Compounds > alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and pentylenetetrazole

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with pentylenetetrazole in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (38.46)18.2507
2000's5 (38.46)29.6817
2010's2 (15.38)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Klitgaard, H; Laudrup, P1
Donevan, SD; Rogawski, MA; Yamaguchi, S1
Chapman, AG; Chimirri, A; Constanti, A; De Sarro, A; De Sarro, G; Gitto, R; Giusti, P; Grasso, S; Libri, V; Quartarone, S; Zappalà, M1
Chimirri, A; Constanti, A; De Sarro, A; De Sarro, G; Gitto, R; Libri, V; Quartarone, S; Zappalà, M1
Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puia, G; Zappalà, M1
Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puja, G; Zappalà, M1
Bevacqua, F; Chimirri, A; De Sarro, A; De Sarro, G; Gitto, R; Quartarone, S; Rizzo, M; Zappalà, M1
Alvarado, R; Camacho-Arroyo, I; Manjarrez, J1
Rensing, N; Rothman, SM; Thio, LL; Weisenfeld, AE; Wong, M; Xu, L; Yamada, KA; Yang, XF; Zhang, HX1
Diano, S; Horvath, TL1
Aizenman, CD; Bell, MR; Deeg, KE; Lee, RH; Marsh-Armstrong, N; Mills, EA; Ruthazer, ES; Schwartz, N1
Banerjee, AG; Das, N; Shrivastava, SK1
Abulkhair, HS; Ahmed, HEA; Akl, EN; Bayoumi, AH; El-Adl, K; El-Morsy, A; El-Zoghbi, MS; Elmeligie, S; Ghiaty, A; Hassan, MH; Zayed, MF1

Other Studies

13 other study(ies) available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and pentylenetetrazole

ArticleYear
Metabotropic excitatory amino acid receptor agonists selectively potentiate behavioral effects induced by ionotropic excitatory amino acid receptor agonists in mice.
    European journal of pharmacology, 1993, Nov-30, Volume: 250, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Drug Synergism; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotoxins; Pentylenetetrazole; Receptors, Glutamate; Seizures

1993
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
    Epilepsy research, 1993, Volume: 15, Issue:3

    Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hindlimb; Kainic Acid; Male; Mice; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures

1993
1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.
    Journal of medicinal chemistry, 1997, Apr-11, Volume: 40, Issue:8

    Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Mice; Mice, Inbred DBA; Pentylenetetrazole; Pyrrolidinones; Receptors, AMPA; Seizures

1997
3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists.
    Journal of medicinal chemistry, 1998, Aug-27, Volume: 41, Issue:18

    Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepines; Convulsants; Electroshock; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; Motor Activity; Olfactory Pathways; Patch-Clamp Techniques; Pentylenetetrazole; Pyrrolidinones; Rats; Receptors, AMPA; Seizures; Structure-Activity Relationship; Thiones

1998
Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists.
    Journal of medicinal chemistry, 1999, Oct-21, Volume: 42, Issue:21

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; Convulsants; Drug Evaluation, Preclinical; Electroshock; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; Mice, Inbred DBA; Motor Activity; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Seizures

1999
Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.
    Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15

    Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; Convulsants; Drug Evaluation, Preclinical; Electroshock; Excitatory Amino Acid Agonists; Isoxazoles; Kainic Acid; Mice; Mice, Inbred DBA; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Phthalazines; Propionates; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Structure-Activity Relationship

2000
Synthesis and evaluation of pharmacological and pharmacokinetic properties of 11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones.
    Journal of medicinal chemistry, 2000, Dec-14, Volume: 43, Issue:25

    Topics: Acoustic Stimulation; Allosteric Regulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepines; Chromatography, High Pressure Liquid; Electroshock; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Inbred DBA; Motor Activity; Pentylenetetrazole; Pyrrolidinones; Receptors, AMPA; Seizures; Structure-Activity Relationship

2000
Differential effects of NMDA antagonists microinjections into the nucleus reticularis pontis caudalis on seizures induced by pentylenetetrazol in the rat.
    Epilepsy research, 2001, Volume: 46, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizocilpine Maleate; Electroencephalography; Excitatory Amino Acid Antagonists; Male; Microinjections; N-Methylaspartate; Pentylenetetrazole; Pons; Rats; Rats, Wistar; Reticular Formation; Seizures

2001
Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents.
    The Journal of clinical investigation, 2008, Volume: 118, Issue:1

    Topics: 4-Aminopyridine; Administration, Intranasal; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Convulsants; Hypothalamus; Janus Kinase 2; Leptin; Male; Mice; Mice, Knockout; Neurons; Pentylenetetrazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Leptin; Seizures; Synaptic Transmission

2008
Anticonvulsant effects of leptin in epilepsy.
    The Journal of clinical investigation, 2008, Volume: 118, Issue:1

    Topics: 4-Aminopyridine; Administration, Intranasal; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Convulsants; Hypothalamus; Janus Kinase 2; Leptin; Male; Mice; Mice, Knockout; Neurons; Pentylenetetrazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Leptin; Seizures; Synaptic Transmission

2008
Neurodevelopmental effects of chronic exposure to elevated levels of pro-inflammatory cytokines in a developing visual system.
    Neural development, 2010, Jan-12, Volume: 5

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Avoidance Learning; Behavior, Animal; Convulsants; Cytokines; Dendrites; Electrophysiology; Excitatory Postsynaptic Potentials; GABA Antagonists; Interleukin-1beta; Interleukin-6; Larva; N-Methylaspartate; Nervous System; Neural Pathways; Neurons; Pentylenetetrazole; Retina; Seizures; Superior Colliculi; Synapses; Synaptic Transmission; Tectum Mesencephali; Time Factors; Tumor Necrosis Factor-alpha; Visual Pathways

2010
Design, synthesis and pharmacological evaluation of N3 aryl/ heteroaryl substituted 2-((benzyloxy and phenylthio) methyl) 6,7- dimethoxyquinazolin-4(3H)-ones as potential anticonvulsant agents.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2014, Volume: 10, Issue:8

    Topics: Alanine Transaminase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Aspartate Aminotransferases; Convulsants; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Electroshock; Female; Injections, Intraventricular; Injections, Subcutaneous; Liver; Male; Mice; Motor Activity; Pentylenetetrazole; Quinazolinones; Rats; Rotarod Performance Test; Seizures; Structure-Activity Relationship

2014
In vivo- and in silico-driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors.
    Archiv der Pharmazie, 2021, Volume: 354, Issue:5

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mice; Molecular Docking Simulation; Molecular Structure; Pentylenetetrazole; Quinoxalines; Seizures; Structure-Activity Relationship

2021