou, A1
Bjorvatn, B; Grønli, J; Sørensen, E; Ursin, R1
Bjorvatn, B; Bjørkum, A; Grønli, J; Sørensen, E; Ursin, R1
Kerr, TM; Parsons, LH; Tecott, LH1
Harrison, AA; Liem, YT; Markou, A1
Cutz, E; Farragher, SM; Fu, XW; Pan, J; Wang, D; Wong, V1
Ivanova, EA; Popova, NK1
Amstislavskaya, TG; Popova, NK1
Gray, K; Newson, M; Pei, Q; Sharp, T; Sprakes, M; Tordera, R1
Bingaman, M; Gillis, RA; Pace, PP; Taveira-DaSilva, AM; Teng, YD; Wrathall, JR1
Bhatt, S; Hassanain, M; Siegel, A1
Chevrette, J; Harrison, AA; Hoyer, D; Markou, A1
Matsumoto, K; Morishige, R; Murakami, Y; Sakakibara, I; Takayama, H; Tohda, M; Watanabe, H1
Bjorvatn, B; Bjørkum, AA; Fiske, E; Grønli, J; Portas, CM; Sørensen, E; Ursin, R1
Carpenter, RE; Earley, RL; Grober, MS; Lorenzi, V; Summers, CH1
Bhatt, RS; Bhatt, S; Siegel, A; Zalcman, SS1
Kondaurova, EM; Naumenko, VS; Popova, NK1
Bai, YJ; Cao, JX; Cui, SY; Cui, XY; Wang, LE; Zhang, J; Zhang, QY; Zhang, YH; Zhao, YY1
Jiang, X; Li, Q; Luo, T; Wang, J1
Che, CT; Huang, Z; Ip, SP; Mao, QQ; Xian, YF1
Wang, LE; Yin, YQ; Zhang, XQ; Zhang, YH1
Cailly, T; Charnay, Y; Dumas, N; Fabis, F; Ginovart, N; Millet, P; Moulin-Sallanon, M; Rault, S; Suzanne, P; Tournier, BB1
Chattopadhyay, A; Jafurulla, M; Kumar, GA; Pande, G; Sarkar, P; Singh, SP; Srinivas, G1

Other Studies

53 other study(ies) available for alpha-aminopyridine and 4-(2'-methoxyphenyl)-1-(2'-(n-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine

ArticleYear
Expression of the human 5-hydroxytryptamine1A receptor in Sf9 cells. Reconstitution of a coupled phenotype by co-expression of mammalian G protein subunits.
    The Journal of biological chemistry, 1995, Aug-04, Volume: 270, Issue:31

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amino Acid Sequence; Aminopyridines; Animals; Baculoviridae; Base Sequence; Cell Line; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Molecular Sequence Data; Peptide Fragments; Piperazines; Protein Processing, Post-Translational; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Recombinant Proteins; Signal Transduction; Spodoptera

1995
Derivatives of 4-(2'-methoxyphenyl)-1-[2'-(N-2"-pyridinyl-p-iodobenzamido)ethyl]pipera zine (p-MPPI) as 5-HT1A ligands.
    Journal of medicinal chemistry, 1994, Dec-23, Volume: 37, Issue:26

    Topics: Affinity Labels; Aminopyridines; Animals; Hippocampus; Ligands; Piperazines; Rats; Receptors, Serotonin; Structure-Activity Relationship

1994
4-(2'-Methoxy-phenyl)-1-[2'-(n-2"-pyridinyl)-p-iodobenzamido]-ethyl- piperazine ([125I]p-MPPI) as a new selective radioligand of serotonin-1A sites in rat brain: in vitro binding and autoradiographic studies.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:1

    Topics: Aminopyridines; Animals; Autoradiography; Guanine Nucleotides; Hippocampus; Magnesium; Male; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists

1995
Effects of novel 5-HT1A receptor antagonists on measures of post-synaptic 5-HT1A receptor activation in vivo.
    Life sciences, 1995, Volume: 56, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Body Temperature; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists

1995
In vivo binding of [123I]4-(2'-methoxyphenyl)-1-[2'-(N-2"-pyridinyl)- p-iodobenzamido-]ethyl-piperazine, p-MPPI, to 5-HT1A receptors in rat brain.
    Synapse (New York, N.Y.), 1994, Volume: 18, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Autoradiography; Brain; Iodine Radioisotopes; Isotope Labeling; Ligands; Male; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Tissue Distribution

1994
A potential 5-HT1A receptor antagonist: p-MPPI.
    Life sciences, 1994, Volume: 55, Issue:19

    Topics: Adenylyl Cyclases; Aminopyridines; Animals; Binding, Competitive; Colforsin; Guanosine Triphosphate; Hippocampus; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Ligands; Piperazines; Rats; Receptors, Serotonin; Serotonin Antagonists; Stimulation, Chemical

1994
Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT1A ligand.
    Journal of medicinal chemistry, 1994, May-13, Volume: 37, Issue:10

    Topics: Aminopyridines; Animals; Brain; In Vitro Techniques; Iodine Radioisotopes; Ligands; Piperazines; Radioligand Assay; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Tissue Distribution

1994
4-(2'-Methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-iodobenzamido]ethyl] piperazine and 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- fluorobenzamido]ethyl]piperazine, two new antagonists at pre- and postsynaptic serotonin-1A receptors.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Autoreceptors; Body Temperature; Brain Chemistry; Dose-Response Relationship, Drug; Guanylyl Imidodiphosphate; Hydroxyindoleacetic Acid; Male; Piperazines; Posture; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists

1996
In vivo SPECT imaging of 5-HT1A receptors with [123I]p-MPPI in nonhuman primates.
    Synapse (New York, N.Y.), 1996, Volume: 24, Issue:3

    Topics: Aminopyridines; Animals; Autoradiography; Brain; Brain Chemistry; Iodine Radioisotopes; Ligands; Macaca fascicularis; Magnetic Resonance Imaging; Piperazines; Receptors, Serotonin; Tissue Distribution; Tomography, Emission-Computed, Single-Photon

1996
Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze.
    Psychopharmacology, 1997, Volume: 129, Issue:4

    Topics: Aminopyridines; Animals; Anxiety; Dose-Response Relationship, Drug; Male; Maze Learning; Mice; Piperazines; Serotonin Antagonists

1997
Serotonin 5-HT1A and 5-HT2/1C receptors in the midbrain periaqueductal gray differentially modulate defensive rage behavior elicited from the medial hypothalamus of the cat.
    Brain research, 1997, Aug-15, Volume: 765, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Behavior, Animal; Cats; Female; Hypothalamus; Immunohistochemistry; Male; Mesencephalon; Periaqueductal Gray; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists

1997
Differentiation of 5-HT1A receptor ligands by drug discrimination.
    European journal of pharmacology, 1997, Aug-27, Volume: 333, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aminopyridines; Animals; Behavior, Animal; Buspirone; Columbidae; Cyclohexylamines; Discrimination Learning; Dose-Response Relationship, Drug; Idazoxan; Ligands; Male; Pindolol; Piperazines; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists

1997
Agonist-independent activation of Gz by the 5-hydroxytryptamine1A receptor co-expressed in Spodoptera frugiperda cells. Distinguishing inverse agonists from neutral antagonists.
    The Journal of biological chemistry, 1997, Dec-26, Volume: 272, Issue:52

    Topics: Aminopyridines; Animals; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Humans; Kinetics; Ligands; Piperazines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Spiperone; Spodoptera; Tetrahydronaphthalenes

1997
Stimulation of 5-HT1A receptor inhibits apoptosis induced by serum deprivation in cultured neurons from chick embryo.
    Brain research, 1997, Nov-28, Volume: 777, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Aminopyridines; Animals; Apoptosis; Cells, Cultured; Chick Embryo; Chlorpromazine; Culture Media, Serum-Free; Dopamine Antagonists; Nerve Growth Factors; Neurons; Neuroprotective Agents; Piperazines; Propranolol; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Telencephalon

1997
Isoindol-1-one analogues of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridyl)-p-iodobenzamido]ethyl]pipera zine (p-MPPI) as 5-HT1A receptor ligands.
    Journal of medicinal chemistry, 1998, Jan-15, Volume: 41, Issue:2

    Topics: Aminopyridines; Animals; Chromatography, High Pressure Liquid; Heterocyclic Compounds; Hippocampus; Humans; Indoles; Iodine Radioisotopes; Isoindoles; Kinetics; Ligands; Male; Microsomes, Liver; Models, Chemical; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Tomography, Emission-Computed, Single-Photon

1998
8-OH-DPAT influences extracellular levels of serotonin and dopamine in the medial preoptic area of male rats.
    Brain research, 1998, Apr-20, Volume: 790, Issue:1-2

    Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Carrier Proteins; Dopamine; Extracellular Space; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Microinjections; Nerve Tissue Proteins; Piperazines; Preoptic Area; Rats; Rats, Inbred Strains; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Sexual Behavior, Animal

1998
Serotonin-1B agonists induce compartmentally organized striatal Fos expression in rats.
    Neuroreport, 1998, Apr-20, Volume: 9, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Corpus Striatum; Immunohistochemistry; Indoles; Male; Nerve Tissue Proteins; Piperazines; Piperidines; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Serotonin Receptor Agonists

1998
G-protein activation at 5-HT1A receptors by the 5-ht1F ligand LY334370 in guinea-pig brain sections and recombinant cell lines.
    British journal of pharmacology, 1998, Volume: 124, Issue:2

    Topics: Aminopyridines; Animals; Autoradiography; Benzamides; Binding Sites; Binding, Competitive; Brain; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; HeLa Cells; Hippocampus; Humans; Indoles; Male; Piperazines; Pyridines; Raphe Nuclei; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan

1998
The 5-HT1A receptor antagonist p-MPPI blocks 5-HT1A autoreceptors and increases dorsal raphe unit activity in awake cats.
    European journal of pharmacology, 1998, Sep-04, Volume: 356, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Aminopyridines; Animals; Autoreceptors; Cats; Drug Interactions; Electroencephalography; Electrophysiology; Male; Motor Activity; Piperazines; Raphe Nuclei; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Wakefulness

1998
Serotonin1B receptor stimulation enhances cocaine reinforcement.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Dec-01, Volume: 18, Issue:23

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Indoles; Injections, Intraventricular; Male; Oxadiazoles; Piperazines; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Self Administration; Serotonin Antagonists; Serotonin Receptor Agonists

1998
p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors.
    European journal of pharmacology, 1998, Oct-23, Volume: 359, Issue:2-3

    Topics: 4-Aminobenzoic Acid; Adrenal Medulla; Adrenalectomy; Aminopyridines; Animals; Blood Glucose; Dose-Response Relationship, Drug; Ergolines; Fenclonine; Hyperglycemia; Indoles; Ketanserin; Male; Methysergide; p-Chloroamphetamine; para-Aminobenzoates; Piperazines; Propranolol; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Ritanserin; Serotonin; Serotonin Agents; Serotonin Antagonists; Tropisetron

1998
Partial antagonism of 8-OH-DPAT'S effects on male rat sexual behavior with a D2, but not a 5-HT1A, antagonist.
    Brain research, 1999, Feb-27, Volume: 820, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Copulation; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Ejaculation; Male; Piperazines; Preoptic Area; Raclopride; Rats; Rats, Long-Evans; Reaction Time; Salicylamides; Serotonin Antagonists; Sexual Behavior, Animal

1999
Neuropeptide FF selectively attenuates the effects of nociceptin on acutely dissociated neurons of the rat dorsal raphe nucleus.
    Brain research, 1999, Oct-23, Volume: 845, Issue:2

    Topics: Aminopyridines; Analgesics, Opioid; Animals; Barium Compounds; Biological Transport; Calcium; Chlorides; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Narcotic Antagonists; Neurons; Nociceptin; Oligopeptides; Opioid Peptides; Piperazines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Serotonin; Serotonin Antagonists; Vasodilator Agents

1999
Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Aminopyridines; Animals; Autoradiography; Body Temperature; Carrier Proteins; Corticosterone; Dose-Response Relationship, Drug; Hypothalamus; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurosecretory Systems; Oxytocin; Piperazines; Pyridines; Raphe Nuclei; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Time Factors

1999
Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Apnea; Buspirone; Diaphragm; Drug Interactions; Electromyography; Male; Morphine; Muscle Contraction; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists

2000
Regulation of galpha i palmitoylation by activation of the 5-hydroxytryptamine-1A receptor.
    The Journal of biological chemistry, 2000, Aug-04, Volume: 275, Issue:31

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; CHO Cells; Cricetinae; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Humans; Palmitic Acid; Piperazines; Protein Processing, Post-Translational; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Signal Transduction; Virulence Factors, Bordetella

2000
The effects of compounds varying in selectivity as 5-HT(1A) receptor antagonists in three rat models of anxiety.
    Neuropharmacology, 2000, Jul-24, Volume: 39, Issue:10

    Topics: Aminopyridines; Animals; Anxiety; Cyclohexane Monoterpenes; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Isoquinolines; Male; Maze Learning; Motor Activity; Pindolol; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Succinimides

2000
Venlafaxine and its interaction with WAY 100635: effects on serotonergic unit activity and behavior in cats.
    European journal of pharmacology, 2000, Sep-15, Volume: 404, Issue:1-2

    Topics: Aminopyridines; Animals; Behavior, Animal; Cats; Cyclohexanols; Drug Interactions; Male; Neurons; Piperazines; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Sodium Chloride; Venlafaxine Hydrochloride

2000
Sleep-wake effects following the selective 5-HT(1A) receptor antagonist p-MPPI in the freely moving rat.
    Behavioural brain research, 2000, Volume: 114, Issue:1-2

    Topics: Aminopyridines; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Sleep; Sleep, REM; Wakefulness

2000
Differential effects of 5-HT agonists and antagonists on the repeated acquisition and performance of response sequences in monkeys.
    Behavioural pharmacology, 2000, Volume: 11, Issue:7-8

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Amphetamines; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Ergolines; Learning; Macaca fascicularis; Macaca mulatta; Piperazines; Pyridines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists

2000
Serotonergic manipulations both potentiate and reduce brain stimulation reward in rats: involvement of serotonin-1A receptors.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Brain; Dose-Response Relationship, Drug; Fluoxetine; Male; Piperazines; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reward; Serotonin Antagonists; Serotonin Receptor Agonists

2001
The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats.
    Behavioural brain research, 2001, Volume: 121, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Arousal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Sleep Stages; Wakefulness

2001
Sleep and waking following microdialysis perfusion of the selective 5-HT1A receptor antagonist p-MPPI into the dorsal raphe nucleus in the freely moving rat.
    Brain research, 2001, Apr-06, Volume: 897, Issue:1-2

    Topics: Aminopyridines; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Male; Microdialysis; Motor Activity; Piperazines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Sleep, REM; Wakefulness

2001
5-HT(1A) receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission.
    Journal of neurochemistry, 2001, Volume: 77, Issue:2

    Topics: Aminopyridines; Animals; Anxiety; Exploratory Behavior; Fluoxetine; Frontal Lobe; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Neurologic Mutants; Microdialysis; Organ Specificity; Phenotype; Piperazines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Signal Transduction; Stress, Psychological; Synaptic Transmission

2001
Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 25, Issue:1

    Topics: Aminopyridines; Amphetamine; Amphetamine-Related Disorders; Animals; Body Weight; Brain; Depression; Disease Models, Animal; Drug Combinations; Electric Stimulation; Fluoxetine; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Antagonists; Piperazines; Rats; Rats, Wistar; Reaction Time; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reward; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Substance Withdrawal Syndrome; Synaptic Transmission; Tobacco Use Disorder

2001
Neuroepithelial bodies in mammalian lung express functional serotonin type 3 receptor.
    American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 281, Issue:4

    Topics: Aminopyridines; Animals; Calcium; Chemoreceptor Cells; Colforsin; Cricetinae; Dose-Response Relationship, Drug; Gene Expression; Humans; Immunohistochemistry; In Situ Hybridization; Indoles; Ion Channel Gating; Ketanserin; Lung; Mammals; Membrane Potentials; Mesocricetus; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Piperazines; Rabbits; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Respiratory Mucosa; RNA, Messenger; Serotonin; Serotonin Antagonists; Tropisetron

2001
5-HT(1A) receptor antagonist p-MPPI attenuates acute ethanol effects in mice and rats.
    Neuroscience letters, 2002, Mar-29, Volume: 322, Issue:1

    Topics: Acute Disease; Alcohol-Induced Disorders, Nervous System; Aminopyridines; Animals; Brain; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Ethanol; Hypothermia; Male; Mice; Mice, Inbred C3H; Neurons; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex, Startle; Serotonin; Serotonin Antagonists; Sleep

2002
Involvement of the 5-HT(1A) and 5-HT(1B) serotonergic receptor subtypes in sexual arousal in male mice.
    Psychoneuroendocrinology, 2002, Volume: 27, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Motivation; Piperazines; Quinoxalines; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Sexual Behavior, Animal

2002
Effect of different 5-HT1A receptor antagonists in combination with paroxetine on expression of the immediate-early gene Arc in rat brain.
    Neuropharmacology, 2003, Volume: 44, Issue:7

    Topics: Aminopyridines; Animals; Apoptosis Regulatory Proteins; Benzopyrans; Brain Chemistry; Gene Expression; Male; Muscle Proteins; Paroxetine; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists

2003
Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, May-15, Volume: 23, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Buspirone; Female; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Respiration; Respiratory Function Tests; Respiratory System Abnormalities; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord Injuries; Wounds, Nonpenetrating

2003
Differential modulation of feline defensive rage behavior in the medial hypothalamus by 5-HT1A and 5-HT2 receptors.
    Brain research, 2003, Aug-15, Volume: 981, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Aminopyridines; Animals; Behavior, Animal; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Female; Hypothalamus, Middle; Indophenol; Periaqueductal Gray; Piperazines; Predatory Behavior; Rage; Reaction Time; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Serotonin Antagonists; Time Factors

2003
Paroxetine combined with a 5-HT(1A) receptor antagonist reversed reward deficits observed during amphetamine withdrawal in rats.
    Psychopharmacology, 2005, Volume: 178, Issue:2-3

    Topics: Affective Symptoms; Aminopyridines; Amphetamine; Animals; Brain; Drug Synergism; Hypothalamus, Posterior; Male; Motivation; Norepinephrine; Paroxetine; Piperazines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reward; Selective Serotonin Reuptake Inhibitors; Self Stimulation; Serotonin 5-HT1 Receptor Antagonists; Substance Withdrawal Syndrome

2005
Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: behavioural and electrophysiological studies.
    European journal of pharmacology, 2005, Jul-11, Volume: 517, Issue:3

    Topics: Alkaloids; Aminopyridines; Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Female; Indole Alkaloids; Ketanserin; Male; Membrane Potentials; Methoxydimethyltryptamines; Mianserin; Mice; Mice, Inbred ICR; Motor Activity; Oocytes; Oxindoles; Patch-Clamp Techniques; Piperazines; Rats; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Xenopus

2005
Increased extracellular 5-HT but no change in sleep after perfusion of a 5-HT1A antagonist into the dorsal raphe nucleus of rats.
    Acta physiologica (Oxford, England), 2008, Volume: 193, Issue:1

    Topics: Aminopyridines; Animals; Chromatography, High Pressure Liquid; Microdialysis; Piperazines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Sleep Stages; Wakefulness

2008
Serotonin, social status and sex change in the bluebanded goby Lythrypnus dalli.
    Physiology & behavior, 2009, Jun-22, Volume: 97, Issue:3-4

    Topics: 5-Hydroxytryptophan; Aminopyridines; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Female; Fenclonine; Fishes; Fluoxetine; Hermaphroditic Organisms; Hierarchy, Social; Hydroxyindoleacetic Acid; Linear Models; Male; Piperazines; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Sex Determination Processes; Sexual Behavior, Animal; Social Behavior

2009
Peripheral and central mediators of lipopolysaccharide induced suppression of defensive rage behavior in the cat.
    Neuroscience, 2009, Nov-10, Volume: 163, Issue:4

    Topics: Aminopyridines; Animals; Autoantibodies; Behavior, Animal; Cats; Electric Stimulation; Female; Head Movements; Hypothalamus; Interleukin-1; Lipopolysaccharides; Periaqueductal Gray; Piperazines; Rage; Receptors, Prostaglandin E; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Time Factors; Tranquilizing Agents; Tumor Necrosis Factor-alpha

2009
Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A receptor.
    Neuroscience letters, 2009, Nov-06, Volume: 465, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Biguanides; Blood-Brain Barrier; Body Temperature; Dose-Response Relationship, Drug; Hypothermia; Male; Mice; Mice, Inbred Strains; Ondansetron; Piperazines; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT3 Receptor Agonists; Serotonin Antagonists; Serotonin Receptor Agonists; Species Specificity

2009
Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT(1A) receptors.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Volume: 17, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Drug Synergism; Drug Therapy, Combination; Drugs, Chinese Herbal; Flavonoids; Glycosides; Male; Monosaccharides; Pentobarbital; Phytotherapy; Piperazines; Rats; Rats, Sprague-Dawley; Seeds; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Sleep; Sleep Initiation and Maintenance Disorders; Sleep, REM; Time Factors; Wakefulness; Ziziphus

2010
Anxiolytic effects of 5-HT₁A receptors and anxiogenic effects of 5-HT₂C receptors in the amygdala of mice.
    Neuropharmacology, 2012, Volume: 62, Issue:1

    Topics: Adenoviridae; Aminopyridines; Amphetamines; Amygdala; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Autoradiography; Disease Models, Animal; Exploratory Behavior; Female; Gene Expression Regulation; Genetic Vectors; Green Fluorescent Proteins; Iodine Radioisotopes; Maze Learning; Mice; Mice, Inbred C57BL; Oligodeoxyribonucleotides, Antisense; Piperazines; Protein Binding; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors

2012
Role of 5-HT(1A) and 5-HT(1B) receptors in the antidepressant-like effect of piperine in the forced swim test.
    Neuroscience letters, 2011, Oct-24, Volume: 504, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alkaloids; Aminopyridines; Animals; Antidepressive Agents; Benzodioxoles; Data Interpretation, Statistical; Male; Methiothepin; Mice; Mice, Inbred ICR; Motor Activity; Piperazines; Piperidines; Polyunsaturated Alkamides; Propanolamines; Pyridines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Swimming

2011
Augmentative effect of spinosin on pentobarbital-induced loss of righting reflex in mice associated with presynaptic 5-HT1A receptor.
    The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Aminopyridines; Analysis of Variance; Animals; Drugs, Chinese Herbal; Flavonoids; Hypothermia; Male; Mice; Mice, Inbred ICR; Pentobarbital; Piperazines; Receptor, Serotonin, 5-HT1A; Receptors, Presynaptic; Reflex, Righting; Serotonin Receptor Agonists

2012
Small-animal single-photon emission computed tomographic imaging of the brain serotoninergic systems in wild-type and mdr1a knockout rats.
    Molecular imaging, 2014, Volume: 13

    Topics: Aminopyridines; Animals; ATP Binding Cassette Transporter, Subfamily B; Brain; Cinanserin; Gene Knockout Techniques; Iodine Radioisotopes; Male; Organ Specificity; Piperazines; Piperidines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Tissue Distribution; Tomography, Emission-Computed, Single-Photon

2014
Exploring Endocytosis and Intracellular Trafficking of the Human Serotonin
    Biochemistry, 2019, 06-04, Volume: 58, Issue:22

    Topics: Aminopyridines; Animals; Antibodies, Monoclonal; Cell Membrane; Drug Inverse Agonism; Endocytosis; Fluorescent Dyes; Goats; HEK293 Cells; Humans; Piperazines; Protein Transport; Pyridines; Rabbits; Receptor, Serotonin, 5-HT1A; Serotonin Antagonists

2019