Compounds > alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and willardiine

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with willardiine in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (54.55)18.2507
2000's5 (45.45)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bleakman, D; Deverill, M; Hoo, K; Jane, DE; Kamboj, R; Mandelzys, A1
Barinka, C; Hlouchová, K; Konvalinka, J; Lubkowski, J; Majer, P; Mlcochová, P; Plechanovová, A; Rovenská, M; Slusher, BS; Tsukamoto, T1
Butini, S; Campiani, G; Christensen, JK; Coccone, SS; De Angelis, M; Fiorini, I; Gemma, S; Guarino, E; Morelli, E; Novellino, E; Pickering, DS; Schousboe, A; Trotta, F1
Jane, DE; Mayer, ML; Patneau, DK; Watkins, JC1
Jane, DE; Mayer, ML; Watkins, JC; Wong, LA1
Beaver, KM; Hawkins, LM; Jane, DE; Roberts, PJ; Sunter, DC; Taylor, PM1
Bowie, D; Smart, TG1
Beart, PM; Ganakas, AM; Lawrence, AJ; Lunn, ML; Mercer, LD1
Gouaux, E; Jin, R1
Alt, A; Bleakman, D; Collingridge, GL; Dolman, NP; Jane, DE; Knauss, JL; More, JC; Troop, HM1
Jayaraman, V; Mankiewicz, KA; Rambhadran, A; Wathen, L1

Other Studies

11 other study(ies) available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and willardiine

ArticleYear
Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.
    Journal of medicinal chemistry, 1997, Oct-24, Volume: 40, Issue:22

    Topics: Alanine; Cell Line; Excitatory Amino Acid Agonists; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrimidinones; Radioligand Assay; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Triazines; Uracil

1997
Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.
    Journal of medicinal chemistry, 2007, Jul-12, Volume: 50, Issue:14

    Topics: Crystallography, X-Ray; Glutamate Carboxypeptidase II; Humans; Models, Molecular; Molecular Mimicry; Protein Conformation; Recombinant Proteins

2007
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.
    Journal of medicinal chemistry, 2008, Oct-23, Volume: 51, Issue:20

    Topics: Animals; Cell Line; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Humans; Ligands; Molecular Structure; Oocytes; Pyrimidinones; Rats; Receptors, Glutamate; Spodoptera; Structure-Activity Relationship; Thiophenes; Xenopus laevis

2008
Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992, Volume: 12, Issue:2

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; Ibotenic Acid; Isomerism; Kainic Acid; Kinetics; Mathematics; Mice; Mice, Inbred C57BL; Models, Neurological; Neurons; Pyrimidinones; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Structure-Activity Relationship; Uracil

1992
Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:6

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Binding Sites; Dose-Response Relationship, Drug; Ganglia, Spinal; Hippocampus; Kainic Acid; Kinetics; Neurons; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Time Factors; Uracil

1994
Binding of the new radioligand (S)-[3H]AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardiine.
    Neuropharmacology, 1995, Volume: 34, Issue:4

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cycloleucine; Male; Pyrimidinones; Quinoxalines; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Stereoisomerism; Synaptic Membranes; Tritium; Uracil

1995
Thiocyanate ions selectively antagonize AMPA-evoked responses in Xenopus laevis oocytes microinjected with rat brain mRNA.
    British journal of pharmacology, 1993, Volume: 109, Issue:3

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Cell Membrane; Cerebellum; Electrophysiology; Female; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Microinjections; Neurons; Oocytes; Pregnancy; Pyrimidinones; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Thiocyanates; Uracil; Xenopus laevis

1993
Localisation and properties of AMPA-insensitive kainate sites: receptor autoradiography and gene expression in rat brain.
    Neuroscience letters, 1996, Feb-02, Volume: 204, Issue:1-2

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Base Sequence; Brain; Brain Chemistry; Excitatory Amino Acid Agonists; Gene Expression Regulation; In Vitro Techniques; Male; Molecular Sequence Data; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Uracil

1996
Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal.
    Biochemistry, 2003, May-13, Volume: 42, Issue:18

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Agonists; Kainic Acid; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Pyrimidinones; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Uracil

2003
Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists.
    Journal of medicinal chemistry, 2006, Apr-20, Volume: 49, Issue:8

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cell Line; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Molecular Structure; Pyrimidinones; Rats; Receptors, Kainic Acid; Recombinant Proteins; Structure-Activity Relationship; Time Factors; Uracil

2006
Chemical interplay in the mechanism of partial agonist activation in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.
    Biochemistry, 2008, Jan-08, Volume: 47, Issue:1

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cell Line; Fluorescence Resonance Energy Transfer; Humans; Protein Binding; Protein Conformation; Protein Structure, Secondary; Pyrimidinones; Receptors, AMPA; Spectroscopy, Fourier Transform Infrared; Uracil

2008