alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate and isoxazoles

alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate has been researched along with isoxazoles in 42 studies

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (23.81)18.2507
2000's26 (61.90)29.6817
2010's6 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benvenga, MJ; Leander, JD; Ornstein, PL1
Abdulla, FA; Calaminici, MR; Gray, JA; Raevsky, VV; Sinden, JD; Stephenson, JD1
Steppuhn, KG; Turski, L1
Arnt, J; Krogsgaard-Larsen, P; Lenz, SM; Madsen, U; Sánchez, C1
Ballyk, BA; Bath, CP; Bleakman, D; Clarke, VR; Collingridge, GL; Davies, CH; Hoo, KH; Kamboj, RK; Lodge, D; Mandelzys, A; Ornstein, PL; Pellizzari, A; Schoepp, DD; Sharpe, EF; Thomas, J1
Sakmann, B; Schiller, J; Schiller, Y; Stuart, G1
Curry, K; Pajouhesh, H1
Cui, C; Mayer, ML1
Borre, L; Ebert, B; Egebjerg, J; Johansen, TN; Krogsgaard-Larsen, P; Madsen, U; Stensbøl, TB1
Bleakman, D; Deverill, M; Ellis, GJ; Hawes, CR; Hoo, K; Krogsgaard-Larsen, P; Legutko, B; Rizkalla, G; Skolnick, P; Stensbol, TB1
Herrera, MT; Lerma, J; Nieto, MA; Paternain, AV1
Lerma, J; López-García, JC; Rodríguez-Moreno, A1
Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puja, G; Zappalà, M1
Huettner, JE; Wilding, TJ1
Chen, A; Li, H; Rogawski, MA; Wei, ML; Xing, G1
Kristensen, BW; Noraberg, J; Zimmer, J1
Bortolotto, ZA; Collingridge, GL; Delany, C; J Clarke, VR; Lauri, SE; Ornstein, PL; T R Isaac, J1
Fedinec, AL; Leffler, CW; Robinson, JS1
Clarke, VR; Collingridge, GL2
Ben-Ari, Y; Cossart, R; Hirsch, J; Khalilov, I1
De Micheli, C; De Sarro, A; De Sarro, G; Ferreri, G; Grasso, S; Micale, N; Puja, G; Toma, L; Zappalà, M1
Camón, L; de Vera, N; Martínez, E; Vivó, M1
Egebjerg, J; Krogsgaard-Larsen, P; Liljefors, T; Nielsen, MM1
Wu, DC; Yu, LC; Zhou, N1
Egebjerg, J; Gouaux, E; Hogner, A; Kastrup, JS; Lunn, ML; Stensbøl, TB1
Kristensen, AS; Madsen, U; Mathiesen, C; Nielsen, EØ; Peters, D; Valgeirsson, J; Varming, T1
Hernández, ME; López-Bayghen, E; Méndez, JA; Ortega, A; Rojas, F1
Breustedt, J; Schmitz, D1
Jung, SY; Kim, YT; Park, YJ; Seo, WS; Suh, CK1
O'neill, MF; Ornstein, PL; Osborne, DJ; Sanger, G; Woodhouse, SM1
Ko, SW; Toyoda, H; Wu, LJ; Zhao, MG; Zhuo, M1
Bräuner-Osborne, H; Egebjerg, J; Frølund, B; Greenwood, JR; Holm, MM; Krogsgaard-Larsen, P; Madsen, U; Nielsen, B; Stensbøl, TB1
Lauri, SE; Malkki, H; Sallert, M; Segerstråle, M; Taira, T1
Albrecht, D; Drephal, C; Schubert, M1
Liu, Y; Xu, J; Zhang, GY1
Li, JM; Li, Q; Peng, F; Yao, ZP; Zhou, D1
Duncan, GE; Koller, BH; Moy, SS1
Han, D; Liu, Y; Lv, Q; Wang, Y; Xu, J; Zhang, GY; Zong, YY1
Li, C; Zhang, GY; Zhang, HJ1
Ishikura, T; Maruyama, T; Matsuura, T; Ohbuchi, T; Ohkubo, J; Suzuki, H; Ueta, Y; Yoshimura, M1
Fritsch, B; Gasior, M; Kaminski, RM; Reis, J; Rogawski, MA1

Other Studies

42 other study(ies) available for alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate and isoxazoles

ArticleYear
Schedule-controlled behavioral effects of the selective 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic acid antagonist LY293558 in pigeons.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Columbidae; Electroshock; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Isoquinolines; Isoxazoles; Male; N-Methylaspartate; Propionates; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Stereoisomerism; Tetrazoles

1995
An iontophoretic study of the effects of alpha-amino-hydroxy-5-methyl-4-isoxazole propionic acid lesions of the nucleus basalis magnocellularis on cholinergic and GABAergic influences on frontal cortex neurones of rats.
    Experimental brain research, 1994, Volume: 98, Issue:3

    Topics: Acetylcholine; Animals; Bicuculline; Carbachol; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Iontophoresis; Isoxazoles; Male; Medulla Oblongata; Neurons; Parasympathetic Nervous System; Propionates; Rats; Rats, Sprague-Dawley

1994
Modulation of the seizure threshold for excitatory amino acids in mice by antiepileptic drugs and chemoconvulsants.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:3

    Topics: Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Drug Administration Routes; Isoxazoles; Kainic Acid; Male; Mice; N-Methylaspartate; Propionates; Receptors, Glutamate; Seizures

1993
Differentiation of in vivo effects of AMPA and NMDA receptor ligands using drug discrimination methods and convulsant/anticonvulsant activity.
    European journal of pharmacology, 1995, Oct-24, Volume: 285, Issue:3

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Convulsants; Cues; Discrimination Learning; Discrimination, Psychological; Excitatory Amino Acid Agonists; Isoxazoles; Ligands; Male; Mice; N-Methylaspartate; Propionates; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures

1995
A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission.
    Nature, 1997, Oct-09, Volume: 389, Issue:6651

    Topics: Animals; Cell Line; Cloning, Molecular; Excitatory Amino Acid Agonists; Hippocampus; Humans; Isoquinolines; Isoxazoles; Kainic Acid; Neural Inhibition; Propionates; Rats; Receptors, GABA-A; Receptors, Kainic Acid; Synapses; Tetrazoles

1997
Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons.
    The Journal of physiology, 1997, Dec-15, Volume: 505 ( Pt 3)

    Topics: Action Potentials; Animals; Axons; Calcium; Dendrites; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Fluorescence; In Vitro Techniques; Isoxazoles; Neocortex; Patch-Clamp Techniques; Propionates; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate

1997
Pharmacological profile of the isomers of the GluR-specific agonist ATPA.
    Canadian journal of physiology and pharmacology, 1998, Volume: 76, Issue:6

    Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Isoxazoles; Kynurenic Acid; Propionates; Quinoxalines; Rats; Receptors, Glutamate; Stereoisomerism

1998
Heteromeric kainate receptors formed by the coassembly of GluR5, GluR6, and GluR7.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Oct-01, Volume: 19, Issue:19

    Topics: Alanine; Alternative Splicing; Cell Line; Excitatory Amino Acid Agonists; Genetic Variation; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Humans; Isoxazoles; Kainic Acid; Macromolecular Substances; Membrane Potentials; Mutagenesis, Site-Directed; Propionates; Pyrimidines; Receptors, Kainic Acid; Recombinant Proteins

1999
Resolution, absolute stereochemistry and molecular pharmacology of the enantiomers of ATPA.
    European journal of pharmacology, 1999, Sep-10, Volume: 380, Issue:2-3

    Topics: Animals; Binding, Competitive; Cerebral Cortex; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Isoxazoles; Molecular Conformation; Oocytes; Propionates; Quinoxalines; Radioligand Assay; Rats; Receptors, AMPA; Recombinant Fusion Proteins; Stereoisomerism; Tritium; Xenopus

1999
[3H]ATPA: a high affinity ligand for GluR5 kainate receptors.
    Neuropharmacology, 1999, Volume: 38, Issue:12

    Topics: Animals; Animals, Newborn; Cell Line; Excitatory Amino Acid Agonists; Ganglia, Spinal; Humans; Isoxazoles; Kainic Acid; Neurons; Propionates; Rats; Receptors, Kainic Acid

1999
GluR5 and GluR6 kainate receptor subunits coexist in hippocampal neurons and coassemble to form functional receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Jan-01, Volume: 20, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Excitatory Amino Acid Agonists; Gene Expression; GluK2 Kainate Receptor; Glutamic Acid; Hippocampus; Ion Channel Gating; Isoxazoles; Kainic Acid; Neurons; Propionates; Protein Structure, Tertiary; Rats; Receptors, Kainic Acid; RNA, Messenger; Structure-Activity Relationship

2000
Two populations of kainate receptors with separate signaling mechanisms in hippocampal interneurons.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Feb-01, Volume: 97, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Bicuculline; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Indoles; Interneurons; Isoxazoles; Kainic Acid; Lidocaine; Maleimides; Naphthalenes; Nerve Tissue Proteins; Patch-Clamp Techniques; Propionates; Protein Kinase C; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, Presynaptic; Signal Transduction; Staurosporine; Virulence Factors, Bordetella

2000
Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.
    Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15

    Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; Convulsants; Drug Evaluation, Preclinical; Electroshock; Excitatory Amino Acid Agonists; Isoxazoles; Kainic Acid; Mice; Mice, Inbred DBA; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Phthalazines; Propionates; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Structure-Activity Relationship

2000
Functional diversity and developmental changes in rat neuronal kainate receptors.
    The Journal of physiology, 2001, Apr-15, Volume: 532, Issue:Pt 2

    Topics: Aging; Animals; Animals, Newborn; Cells, Cultured; Electric Conductivity; Embryo, Mammalian; Excitatory Amino Acid Agonists; Ganglia, Spinal; Hippocampus; Isoxazoles; Kainic Acid; Neurons; Propionates; Rats; Rats, Long-Evans; Receptors, Kainic Acid; Spinal Cord

2001
Kainate receptor-mediated heterosynaptic facilitation in the amygdala.
    Nature neuroscience, 2001, Volume: 4, Issue:6

    Topics: Amygdala; Animals; Calcium; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Antagonists; GluK2 Kainate Receptor; In Vitro Techniques; Isoxazoles; Male; Neurons; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; Synapses; Synaptic Transmission

2001
Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures.
    Brain research, 2001, Oct-26, Volume: 917, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Isoxazoles; Kainic Acid; Microtubule-Associated Proteins; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Nissl Bodies; Nuclear Proteins; Propidium; Propionates; Quinoxalines; Rats; Rats, Wistar

2001
Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses.
    Neuropharmacology, 2001, Volume: 41, Issue:8

    Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Isoxazoles; Mossy Fibers, Hippocampal; Propionates; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Presynaptic; Signal Transduction; Synapses; Synaptic Transmission

2001
Role of carbon monoxide in glutamate receptor-induced dilation of newborn pig pial arterioles.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:6

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Arterioles; Carbon Monoxide; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Heme Oxygenase (Decyclizing); Isoxazoles; Mesoporphyrins; Metalloporphyrins; Propionates; Protoporphyrins; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Swine; Vasodilation

2002
Characterisation of the effects of ATPA, a GLU(K5) receptor selective agonist, on excitatory synaptic transmission in area CA1 of rat hippocampal slices.
    Neuropharmacology, 2002, Volume: 42, Issue:7

    Topics: Animals; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Isoquinolines; Isoxazoles; Propionates; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; Synaptic Transmission

2002
Paradoxical anti-epileptic effects of a GluR5 agonist of kainate receptors.
    Journal of neurophysiology, 2002, Volume: 88, Issue:1

    Topics: Animals; Animals, Newborn; Anticonvulsants; Hippocampus; Interneurons; Isoxazoles; Neural Inhibition; Propionates; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; Seizures

2002
Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters.
    Journal of medicinal chemistry, 2002, Sep-26, Volume: 45, Issue:20

    Topics: Acoustic Stimulation; Animals; Anticonvulsants; Cerebellum; Dioxoles; Excitatory Amino Acid Antagonists; Isoxazoles; Kainic Acid; Male; Mice; Mice, Inbred DBA; Models, Molecular; Motor Activity; Neurons; Patch-Clamp Techniques; Phenylacetates; Propionates; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Semicarbazones; Structure-Activity Relationship

2002
Lesion of substantia nigra pars compacta by the GluR5 agonist ATPA.
    Brain research, 2002, Nov-15, Volume: 955, Issue:1-2

    Topics: Animals; Dopamine; Isoxazoles; Male; Motor Activity; Neurons; Propionates; Rats; Rats, Wistar; Receptors, Kainic Acid; Substantia Nigra

2002
The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741.
    Molecular pharmacology, 2003, Volume: 63, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Isoxazoles; Models, Molecular; Mutagenesis; Propionates; Receptors, AMPA; Receptors, Kainic Acid; Serine; Xenopus laevis

2003
Anti-nociceptive effect induced by intrathecal injection of ATPA, an effect enhanced and prolonged by concanavalin A.
    Brain research, 2003, Jan-10, Volume: 959, Issue:2

    Topics: Analgesics; Animals; Concanavalin A; Drug Synergism; Injections, Spinal; Isoxazoles; Male; Pain Measurement; Propionates; Rats; Rats, Wistar; Receptors, Kainic Acid

2003
Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity.
    Journal of medicinal chemistry, 2003, Feb-27, Volume: 46, Issue:5

    Topics: Binding Sites; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Agonists; Isoxazoles; Ligands; Models, Molecular; Propionates; Protein Conformation; Protein Subunits; Receptors, AMPA; Stereoisomerism; Zinc

2003
2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5.
    Journal of medicinal chemistry, 2003, Dec-18, Volume: 46, Issue:26

    Topics: Animals; Benzoates; Cell Line; Excitatory Amino Acid Agonists; Humans; Isoxazoles; Mice; Muscle Rigidity; Patch-Clamp Techniques; Propionates; Quantitative Structure-Activity Relationship; Radioligand Assay; Receptors, Kainic Acid; Urea

2003
Glutamate regulates Oct-2 DNA-binding activity through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors in cultured chick Bergmann glia cells.
    Journal of neurochemistry, 2004, Volume: 88, Issue:4

    Topics: Animals; Blotting, Western; Carcinogens; Carrier Proteins; Cells, Cultured; Chick Embryo; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Interactions; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Glutamic Acid; Humans; Immunohistochemistry; Isoxazoles; Neuroglia; Octamer Transcription Factor-2; Precipitin Tests; Propionates; Receptors, Glutamate; Silencer Elements, Transcriptional; Telencephalon; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factors

2004
Characterisation of the effects of ATPA, a GLU(K5) kainate receptor agonist, on GABAergic synaptic transmission in the CA1 region of rat hippocampal slices.
    Neuropharmacology, 2004, Volume: 47, Issue:3

    Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; Drug Interactions; Electric Impedance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Kainic Acid; Membrane Potentials; Neural Inhibition; Propionates; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; Synaptic Transmission; Valine

2004
Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Nov-10, Volume: 24, Issue:45

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids, Dicarboxylic; Animals; Benzodiazepines; Cyclopropanes; Excitatory Postsynaptic Potentials; Gene Deletion; GluK2 Kainate Receptor; Glycine; Isoquinolines; Isoxazoles; Kainic Acid; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Neuronal Plasticity; Patch-Clamp Techniques; Potassium; Propionates; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Kainic Acid; Synaptic Transmission

2004
Effects of Na+-Ca2+ exchanger activity on the alpha-amino-3-hydroxy-5-methyl-4-isoxazolone-propionate-induced Ca2+ influx in cerebellar Purkinje neurons.
    Neuroscience, 2005, Volume: 131, Issue:3

    Topics: Agatoxins; Animals; Animals, Newborn; Bepridil; Calbindins; Calcium; Calcium Channel Blockers; Cells, Cultured; Cerebellum; Diagnostic Imaging; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Glutamic Acid; Isoxazoles; Microscopy, Confocal; Oligonucleotides, Antisense; Polyamines; Propionates; Purkinje Cells; Quinoxalines; Rats; S100 Calcium Binding Protein G; Sodium; Sodium Channel Blockers; Sodium-Calcium Exchanger; Thiourea

2005
Locomotor activity detects subunit-selective effects of agonists and decahydroisoquinoline antagonists at AMPA/kainic acid ionotropic glutamate receptors in adult rats.
    Psychopharmacology, 2005, Volume: 179, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Isoquinolines; Isoxazoles; Kainic Acid; Male; Motor Activity; Propionates; Rats; Receptors, AMPA; Receptors, Kainic Acid

2005
Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex.
    Journal of neurophysiology, 2005, Volume: 94, Issue:3

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzodiazepines; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GluK2 Kainate Receptor; Gyrus Cinguli; In Vitro Techniques; Isoxazoles; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Patch-Clamp Techniques; Propionates; Receptors, Kainic Acid; Synaptic Transmission

2005
Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology.
    Bioorganic & medicinal chemistry, 2005, Sep-15, Volume: 13, Issue:18

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Line; Computer Simulation; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Isoxazoles; Models, Molecular; Oocytes; Patch-Clamp Techniques; Propionates; Rats; Receptors, Glutamate; Xenopus laevis

2005
Effects of the kainate receptor agonist ATPA on glutamatergic synaptic transmission and plasticity during early postnatal development.
    Neuropharmacology, 2007, Volume: 52, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Electrophysiology; Excitatory Amino Acid Agonists; Glutamates; Hippocampus; In Vitro Techniques; Isoxazoles; Neuronal Plasticity; Propionates; Rats; Rats, Wistar; Receptors, Kainic Acid; Signal Transduction; Synapses; Synaptic Transmission

2007
Gender-dependent ATPA-induced changes in long-term potentiation in the rat lateral amygdala.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Volume: 22, Issue:4

    Topics: Amygdala; Animals; Female; Isoxazoles; Long-Term Potentiation; Male; Mitogen-Activated Protein Kinases; Propionates; Rats; Rats, Wistar; Receptors, Kainic Acid; Sex Factors

2008
Neuroprotection of GluR5-containing kainate receptor activation against ischemic brain injury through decreasing tyrosine phosphorylation of N-methyl-D-aspartate receptors mediated by Src kinase.
    The Journal of biological chemistry, 2008, Oct-24, Volume: 283, Issue:43

    Topics: Animals; Brain; Disks Large Homolog 4 Protein; Intracellular Signaling Peptides and Proteins; Ischemia; Isoxazoles; Male; Membrane Proteins; Patch-Clamp Techniques; Phosphorylation; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; src-Family Kinases; Tyrosine

2008
[Different expression of GluR5 and GluR6 in rat astrocyte induced with coriaria lactone and ATPA].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2010, Volume: 41, Issue:4

    Topics: Animals; Animals, Newborn; Astrocytes; Epilepsy; GluK2 Kainate Receptor; Isoxazoles; Lactones; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; RNA, Messenger

2010
Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function.
    Brain research, 2012, Mar-14, Volume: 1443

    Topics: Alanine; Animals; Antipsychotic Agents; Carrier Proteins; Disease Models, Animal; Gene Knockdown Techniques; Isoxazoles; Mice; Nerve Tissue Proteins; Propionates; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Uracil

2012
Neuroprotection of GluK1 kainate receptor agonist ATPA against ischemic neuronal injury through inhibiting GluK2 kainate receptor-JNK3 pathway via GABA(A) receptors.
    Brain research, 2012, May-25, Volume: 1456

    Topics: Animals; Enzyme Activation; gamma-Aminobutyric Acid; GluK2 Kainate Receptor; Isoxazoles; Male; Mitogen-Activated Protein Kinase 10; Neurons; Neuroprotective Agents; Propionates; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Kainic Acid; Reperfusion Injury; Signal Transduction

2012
ATPA induced GluR5-containing kainite receptor S-nitrosylation via activation of GluR5-Gq-PLC-IP(3)R pathway and signalling module GluR5·PSD-95·nNOS.
    The international journal of biochemistry & cell biology, 2012, Volume: 44, Issue:12

    Topics: Animals; Apoptosis; Calcimycin; Calcium Signaling; Disks Large Homolog 4 Protein; GTP-Binding Protein alpha Subunits, Gq-G11; HEK293 Cells; Hippocampus; Humans; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Signaling Peptides and Proteins; Isoxazoles; Membrane Potentials; Membrane Proteins; N-Methylaspartate; Neurons; Nitric Oxide Synthase Type I; Patch-Clamp Techniques; Propionates; Protein Multimerization; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Type C Phospholipases

2012
Electrophysiological effects of kainic acid on vasopressin-enhanced green fluorescent protein and oxytocin-monomeric red fluorescent protein 1 neurones isolated from the supraoptic nucleus in transgenic rats.
    Journal of neuroendocrinology, 2014, Volume: 26, Issue:1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Alanine; Animals; Arginine Vasopressin; Cell Separation; Electric Conductivity; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Green Fluorescent Proteins; Isoxazoles; Kainic Acid; Luminescent Proteins; Neurons; Oxytocin; Patch-Clamp Techniques; Primary Cell Culture; Propionates; Rats; Rats, Transgenic; Receptors, Ionotropic Glutamate; Receptors, Kainic Acid; Red Fluorescent Protein; Supraoptic Nucleus; Thymine

2014
Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, Apr-23, Volume: 34, Issue:17

    Topics: Amygdala; Animals; Epilepsy; Excitatory Amino Acid Agonists; GluK2 Kainate Receptor; Hippocampus; Isoxazoles; Mice; Mice, Knockout; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Seizures

2014